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选区激光熔化成形Ti6Al4V制件的断裂机制研究

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应用激光 2021年第6期41卷 1215-1222页

作者：施承坤袁艳萍李震相世博陈继民北京工业大学材料与制造学部激光工程研究院北京100124 北京工业大学北京市数字化医疗3D打印工程技术研究中心北京100124 中国人民解放军61646部队北京100089

选区激光熔化成形过程中的加工参数对其制件的性能有重要的影响,因此,研究了选区激光熔化加工过程中不同扫描速度和不同激光功率对成形的Ti6Al4V合金制件的性能的影响,主要包括制件的断裂行为,并从其微观组织结构着手,研究了Ti6Al4V合... 详细信息

选区激光熔化成形过程中的加工参数对其制件的性能有重要的影响,因此,研究了选区激光熔化加工过程中不同扫描速度和不同激光功率对成形的Ti6Al4V合金制件的性能的影响,主要包括制件的断裂行为,并从其微观组织结构着手,研究了Ti6Al4V合金制件的断裂机制。试验结果表明:在不同的加工参数下,制备的Ti6Al4V合金制件的断口形貌有显著差异;通过选择不同的扫描速度和激光功率,可有效调控Ti6Al4V合金制件断口处金属晶粒的大小、内部孔洞缺陷等。通过对选区激光熔化成形Ti6Al4V合金制件的断口形貌分析,得到最优化的加工参数为:激光功率240 W、扫描速度1200 mm/s、铺粉层厚0.03 mm及扫描间距0.14 mm。此时,Ti6Al4V合金制件的抗拉强度达到1177 MPa。

关键词：选区激光熔化 Ti6Al4V 断口形貌力学性能

Photodegradation of methylmercury in the water body of the Three Gorges Reservoir

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Science China Chemistry 2015年第6期58卷 1073-1081页

作者： Rongguo Sun Dingyong Wang Wen Mao shibo Zhao Cheng Zhang xiang Zhang Chongqing Key Laboratory of Soil Multiscale Interfacial Process College of Resource and Environment Southwest University School of Chemistry and Material Guizhou Normal University Chongqing Key Laboratory of Agricultural Resources and Environment

Biogeochemical cycling of mercury in the young Three Gorges Reservoir （TGR）, China, is strongly considered. Although methylmercury （MMHg） photodegradation （PD） is an important process involved in mercury cycling in this zone, little is known about this process. In situ incubation experiments were therefore performed to quantify the effect of different wave- length radiations and environmental factors on the PD process of MMHg in the water bodies of TGR. It was found that the ef- fect of solar radiation on MMHg PD was highly dependent on wavelength and water depth. All PD-rate constants resulting from each wavelength range decreased rapidly with water depth. For surface water, UV-A radiation （320-400 nm） was the key driver, accounting for 49%-62% of MMHg PD. For the entire water column, both photosynthetically active radiation （PAR, 400-700 nm） and UV-A were responsible for MMHg PD. MMHg PD fluxes peaked in summer （7.5-18 ng m-2 d-1）, followed by spring （3.3-8.0 ng m-2 d-1）, autumn （1.0-2.7 ng m-2 d-1）, and winter （0.060-0.15 ng m-2 d-1）. The annual fluxes of MMHg PD were estimated to be 1.1-2.8 μg m-2 at. Filtering the reservoir water and amending it with chemicals （i.e., CV, NO C, and dissolved organic matter （DOM）） showed significant effects on MMHg PD rate constants. Stepwise regression analysis showed that intensity of solar radiation, suspended particulate matter （SPM）, DOM, CI-, and NO3- were involved in the PD process. Path analysis clarified the relationship between MMHg PD rate constants and environmental variables, as well as the comparative strength of direct and indirect relationships among variables. The results are of great importance for understanding MMHg cycling characteristics in TGR and also facilitate the understanding of the underlying process, MMHg PD, in natural waters.

关键词： methylmercury photodegradation influencing factor stepwise regression analysis path analysis Three GorgesReservoir

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2069-2087页

作者： Qianqian Zhang Rong xiang Shanshan Huo Yunjiao Zhou shibo Jiang Qiao Wang Fei Yu key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina College of Life Sciences Hebei Agricultural UniversityBaodingChina

The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has resulted in an unprecedented setback for global economy and ***-CoV-2 has an exceptionally high level of transmissibility and extremely broad tissue ***,the underlying molecular mechanism responsible for sustaining this degree of virulence remains largely *** this article,we review the current knowledge and crucial information about how SARS-CoV-2 attaches on the surface of host cells through a variety of receptors,such as ACE2,neuropilin-1,AXL,and antibody-FcyR *** further explain how its spike(S)protein undergoes conformational transition from prefusion to postfusion with the help of proteases like furin,TMPRSS2,and *** then review the ongoing experimental studies and clinical trials of antibodies,peptides,or small-molecule compounds with anti-SARS-CoV-2 activity,and discuss how these antiviral therapies targeting host-pathogen interaction could potentially suppress viral attachment,reduce the exposure of fusion peptide to curtail membrane fusion and block the formation of six-helix bundle(6-HB)fusion ***,the specter of rapidly emerging SARS-CoV-2 variants deserves a serious review of broad-spectrum drugs or vaccines for long-term prevention and control of COVID-19 in the future.

关键词： prevention drugs respiratory

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 733-744页

作者： Fei Yu Rong xiang Xiaoqian Deng Lili Wang Zhengsen Yu Shijun Tian Ruiying Liang Yanbai Li Tianlei Ying shibo Jiang College of Life Sciences Hebei Agricultural UniversityBaodingChina Research Center of Chinese Jujube Hebei Agricultural UniversityBaodingChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghaiChina

The outbreaks of severe acute respiratory syndrome(SARS)and Coronavirus Disease 2019(COVID-19)caused by SARS-CoV and SARS-CoV-2,respectively,have posed severe threats to global public health and the *** and prevention of these viral diseases call for the research and development of human neutralizing monoclonal antibodies(NMAbs).Scientists have screened neutralizing antibodies using the virus receptor-binding domain(RBD)as an antigen,indicating that RBD contains multiple conformational neutralizing epitopes,which are the main structural domains for inducing neutralizing antibodies and T-cell immune *** review summarizes the structure and function of RBD and RBD-specific NMAbs against SARS-CoV and SARS-CoV-2 currently under development.

关键词： antibodies monoclonal prevention

Developing polydopamine modified molybdenum disulfide/epoxy resin powder coatings with enhanced anticorrosion performance and wear resistance on magnesium lithium alloys

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Journal of Magnesium and Alloys 2022年第9期10卷 2534-2545页

作者： shibo Chen Changqing Yin Yi Wang Shuang Yi xiang Gao Xujuan Zhang Qiyu Liao Yuxin Zhang Xia Zhao Jinsong Rao Baorong Hou School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China College of Material Science and Engineering Chongqing UniversityChongqing 400044China Pilot National Laboratory for Marine Science and Technology Open Studio for Marine Corrosion and ProtectionQingdao 266237China Weifang East Steel Pipe Co.LTD. Weifang 261055China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China China Academy of Space Technology(Xi’an) Xi’an 710100China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

Epoxy resin powder coating has been successfully applied on the corrosion protection of magnesium lithium ***,poor wear resistance and microcracks formed during the solidification have limited it extensive *** are limited approaches to exploit such anti-corrosion and mechanical properties of magnesium lithium ***,the epoxy resin powder coating with polydopamine modified molybdenum disulfide(MoS_(2)@PDA-EP powder coating with 0,0.1,0.2,0.5,1.0 wt.%loading)was well prepared by melt extrusion to investigate its anticorrosion performance and wear *** results revealed that the addition of MoS_(2)@PDA enhanced the adhesion strength between coatings and alloys,wear resistance and corrosion protection of the powder *** them,the optimum was obtained by 0.2 wt.%MoS_(2)@PDA-EP powder coating which could be attributed to well dispersion and efficient adhesion with coating *** conclude,MoS_(2)@PDA-EP powder coating is meaningfully beneficial for the anticorrosive and wear performance improvement of magnesium lithium alloys.

关键词： Magnesium lithium alloys Epoxy resin powder coating Molybdenum disulfide Polydopamine Anticorrosion performance Wear resistance

The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(II) detection and poisoning

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Chinese Chemical Letters 2022年第4期33卷 1861-1864页

作者： xiang Cheng Shuai Huang Qian Lei Fei Chen Fan Zheng shibo Zhong Xueyan Huang Bin Feng Xueping Feng Wenbin Zeng xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China The Molecular Imaging Research Center Central South UniversityChangsha 410013China Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Central South UniversityChangsha 410013China xiangya Hospital Central South UniversityChangsha 410013China

Excessive mercury ions(Hg^(2+)) in the environment can accumulate in human body along with the food chain to cause serious physiological *** fluorescence probes were considered as convenient tool with great potential for Hg^(2+) *** existing probes suffer from aggregation-induced quenching(ACQ) effects and insufficient ***,a novel type of fluorophore was developed by combining the aggregation-induced emission(AIE) and excited state intramolecular proton transfer(ESIPT) ***,a phenyl thioformate group with photoinduced electron transfer(PET)effect was connected to give an efficient "turn-on" probe(HTM),which exhibited good selectivity toward Hg^(2+),short response time(30 min),coupled with extremely low detection limit(LOD=1.68 nmol/L).In addition,HTM was used successfully in real samples,cells and drug evaluation,underlying the superiority of HTM to detect Hg^(2+) in practical applications.

关键词： Aggregation-induced emission Excited state intramolecular proton transfer Photoinduced electron transfer Mercury ions Fluorescent imaging

Recent advances in developing small-molecule inhibitors against SARS-CoV-2

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1591-1623页

作者： Rong xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu shibo Jiang College of Life Sciences Hebei Agricultural UniversityBaoding 071001China Research Center of Chinese Jujube Hebei Agricultural UniversityBaoding 071001China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Diseases and BiosecurityFudan UniversityShanghai 200032China Beijing Pharma and Biotech Center Beijing 100176China

The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire *** though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag ***,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic *** the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of ***,we summarized the potential therapeutic targets involved in the life cycle of the *** the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection.

关键词： SARS-CoV-2 COVID-19 Therapeutic Prophylactic Small-molecule inhibitors

PandaX-xT——A deep underground multi-ten-tonne liquid xenon observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 105-120页

作者： Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Chen Cheng Zhaokan Cheng xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Linhui Gu Xunan Guo Xuyuan Guo Zhichao Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou Yu Hou xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong Lu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao Xiao xiang Xiao Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang shibo Zhang Shu Zhang Tao Zhang Wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang Li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou Yubo Zhou Zhizhen Zhou New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinesen Academy of SciencesHuizhou 516000China Yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China School of Physics Nankai UniversityTianjin 300071China SJTU Paris Elite I

We propose a major upgrade to the existing PandaX-4T experiment at the China Jinping Underground *** new experiment,PandaX-xT,will be a multi-ten-tonne liquid xenon,ultra-low background,and general-purpose *** full-scaled PandaX-xT contains a 43-t liquid xenon active *** an experiment will significantly advance our fundamental understanding of particle physics and *** sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits,approaching the so-called“neutrino floor”for a dark matter mass above 10 GeV/c^(2),providing a key test to the Weakly Interacting Massive Particle *** searching for the neutrinoless double beta decay of^(136)Xe isotope in the detector,the effective Majorana neutrino mass can be measured to a 10-41 meV/c^(2) sensitivity,providing a key test to the Dirac/Majorana nature of *** neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level,opening up new windows of *** on the findings,PandaX-xT will seek the next stage upgrade utilizing isotopic separation of natural xenon.

关键词： dark matter neutrino less double beta decay astrophysical neutrinos liquid xenon

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基于反射光谱的煤岩感知实验研究

煤炭学报 2019年第12期44卷 3912-3920页

作者：杨恩王世博葛世荣向阳中国矿业大学机电工程学院

为研究利用反射光谱进行煤岩感知识别,收集了同一综采工作面煤层与顶板交界处外观较为相似的炭质页岩和烟煤块状试样75个,在实验室搭建了由近红外分光光谱仪、卤钨光源、光纤准直镜、Y型光纤等部件组成的煤岩反射光谱采集实验装置。根... 详细信息

为研究利用反射光谱进行煤岩感知识别,收集了同一综采工作面煤层与顶板交界处外观较为相似的炭质页岩和烟煤块状试样75个,在实验室搭建了由近红外分光光谱仪、卤钨光源、光纤准直镜、Y型光纤等部件组成的煤岩反射光谱采集实验装置。根据常见顶板高度,设置光纤准直镜与试样距离为3 m,采集了试样表面近红外波段(1000~2500 nm)反射光谱,然后测定了试样表面光谱采集区域的灰分产率。使用一阶微分(FD)、二阶微分(SD)、连续统去除(CR)、标准正态变量变换(SNV)4种方法对13点Savitzky-Golay(SG)卷积去噪后的试样光谱反射率曲线进行了预处理,对其中50个煤岩试样的灰分产率与其预处理后光谱进行了相关性分析,得到最大相关系数为0.777,由连续统去除预处理方法获得,其所在波长点为1698 nm,位于与煤岩主要有机成分有关的1700 nm光谱带附近。取此50个试样最大相关系数波长点1698 nm左右区间[1693 nm,1703 nm]共11个波长点处的连续统去除预处理光谱值,及其灰分产率、煤岩类型,建立了支持向量煤岩灰分回归(SVR)、支持向量煤岩分类(SVC)模型,2种原位煤岩感知识别模型对其余25个测试煤岩试样的预测精度分别为92%,96%,同时对单个样本识别总耗时均小于0.1 s,其中,支持向量煤岩灰分回归模型对此25个测试煤岩试样表面灰分产率的预测均方根误差(RMSE)达到了5%,决定系数达到0.88。

关键词：反射光谱近红外煤岩感知识别灰分产率支持向量机