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Ligation-assisted endoscopic submucosal resection with circumferential mucosal incision for duodenal carcinoid tumor

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World Journal of Gastroenterology 2015年第34期21卷 10041-10044页

作者： Iri Take Qiang shi Zhi-peng Qi shi-lun Cai li-Qing Yao ping-hong Zhou yun-shi zhong Endoscopy Center Zhongshan Hospital of Fudan University Endoscopy Research Institute of Fudan University

Here we present the case of a 64-year-old female with a duodenal carcinoid tumor treated by ligation-assisted endoscopic submucosal resection(ESMR-L) with circumferential mucosal incision(CMI). Band ligation was effective in resecting the duodenal carcinoid tumor after CMI,with an uneventful post-procedural course. Histopathological examination showed clear tumor margins at deeper tissue levels. Thus,in the present case,ESMR-L with CMI was useful for the treatment of duodenal carcinoid tumor.

关键词： Carcinoid tumor Submucosal tumor Duodenum Ligation

X-ray-activated Bi^(3+)/Pr^(3+)co-doped LiYGeO_4 phosphor with UV and NIR dual-emissive persistent luminescence

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Journal of Rare Earths 2024年第5期42卷 955-961,I0005页

作者： Xianggui Yin Hongyun zhong Lin Liu Junpeng shi Xia Sun yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

X-ray-activated luminescence materials have broad application prospects in photodynamic therapy of deep *** them,X-ray-activated persistent luminescence materials(PLMs)exhibiting multiple emission peaks have drawn extensive attention for the ir capacity to achieve a combination of bioimaging and therapeutic ***,we developed a novel PLM,LiYGeO_4:Bi^(3+),Pr^(3+),that simultaneously exhibits UV and NIR dual persistent luminescence(PersL)emissions after irradiation by *** material can be re peatedly excited by X-ray and emits similar lumine scence intensity every time,which shows good PersL *** addition,LiYGeO_4:Bi^(3+),Pr^(3+)exhibits photostimulated PersL properties by stimulation with a red light-emitting diode(LED)or NIR laser after long-term *** work provides a new choice of X-ray-excited PLMs with UV and NIR dual emission and the novel phosphor shows promise as a potential candidate for the integration of treatment and diagnosis of deep tumors.

关键词： Co-doping X-ray-activated Dual emissions Persistent luminescence Rare earths

An esophageal submucosal tumor treated with submucosal tunneling endoscopic resection:an unexpected result

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Gastroenterology Report 2021年第3期9卷 269-271,I0003页

作者： Ming-Yan Cai Mariana Ferreira Cardoso Yan Zhu yun-shi zhong Ping-Hong Zhou Endoscopy Center Zhongshan HospitalFudan UniversityShanghaiP.R.China Gastroenterology Department Hospital Professor Doutor Fernando FonsecaAmadoraPortugal

Case presentation A 66-year-old female patient underwent esophagogastroduodenoscopy(EGD)in our center because of occasional dysphagia,and a large submucosal tumor(SMT)was identified 32–36cm from the incisors,occupying nearly half of the luminal circumference(Figure 1A).Mini-probe endoscopic ultrasonography(EUS)revealed a hypoechoic submucosal lesion,measuring 20×15mm and originating from the superficial muscularis propria layer(Figure 1B).It was covered by normal-appearing mucosa.

关键词：食管黏膜下肿瘤 superficial Figure

The efficacy of full-thickness endoscopic resection of subepithelial tumors in the gastric cardia

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2111-2119页

作者： En-Pan Xu Zhi-Peng Qi Bing Li zhong Ren Ming-Yan Cai shi-Lun Cai Zhen-Tao Lyv Zhang-Han Chen Jing-Yi Liu Qiang shi yun-shi zhong Endoscopy Center Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Gastric subepithelial tumors(SETs)may harbor potential *** it is well recognized that large SETs should be resected,the precise treatment strategy remains *** to surgical resection,endoscopic resection(ER)has many advantages;however,ER of SETs in the cardia is *** To evaluate the safety and efficacy of endoscopic full-thickness resection(EFTR)for the treatment of gastric cardia *** We retrospectively reviewed data from all patients with SETs originating from the muscularis propria layer in the gastric cardia that were treated by EFTR or submucosal tunneling ER(STER)at zhongshan Hospital Fudan University between November 2014 and May *** characteristics and clinical outcomes,including procedure times and complications rates,were compared between groups of patients receiving EFTR and *** A total of 171 tumors were successfully removed[71(41.5%)tumors in the EFTR and 100(58.5%)tumors in the STER group].Gastrointestinal stromal tumors(GISTs)were the most common *** en bloc resection rate was 100%in the EFTR group vs 97.0%in STER group(P>0.05).Overall,the EFTR group had a higher complete resection rate than the STER group(98.6%vs 91.0%,P<0.05).The procedure time was also shorter in the EFTR group(44.63±28.66 min vs 53.36±27.34,P<0.05).The most common major complication in both groups was electrocoagulation *** was no significant difference in total complications between the two groups(21.1%vs 22.0%,P=0.89).CONCLUSION EFTR of gastric cardia SETs is a very promising method to facilitate complete resection with similar complications and reduced operative times compared to *** cases of suspected GISTs or an unclear diagnosis,EFTR should be recommended to ensure complete resection.

关键词： Endoscopic full-thickness resection Submucosal tunneling endoscopic resection Gastrointestinal stromal tumor Gastric cardia Gastric subepithelial tumors

Postoperative morbidity adversely impacts oncological prognosis after curative resection for hilar cholangiocarcinoma

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World Journal of Gastroenterology 2022年第9期28卷 948-960页

作者： Zhi-Peng Liu Wei-Yue Chen Yan-Qi Zhang Yan Jiang Jie Bai Yu Pan shi-yun zhong yun-Ping zhong Zhi-Yu Chen Hai-Su Dai Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Clinical Center of Oncology Lishui Hospital of Zhejiang UniversityLishui 323000Zhejiang ProvinceChina Department of Health Statistics Third Military Medical University(Army Medical University)Chongqing 400038China

BACKGROUND Postoperative morbidity after curative resection for hilar cholangiocarcinoma(HCCA)is common;however,whether it has an impact on oncological prognosis is *** To evaluate the influence of postoperative morbidity on tumor recurrence and mortality after curative resection for *** Patients with recently diagnosed HCCA who had undergone curative resection between January 2010 and December 2017 at The First Affiliated Hospital of Army Medical University in China were *** independent risk factors for morbidity in the 30 d after surgery were investigated,and links between postoperative morbidity and patient characteristics and outcomes were *** morbidities were divided into five grades based on the Clavien-Dindo classification,and major morbidities were defined as Clavien-Dindo≥*** and multivariate Cox regression analyses were used to evaluate the risk factors for recurrence-free survival(RFS)and overall survival(OS).RESULTS Postoperative morbidity occurred in 146 out of 239 patients(61.1%).Multivariate logistic regression revealed that cirrhosis, intraoperative blood loss > 500 mL, diabetes mellitus,and obesity were independent risk factors. Postoperative morbidity was associated with decreasedOS and RFS (OS: 18.0 mo vs 31.0 mo, respectively, P = 0.003;RFS: 16.0 mo vs 26.0 mo, respectively,P = 0.002). Multivariate Cox regression analysis indicated that postoperative morbidity wasindependently associated with decreased OS [hazard ratios (HR): 1.557, 95% confidence interval(CI): 1.119-2.167, P = 0.009] and RFS (HR: 1.535, 95%CI: 1.117-2.108, P = 0.008). Moreover, majormorbidity was independently associated with decreased OS (HR: 2.175;95%CI: 1.470-3.216, P <0.001) and RFS (HR: 2.054;95%CI: 1.400-3.014, P < 0.001) after curative resection for *** morbidity (especially major morbidity) may be an independent risk factor forunfavorable prognosis in HCCA patients following curative resection

关键词： Hilar cholangiocarcinoma Morbidity Surgery Oncology Survival Recurrence

Self-expandable metallic stent placement plus laparoscopy for acute malignant colorectal obstruction

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World Journal of Gastroenterology 2013年第33期19卷 5513-5519页

作者： Jia-Min Zhou Li-Qing Yao Jian-Min Xu Mei-Dong Xu Ping-Hong Zhou Wei-Feng Chen Qiang shi zhong Ren Tao Chen yun-shi zhong Department of Endoscopic Center Zhongshan HospitalFudan University Department of General Surgery Zhongshan HospitalFudan University

AIM:To investigate the clinical advantages of the stent-laparoscopy approach to treat colorectal cancer(CRC)patients with acute colorectal obstruction(ACO).METHODS:From April 2008 to April 2012,surgeryrelated parameters,complications,overall survival(OS),and disease-free survival(DFS)of 74 consecutive patients with left-sided CRC presented with ACO who underwent self-expandable metallic stent(SEMS)placement followed by one-stage open(n=58)or laparoscopic resection(n=16)were evaluated *** stent-laparoscopy group was also compared with a control group of 96 CRC patients who underwent regular laparoscopy without ACO between January 2010 and December 2011 to explore whether SEMS placement influenced the laparoscopic procedure or reduced long-term survival by influencing CRC oncological ***:The characteristics of patients among these groups were *** rate of conversion to open surgery was 12.5%in the stent-laparoscopy *** function recovery and postoperative hospital stay were significantly shorter(3.3±0.9 d vs 4.2±1.5 d and 6.7±1.1 d vs 9.5±6.7 d,P=0.016 and P=0.005),and surgical time was significantly longer(152.1±44.4 min vs 127.4±38.4 min,P=0.045)in the stent-laparoscopy group than in the stent-open ***-related complications and the rate of admission to the intensive care unit were lower in the stent-laparoscopy *** were no significant differences in the interval between stenting and surgery,intraoperative blood loss,OS,and DFS between the two stent *** with those in the stentlaparoscopy group,all surgery-related parameters,complications,OS,and DFS in the control group were ***:The stent-laparoscopy approach is a feasible,rapid,and minimally invasive option for patients with ACO caused by left-sided CRC and can achieve a favorable long-term prognosis.

关键词： Self-expandable metallic stent Colorectal cancer Endoscopy Laparoscopy Efficiency Safety

High-resolution remote thermometry based on Bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi shi Shu-Hua Xue Jin-yun Wang Liang-Jin Xu zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through Bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi^(3+)is mainly responsible for the blue emission. Single crystals of Bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids Bi^(3+)doping blue emission temperature sensing

Weakly Compact Sets and Riesz Representation Theorem in Musielak Sequence Spaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 467-484页

作者： Wan zhong GONG Si Yu shi zhong Rui shi Department of Mathematics Anhui Normal UniversityWuhu 241000P.R.China Smeal College of Business Pennsylvania State UniversityUniversity ParkPennsylwania 16802USA Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

In this work,we give some criteria of the weakly compact sets and a representation theorem of Riesz's type in Musielak sequence spaces using the ideas and techniques of sequence spaces and Musielak ***,as an immediate consequence of the criteria considered in this paper,the criteria of the weakly compact sets of Orlicz sequence spaces are deduced.

关键词： Compact set weak topology Banach space dual space Musielak sequence spaces

Endoscopic resection for calcifying fibrous tumors of the gastrointestinal tract

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World Journal of Clinical Oncology 2024年第2期15卷 282-289页

作者： Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-Fan Qu shi-Yao Chen yun-shi zhong Yi-Qun Zhang Wei-Feng Chen Wen-Zheng Qin Jian-Wei Hu Ming-Yan Cai Li-Qing Yao Quan-Lin Li Ping-Hong Zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Collaborative Innovation Center of Endoscopy Shanghai 200032China

BACKGROUND Calcifying fibrous tumors(CFTs)are rare mesenchymal lesions that can occur in various sites throughout the body,including the tubular gastrointestinal(GI)*** To analyze the clinical findings of 36 patients with GI tract CFTs to provide guidance for diagnosis and *** This retrospective study included 36 patients diagnosed with CFTs of the GI *** collected demographic and clinical information and conducted regular follow-ups to assess for local *** The stomach was the most commonly involved site,accounting for 72.2%of the 36 *** mucosal resection(n=1,2.8%),endoscopic submucosal dissection(n=14,38.9%),endoscopic full-thickness resection(n=16,44.4%),and submucosal tunneling endoscopic resection(n=5,13.9%)were used to resect calcifying fibrous ***,34(94.4%)CFTs underwent complete endoscopic resections with a mean procedure time of 39.8±29.8 *** average maximum diameter of the tumors was 10.6±4.3 *** complications,such as bleeding or perforation,occurred during an average hospital stay of 2.9±1.2 *** addition,two patients developed new growth of CFTs near the primary tumor sites,and none of the patients developed distant metastases during the follow-up *** GI tract CFTs are rare and typically benign tumors that can be effectively managed with endoscopic procedures.

关键词： Endoscopic resection Calcifying fibrous tumor Gastrointestinal tract