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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

The 4th Across-strait Workshop on Shock Wave/Vortex Interaction

作者： Chang-hsien Tai Jyh-tong Teng shi-wei lo Uzu-kuei Hsu Department of Vehicle Engineering Pingtung University of Science and Technology Department of Mechanical Engineering Chung Yuan Christian University

The blast effects caused by the explosion generate serious damage during propagation and interaction.A great injuries and deaths incident incurred because of explosion in petrochemical industry,firecracker factory and car-mounted gas,*** the world in recent ***, the 911 crashes in 2001,Bali’s series of explosion in 2002,and Benazir Bhutto assassinated in

关键词： blast wave CFD dynamic mesh overpressure reflection tunnel vehicles

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Case Report:Metastasis of gastric carcinoma to the thyroid and lung:a case report and review of literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 542-546页

作者： Hwa-chan LEE Fen-fen CHEN Ching-chu lo Chung-jing WANG wei-chun lo shi-ping LUH Department of Surgery St. Martin de Porres Hospital Chia-Yi City 60069 Taiwan China 2Department of Emergency Medicine St Martin de Porres Hospital Chia-Yi City 60069 Taiwan China Department of Pathology St. Martin de Porres Hospital Chia- Yi City 60069 Taiwan. China Department of Gastroenterology St. Martin de PorresHospital Chia-Yi City 60069 Taiwan China

Cancer metastasis to the thyroid is extremely rare. The more commonly reported primary sites for metastasis to the thyroid are the kidney, breast, lung, colon, esophagus, and uterus. Thyroid metastasis from the stomach has only been reported in three cases. Herein, we report a 71-year-old man presenting with bilateral thyroid multinodular lesions. Bilateral near-total thyroidectomy was performed due to airway compression with related symptoms. Wedge resection of a suspicious pulmonary nodule, detected on CT, was performed for diagnosis. Polypoid lesions in the stomach were examined by trans-scopic biopsy. Poorly differentiated adenocarcinomas with the same histological profiles were noted at these three sites. The immunohistochemical staining for thyroglobulin of these specimens was negative. We conclude that a new thyroid mass appearing in a patient with present or prior malignancies should raise the concern of metastatic disease.

关键词： Gastric carcinoma Thyroid metastasis Lung metastasis

Spatial Patterns of Car Sales and Their Socio-economic Attributes in China

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Chinese Geographical Science 2017年第5期27卷 684-696页

作者： LIU Daqian lo Kevin SONG wei XIE Chunyan Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China Department of Geography Hong Kong Baptist UniversityHong Kong 999077China Department of Geography and Geosciences University of LouisvilleLouisville KY 40292USA FAW-Volkswagen Automotive Company Ltd. Changehun 130061China

Using data from the Economic Advisory Center of the State Information Center(SIC), we examined the spatial patterns of car sales in China at the prefectural level in 2012. We first analyzed the spatial distributions of car sales of different kinds of automakers(foreign automakers, Sino-foreign joint automakers, and Chinese automakers), and then identified spatial clusters using the local Moran's indexes. location quotient analysis was applied to examine the relative advantage of each type of automaker in the local markets. To explain the variations of car sales across cities, we collected several socioeconomic variables and conducted regression analyses. Further, factor analysis was used to extract independent variables to avoid the problem of multicollinearity. By incorporating a spatial lag or spatial error in the models, we calibrated our spatial regression models to address the spatial dependence problem. The analytical results show that car sales varied significantly across cities in China, and most of the cities with higher car sales were the developed cities. Different automakers exhibit diverse spatial patterns in terms of car sales volume, spatial clusters, and location quotients. The scale and incomes factor were extracted and verified as the two most significant and positive factors that shape the spatial distributions of car sales, and together with the spatial effect, explained most of the variations of car sales across cities.

关键词： car sales spatial clusters location Quotient socio-economic attributes China

An elliptical blade is not a true ellipse,but a superellipse–Evidence from two Michelia species

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Journal of Forestry Research 2022年第4期33卷 1341-1348页

作者： Yuping Li Karl JNiklas Johan Gielis Ülo Niinemets Julian Schrader Rong Wang Peijian shi College of Horticulture Jinling Institute of TechnologyNanjing 210038People’s Republic of China Bamboo Research Institute Nanjing Forestry UniversityNanjing 210037People’s Republic of China Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA Department of Biosciences Engineering University of AntwerpB-2020 AntwerpBelgium Institute of Agricultural and Environmental Sciences Estonian University of Life Sciences51006 TartuEstonia Estonian Academy of Sciences 10130 TallinnEstonia Department of Biological Sciences Macquarie UniversitySydneyNSW 2109Australia Biodiversity Macroecology and BiogeographyUniversity of Göttingen37077 GöttingenGermany

The shape of leaf laminae exhibits considerable diversity and complexity that reflects adaptations to environmental factors such as ambient light and precipitation as well as phyletic *** leaves appear to be elliptical which may represent a‘default’developmental ***,whether their geometry truly conforms to the ellipse equation(EE),i.e.,(x/a)^(2)+(y/b)^(2)=1,remains *** alternative is described by the superellipse equation(SE),a generalized version of EE,i.e.,|x/a|^(n)+|y/b|^(n)=*** test the efficacy of EE versus SE to describe leaf geometry,the leaf shapes of two Michelia species(i.e.,*** ***,and ***),were investigated using 60 leaves from each *** shows that the majority of leaves(118 out of 120)had adjusted root-mean-square errors of<0.05 for the nonlinear fitting of SE to leaf geometry,i.e.,the mean absolute deviation from the polar point to leaf marginal points was smaller than 5%of the radius of a hypothesized circle with its area equaling leaf *** estimates of n for the two species were<2,indicating that all sampled leaves conformed to SE and not to *** study confirms the existence of SE in leaves,linking this to its potential functional advantages,particularly the possible influence of leaf shape on hydraulic conductance.

关键词： Bilateral symmetry Leaf ellipticalness index Leaf laminae Leaf roundness index Magnoliaceae

Preparation of cross-linked magnetic chitosan with quaternary ammonium and its application for Cr(Ⅵ) and P(Ⅴ) removal

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Journal of Environmental Sciences 2014年第12期26卷 2379-2386页

作者： wei Yao Pinhua Rao Irene M.C.lo Wenqi Zhang Wenrui Zheng School of Chemistry and Chemical Engineering Shanghai University of Engineering Science Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology

Pollutants that exist in anionic species are issues of concern in water treatment. Compared to cationic pollutants, the removal of anionic pollutants by adsorption is more difficult because most adsorbents carry predominantly negative charges in neutral and alkaline environments. In this study, a cross-linked chitosan derivative with quaternary ammonium and magnetic properties（QM-chitosan） was prepared and employed to remove chromium（VI） and phosphorus（V）（Cr（VI） and P（V）） from aqueous environments. The QM-chitosan was characterized by Fourier transform infrared spectrometry（FT-IR）,thermogravimetric analysis（TGA）, energy dispersive X-ray（SEM-EDX） and zeta *** experiments show that QM-chitosan can effectively remove Cr（VI） and P（V）, and the main mechanism was believed to be electrostatic interaction. A pseudosecond-order model was fitted to describe the kinetic processes of Cr（VI） and P（V） removal. The adsorption isotherms of both Cr（VI） and P（V） on the QM-chitosan were well fitted by the Langmuir isotherm equation. The saturated adsorption capacity of P（V）（2.783 mmol/g） was found to be higher than that of Cr（VI）（2.323 mmol/g）, resulting from the size of the H2PO-4ions being smaller than that of the HCr O-4ions. However, the theoretical calculation and experimental results showed that QM-chitosan had a stronger affinity for Cr（VI） than P（V）. The adsorption–desorption of the QM-chitosan was evaluated, and high regeneration rates were demonstrated.

关键词： Magnetic chitosan Quaternary ammonium Cr(VI) P(V) Adsorption

Game theory model of exit selection in pedestrian evacuation considering visual range and choice firmness

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Chinese Physics B 2020年第8期29卷 355-362页

作者： wei-Li Wang Fang-Fang Wan Siu-Ming lo Institute of logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China Department of Architecture and Civil Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina

Exit choice is one of the most important pedestrian behaviors during *** to the exit is a generally recognized factor influencing expected moving time to the *** range determines how much information a pedestrian can perceive,thus the number of pedestrians within the visual field can be used to estimate waiting time at the ***,the choice firmness that reflects the degree to which a pedestrian would persist in his/her previous choice of exit is *** integrating game theory into a cellular automata simulation framework,the pedestrian exit choice mechanism is investigated and explicitly modeled in this paper.A systematic analysis of the key factors influencing pedestrian evacuation is conducted,including visual radius and choice firmness of a pedestrian,initial crowd distribution of the room,exit layout as well as exit *** is found that low choice firmness level can lead to unnatural pedestrian behavior such as wandering,which is adverse to *** longer the pedestrian's visual radius,the earlier the pedestrian can determine his/her final selection of the *** with the scenario where the pedestrians are randomly distributed,pedestrians clustered together in a corner of the room lead to high crowd density and imbalanced use of ***,the exit layout and exit width also have a certain influence on pedestrian evacuation *** results of this paper may be of benefit to the formulation of behavioral rules in other pedestrian simulation models.

关键词： game theory exit selection visual range choice firmness

F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure

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Science China Chemistry 2012年第9期55卷 1922-1930页

作者： ZIMMER Christopher C shi LiFang shiH YiPing LI JieRen JIN LeeWay lo SuHao LIU GangYu Department of Chemistry University of California Davis CA 95616 USA Department of Biochemistry and Molecular Medicine Center.for Tissue Regeneration and Repair University of California Davis Medical Center Sacramento CA 95817 USA M.I.N.D. Institute and Department of Pathology and Laboratory Medicine ' Alzheimer's Disease Center University of California Davis Medical Center Sacramento CA 95817 USA

Focal adhesions play an important role in cell spreading,migration,and overall mechanical *** relationship of cell structural and mechanical properties was investigated in the context of focal adhesion *** atomic force microscopy(AFM) and laser scanning confocal microscopy(LSCM) was utilized to measure single cell mechanics,in correlation with cellular morphology and membrane structures at a nanometer *** stages of focal adhesion were verified via confocal fluorescent studies,which confirmed three representative F-actin assemblies,actin dot,filaments network,and long and aligned fibrous bundles at ***-deformation profiles of living cells were measured at the single cell level,and displayed as a function of height deformation,relative height deformation and relative volume *** focal adhesion progresses,single cell compression profiles indicate that both membrane and cytoskeleton stiffen,while spreading increases especially from focal complex to focal ***,AFM imaging reveals morphological geometries of spherical cap,spreading with polygon boundaries,and elongated or polarized *** features are dominated by protrusions of 41-207 nm tall,short rods with 1-6 μm in length and 10.2-80.0 nm in height,and long fibrous features of 31-246 nm tall,*** protrusion is attributed to local membrane folding,and the rod and fibrous features are consistent with bilayer decorating over the F-actin *** collectively,the reassembly of F-actin during focal adhesion formation is most likely responsible for the changes in cellular mechanics,spreading morphology,and membrane structural features.

关键词： focal adhesion actin fibers actin assembly fibroblast membrane structure single cell mechanics atomic forcemicroscopy laser scanning confocal microscopy

Cross-Frequency Coupling and Intelligent Neuromodulation

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Cyborg and Bionic Systems 2023年第1期4卷 284-297页

作者： Chien-Hung Yeh Chuting Zhang Wenbin shi Men-Tzung lo Gerd Tinkhauser Ashwini Oswal School of Information and Electronics Beijing Institute of TechnologyBeijingChina Department of Biomedical Sciences and Engineering National Central UniversityTaoyuanTaiwan Department of Neurology Bern University Hospital and University of BernBernSwitzerland MRC Brain Network Dynamics Unit University of OxfordOxfordUK

Cross-frequency coupling(CFC)reflects(nonlinear)interactions between signals of different *** from both patient and healthy participant studies suggests that CFC plays an essential role in neuronal computation,interregional interaction,and disease *** present review discusses methodological advances and challenges in the computation of CFC with particular emphasis on potential solutions to spurious coupling,inferring intrinsic rhythms in a targeted frequency band,and causal *** specifically focus on the literature exploring CFC in the context of cognition/memory tasks,sleep,and neurological disorders,such as Alzheimer's disease,epilepsy,and Parkinson's ***,we highlight the implication of CFC in the context and for the optimization of invasive and noninvasive neuromodulation and ***,CFC could support advancing the understanding of the neurophysiology of cognition and motor control,serve as a biomarker for disease symptoms,and leverage the optimization of therapeutic interventions,e.g.,closed-loop brain *** the evident advantages of CFC as an investigative and translational tool in neuroscience,further methodological improvements are required to facilitate practical and correct use in cyborg and bionic systems in the field.

关键词： epilepsy spite evident