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Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine

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Journal of Integrative Medicine 2020年第4期18卷 275-283页

作者： shi-xin wang Yan wang Yu-bao Lu Jie-yun Li Yu-jun Song Munkhtuya Nyamgerelt Xue-xi wang School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000Gansu ProvinceChina

Since the outbreak of novel coronavirus pneumonia(coronavirus disease 2019,COVID-19),it has rapidly spread to 187 countries,causing serious harm to the health of people and a huge social ***,currently,drugs specifically approved for clinical use are not available,except for vaccines against COVID-19 that are being *** Chinese medicine(TCM)is capable of performing syndrome differentiation and treatment according to the clinical manifestations of patients,and has a better ability of epidemic prevention and *** authors comprehensively analyzed the etiology and pathogenesis of COVID-19 based on the theory of TCM,and discussed its syndrome differentiation,treatment and prevention measures so as to provide strategies and reference for the prevention and treatment with TCM.

关键词： Coronavirus Novel coronavirus Coronavirus disease 2019 COVID-19 Novel coronavirus pneumonia Severe acute respiratory syndrome coronavirus 2 Traditional Chinese medicine

Influence of Geometric Structure of Immobilized Aluminium Chloride Catalyst on Catalytic Property in Isobutene Polymerization

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Chinese Chemical Letters 2001年第7期12卷 647-650页

作者： Tian Xi CAI, Min HE, Xian Zhe shi, xin Ping wang State Key Laboratory for Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116012 State Key Lab. for Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116012 China

The catalytic property of AICl(3) catalyst immobilized on gamma -Al2O3 for isobutene polymerization has been studied. It was found that the activity, selectivity and stability of the catalyst are dependent greatly on geometric characteristic pf the pore structure and size of catalyst. Although the activity and selectivity of the catalysts with micro- and meso-pore structure are all high in initial stage, but their stability is low, while those with bimodal meso- and macro-pore structure are excellent. Increasing granularity of the catalyst(particle become fine) brings about an increase in isobutene conversion, but a decrease in selectivity, resulting in lower average molecular weight and iis broader distribution.

关键词： AlCl3 immobilization gamma-Al2O3 bimodal meso- and macro-pore structure isobutene polymerization stability

Management of Acute Lower Extremity Thrombosis Associated with Bilateral Popliteal Aneurysms Using Combined Thrombolytic Therapy and Stent Graft Repair

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Chinese Medical Journal 2015年第4期128卷 564-566页

作者： Bao-Lei Guo Wei-Guo Fu Zhen-Yu shi Li-xin wang Da-Qiao Guo Department of Vascular Surgery Zhongshan Hospital Fudan University Institute of Vascular Surgery Shanghai 200032 China

To the Editor：This is a brief clinical report on different endovascular procedures in the treatment of popliteal artery aneurysms （PAAs）.A 75-year-old man presented at the vascular clinic with progressive left lower limb pain at rest associated with coolness,pain,and *** medical history was significant for hypertension and *** femoral and popliteal pulsations were only felt in the left ***,pallor,paresthesia,delayed capillary refilling,and color changes were noted in the left limb together with rest *** ultrasound was performed and an embolization （Rutherford Grade 2b） and bilateral PAAs were found,which on computed tomography angiogram （CTA） measured 62 mm and 82 mm with the maximum diameters in the right and left popliteal artery,*** was found in both aneurysm sacs [Figure 1 a and b].Thromboembolism from the left PAA could be seen in the distal *** potentially associated aneurysms were excluded by magnetic resonance *** erythrocyte sedimentation rate and C-reactive protein were moderately elevated,and thrombophilia profile was negative,and history for any orogenital ulcers was negative.

关键词： Popliteal Artery Aneurysms Endovascular Therapy Stent Grafts

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu wang Jue Tang Mansheng Chu Quan shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Determination of residual formamide in alginate sulfate

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Determination of residual formamide in alginate sulfate

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

中国化学会第三届全国糖化学会议

作者： Huan LIU Mei-jie XU Li wang Ni SONG shi-xin wang Chun-xia LI Key Laboratory of Marine Drugs Ministry of EducationShandong Provincial Key Laboratory of glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of China Marine Biomedical Research Institute of Qingdao Marine Glycodrug Research and Development Laboratory

Alginate sulfate is an anti-HIV sulfated polysaccharide candidate drug obtained by molecular modification of alginate showing good application prospects in *** the preparation of alginate sulfate,the introduction of the sulfate group is carried out by the chlorosulfonic acid-formamide method,which may lead to the residual of *** order to improve the quality control of the raw material drug,the amount of formamide remaining in the alginate sulfate should be *** recent years,gas chromatography-mass spectrometry(GCMS) has played an important role in the qualitative identification and quantitative analysis of substances,Which combining the excellent separability of gas chromatography with the high selectivity of mass *** this paper,ultrasonic extraction method was used to pretreat the samples,and the content of formamide in the samples was determined by gas chromatography-mass spectrometry(GC-MS).Result:Our work showed the separation of formamide and solvent peak was *** method was proved to be accurate,stable and *** can be used for the determination of formamide solvent residues in alginate sulfate.

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来源： cnki会议评论

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong wang Pengyang wang Yali Liu Shanshan Qi Biao shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

干扰素调控因子3:细胞抗病毒反应的核心转录因子

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生物化学与生物物理进展 2010年第8期37卷 817-825页

作者：刘星石贺欣王琛中国科学院上海生命科学研究院生物化学与细胞生物学研究所上海200031

固有免疫系统是宿主抵御病毒入侵的第一道防线.Ⅰ型干扰素是关键的抗病毒细胞因子,它在细胞建立抗病毒状态的过程中发挥了核心的作用.Ⅰ型干扰素的诱导表达是固有免疫的重要调节与效应机制.已有的研究表明:多种转录因子(NF-kappa B、ATF... 详细信息

固有免疫系统是宿主抵御病毒入侵的第一道防线.Ⅰ型干扰素是关键的抗病毒细胞因子,它在细胞建立抗病毒状态的过程中发挥了核心的作用.Ⅰ型干扰素的诱导表达是固有免疫的重要调节与效应机制.已有的研究表明:多种转录因子(NF-kappa B、ATF-2/c-Jun、IRF3、IRF7)通过在Ⅰ型干扰素的转录调控区形成稳定的转录增强复合物(enhanceosome),迅速并大量地诱导Ⅰ型干扰素表达.体内与体外的生物学分析已确立,干扰素调控因子3(IRF3)是介导细胞表达Ⅰ型干扰素最关键的转录因子,其转录活力与生物学功能直接影响细胞的抗病毒的能力.近年来,IRF3相关的细胞信号转导与调控机制等研究取得重大进展.围绕IRF3的结构、功能以及分子调控机制等方面,概述相关的研究进展,并做前沿展望。

关键词：干扰素调控因子3 转录活性调控蛋白质翻译后修饰细胞信号转导抗病毒分子机制

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滚筒式残膜回收机的性能试验研究

农业工程学报 2017年第16期33卷 26-31页

作者：刘旋峰石鑫郭兆峰王春耀王学农新疆农业科学院农业机械化研究所乌鲁木齐830091 新疆大学机械工程学院乌鲁木齐830008

针对"11SM-1.5型滚筒式残膜回收机"核心工作参数匹配不合理,机具在作业时,常常由于使用者操作方式与水平存在差异,影响残膜回收的总体拾膜性能,进而降低残膜拾净率。滚筒式残膜回收机是一种以弧线往复式挑膜装置为核心部件的典型残膜回... 详细信息

针对"11SM-1.5型滚筒式残膜回收机"核心工作参数匹配不合理,机具在作业时,常常由于使用者操作方式与水平存在差异,影响残膜回收的总体拾膜性能,进而降低残膜拾净率。滚筒式残膜回收机是一种以弧线往复式挑膜装置为核心部件的典型残膜回收机具,该研究根据滚筒式残膜回收机的结构和工作原理,分析弧线往复式挑膜装置的挑膜齿尖运动轨迹特点,确定影响机具性能的主要因子为挑膜装置转速、机具前进速度和挑膜齿入土深度,采用正交试验分析法进行田间试验,分析不同参数配比对残膜拾净率的影响,得出各因素的影响显著性及主次顺序。综合考虑挑膜装置各项指标,选择最优的水平组合,获取机具的最佳工作参数匹配,即:挑膜装置转速45 r/min、机具工作速度4 km/h和挑膜齿入土深度35 mm时,残膜拾净率为88.2%,达到残膜回收机设计标准,比目前成熟的秸秆还田联合式残膜回收机的官方测定捡拾率高6.2个百分点,为机具优化设计提供数据参考,进而指导实际生产。

关键词：农业机械塑料薄膜试验残膜回收挑膜装置残膜拾净率