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Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A Retrospective Study

Current Medical Science 2024年第3期44卷 568-577页

作者： Fen WANG Xiao-ling ZHANG Jing ZHANG Song GONG Jing TAO Hui XIANG Xiao-qing FU Xu-na BIAN Xue-feng YU An-hui XU Cheng-la YI shi-ying shao Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical Research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of ***-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich *** study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical *** Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were *** clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was *** Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)*** severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–*** initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)*** median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh *** overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining *** treatment did not change the percentage of complete epithelialization or healing *** Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for D

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

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Role of Peripheral Regulatory T Lymphocytes in Patients with Thyroid Associated Ophthalmopathy During Systemic Glucocorticoid Treatment:A Prospective Observational Study

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Current Medical Science 2023年第1期43卷 130-138页

作者： Qin-qin XU Xiao-ling ZHANG Ban LUO Tao LI Gang YUAN shi-ying shao Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of the National Clinical Research Center for Metabolic Diseases Wuhan430030China Depatment of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Thyroid-associated ophthalmopathy(TAO)is an autoimmune disorder involving the orbital *** study aimed to understand the role of regulatory T cells(Tregs)in TAO during 12-week systemic glucocorticoid(GC)*** Thirty-two moderate-severe TAO patients with a clinical activity score(CAS)≥3/7 or with prolonged T2 relaxation time(T2RT)on at least one side of extraocular muscle(EOM)were *** percentage of the peripheral CD4+CD25(high)CD127(−/low)Tregs was analyzed using flow cytometry before and after the GC *** activity and severity of TAO,T2RT,and the clinical outcomes after the GC treatment were *** correlation with the peripheral Tregs was *** There was no significant association between the baseline Treg fraction and the activity and severity of TAO or the treatment response.A significant reduction of Tregs was observed after the GC therapy merely in patients without any clinical *** Treg reduction after systemic GC therapy is indicative of a poor therapeutic ***,dynamic alterations of Tregs could help to evaluate the effectiveness of the GC treatment.

关键词： thyroid-associated ophthalmopathy regulatory T cells intravenous methylpred-nisolone glucocorticoids T2 relaxation time

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Supercritical CO_(2) Cycles for Nuclear-Powered Marine Propulsion:Preliminary Conceptual Design and Off-Design Performance Assessment

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Journal of Thermal Science 2024年第1期33卷 328-347页

作者： LI Zhaozhi shi Mingzhu shao yingjuan ZHONG Wenqi Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Using the efficient,space-saving,and flexible supercritical carbon dioxide(sCO_(2)) Brayton cycle is a promising approach for improving the performance of nuclear-powered *** purpose of this paper is to design and compare sCO_(2) cycle power systems suitable for nuclear-powered *** the characteristics of nuclear-powered ships,this paper uses different indicators to comprehensively evaluate the efficiency,cost,volume,and partial load performance of several nuclear-powered sCO_(2) *** load-following strategies are also designed and *** results show that the partial cooling cycle is most suitable for nuclear-powered ships because it offers both high thermal efficiency and low volume and cost,and can maintain relatively high thermal efficiency at partial ***,the new load-following strategy that adjusts the turbine speed can keep the compressor away from the surge line,making the cycle more flexible and efficient compared to traditional inventory and turbine bypass strategies.

关键词： supercritical CO_(2)cycle nuclear marine propulsion off-design performance

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“存亡歧路”抑或“话语权相争”——“丙子斥和”及“三学士”事件述评

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安徽史学 2014年第2期 99-108页

作者：石少颖山东大学历史文化学院山东济南250100

"丙子之役"的爆发使朝鲜在义理与现实之间陷入了两难抉择,加速了主和派与斥和派的意见分化。与此同时,在这场"存亡歧路"的外交争辩中,"台阁"与"庙堂"的话语权矛盾也迅速突显。士林虽然是朝鲜公论政治的主体,但却无法摆脱"浮薄"的软肋。... 详细信息

"丙子之役"的爆发使朝鲜在义理与现实之间陷入了两难抉择,加速了主和派与斥和派的意见分化。与此同时,在这场"存亡歧路"的外交争辩中,"台阁"与"庙堂"的话语权矛盾也迅速突显。士林虽然是朝鲜公论政治的主体,但却无法摆脱"浮薄"的软肋。他们为国家高举了义理,却败倒在政争面前。虽然"三学士"的择选背后充斥着官员间互相倾轧乃至兵谏相逼的隐情,但是,朝廷以"浮议误国"取代"斥和误国"的论断,却在根本上肯定了义理,敷衍了清朝对于朝鲜反清言论的问责,以实际行动平息了朝野上下对于斥和论的非议。这就为协调战后各派间利益关系、加强国家政治稳定,提供了有利契机。

关键词：丙子斥和三学士事件义理士林朝鲜清朝

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Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

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Biomedical and Environmental Sciences 2024年第1期37卷 112-116页

作者： ZHANG ying TIAN Qi Qi HU Wen Dong ZHANG shao Bo WANG shi Gong ZHENG Can Jun Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225SichuanChina Yunnan R&D Institute of Natural Disaster on Chengdu University of Information Technology Kunming 650034YunnanChina Chengdu Plain Urban Meteorology and Environment Sichuan Provincial Field Scientific Observation and Research Station Chengdu 610225SichuanChina Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and PreventionBeijing 102206China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant ***,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

关键词： mixtures monoxide consequences

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An M-VCUT level set-based data-driven model of microstructures and optimization of two-scale structures

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Frontiers of Mechanical Engineering 2024年第4期19卷 73-86页

作者： Minjie shao Tielin shi Qi XIA State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

The optimization of two-scale structures can adapt to the different needs of materials in various regions by reasonably arranging different microstructures at the macro scale,thereby considerably improving structural ***,a multiple variable cutting(M-VCUT)level set-based data-driven model of microstructures is presented,and a method based on this model is proposed for the optimal design of two-scale *** geometry of the microstructure is described using the M-VCUT level set method,and the effective mechanical properties of microstructures are computed by the homogenization ***,a database of microstructures containing their geometric and mechanical parameters is *** two sets of parameters are adopted as input and output datasets,and a mapping relationship between the two datasets is established to build the data-driven model of *** the optimization of two-scale structures,the data-driven model is used for macroscale finite element and sensitivity *** efficiency of the analysis and optimization of two-scale structures is improved because the computational costs of invoking such a data-driven model are much smaller than those of homogenization.

关键词： two-scale structure structural optimization M-VCUT level set homogenization radial basis function data-driven

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Primordial black holes and curvature perturbations from false vacuum islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 58-72页

作者： Rong-Gen Cai Yu-shi Hao shao-Jiang Wang School of Physical Science and Technology Ningbo UniversityNingbo 315211China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Asia Pacific Center for Theoretical Physics Pohang 37673Republic of Korea

Recently,much attention has been focused on the false vacuum islands that are flooded by an expanding ocean of true-vacuum bubbles slightly later than most of the other parts of the *** delayed decay regions will accumulate locally larger vacuum energy density by staying in the false vacuum longer than those already transited into the true vacuum.A false vacuum island with thus acquired density contrast of a super-horizon size will evolve locally from radiation dominance to vacuum dominance,creating a local baby Universe that can be regarded effectively as a local closed *** such density contrasts of super-horizon sizes can ever grow large enough to exceed the threshold of gravitational collapse,primordial black holes will form similar to those collapsing curvature perturbations on super-horizon scales induced by small-scale enhancements during *** not,such density contrasts can still induce curvature perturbations potentially observable *** this paper,we revisit and elaborate on the generations of primordial black holes and curvature perturbations from delayed-decayed false vacuum islands during asynchronous first-order phase transitions with fitting formulas convenient for future model-independent studies.

关键词： first-order phase transitions primordial black holes curvature perturbations

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乌孙归汉与西汉外交

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湖北大学学报（哲学社会科学版） 2006年第3期33卷 340-344页

作者：石少颖山东大学历史文化学院山东济南250100

乌孙为西域大国,在汉、匈关系中一度举足轻重,西汉“断匈奴右臂”的战略,首先因乌孙而提出,进而拓展为对于整个西域的宏伟设想。西汉采取了联姻与军事威慑相结合的外交策略,促使乌孙的立场由“观望”转为“归汉,”这是西汉外交在“大宛... 详细信息

乌孙为西域大国,在汉、匈关系中一度举足轻重,西汉“断匈奴右臂”的战略,首先因乌孙而提出,进而拓展为对于整个西域的宏伟设想。西汉采取了联姻与军事威慑相结合的外交策略,促使乌孙的立场由“观望”转为“归汉,”这是西汉外交在“大宛之役”后的重大突破,亦对古代中亚国际关系产生了深远影响。

关键词：西汉西域乌孙外变政策华夷观

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Effect of nano-carbon black content on wetting phenomenon of molten steel and alumina-carbon ceramic filter substrates

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Journal of Iron and Steel Research International 2024年第8期31卷 1900-1913页

作者： Jin-wen Song Wen Yan Zhe Chen ying Liu shao-song Hong The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina National-provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Jiangsu Sheng Nai New Materials Co. Ltd.Taizhou 225503JiangsuChina

The effect of nano-carbon black content(O,8 and 12 wt.%)on the wettability of molten steel on Al_(2)O_(3)-C substrates was investigated by the sessile drop wetting method at 1500℃ under argon *** the beginning of the wetting experiment,the contact angle decreased with the increase in nano-carbon black *** the wetting experiment progressed,FeAl_(2)0_(4) layer and sheet Al_(2)O_(3) layer were found at the interface between the molten steel and the Al_(2)O_(3)-C substrates with O and 8 wt.% nano-carbon black content,and the contact angle deceased with *** the content of nano-carbon black was 12 wt.%,a large number of nano-Al_(2)O_(3) whiskers were observed,which made the contact angle between the molten steel and Al_(2)O_(3)-C substrate become *** on the scanning electron microscope and energy dispersive spectrometry results,the formation mechanism of FeAl2O4 layer and Al_(2)O_(3) layer and the interfacial reaction mechanism were proposed.

关键词： Contact angle Nano-carbon black Al_(2)O_(3)-C substrate Molten steel Interfacial reaction

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A Deep Learning Based Broadcast Approach for Image Semantic Communication over Fading Channels

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China Communications 2024年第7期21卷 78-94页

作者： Ma Kangning shi Yuxuan shao Shuo Tao Meixia The Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China The School of Cyber and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

We consider an image semantic communication system in a time-varying fading Gaussian MIMO channel,with a finite number of channel states.A deep learning-aided broadcast approach scheme is proposed to benefit the adaptive semantic transmission in terms of different channel *** combine the classic broadcast approach with the image transformer to implement this adaptive joint source and channel coding(JSCC)***,we utilize the neural network(NN)to jointly optimize the hierarchical image compression and superposition code mapping within this *** learned transformers and codebooks allow recovering of the image with an adaptive quality and low error rate at the receiver side,in each channel *** simulation results exhibit our proposed scheme can dynamically adapt the coding to the current channel state and outperform some existing intelligent schemes with the fixed coding block.

关键词： broadcast approach deep learning fading channels semantic communication

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