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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： shichang liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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YOLO-Drone:A Scale-Aware Detector for Drone Vision

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Chinese Journal of Electronics 2024年第4期33卷 1034-1045页

作者： Yutong LI Miao MA shichang liu Chao YAO Longjiang GUO School of Computer Science Shaanxi Normal University Key Laboratory of Modern Teaching Technology Ministry of Education College of Computer Science Sichuan University

Object detection is an important task in drone vision. Since the number of objects and their scales always vary greatly in the drone-captured video, small object-oriented feature becomes the bottleneck of model performance, and most existing object detectors tend to underperform in drone-vision scenes. To solve these problems, we propose a novel detector named YOLO-Drone. In the proposed detector, the backbone of YOLO is firstly replaced with ConvNeXt, which is the state-of-the-art one to extract more discriminative features. Then, a novel scale-aware attention(SAA) module is designed in detection head to solve the large disparity scale problem. A scale-sensitive loss(SSL) is also introduced to put more emphasis on object scale to enhance the discriminative ability of the proposed detector. Experimental results on the latest VisDrone 2022 test-challenge dataset(detection track) show that our detector can achieve average precision(AP) of 39.43%, which is tied with the previous state-of-the-art, meanwhile,reducing 39.8% of the computational cost.

关键词： YOLO Costs Object oriented modeling Computational modeling Detectors Feature extraction Data models

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Theoretical and experimental research on influence of rotor taper on performance of cone-shape helical pumps

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High Technology Letters 2019年第2期25卷 174-181页

作者： Zhao Jianhua Gao Dianrong liu shichang Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Yanshan University

The structure of a rotor has full impact on the performance of cone-shaped helical pumps. Numerical simulation and experimental tests are applied to get pressure, velocity and flow of a cone-shaped helical pump, and explores flow condition of blood in artificial blood pump. Rotors with four different tapers of artificial pump are designed. The flow condition of blood at the entrance, near the front diffuser, near the rotor, near the rear diffuser and at the exit, the pressure difference between entrance and exit and flow of artificial blood pump with different taper rotors are simulated, and then the influence rules of rotor taper on the performance of cone-shaped helical pump are revealed. In order to verify the correctness of theoretical analysis, rotors with three different tapers are manufactured, physical model of artificial blood pump are built, and then the actual lift and flow of blood pump with different rotors are measured respectively. The results show that taper of rotor increases, the circumfluence of blood near the front and rear diffuser decreases, the blood flows more smoothly, the energy consumption is less, and then the guide role of blade is greater. The blood at the exit of blood pump flows along the axial direction steadily. As taper of rotor increases, the pressure difference between the entrance and exit and the flow of blood pump increase subsequently. The flow condition of blood and performance of blood pump with No.3 rotor are the best. The proposed research analyzes the influence of rotor taper on performance of blood pump quantitatively, and provides the theoretical reference for the design and improving of cone-shaped helical pump.

关键词： cone-shaped helical pump rotor taper circumfluence flow condition energy consumption

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Deep learning based water leakage detection for shield tunnel lining

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 887-898页

作者： shichang liu Xu XU Gwanggil JEON Junxin CHEN Ben-Guo HE College of Computer Science Sichuan UniversityChengdu 610065China School of Computer Science and Engineering Northeastern UniversityShenyang 110004China Department of Embedded Systems Engineering Incheon National UniversityIncheon 22012Korea School of Software Dalian University of TechnologyDalian 116621China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China

Shield tunnel lining is prone to water leakage,which may further bring about corrosion and structural damage to the walls,potentially leading to dangerous *** avoid tedious and inefficient manual inspection,many projects use artificial intelligence(Al)to detect cracks and water leakage.A novel method for water leakage inspection in shield tunnel lining that utilizes deep learning is introduced in this *** proposal includes a ConvNeXt-S backbone,deconvolutional-feature pyramid network(D-FPN),spatial attention module(SPAM).and a detection *** can extract representative features of leaking areas to aid inspection *** further improve the model's robustness,we innovatively use an inversed low-light enhancement method to convert normally illuminated images to low light ones and introduce them into the training *** experiments are performed,achieving the average precision(AP)score of 56.8%,which outperforms previous work by a margin of 5.7%.Visualization illustrations also support our method's practical effectiveness.

关键词： water leakage detection deep learning deconvolutional-feature pyramid spatial attention

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Achieving Fine-Grained Microstructure and Superior Mechanical Property in a Plain Low-Carbon Steel Using Heavy Cold Rolling Combined with Short-Time Heat Treatment

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Acta Metallurgica Sinica(English Letters) 2023年第10期36卷 1719-1734页

作者： Yuxuan liu shichang liu Liming Fu Huanrong Wang Wei Wang Mao Wen Aidang Shan School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Shenyang Research Institute of Foundry Shenyang110022China Baosteel Research Institute Baoshan Iron and Steel Co.Ltd.Shanghai201900China

A new thermomechanical process consisting of heavy cold rolling(HCR)and short-time heat treatment(STH)is developed to fabricate fine-grained martensite microstructure in a low-cost plain low-carbon *** achieve the optimal mechanical properties after STH,three different ferrite-pearlite(F-P)dual-phase microstructures are prepared via hot rolling(HR),HR and austenitizing,and HR and *** microstructure evolution and the comprehensive mechanical properties of the alloy during STH are then *** find that the volume fractions of transformed martensite after STH increase with decreasing grain sizes of the pre-STH F-P dual *** rapid heating and short-time holding of STH promote grain nucleation and inhibit grain growth,resulting in microstructure *** formation of martensites with different morphologies and different carbon concentrations in the HR and HCR+STH alloy is identified,owing to the inhomogeneous carbon distribution by *** experiments demonstrate that STH greatly improves the comprehension mechanical properties of the *** mechanical properties,with a yield strength of 1224 MPa,a tensile strength of 1583 MPa,a uniform elongation of 4.0%and a total elongation of 7.3%are achieved in the HR and HCR+STH *** excellent mechanical properties are principally attributed to the microstructure refinement and martensite formation induced by STH,with a yield strength improvement of 134%and a tensile strength improvement of 150%relative to the HR alloy.

关键词： Heat treatment Microstructure Plain low-carbon steel Mechanical properties

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Quantitative Analysis of Cytokinins in Plants by High Performance Liquid Chromatography:Electronspray Ionization Ion Trap Mass Spectrometry

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Journal of Integrative Plant Biology 2010年第10期52卷 925-932页

作者： Weiqi Chen Ying Gai shichang liu Renxiao Wang Xiangning Jiang College of Life Sciencesand Biotechnology Bering Forestry University The Tree and Ornamental Plant Bree~ng and BiotechnologyLaboratory of Chinese Forestry Administration National Engineering Laboratory for Tree Breeding Beijing 100083 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

The present paper introduces a highly sensitive and selective method for simultaneous quantification of 12 cytokinins （free form and their conjugates）. The method includes a protocol of extraction with methanol/water/formic acid （15/4/1, v/v/v） to the micro-scale samples, pre-purification with solid phase extraction （SPE） cartridges of the extracts, separation with a high performance liquid chromatography （HPLC） and detection by an electrospray ionization ion trap mass spectrometry （ESl-lon trap-MS） system in a consecutive ion monitoring （CRM） mode at the three stage fragmentation of mass spectrometry （MS3）. The lowest detection level of the cytokinins of the method reaches 0.1-2.0 pg with a very wide range of linear regression from 1-512 pg, at the coefficient factors of 0.98-0.99. The feasibility of this method has been proven in the application of the method to the analysis of the trace-amount contents of cytokinins in the micro-scale samples of various types of plant materials, such as aerial parts of rice and poplar leaves etc. 12 endogenous cytokinins had been identified and quantified in the plant tissues, with an acceptable relatively higher recovery rate from 40% to 70%.

关键词： CYTOKININS HIGH performance liquid chromatography ION traps MASS spectrometry QUANTITATIVE research EXTRACTION (Chemistry) PLANT cells & tissues REGRESSION analysis FORMIC acid PLANT extracts

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High strength-ductility nano-structured high manganese steel produced by cryogenic asymmetry-rolling

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Journal of Materials Science & Technology 2018年第4期34卷 695-699页

作者： Bin Fu Liming Fu shichang liu Huan Rong Wang Wei Wang Aidang Shan School of Materials Science and Engineering Shanghaifiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai 201418China Shenyang Research Institute of Foundry Shenyang 110022China Baosteel Research Institute Shanghai 201900China

A bulk nanostructured twinning-induced plasticity （TWIP） steel with high ductility and high strength was fabricated by cryogenic asymmetry-rolling （cryo-ASR） and subsequent recovery treatment. It was found that the cryo-ASRed TWIP steels exhibit simultaneous improvements in the ductility, strength and work hardening. Typical microstructures of the cryo-ASR TWIP steel were characterized by shear bands and intensive mechanical nano-sized twins induced by cryogenic deformation. These mechanical nano-scale twins remain thermally stable during the subsequent recovery treatment. It is believed that the ductility enhancement and high work-hardening ability for the cryo-ASR TWIP steels should be mainly attributed to the high-densitv pre-existing nano-scale twins.

关键词： Nano-structured TWIP steel Cryogenic deformation Asymmetric rolling (ASR) Nano-scale twins Work hardening ability

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Research Progress of Metal-Based Shielding Materials for Neutron and Gamma Rays

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Acta Metallurgica Sinica(English Letters) 2021年第12期34卷 1609-1617页

作者： Bin Gan shichang liu Zhen He Fucai Chen Haoxuan Niu Jingchang Cheng Bo Tan Bo Yu Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu610213China State Key Laboratory of Light Alloy Casting Technology for High-End Equipment Shenyang Research Institute of Foundry Co.Ltd.Shenyang110022China

The radiation generated by nuclear reaction is harmful to human body and equipment,thus the radiation shielding materials that employ the shielding ability from neutron and gamma rays are the best candidates according to application situations and radiation *** this paper,the researches of metal-based neutron and gamma rays or multiple purpose shielding materials are systematically summarized,and the respective and principal problems of these materials with respect to shielding effectiveness and other performances,such as corrosion,mechanical properties,manufacture,etc.,are ***,the prospect of shielding materials is outlined,which suggests that the development of highly efficient and multiply functional radiation shielding materials with good environmental compatibility is one of the future development trends.

关键词： Radiation shielding materials Metal-based Boron-containing shielding materials High density alloys

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Capturing the hierarchically assorted modules of protein–protein interactions in the organized nucleome

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Molecular Plant 2023年第5期16卷 930-961页

作者： Shuaijian Dai shichang liu Chen Zhou Fengchao Yu Guang Zhu Wenhao Zhang Haiteng Deng Al Burlingame Weichuan Yu Tingliang Wang Ning Li Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina Tsinghua-Peking Joint Centre for Life Sciences Centre for Structural BiologySchoolof Life Sciences and Schoolof MedicineTsinghua UniversityBejing 100084China The Hk.UST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhenGuangdong 518057China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong SARChina Department of Pharmaceutical Chemistry University of CaliforniaSan FranciscoSan FranciscoCAUSA

Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear *** decipher the global connectivity of nuclear proteins and the hierarchically organized modules of their interactions,we conducted two rounds of cross-linking mass spectrometry(XL-MS)analysis,one of which followed a quantitative double chemical cross-linking mass spectrometry(in vivo qXL-MS)workflow,and identified 24,140 unique crosslinks in total from the nuclei of soybean *** in vivo quantitative interactomics enabled the identification of 5340 crosslinks that can be converted into 1297 nuclear protein–protein interactions(PPIs),1220(94%)of which were non-confirmative(or novel)nuclear PPIs compared with those in *** were 250 and 26 novel interactors of histones and the nucleolar box C/D small nucleolar ribonucleoprotein complex,*** analysis of orthologous Arabidopsis PPIs produced 27 and 24 master nuclear PPI modules(NPIMs)that contain the condensate-forming protein(s)and the intrinsically disordered region–containing proteins,*** NPIMs successfully captured previously reported nuclear protein complexes and nuclear bodies in the ***,these NPIMs were hierarchically assorted into four higher-order communities in a nucleomic graph,including genome and nucleolus *** combinatorial pipeline of 4C quantitative interactomics and PPI network modularization revealed 17 ethylene-specific module variants that participate in a broad range of nuclear *** pipeline was able to capture both nuclear protein complexes and nuclear bodies,construct the topological architectures of PPI modules and module variants in the nucleome,and probably map the protein compositions of biomolecular condensates.

关键词： nucleome 4C interactomics in vivo qXL-MS biomolecular modulomics CHAMPION 4D biomolecular modulomes

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基于CENDL-3.2的多群截面库含Be快临界基准分析

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核技术 2022年第6期45卷 73-78页

作者：吴军刘仕倡陈义学华北电力大学核科学与工程学院北京102206

中国评价核数据库最新版CENDL-3.2(Chinese Evaluated Nuclear DataLibrary)已于2020年6月发布,对包括核工程计算中常用的^(235)U、^(238)U、^(239)Pu、^(56)Fe等134个核素的中子反应数据重新进行了评价和计算,与CENDL-3.1相比,CENDL-3.2数据种类和数据质量均有大幅提高。Be由于其散射截面大、吸收截面小,常被用作熔盐堆燃料载体盐成分之一,其反应截面数据的准确性在熔盐堆设计中不容忽视。基于CENDL-3.2评价核数据库,采用NJOY制作了199群中子、42群光子的MATXS格式多群截面库,挑选了35个含Be快临界基准对其进行检验分析,并与基于ENDF/B-7.1和JENDL-4.0的多群截面库计算结果进行对比。分析表明:基于CENDL-3.2多群截面库计算的26个基准题(74.29%)的结果与实验值偏差在0.5%以内,整体上优于ENDF/B-7.1和JENDL-4.0。表明CENDL-3.2中的Be数据和基于CENDL-3.2的多群截面库及其制作方法是可靠的,能够用于熔盐堆相关设计计算。

关键词： CENDL-3.2 多群截面库 Be 快临界基准

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