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Facilitative effect of GABA on regulation of baroreflex in the hypothalamic PVN region in conscious rats

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Facilitative effect of GABA on regulation of baroreflex in t...

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yan-Hua BING,Hao feng,shi wang,Nan-Shou YU,Qing-Hua JIN~* Department of Physiology,Yanbian University Medical College,Yanji 133000,China

The hypothalamic paraventricular nucleus(PVN) is a central site for the integration of the neuroendocrine system and the autonomic nervous system,and the PVN appears to be an important regulatory region on *** some studies indicate that y-aminobutyric acid(GABA) neurons and its receptors exist in the PVN,the effects of GABA on regulation of baroreflex in the PVN remain to be ***,to investigate the possible involvement of GABA in the central regulation of baroreflex,the extracellular concentrations of GABA in the PVN region were measured during the baroreflex induced by *** in conscious *** extracellular levels of GABA in the PVN region showed an immediate increase during ***,to determine whether the observed GABA release was involved in the baroreflex,bicuculline(an antagonist of GABA receptor) and salcofen(an antagonist of GABA receptor) were perfused in the PVN region during *** perfusion of bicuculline significantly decreased the baroreflex sensitivity,whereas saclofen did not influence the sensitivity. In addition,perfusion of muscimol(an agonist of GABA receptor) in the PVN region significantly increased the baroreflex sensitivity,whereas baclofen(an agonist of GABA receptor) did not affect the *** results suggest that *** elicits a local release of GABA in the PVN region,which may act via GABA receptor to produce a facilitative effect on the baroreflex.

关键词： PVN baroreflex GABA conscious rats phenylephrine

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue wang shijie Su Weicheng feng Yaona Lai Kongli Huang Dandan Cao Qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin shi Zhanli Liu Kaijie wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

Banach空间中一类具阻尼的二阶微分包含的可控性

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数学的实践与认识 2016年第21期46卷 255-261页

作者：刘宏亮石峰朱琳王超于金凤哈尔滨师范大学数学科学学院黑龙江哈尔滨150025

主要研究了Banach空间一类具有阻尼项的二阶微分包含的可控性,利用集值映射不动点定理,讨论了集值函数取凸值的情况,给出了微分包含可控性的充分条件.

关键词：微分包含可控性不动点

历史街区的社会网络保护评价与研究——以重庆偏岩镇、白沙镇与宁厂镇为例

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重庆师范大学学报（自然科学版） 2017年第5期34卷 134-140页

作者：黄勇石亚灵冯洁王亚风重庆大学建筑城规学院重庆大学山地城镇建设与新技术教育部重点实验室重庆400030

【目的】保护历史街区的社会网络,改善快速城镇化进程中历史街区出现的"重物轻人、重量轻质、重经济轻文化、重个体轻网络"等问题。【方法】采用社会网络分析方法,选取重庆市北碚区偏岩镇、江津区白沙镇及巫溪县宁厂镇3个国家级历史文... 详细信息

【目的】保护历史街区的社会网络,改善快速城镇化进程中历史街区出现的"重物轻人、重量轻质、重经济轻文化、重个体轻网络"等问题。【方法】采用社会网络分析方法,选取重庆市北碚区偏岩镇、江津区白沙镇及巫溪县宁厂镇3个国家级历史文化名镇,构建核心保护街区的居民户"点"单元与社会关系的"线"关系的语义模型,借助Ucinet 6.0平台构建社会关系网络拓扑结构。计算由网络密度、K-核、切点等6项指标所构建的网络结构稳定性、脆弱性与均衡性社会网络保护评价体系。【结果】偏岩镇的社会网络稳定性值、脆弱值、均衡值分别为1.008,1.27%,1.578 1;白沙镇的分别为0.899,0,0.378 6;宁厂镇的分别为0.643 9,1.72%,0.512 4,整体上偏岩镇的社会网络保护较好。【结论】以社会网络的稳定性、脆弱性、结构均衡性等指标为依据,指导历史街区三区划定、空间格局保护、建筑物分类保护等规划更新。

关键词：历史街区社会网络保护

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing wang Aizhen Zuo Cen Jin Nan wang Huiqi Sun Luqian feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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一种赋形阵列天线的优化设计

微波学报 2010年第S1期26卷 119-122页

作者：石泽锋王建电子科技大学电子工程学院成都611731

给出一种S波段波束赋形阵列天线的优化设计过程,由带状耦合结构的印刷阵子天线并排组成16元直线阵列。为使天线的辐射波束达到给定方向图的主瓣和副瓣要求,采用联合应用DFP和BFGS公式的变度量优化算法,对阵列天线各单元的馈电幅度和相... 详细信息

给出一种S波段波束赋形阵列天线的优化设计过程,由带状耦合结构的印刷阵子天线并排组成16元直线阵列。为使天线的辐射波束达到给定方向图的主瓣和副瓣要求,采用联合应用DFP和BFGS公式的变度量优化算法,对阵列天线各单元的馈电幅度和相位同时进行优化,并考虑阵列中各单元之间的互耦对阵列的影响,通过全波电磁仿真软件HFSS进行了验证,所得的方向图与理论计算十分吻合。根据仿真优化的结果,制作了天线阵实物并进行了测试,得到的测试结果与仿真结果一致。

关键词：阵列天线印刷振子波束赋形优化算法

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胆管癌应用肝血管切除重建的治疗效果研究

血管与腔内血管外科杂志 2017年第3期3卷 779-781页

作者：石峰王亚东阜宁县人民医院普外科江苏盐城224400

目的探讨胆管癌患者应用肝血管切除重建术治疗的效果。方法选取2014年6月至2015年12月本院收治的60例胆管癌患者作为研究对象,根据治疗方法不同分为对照组和观察组,每组各30例。对照组患者采取常规姑息性治疗,观察组患者采取肝血管切除... 详细信息

目的探讨胆管癌患者应用肝血管切除重建术治疗的效果。方法选取2014年6月至2015年12月本院收治的60例胆管癌患者作为研究对象,根据治疗方法不同分为对照组和观察组,每组各30例。对照组患者采取常规姑息性治疗,观察组患者采取肝血管切除重建术治疗,对比2组患者的治疗效果和并发症的发病率。结果观察组患者的手术出血量、手术时间、住院时间和下床活动时间明显优于对照组,差异有统计学意义(P<0.01);观察组患者术后并发症的发病率低于对照组,差异有统计学意义(P<0.05)。结论在胆管癌患者的临床治疗中,采取肝血管切除方法,不仅可以增加手术的切除率,还可以减少术后并发症的发病率,具有可行性。

关键词：胆管癌肝血管切除

Rapid and Efficient Synthesis of Diaryl Carbazones using Microwave Technology

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合成化学 2004年第Z1期12卷 72-72页

作者： shi Lei PAN feng wang Yu-lu School of Chemistry and Environmental Science Henan Normal University Xinxiang 453002 China School of Chemistry and Environmental Science Henan Normal University Xinxiang 453002 China School of Chemistry and Environmental Science Henan Normal University Xinxiang 453002 China

Diaryl carbazone is an important organic analytical reagent normally prepared by the oxidation of diaryl carbazine, but in literatures' methods, the yields were low and the procedures were trouble1,2. Recently, our laboratory reported some new methods for the preparation of diaryl carbazone from diaryl carbazine3,4. Generally, these methods have drawbacks such as tedious operation3, using large amounts of volatile and poisonous solvent which will pollute the environment inevitably3, long reaction time and complicated oxidation system4. In continuation of our studies on the synthesis of azo compounds, we decided to develop a new method to overcome the *** we know, the application of microwave techniques for organic synthesis has attracted considerable interests in recent years5. Using microwave technology can enhance the selectivity and reactivity, increase the chemical yields and shorten the reaction time6. It has been widely used in a variety of organic reactions7,8. However, the synthesis of diaryl carbazones using microwave has not been reported so *** this paper, a rapid and efficient synthesis of diaryl carbazones with NaBrO3/H2SO4 as oxidation system using microwave technology is reported for the first time. By this method, in short time (0.5 rmin), we have synthesized ten diaryl carbazones in good *** the oxidation study, we found that the acidic condition is necessary in these *** method only needs cheap and easily available oxidants, simple instruments and easy *** conclusion, It is a facile and rapid method for the preparation of diaryl carbazones from diaryl carbazines with NaBrO3/H2SO4.

关键词： Diaryl carbazones NaBrO3/H2SO4 microwave technology