检索结果-南通市图书馆

White adipose tissue browning and obesity

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2017年第1期31卷 1-2页

作者： Xiao-Bing Cui shi-you chen Department of Physiology & Pharmacology University of Georgia Athens GA 30602 USA

Obesity and metabolic disorders are major health concems worldwide. Although a range of therapies have been developed, these pharmaceutical treatments often have adverse side effects or limited efficacy. Therefore, there is a growing need of novel therapeutics to prevent or treat obesity. Obesity is thought to be caused by an imbalance between energy intake and energy consumption. Increasing energy consumption is considered as a potential therapeutic strategy to treat obesity and its related disorders.

关键词： obesity adipose pharmaceutical intake imbalance metabolism embryonic uncoupling downstream brown

From nerve to blood vessel:a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2015年第4期29卷 261-263页

作者： Ning shi shi-you chen Department of Physiology & Pharmacology University of Georgia

Vascular smooth muscle cell （SMC） differentiation is an important process in vasculogenesis and angio- genesis during embryonic development. The altera- tions in the differentiated state in SMCs contribute to a variety of major cardiovascular diseases such as atherosclerosis, hypertension, restenosis and vascular aneurysm . A better understanding of the cellular and molecular mechanisms that control SMC differen-tiation is essential to help develop new approaches to both prevent and treat these diseases. Therefore, development of reliable and reproducible in vitro cellular models in order to study the differentiation mechanisms is important although it has been challenging because of intrinsic peculiarities of SMC.

关键词： From nerve to blood vessel cell stem SMC

Transforming growth factor-β signaling in systemic sclerosis

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2018年第1期32卷 3-12页

作者： Nolan B.Ayers chenming Sun shi-you chen Department of Physiology & Pharmacology University of Georgia

Systemic sclerosis（SSc） is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific Immune system, resulting in autoantibody production, vascular endothelial activation of small blood vessels, and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc. Regardless, recent research has elucidated the roles of various ubiquitous molecular mechanisms that contribute to the clinical manifestation of the disease. Transforming growth factor β（TGF-β） has been identified as a regulator of pathological fibrogenesis in SSc. Various processes, including cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis are regulated by TGF-β,a type of cytokine secreted by macrophages and many other cell types. Understanding the essential role TGF-β pathways play in the pathology of systemic sclerosis could provide a potential outlet for treatment and a better understanding of this severe disease.

关键词： systemic sclerosis transforming growth factor-β mechanism therapeutics

Transforming growth factor-β and smooth muscle differentiation

在线全文

学校读者我要写书评

暂无评论

World Journal of Biological Chemistry 2012年第3期3卷 41-52页

作者： Xia Guo shi-you chen Xia Guo Shi-You Chen Department of Physiology and Pharmacology University of Georgia Athens GA 30602 United States.

Transforming growth factor(TGF)-β family members are multifunctional cytokines regulating diverse cel- lular functions such as growth,adhesion,migration, apoptosis,and ***-βs elicit their effects via specific typeⅠand typeⅡserine/threonine kinase receptors and intracellular Smad transcription factors. Knockout mouse models for the different components of the TGF-β signaling pathway have revealed their critical roles in smooth muscle cell(SMC)differentia- *** studies in humans have linked mutations in these signaling components to specific cardiovascular disorders such as aorta aneurysm and congenital heart diseases due to SMC *** this review,the current understanding of TGF-β function in SMC differentiation is highlighted,and the role of TGF-βsignaling in SMC- related diseases is discussed.

关键词： Transforming growth factor β Smad Smooth muscle cell Differentiation Cardiovascular diseases

Properties of long light filaments in natural environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第8期27卷 364-367页

作者： shi-you chen Hao Teng Xin Lu Zong-Wei Shen Shuang Qin Wen-Shou Wei Rong-Yi chen Li-Ming chen Yu-Tong Li Zhi-Yi Wei Beijing National Laboratory lbr Condensed Matter Physics Institute of Physics.Chinese Academy of Sciences.Be（jing 100190China School of Physical Sciences University of Chinese Academy of Sicenccs.Be（ring 100049.China Institute of Desert Meteorology.China Meteorological Administration l_h＇umqi 830002China IFSA Collabon~tive lnnowltion Center Shanghai.liao Tong UniversityShanghai 200240China School of Instrumentation Science and Optoelectronics Engineering Beijing hTt＇ormation Science ＆ Technology Univer.sityBeijing 100192.China

The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated fs laser pulse freely propagating in an open atmosphere. This study provides the first quantitative experimental data about the electron density of a long range light filament in the atmosphere. The electron density of such a filament is quantitatively detected by using an electric method, showing that it is at the 1011-cm -3 level.

关键词： laser-plasma interactions filamentation propagation

珠江口磨刀门水道枯季咸潮上溯与盐度输运机理分析

在线全文

学校读者我要写书评

暂无评论

海洋通报 2016年第6期35卷 625-631页

作者：高时友陈子燊中山大学地理和规划学院广东广州510275 珠江水利科学研究院广东广州510611

以珠江河口磨刀门盐度和流速观测资料为基础,采用盐度输运分解的计算方法对磨刀门盐度输运特征进行分析,对比各分解项动力成因和对盐度输运贡献的大小,分析磨刀门水道盐度分布特征和输运特征,结果表明:(1)磨刀门水道盐度输运主要由径流... 详细信息

以珠江河口磨刀门盐度和流速观测资料为基础,采用盐度输运分解的计算方法对磨刀门盐度输运特征进行分析,对比各分解项动力成因和对盐度输运贡献的大小,分析磨刀门水道盐度分布特征和输运特征,结果表明:(1)磨刀门水道盐度输运主要由径流为主要作用的欧拉输运、潮流剪切输运和由河口密度梯度产生的垂向环流输运为主,其中欧拉输运方向向海,潮流剪切和重力环流输运向陆,两种不同方向的盐度输运在大、小潮期相对强弱的变化,导致了咸潮上溯的增强或者减弱。小潮期间,垂向环流和潮流剪切输运大于欧拉输运,净输运方向向陆导致咸潮上溯;大潮期间,垂向环流输运显著减小,净输运方向向海导致咸潮后退。(2)洪湾水道盐度输运主要以欧拉输运为主,垂向环流输运很小,与磨刀门水道盐度输运具有显著的不同。

关键词：咸潮上溯盐度输运垂向环流

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing Dong Dong chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 193-202页

作者： Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and shi-you chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA Cancer Center Renmin Hospital of Wuhan University Wuhan 430060 China Cancer Center the 82nd Hospital of the Chinese PLA Huai'an 223001 China Department of Physiology Medical College of Wuhan University Wuhan 430071 China Department of Physiology & Pharmacology University of Georgia Athens GA 30602 USA

BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor ***,its role in hepatocellular carcinoma(HCC) cells remains ***:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical *** was evaluated by TUNEL *** viability and apoptosis were determined by MTT assay and flow cytometry,***-related proteins in SMMC-7721 and HepG2 cells were detected by Western ***:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of *** inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent *** in vivo study demonstrated that baicalein also reduced neoplastic ***,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of ***,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of ***:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment.

关键词： hepatocellular carcinoma 12-lipoxygenase proliferation apoptosis

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi shi Wei chen shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine