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Chemical Research in Chinese Universities 2011年第1期27卷 49-53页

作者： CHEN jiao shi Jian yan Chao-guo College of Chemistry ＆ Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China

The 1,4-diazabicyclo[2.2.2]octane（DABCO） catalyzed reaction of cyclohexane-1,3-dione or dimedone with various aldehydes in acetonitrile resulted in the polysubstituted tetraketones, spiro dihydrofurans or 1,8-dioxo-... 详细信息

关键词： Tandem reaction Dimedone Spiro dihydrofuran Tetraketone 1,8-Dioxo-xanthene

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基于空间注意力与过滤网络的遥感图像配准

计算机仿真 2024年第2期41卷 202-206,231页

作者：李先静陈颖石艳娇上海应用技术大学上海201418

针对部分遥感图像配准算法存在特征提取能力不足,存在较多误匹配点的问题,提出了一个算法。在特征提取阶段加入改进的空间注意力机制关注图像的重要区域以及显著特征,增强网络的特征表达能力。匹配阶段提出粗过滤加细过滤双层过滤的方式... 详细信息

针对部分遥感图像配准算法存在特征提取能力不足,存在较多误匹配点的问题,提出了一个算法。在特征提取阶段加入改进的空间注意力机制关注图像的重要区域以及显著特征,增强网络的特征表达能力。匹配阶段提出粗过滤加细过滤双层过滤的方式,提高模型的鲁棒性和配准精度。同时改进了损失函数,提高模型的泛化性和拟合能力。仿真中,与多种先进的方法相比,所提算法能获得更高的配准精度和更低的配准误差,并且针对不同类型的图像也能取得较好的配准效果。

关键词：图像配准空间注意力双层过滤损失函数

Evaluation of teaching-in-English reform in five-year clinical tropical medicine program–Case analysis of curriculum reform of clinical medicine in Hainan Medical University

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1125-1128页

作者： shi-jiao yan Yun-Qiang Chen jiao Chen Chuan-Zhu Lv Hainan Medical University Haikou 571199HainanChina

Objective: To investigate the model, quality as well as effect of teaching-in-English in five-year clinical medicine program of Hainan Medical ***: The questionnaire was carried out among clinical medicine undergraduates of2012–2015 grades in Hainan Medical University, to investigate studying time, studying habits and the impact of teaching in English. Additionally results of CET-4, CET-6 and overseas internship from undergraduates of 2012–2015 grade, as well as the result of phased medical licensing examination and post-graduate entrance examination from undergraduates of 2012 were accordingly collected from the Teaching Management ***: For the Chinese students in international classes, the average time of self-study was 161.49 min, 58.3% had preview before classes, and 90.7% had habit of review after classes. Thus the first time pass rate, total pass rate, first time excellent rate and total excellent rate of CET-4 and CET-6 of international classes were significantly higher than those of regular classes. The result of post-graduate entrance examination in 2016 showed that the score, pass rate and acceptance rate of international classes of 2012 grade were significantly higher those of regular classes(P < 0.01).Conclusions: Teaching-in-English reform in Hainan Medical University has achieved initial success. Chinese students from international classes are superior to those from regular classes in many aspects. However, there are still many problems, and effective measures should be implemented to promote teaching quality continuously.

关键词： Five-year clinical medicine program Teaching-in-English Teaching reform Effect

Adaptively Enhancing Facial Expression Crucial Regions via a Local Non-local Joint Network

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Machine Intelligence Research 2024年第2期21卷 331-348页

作者： Guanghui shi Shasha Mao Shuiping Gou Dandan yan Licheng jiao Lin Xiong School of Artificial Intelligence Xidian UniversityXi'an 710000China Applied Research Laboratory Sense TimeXi'an 710000China

Facial expression recognition(FER)is still challenging due to the small interclass discrepancy in facial expression *** view of the significance of facial crucial regions for FER,many existing studies utilize the prior information from some annotated crucial points to improve the performance of ***,it is complicated and time-consuming to manually annotate facial crucial points,especially for vast wild expression *** on this,a local non-local joint network is proposed to adaptively enhance the facial crucial regions in feature learning of FER in this *** the proposed method,two parts are constructed based on facial local and non-local information,where an ensemble of multiple local networks is proposed to extract local features corresponding to multiple facial local regions and a non-local attention network is addressed to explore the significance of each local *** particular,the attention weights obtained by the non-local network are fed into the local part to achieve interactive feedback between the facial global and local ***,the non-local weights corresponding to local regions are gradually updated and higher weights are given to more crucial ***,U-Net is employed to extract the integrated features of deep semantic information and low hierarchical detail information of expression ***,experimental results illustrate that the proposed method achieves more competitive performance than several state-of-the-art methods on five benchmark datasets.

关键词： Facial expression recognition deep neural network multiple network ensemble attention network facial crucial regions

Modeling human gastric cancers in immunocompetent mice

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Cancer Biology & Medicine 2024年第7期21卷 553-570页

作者： Weihong Zhang shilong Wang Hui Zhang yan Meng shi jiao Liwei An Zhaocai Zhou Department of Stomatology Department of Medical UltrasoundShanghai Tenth People's HospitalTongji University Cancer CenterTongji University School of MedicineShanghai 200072China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China Collaborative Innovation Center for Cancer Personalized Medicine School of Public HealthNanjing Medical UniversityNanjing 211166China

Gastric cancer(GC)is a major cause of cancer-related mortality *** is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high heterogeneity,with different cellular origins and diverse histological and molecular *** heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient *** the past decade,great progress has been made in the study of GC,particularly in molecular subtyping,investigation of the immune microenvironment,and defining the evolutionary path and *** mouse models,particularly immunocompetent models that mimic the cellular and molecular features of human GC,in combination with organoid culture and clinical studies,have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion,and the development of novel therapeutic ***,we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models,emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

关键词： Gastric cancer heterogeneity mouse model GEMM immunocompetent

The relationship between physical activity in early pregnancy and hypertensive disorders of pregnancy: a cohort study in Chinese women

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World Journal of Emergency Medicine 2023年第3期14卷 204-208页

作者： Qian Lu shi-jiao yan Huan-jun Chen Xiong-fei Pan Yi-xiang Ye Xing-yue Song Ri-xing Wang Chuan-zhu Lyu International School of Public Health and One Health Hainan Medical UniversityHaikou 570100China Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical UniversityHaikou 570100China Section of Epidemiology and Population Health Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenWest China Second University Hospital&West China Biomedical Big Data CenterWest China HospitalSichuan UniversityShuangliu Institute of Women's and Children's HealthShuangliu Maternal and Child Health HospitalChengdu 610041China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Department of Emergency Hainan Clinical Research Center for Acute and Critical Diseasesthe Second Affi liated Hospital of Hainan Medical UniversityHaikou 570100China Emergency Medicine Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Ministry of Education Key Laboratory of Emergency and Trauma Hainan Medical UniversityHaikou 570100China

BACKGROUND:We aimed to examine prospective associations between diff erent intensities and diff erent types of physical activity(PA)in early pregnancy and hypertensive disorders of pregnancy(HDP)among Chinese ***:A total of 6,820 pregnant women from the Tongji-Shuangliu Birth Cohort were included in this *** pregnancy physical activity questionnaire(PPAQ)was used to assess PA,including household/caregiving,occupational,sports/exercise,and transportation activities in the first trimester of *** diagnosis of HDP was collected,including gestational hypertension(GH)and preeclampsia(PE).Data were analyzed by unconditional multivariate logistic regression,and the odds ratio(OR)and 95%confi dence interval(CI)were ***:A total of 178(2.6%)of the 6,820 women were diagnosed with HDP,of which 126(1.8%)were GH and 52(0.8%)were ***,we found no association between PA in early pregnancy and PE.A trend toward lower risk was found only among women with GH and among those with higher levels of moderate-to-vigorous intensity physical activity(MVPA)(adjusted OR 0.54,95%CI 0.31–0.96).No association was observed between PA and HDP in early pregnancy,regardless of diff erent intensities or types of ***:MVPA in the first trimester is an influencing factor of *** pregnant women to engage in MVPA in the fi rst trimester may help to prevent GH.

关键词： Physical activity Gestational hypertension Preeclampsia Prospective cohort study

Strong light–matter interactions based on excitons and the abnormal all-dielectric anapole mode with both large field enhancement and low loss

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Photonics Research 2024年第4期12卷 854-864页

作者： yan-HUI DENG YU-WEI LU HOU-jiao ZHANG ZHONG-HONG shi ZHANG-KAI ZHOU XUE-HUA WANG State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Quantum Science Center of Guangdong–Hong Kong–Macao Greater Bay Area(Guangdong) Shenzhen 518045China

The room temperature strong coupling between the photonic modes of micro/nanocavities and quantum emitters(QEs) can bring about promising advantages for fundamental and applied *** the electric fields(EFs) by using plasmonic modes and reducing their losses by applying dielectric nanocavities are widely employed approaches to achieve room temperature strong ***,ideal photonic modes with both large EFs and low loss have been ***,we propose the abnormal anapole mode (AAM),showing both a strong EF enhancement of~70-fold (comparable to plasmonic modes) and a low loss of 34 meV,which is much smaller than previous records of isolated all-dielectric *** realizing strong coupling,we further show that by replacing the normal anapole mode with the AAM,the lasing threshold of the AAM-coupled QEs can be reduced by one order of magnitude,implying a vital step toward on-chip integration of nanophotonic devices.

关键词： dielectric mode coupling

Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou yan shi Jing Xu Long Li Bin shi Quansheng Ouyang jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with LiNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes FillersLithium metal batteries

Global research trends in cardiac arrest research:a visual analysis of the literature based on CiteSpace

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World Journal of Emergency Medicine 2022年第4期13卷 290-296页

作者： shi-jiao yan Mei Chen Jing Wen Wen-ning Fu Xing-yue Song Huan-jun Chen Ri-xing Wang Mei-ling Chen Xiao-tong Han Chuan-zhu Lyu School of Public Health Hainan Medical UniversityHaikou 570100China Research Unit of Island Emergency Medicine Chinese Academy of Medical Sciences(No.2019RU013)Hainan Medical UniversityHaikou 570100China Guizhou Center for Disease Control and Prevention Guiyang 550004China School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Department of Emergency Hainan Clinical Research Center for Acute and Critical Diseasesthe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570100China Emergency and Trauma College Hainan Medical UniversityHaikou 570100China Department of Emergency Medicine Hunan Provincial Institute of Emergency MedicineHunan Provincial Key Laboratory of Emergency and Critical Care MetabolomicsHunan Provincial People's Hospital/the First Affiliated HospitalHunan Normal UniversityChangsha 410000China Emergency Medicine Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China

BACKGROUND:The high morbidity,high mortality and low survival rate of cardiac arrest(CA)cause a heavy global *** aimed to analyze the changes in scientific output related to CA over the past two ***:We analyzed the scientific output related to CA from 2000 to 2020 via the Web of *** data were analyzed using CiteSpace ***:In total,28,312 articles relating to CA were identified in the Web of *** volume of scientific research output in the field of global CA research was mainly distributed in the Americas,Europe and Asia,covering a wide *** the 28,312 articles,the research content of the highly cited literature mainly focused on CA,mild hypothermia treatment,and prognosis of CA ***:Various scientific methods were applied to reveal scientific productivity,collaboration,and research hotspots in the CA research *** resuscitation(CPR),extracorporeal membrane oxygenation(ECMO),survival and target temperature management are research *** research on CA will continue to focus on its treatment and prognosis to improve the survival rate of CA patients.

关键词： Cardiac arrest Bibliometrics CiteSpace Research hotspots Cardiopulmonary resuscitation

Theoretical screening of cooperative N-bridged dual-atom sites for efficient electrocatalytic nitrogen reduction with remolding insight

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Nano Research 2024年第4期17卷 3413-3422页

作者： Huimei Chen yan yang Chi jiao Zhiwen Zhuo Junjie Mao yan Liu Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The electrocatalytic nitrogen reduction reaction(e-NRR)is a promising alternative method for the Haber–Bosch ***,it still faces many challenges in searching for high activity,stability,and selectivity catalysts and ascertaining the catalytic mechanism with complete ***,a series of graphene-based N-bridged dual-atom catalysts(M1-N-M2/NC)are systematically investigated via first-principle calculation and a high-throughput screening *** result unveils that N_(2) adsorption on M1-N-M2/NC in bridge-on adsorption mode can effectively break the scaling relationship on single-atom catalysts(SACs).Moreover,V-N-Ru/NC and V-N-Os/NC are systematically screened out as promising e-NRR catalysts,with extremely low limiting potentials of-0.20 and-0.18 V,***,the adsorption site competition between*N_(2) and*H,as well as the competitive twin reactions of hydrogen evolution reaction(HER)on intermediates(N_(n)H_(m))during the e-NRR process,is systematically evaluated to form a remodeling insight for the reactions in mechanism,and the e-NRR of new proposed dual-atom catalysts(DACs)is strategically optimized for its high-efficiency performance potential via our remolding insight in e-NRR *** work provides new ideas and insights for the design and mechanism of e-NRR catalysts and an effective strategy for rapidly screening highly efficient e-NRR catalysts.

关键词： nitrogen reduction dual-atom catalysts high-throughput screening hydrogen evolution reaction density functional theory calculations