检索结果-南通市图书馆

Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第3期3卷 30-42页

作者： Borui Su Dong Gao Nini Xin Kai Wu Mei Yang shichao Jiang Yusheng Zhang Jie ding Chengheng Wu Jing Sun Dan Wei Hongsong Fan Zhenzhen Guo National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan 610064China Institute of Regulatory Science for Medical Devices Sichuan UniversityChengduSichuan 610064China Department of Gastroenterology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610o72China

Lipid droplets(LDs)participating in various cellular activities and are increasingly being *** imaging provides powerful tool for dynamic tracking of LDs,however,most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield(PLQY),poor photostability and tedious washing ***,a novel yellow-emissive carbon dot(OT-cD)has been synthesized conveniently with high PLQY up to 90%.Besides,OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid-water partition coefficient higher than 2,which is much higher than most LDs *** characters enable OT-CD high brightness,stable and wash-free LDs probing,and feasible for in vivo ***,detailed observation of LDs morphological and polarity variation dynamically in different cellular states were recorded,including ferroptosis and other diseases ***,fast whole imaging of zebrafish and identifed LD enrichment in injured liver indicate its further feasibility for in vivo *** contrast to the reported studies to date,this approach provides a versatile conventional synthesis system for high-performance LDs targeting probes,combing the advantages of easy and high-yield production,as well as robust brightness and stability for long-term imaging,facilitating investigations into organelle interactions and LD-associated diseases.

关键词： lipid droplet probe carbon dots fluorescence imaging wash-free dynamic monitoring

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于AHP的大学国际化风险评价研究

科技管理研究 2015年第17期35卷 59-65页

作者：丁仕潮周密李媛安庆师范学院经济与管理学院安徽安庆246133 中国科学技术大学国际合作与交流部安徽合肥230026

大学国际化建设过程中面临不确定因素较多,这给国际化目标的实现带来了较大风险。结合我国大学国际化的内涵,从战略管理的角度构建大学国际化风险指标体系;通过利用层次分析法建立风险评价模型;通过案例分析计算出各指标的相对权重并进... 详细信息

大学国际化建设过程中面临不确定因素较多,这给国际化目标的实现带来了较大风险。结合我国大学国际化的内涵,从战略管理的角度构建大学国际化风险指标体系;通过利用层次分析法建立风险评价模型;通过案例分析计算出各指标的相对权重并进行排序,由此确定大学国际化风险的等级程度,为大学国际化的风险管理提供依据。

关键词：层次分析法大学国际化风险评价

Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma

在线全文

学校读者我要写书评

暂无评论

Research 2021年第1期2021卷 1379-1390页

作者： Xiaoli Cai Mingming Wang Peng Mu Tengyue Jian Dong Liu shichao ding Yanan Luo Dan Du Yang Song Chun-Long Chen Yuehe Lin School of Mechanical and Materials Engineering Washington State UniversityPO Box 642920 PullmanWashington 99164USA Physical Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Mechanical Engineering and Materials Science and Engineering Program State University of New YorkBinghamtonNew York 13902USA

Near-infrared(NIR)laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer ***,insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen(1 O2)distribution over tumors from phototherapy results in tumor recurrence and inferior *** achieve high tumor killing efficacy,one of the solutions is to employ the combinational treatment of phototherapy with other modalities,especially with chemotherapeutic *** this paper,a simple and effective multimodal therapeutic system was designed via combining chemotherapy,photothermal therapy(PTT),and photodynamic therapy(PDT)to achieve the polytherapy of malignant glioma which is one of the most aggressive tumors in the ***-780(IR780)dye-labeled tube-forming peptoids(PepIR)were synthesized and self-assembled into crystalline nanotubes(PepIR nanotubes).These PepIR nanotubes showed an excellent efficacy for PDT/PTT because the IR780 photosensitizers were effectively packed and separated from each other within crystalline nanotubes by tuning IR780 density;thus,a self-quenching of these IR780 molecules was significantly ***,the efficient DOX loading achieved due to the nanotube large surface area contributed to an efficient and synergistic chemotherapy against glioma *** the unique properties of peptoids and peptoid nanotubes,we believe that the developed multimodal DOX-loaded PepIR nanotubes in this work offer great promises for future glioma therapy in clinic.

关键词： chemotherapy IR780 modal

区域科技创新与文化产业耦合协调发展研究——以安徽省为例

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

滁州学院学报 2018年第2期20卷 1-6页

作者：丁仕潮安庆师范大学经济与管理学院

文化产业已成为新时期安徽省国民经济重要的增长点之一。科技创新对文化产业具有重要的推动和支撑作用。文章通过分析区域科技创新与文化产业的耦合机制,构建了区域科技创新与文化产业的耦合度与耦合协调度模型,并利用2013年的截面数据... 详细信息

文化产业已成为新时期安徽省国民经济重要的增长点之一。科技创新对文化产业具有重要的推动和支撑作用。文章通过分析区域科技创新与文化产业的耦合机制,构建了区域科技创新与文化产业的耦合度与耦合协调度模型,并利用2013年的截面数据,对安徽省16个地级市的科技创新与文化产业的耦合协调效应进行了评价。结果表明:安徽省科技创新与文化产业耦合协调度整体偏低,不同地级市的耦合协调度差异明显,呈现由东向西的递减特征,而且合肥市表现一枝独秀,合芜蚌创新试验区优势突出。

关键词：科技创新文化产业耦合协调度

生命周期视角下国际合著论文的国际化水平测度研究

在线全文

学校读者我要写书评

暂无评论

科学学与科学技术管理 2016年第12期37卷 33-40页

作者：范杜芳周密丁仕潮中国科学技术大学管理学院合肥230026 中国科学技术大学国际合作与交流部合肥230026 安庆师范大学经济与管理学院安徽安庆246133

国际科研交流与学术合作是实现高等教育国际化发展的重要举措,也是世界一体化、科技全球化下的必然要求。高校国际化水平测度和科研人员的国际合作绩效评价中经常使用国际合著论文指标。引入生命周期理论,将国际合著论文的国际化水平定... 详细信息

国际科研交流与学术合作是实现高等教育国际化发展的重要举措,也是世界一体化、科技全球化下的必然要求。高校国际化水平测度和科研人员的国际合作绩效评价中经常使用国际合著论文指标。引入生命周期理论,将国际合著论文的国际化水平定义为论文在"生产—发表—利用"3个不同生命阶段中对科学领域产生的国际影响程度。通过对国际合著论文在3个生命阶段中的国际化水平测度,用TOPSIS法建立了国际合著论文国际化水平综合评价的数学模型。

关键词：生命周期国际合著论文大学国际化科研绩效

新型城镇化与文化产业发展的耦合协调研究——以安徽省为例

在线全文

学校读者我要写书评

暂无评论

安徽理工大学学报（社会科学版） 2018年第1期20卷 24-31页

作者：丁仕潮安庆师范大学经济与管理学院安徽安庆246133

新型城镇化是我国全面建成小康社会的重要战略路径。新型城镇化以人为核心,强调特色与产业支撑。文化产业是实现新型城镇化的重要渠道,而新型城镇化也为文化产业发展奠定了坚实基础,二者耦合关系显著。通过分析新型城镇化与文化产业的... 详细信息

新型城镇化是我国全面建成小康社会的重要战略路径。新型城镇化以人为核心,强调特色与产业支撑。文化产业是实现新型城镇化的重要渠道,而新型城镇化也为文化产业发展奠定了坚实基础,二者耦合关系显著。通过分析新型城镇化与文化产业的耦合机制,构建了新型城镇化与文化产业的耦合度与耦合协调度模型,利用2013年的截面数据,对安徽省16个地级市的新型城镇化与文化产业的耦合协调效应进行了评价。研究发现:安徽省新型城镇化与文化产业耦合协调度整体偏低,不同地级市的耦合协调度差异明显,呈现由东向西的递减特征,绝大多数处于低度失调及以下水平,合肥一枝独秀,远超其他城市。

关键词：新型城镇化文化产业耦合协调

A New Residual Stress Measurement Method for Roll Formed Products

在线全文

学校读者我要写书评

暂无评论

A New Residual Stress Measurement Method for Roll Formed Pro...

Single-Atomic Site Catalyst Enhanced Lateral Flow Immunoassay for Point-of-Care Detection of Herbicide

“第十届中国钢铁年会”暨“第六届宝钢学术年会”

作者： Sun Yong Li Yaguang Liu Zhaobing Daniel W.J.T. Li Dayong ding shichao School of Mechanical and Mining Engineering The University of Queensland Institute of PFKBE School of Mechanical EngineeringShanghai Jiaotong University

The residual stress in a roll formed product is generally very high and un-predictable. This is due to the occurrence of redundant plastic deformation in the roll forming process and it cancause various product defects. Although the residual stress of a roll formed product consists of longitudinal and transverse residual stress components, the longitudinal residual stressplays a key role in causingproduct defects of a roll formed product and therefore, the longitudinal residual stress is of mostconcern to the roll forming scholars and engineers. However, how to inspect the residual stress of a product quickly and economically as a routine operation is still a challenge. This paper introduces a new residual stress measurement method to study the longitudinal residual stressvariation through layers of the thickness of a roll formed product. The new method is also extendable to a product with similar processing such as a rolled *** detailed measuring procedure is given and discussed. The residual stress variation through eachlayer can be derived based on the variation of curvature in different layers and steps. This new method has been explored and validated by experimental study on a roll formed square tube. The new method is expected to be a routine testing method to monitor the quality of a product that has been formed and that could have a great impact on the roll forming industry.

关键词： roll forming residual stress measurement method

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Research 2023年第1期2022卷 63-74页

作者： Zhaoyuan Lyu shichao ding Peter Tieu Lingzhe Fang Xin Li Tao Li Xiaoqing Pan Mark H.Engelhard Xiaofan Ruan Dan Du Suiqiong Li Yuehe Lin School of Mechanical and Material Engineering Washington State UniversityPullmanWA 99164USA Department of Chemistry University of CalforniaIrvineIrvineCA 92697USA Department of Chemistry and Biochemistry Northern Ilinois UniversityDeKalbIL 60115USA X-ray Science Division Argonne National LaboratoryLemontIL 60439USA Irvine Materials Research Institute(IMRI) Department of Materials Science and EngineeringUniversity of CaliforniaIrvineIrvineCA92697USA Environmental Molecular Sciences Laboratory Pacific Northwest National LaboratoryRichlandWA 99354USA DL ADV-Tech PullmanWA 99163USA

Point-of-care(POC)detection of herbicides is of great importance due to their impact on the environment and potential risks to human ***,we design a single-atomic site catalyst(SASC)with excellent peroxidase-like(POD-like)catalytic activity,which enhances the detection performance of corresponding lateral flow immunoassay(LFIA).The iron single-atomic site catalyst(Fe-SASC)is synthesized from hemin-doped ZIF-8,creating active sites that mimic the Fe active center coordination environment of natural enzyme and their *** to its atomically dispersed iron active sites that result in maximum utilization of active metal atoms,the Fe-SASC exhibits superior POD-like activity,which has great potential to replace its natural ***,the catalytic mechanism of Fe-SASC is systematically *** its outstanding catalytic activity,the Fe-SASC is used as label to construct LFIA(Fe-SASC-LFIA)for herbicide *** 2,4-dichlorophenoxyacetic acid(2,4-D)is selected as a target here,since it is a commonly used herbicide as well as a biomarker for herbicide exposure evaluation.A linear detection range of 1-250 ng/mL with a low limit of detection(LOD)of 0.82 ng/mL has been ***,excellent specificity and selectivity towards 2,4-D have been *** outstanding detection performance of the Fe-SASC-LFIA has also been demonstrated in the detection of human urine samples,indicating the practicability of this POC detection platform for analyzing the 2,4-D exposure level of a *** believe this proposed Fe-SASC-LFIA has potential as a portable,rapid,and high-sensitive POC detection strategy for pesticide exposure evaluation.

关键词： catalyst replace dispersed

独立董事地缘关系会影响企业投资效率吗?——基于A股资本市场经验证据

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

淮南师范学院学报 2019年第1期21卷 26-33页

作者：胡琴丁仕潮安庆师范大学经济与管理学院安徽安庆246133

在公司治理结构中,作为重要内部治理机制之一的独立董事制度不可或缺。本地独立董事与上市公司之间形成的地缘关系会对企业投资行为产生影响。结合我国上市公司制度背景与市场环境,运用实证研究方法,探讨独立董事地缘关系对企业投资效... 详细信息

在公司治理结构中,作为重要内部治理机制之一的独立董事制度不可或缺。本地独立董事与上市公司之间形成的地缘关系会对企业投资行为产生影响。结合我国上市公司制度背景与市场环境,运用实证研究方法,探讨独立董事地缘关系对企业投资效率的影响。研究表明:(1)独立董事地缘关系显著提高了企业投资效率;(2)将非效率投资分为投资过度和投资不足两种情形,发现独立董事地缘关系可以抑制公司投资过度行为,但对投资不足的弥补作用并不明显;(3)相对于国企,非国企中独立董事地缘关系对投资过度的抑制作用更加明显。

关键词：独立董事地缘关系公司治理投资效率