Graphene and graphene-based materials in axonal repair of spinal cord injury

作     者：Shi-Xin Wang Yu-Bao Lu Xue-Xi Wang Yan Wang Yu-Jun Song Xiao Wang Munkhtuya Nyamgerelt Shi-Xin Wang;Yu-Bao Lu;Xue-Xi Wang;Yan Wang;Yu-Jun Song;Xiao Wang;Munkhtuya Nyamgerelt

作者机构：School of Basic Medical SciencesLanzhou UniversityLanzhouGansu ProvinceChina The Second Clinical Medical CollegeLanzhou UniversityLanzhouGansu ProvinceChina Department of Spine SurgeryThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu ProvinceLanzhouGansu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第10期

页      面：2117-2125页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Lanzhou Talent Innovation and Entrepreneurship Project,No.2020-RC-40(to XXW and YBL) Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital,Nos.CYXZ2020-03,CYXZ2021-01(both to YBL) 

主　　题：axonal regeneration graphene graphene oxide nerve axon regeneration reduced graphene oxide spinal cord contusions spinal cord injury spinal cord trauma 

摘      要：Graphene and graphene-based materials have the ability to induce stem cells to differentiate into neurons,which is necessary to overcome the current problems faced in the clinical treatment of spinal cord *** review summarizes the advantages of graphene and graphene-based materials(in particular,composite materials)in axonal repair after spinal cord *** materials have good histocompatibility,and mechanical and adsorption properties that can be targeted to improve the environment of axonal *** also have good conductivity,which allows them to make full use of electrical nerve signal stimulation in spinal cord tissue to promote axonal ***,they can be used as carriers of seed cells,trophic factors,and drugs in nerve tissue engineering scaffolds to provide a basis for constructing a local microenvironment after spinal cord ***,to achieve clinical adoption of graphene and graphene-based materials for the repair of spinal cord injury,further research is needed to reduce their toxicity.