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按照“三个紧贴”要求改进创新部队思想政治工作

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军队政工理论研究 2009年第3期10卷 8-9,16页

作者：戴时木广西军区北海军分区广西北海536000

按照"三个紧贴"要求改进创新部队思想政治工作,必须紧贴时代发展,努力实现与时代要求同频共振;紧贴使命任务,切实做到向中心工作聚焦用力;紧贴官兵实际,自觉坚持把以人为本落到实处。

关键词：思想政治工作 “三个紧贴” 改进创新

Influence of the Arctic on the Predictability of Eurasian Winter Extreme Weather Events

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Advances in Atmospheric Sciences 2020年第4期37卷 307-317页

作者： Guokun dai mu mu Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China

The linkage between the Arctic and midlatitudes has received much attention recently due to the rapidly changing *** investigations have been conducted to reveal the relationship between the Arctic and Eurasian extreme events from the perspective of climatological *** a prediction source for extreme events in Eurasia,Arctic conditions are crucial for extreme event ***,it is urgent to explore the Arctic influence on the predictability of Eurasian extreme events due to the large uncertainties in Arctic *** the sensitivity and nonlinearity of the atmospheric circulations in midlatitude to Arctic conditions,it is necessary to investigate the Arctic influences on Eurasian extreme weather events in case studies at weather time *** studies indicate that only perturbations in specific patterns have fast ***,the conditional nonlinear optimal perturbation approach is recommended for exploring the uncertainties in Arctic initial and boundary conditions and their synergistic effect on Eurasian extreme ***,the mechanism for extreme event formation may differ in different ***,more extreme cases should be investigated to reach robust conclusions.

关键词： Arctic uncertainties Eurasian extreme weather events synergistic effect optimization algorithms

An AP-DE Algorithm Based on multi-step Gradient Method

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Chinese Journal of Electronics 2016年第1期25卷 146-151页

作者： dai Dameng mu Dejun College of Physics and Electronic Information Engineering Wenzhou University Department of Automatic Control Northwestern Polytechincal University

Aim to improve the convergence of the adaptive filtering, based on the multi-step gradient method, a new affine pro jection algorithm with direction error is presented. The statistical behavior of the proposed algorithm is analyzed. The deterministic recursive equations for the weight error and for the Mean-square error(MSE) are derived in the weight update direction of the adaptive filtering. The steady-state MSE is also *** results show that the proposed algorithm improve the adaptive filtering convergence and corroborate the theoretical analytical results.

关键词： Affine projection Statistical behavior Adaptive filtering System identification

lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting mi R-490-3p/histone deacetylase 2 axis

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World Journal of Gastroenterology 2019年第38期25卷 5789-5799页

作者： Wei dai Jia-Liang dai Mao-Hua Tang mu-shi Ye Shuo Fang Department of Hepatobiliary Surgery the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina Department of Infectious Disease the Second Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524003Guangdong ProvinceChina Department of Surgery the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina The Seventh Affiliated Hospital Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Li Kashing Faculty of Medicine the University of Hong KongHong KongChina

BACKGROUND Hepatocellular carcinoma(HCC)has become a great threat for people’s *** long noncoding RNAs are involved in the pathogenesis of ***15,as a tissue specific long noncoding RNAs,has been studied in many human cancers,except *** To explore the regulatory mechanism of SNHG15 in *** In the present research,101 HCC patient samples,two HCC cell lines and one normal liver cell line were ***-qPCR and Western blot analysis were applied to detect SNHG15,miR-490-3p and histone deacetylase 2(HDAC2)*** regulatory mechanism of SNHG15 was investigated using CCK-8,Transwell and luciferase reporter *** Our research showed that up-regulation of SNHG15 was found in HCC and was related to aggressive behaviors in HCC ***,knockdown of SNHG15 restrained HCC cell proliferation,migration and *** addition,SNHG15 served as a molecular sponge for ***,miR-490-3p directly targets ***2 was involved in HCC progression by interacting with the SNHG15/miR-490-3p *** In conclusion,long noncoding RNA SNHG15 promotes HCC progression by mediating the miR-490-3p/HDAC2 axis in HCC.

关键词： SNHG15 miR-490-3p Hepatocellular carcinoma Histone deacetylase 2 Pathogenesis Regulatory mechanism

Evaluation of the Forecast Performance for North Atlantic Oscillation Onset

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Advances in Atmospheric Sciences 2019年第7期36卷 753-765页

作者： Guokun dai mu mu Zhina JIANG Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai200438China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing100081China

By utilizing operational forecast products from TIGGE(The International Grand Global Ensemble) during 2006 to 2015,the forecasting performances of the European Centre for Medium-Range Weather Forecasts(ECMWF), National Centers for Environmental Prediction(NCEP), Japan Meteorology Agency(JMA) and China Meteorological Administration(CMA) for the onset of North Atlantic Oscillation(NAO) events are assessed against daily NCEP–NCAR reanalysis data. Twenty-two positive NAO(NAO+) and nine negative NAO(NAO-) events are identified during this time period. For these NAO events,control forecasts, one member of the ensemble that utilizes the currently most proper estimate of the analysis field and the best description of the model physics, are able to predict their onsets three to five days in advance. Moreover, the failure proportion for the prediction of NAO-onset is higher than that for NAO+ onset, which indicates that NAO-onset is harder to forecast. Among these four operational centers, ECMWF has performs best in predicting NAO onset, followed by NCEP,JMA, and then *** forecasting performance of the ensemble mean is also investigated. It is found that, compared with the control forecast, the ensemble mean does not improve the forecasting skill with respect to the onset time of NAO events. Therefore,a confident forecast of NAO onset can only be achieved three to five days in advance.

关键词： NAO onset operational forecast TIGGE dataset

Targeted Observations for Improving Prediction of the NAO Onset

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Journal of Meteorological Research 2019年第6期33卷 1044-1059页

作者： Guokun dai mu mu Zhina JIANG Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

Based on the viewpoint that the North Atlantic Oscillation(NAO)has an intrinsic timescale of approximate two weeks and can be treated as an initial value problem,targeted observations for improving the prediction of the onset of NAO events are investigated by using the conditional nonlinear optimal perturbation(CNOP)method with a quasigeostrophic *** results show that flow-dependent sensitive areas for the prediction of NAO onset are mainly located over North Atlantic and its upstream *** observations over the main sensitive areas could improve NAO onset prediction in most cases(approximately 75%)due to reduced errors in anomalous eddy vorticity forcing(EVF)projection in the typical NAO ***,a flow-independent sensitive area is determined based on the winter climatological flow,which is located over North America and its adjacent *** NAO onset prediction can also be improved by targeted observations over the flow-independent sensitive area,but the skill improvement is somewhat lower than that derived from observations over the flow-dependent sensitive *** above results indicate that targeted observations over sensitive areas identified by the CNOP method can help to improve the onset prediction of NAO events.

关键词： North Atlantic Oscillation(NAO) targeted observations eddy vorticity forcing(EVF) conditional nonlinear optimal perturbation(CNOP)

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A Nonlinear Representation of Model Uncertainty in a Convective-Scale Ensemble Prediction System

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Advances in Atmospheric Sciences 2022年第9期39卷 1432-1450页

作者： Zhizhen XU Jing CHEN mu mu Guokun dai Yanan MA Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Numerical Weather Prediction Center China Meteorological AdministrationBeijing 100081China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

How to accurately address model uncertainties with consideration of the rapid nonlinear error growth characteristics in a convection-allowing system is a crucial issue for performing convection-scale ensemble *** this study,a new nonlinear model perturbation technique for convective-scale ensemble forecasts is developed to consider a nonlinear representation of model errors in the Global and Regional Assimilation and Prediction Enhanced System(GRAPES)Convection-Allowing Ensemble Prediction System(CAEPS).The nonlinear forcing singular vector(NFSV)approach,that is,conditional nonlinear optimal perturbation-forcing(CNOP-F),is applied in this study,to construct a nonlinear model perturbation method for *** experiments are performed:One of them is the CTL experiment,without adding any model perturbation;the other two are NFSV-perturbed experiments,which are perturbed by NFSV with two different groups of constraint radii to test the sensitivity of the perturbation magnitude *** results show that the NFSV-perturbed experiments achieve an overall improvement and produce more skillful forecasts compared to the CTL experiment,which indicates that the nonlinear NFSV-perturbed method can be used as an effective model perturbation method for convection-scale ensemble ***,the NFSV-L experiment with large perturbation constraints generally performs better than the NFSV-S experiment with small perturbation constraints in the verification for upper-air and surface weather *** for precipitation verification,the NFSV-S experiment performs better in forecasts for light precipitation,and the NFSV-L experiment performs better in forecasts for heavier precipitation,indicating that for different precipitation events,the perturbation magnitude constraint must be carefully *** the findings above lay a foundation for the design of nonlinear model perturbation methods for future CAEPSs.

关键词： Convection-Allowing Ensemble Prediction System model uncertainty nonlinear forcing singular vector

Signpost in the maze: high-quality genome of drought-resistant maize germplasm released

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Science China(Life Sciences) 2023年第9期66卷 2196-2197页

作者： Yang mu Mingqiu dai National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China

With the exacerbation of global abnormal climate, drought has become one of the main environmental disasters causing crop yield loss. Maize, an important source of food,feed, and industrial raw materials, is highly vulnerable to water scarcity. Breeding new varieties of high-yield and drought-resistant maize is an urgent demand for the corn industry of China. The identification and utilization of maize drought-resistant germplasm resources are important for breeding new varieties with drought resistance and high yields.

关键词： germplasm breeding drought