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Circadian disturbance induces erectile dysfunction by impairing endothelial function

Asian Journal of Andrology 2024年第2期26卷 205-211页

作者： Tao Li Yi-Ting Jiang Xin-Zhu Qi Peng Chen Jun-Hao Zhang Fu Luo Jun Qiao Jiang Gu Guang-shi Du qiang Wang Department of Urology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Guizhou Provincial People's HospitalGuiyang 550002China Department of Otorhinolaryngology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Guizhou Institute for Food and Drug Control Guiyang 550004China Department of Reproductive Center Guizhou Provincial People's HospitalGuiyang 550002China Translational Medicine Research Center of Guizhou Medical University Guiyang 550025China

In order to explore the impact of circadian disturbance on erectile function,we randomly divided 24 adult male rats into groups of control(light on at 8:00 *** off at 8:00 p.m.),dark/dark(DD;constant dark),light/light(LL;constant light),and shift dark/light(DL;light off at 8:00 *** on at 8:0o p.m.).Four weeks later,erectile function was measured and corpora cavernosa were harvested for *** maximum intracavernous pressure(mlcP)and mCP/mean arterial pressure(MAP)ratio in the DD,LL,and DL groups were significantly lower than that in the control *** LL and DL groups showed significantly attenuated endothelial nitric oxide synthase(eNOS),while DD,LL,and DL showed reduced neuronal nitric oxide synthase(nNOS)at both mRNA and protein *** production of nitric oxide(NO)and cyclic guanosinemonophosphate(cGMP)was inhibited by altered light/dark cycles to varying *** disturbance impaired endothelial function and contributed to erectile *** the core circadian elements,mRNA expression of circadian locomotor output cycles kaput(Clock)and brain/muscle aryl-hydrocarbon receptor nuclear translocator-like protein 1(Bmal1)was elevated in the DL group,but their protein expression was not significantly ***,LL,and DL increased period 1(Per1)and Per3 levels,while LL and DL increased PER1 *** significant difference was found for Per2levels,and PER2 and PER3 concentrations were not significantly ***,LL and DL significantly increased cryptochrome-1(CRY1)and CRY2 at both mRNA and protein *** altered light/dark rat model showed that circadian disturbance contributed to erectile dysfunction probably by impairing endothelial ***,the core circadian elements were detected in the corpora cavernosa,but these were ***,which circadian element regulates erectile function and how it works need further analysis.

关键词： circadian disturbance endothelial function erectile function light/dark cycle NO/cGMP

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Effects of dense planting patterns on photosynthetic traits of different vertical layers and yield of wheat under different nitrogen rates

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The Crop Journal 2024年第2期12卷 594-604页

作者： Cuicun Wang Ke Zhang Qing Liu Xiufeng Zhang Zhikuan shi Xue Wang Caili Guo qiang Cao Yongchao Tian Yan Zhu Xiaojun Liu Weixing Cao National Engineering and Technology Center for Information Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina MOE Engineering Research Center of Smart Agricultural Nanjing Agricultural UniversityNanjing 210095JiangsuChina MARA Key Laboratory for Crop System Analysis and Decision Making Nanjing Agricultural UniversityNanjing 210095JiangsuChina Jiangsu Key Laboratory for Information Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Smart Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina

A two-year field experiment was conducted to measure the effects of densification methods on photosynthesis and yield of densely planted ***-plant and inter-row distances were used to define ratefixed pattern(RR)and row-fixed pattern(RS)density ***,four nitrogen(N)rates(0,144,192,and 240 kg N ha-1,termed N0,N144,N192,and N240)were applied with three densities(225,292.5,and 360×10^(4)plants ha^(-1),termed D225,D292.5,and D360).The wheat canopy was clipped into three equal vertical layers(top,middle,and bottom layers),and their chlorophyll density(Ch D)and photosynthetically active radiation interception(FIPAR)were *** showed that the response of Ch D and FIPAR to N rate,density,and pattern varied with different layers.N rate,density,and pattern had significant interaction effects on Ch *** maximum values of whole-canopy Ch D in the two seasons appeared in N240 combined with D292.5 and D360 under RR,*** two growing seasons,FIPAR values of RR were higher than those of RS by 29.37%for the top layer and 5.68%for the middle layer,while lower than those of RS by 20.62%for the bottom layer on *** a low N supply(N0),grain yield was not significantly affected by density for both *** N240,increasing density significantly increased yield under RR,but D360 of RS significantly decreased yield by 3.72%and 9.00%versus D225 in two seasons,*** an appropriate and sufficient N application,RR increased the yield of densely planted wheat more than ***,the maximum yield in two seasons appeared in the combination of D360 with N144 or N192 rather than of D225 with N240 under both patterns,suggesting that dense planting combined with an appropriate N-reduction application is feasible to increase photosynthesis capacity and yield.

关键词： Chlorophyll density Densification method Nitrogen Photosynthetically active radiation interception Wheat

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DIR:Dynamic Request Interleaving for Improving the Read Performance of Aged Solid-State Drives

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Journal of Computer Science & Technology 2024年第1期39卷 82-98页

作者：聂世强张驰伍卫国 Department of Computer Science and Technology Xi'an Jiaotong UniversityShaanci 710049China

Triple-level cell(TLC)NAND flash is increasingly adopted to build solid-state drives(SSDs)for modern computer *** TLC NAND flash effectively improves storage density,it faces severe reliability issues;in partic-ular,the pages exhibit different raw bit error rates(RBERs).Integrating strong low-density parity-check(LDPC)code helps to improve reliability but suffers from prolonged and proportional read latency due to multiple read retries for worse *** straightforward idea is that dispersing page-size data across several pages in different types can achieve a low-er average RBER and reduce the read ***,directly implementing this simple idea into flash translation lay-er(FTL)induces the read amplification issue as one logic page residing in more than one physical page brings several read *** this paper,we propose the Dynamic Request Interleaving(DIR)technology for improving the performance of TLC NAND flash-based SSDs,in particular,the aged ones with large *** exploits the observation that the la-tency of an I/O request is determined,without considering the queuing time,by the access of the slowest device page,i.e.,the page that has the highest *** grouping consecutive logical pages that have high locality and interleaving their encoded data in different types of device pages that have different RBERs,DIR effectively reduces the number of read re-tries for LDPC with limited read *** meet the requirement of allocating hybrid page types for interleaved data,we also design a page-interleaving friendly page allocation scheme,which splits all the planes into multi-plane re-gions for storing the interleaved data and single-plane regions for storing the normal *** pages in the multi-plane re-gion can be read/written in parallel by the proposed multi-plane command and avoid the read amplification *** on the DIR scheme and the proposed page allocation scheme,we build DIR-enable FTL,which integrates the pro

关键词： triple-layer cell solid-state drive(TLC SSD) performance interleaving data unbalanced bit error rate

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Energy band modulation of N-doped rutile/anatase TiO2 photoanode promoting charge separation toward prominent photoelectrochemical performance

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Rare Metals 2024年第8期43卷 3784-3797页

作者： Juan Gao shi-Xuan Wang Jia-Le Deng Ping-Ping Wei Fu-Zhang Chen Ling-Cheng Zheng Yue-Qin Wang Yang Li yin Liu Gang He School of Mechanics and Photoelectric Physics Anhui University of Science and Technology School of Materials Science and Engineering Anhui University Tianneng Battery (Wuhu) Co. Ltd. School of Materials Science and Engineering Anhui University of Science and Technology

To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO2-based materials,a simple N-doped anatase/rutile TiO2heterophase nanorod film was designed by a low-temperature hydrothermal method in this *** enhanced separation and transport of photogenerated charges were facilitated by the smaller contact barrier and appropriate band matching between anatase TiO2nanoparticles and rutile *** introduction of N doping in anatase TiO2resulted in an upward shift of the valence band and a narrowing of the band gap,consequently enhancing the efficiency of visible light *** combination of the heterophase junction and N-doping exhibited a synergistic effect,effectively suppressing the recombination of photogenerated charges and enhancing the photoelectric conversion efficiency of the *** AM 1.5G irradiation,the photocurrent density（J） of the A-TO（N）@R-TONR photoanode reached2.19 mA·cm-2(VRHE,1.23 eV).Additionally,the incident photon-electron conversion efficiency（IPCE） and the charge injection efficiency（η） reached 81.4% and 51.6% at320 ***,the J,IPCE,and η values of the A-TO（N）@R-TONR photoanode were 2.96,2.1 and 3.2times those of pure R-TONR photoanode,*** work presents a rational strategy for designing efficient TiO2-based photoanodes.

关键词： TiO 2 Heterophase junction Photoanode

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Low-noise and low-power pixel sensor chip for gas pixel detectors

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Nuclear Science and Techniques 2024年第3期35卷 142-152页

作者： Zhuo Zhou shi-qiang Zhou Dong Wang Xiang-Ming Sun Chao-Song Gao Peng-Zhen Zhu Wei-Ping Ren Jun Liu Mu-Xian Li Chen Lian Chun-Lai Dong PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China

Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in *** pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μ*** array is divided into 16 subarrays,with pixels of 400 rows×32 columns per *** pixel incorporates two charge sensors:a diode sensor and a Topmetal *** in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival *** pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μ*** an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~*** this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of ***,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.

关键词： Charge collection Gas detectors Semiconductor detectors X-ray detectors

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Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye yin-Hua Huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

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Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

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Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu Jiawei Yang Chaofan Zhou Zhaoning Hu Saiyu Bu Bingbing Guo Yixuan Zhao Junhao Liao Mingpeng Shang Ge Chen Kaicheng Jia Jianbo yin qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China Second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

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Inonotus obliquus polysaccharides prevent UVB-induced skin photodamage by modulating Sirt3-activated Foxo3a/PINK1-Parkin pathway: an in vitro and in vivo study

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Food Science and Human Wellness 2024年

作者： Pei Lin yin-ying Lu Hong-yu shi Zhen-dong Chen Jun Lin School of Life Sciences and Health Engineering Jiangnan University

Inonotus obliquus， an edible and medicinal fungus， has proven to be beneficial for relieving body aging. Previous research has shown that Inonotus obliquus polysaccharide (IOP) can effectively reduce oxidative stress and alleviate photoaging in UVB-treated HaCaT cells. However， the underlying mechanism is still unclear. This study aimed to investigate the mechanism through which IOP mitigates skin photodamage by modulating mitochondrial autophagy through both in vivo and in vitro experiments. The results indicated that IOP alleviated the thickening of the stratum corneum and inflammatory infiltration caused by UVB radiation. Moreover， IOP effectively inhibited the mRNA expression of MMP1 and MMP3 to prevent collagen breakdown and decreased the expression of aging-related proteins (P53 and P21) and inflammatory factors (TNF-α and IFN-γ) in UVB-induced mice. Both in vitro and in vivo studies demonstrated that IOP increased Sirt3 expression， activated the Foxo3a/PINK1-Parkin pathway and enhanced mitochondrial autophagy to reduce photodamage. Additionally， IOP could regulate the gut microbes in photodamaged mice and increase the relative abundance of Clostridium＿XlVa， Desulfovibrio， and Barnesiella， which are important for protecting the intestinal barrier and alleviating intestinal dysfunction. These results provide a theoretical foundation for the use of IOP as a natural component to reduce skin photodamage.

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Unexpected Diversity in Ecosystem Nutrient Responses to Experimental Drought in Temperate Grasslands

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 831-841页

作者： Biying Qiu Niwu Te Lin Song Yuan shi Chuan Qiu Xiaoan Zuo qiang Yu Jianqiang Qian Zhengwen Wang Honghui Wu Wentao Luo School of Life Sciences Hebei UniversityBaoding071002China Liaoning Northwest Grassland Ecosystem National Observation and Research Station Erguna Forest-Steppe Ecotone Research StationInstitute of Applied EcologyChinese Academy of SciencesShenyang110164China Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou730030China School of Grassland Science Beijing Forestry UniversityBeijing100083China College of Forestry Henan Agricultural UniversityZhengzhou450002China State Key Laboratory of Efficient Utilization of Arid and Semi-Arid Arable Land in Northern China Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing100081China Key Laboratory of Arable Land Quality Monitoring and Evaluation Ministry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing100081China

The responses of ecosystem nitrogen (N) and phosphorus (P) to drought are an important component of globalchange studies. However, previous studies were more often based on site-specific experiments, introducing a significantuncertainty to synthesis and site comparisons. We investigated the responses of vegetation and soil nutrientsto drought using a network experiment of temperate grasslands in Northern China. Drought treatment (66%reduction in growing season precipitation) was imposed by erecting rainout shelters, respectively, at the driest,intermediate, and wettest sites. We found that vegetation nutrient concentrations increased but soil nutrient concentrationsdecreased along the aridity gradient. Differential responses were observed under experimentaldrought among the three grassland sites. Specifically, the experimental drought did not change vegetation andsoil nutrient status at the driest site, while strongly reduced vegetation but increased soil nutrient concentrationsat the site with intermediate precipitation. On the contrary, experimental drought increased vegetation N concentrationsbut did not change vegetation P and soil nutrient concentrations at the wettest site. In general, the differentialeffects of drought on ecosystem nutrients were observed between manipulative and observationalexperiments as well as between sites. Our research findings suggest that conducting large-scale, consistent, andcontrolled network experiments is essential to accurately evaluate the effects of global climate change on terrestrialecosystem bio-geochemistry.

关键词： Climate change drought experiment precipitation nutrient cycles

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Evaluation of genetic response of mesenchymal stem cells to nanosecond pulsed electric fields by whole transcriptome sequencing

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World Journal of Stem Cells 2024年第3期16卷 305-323页

作者： Jian-Jing Lin Tong Ning shi-Cheng Jia Ke-Jia Li Yong-Can Huang qiang Liu Jian-Hao Lin Xin-Tao Zhang Department of Sports Medicine and Rehabilitation Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Institute of Medical Science The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Biomedical Engineering Institute of Future TechnologyPeking UniversityBeijing 100871China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijing 100044China

BACKGROUND Mesenchymal stem cells(MSCs)modulated by various exogenous signals have been applied extensively in regenerative medicine ***,nanosecond pulsed electric fields(nsPEFs),characterized by short duration and high strength,significantly influence cell phenotypes and regulate MSCs differentiation via multiple ***,we used transcriptomics to study changes in messenger RNA(mRNA),long noncoding RNA(lncRNA),microRNA(miRNA),and circular RNA expression during nsPEFs *** To explore gene expression profiles and potential transcriptional regulatory mechanisms in MSCs pretreated with *** The impact of nsPEFs on the MSCs transcriptome was investigated through whole transcriptome *** were pretreated with 5-pulse nsPEFs(100 ns at 10 kV/cm,1 Hz),followed by total RNA *** transcript was normalized by fragments per kilobase per *** change and difference significance were applied to screen the differentially expressed genes(DEGs).Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to elucidate gene functions,complemented by quantitative polymerase chain reaction *** In total,263 DEGs were discovered,with 92 upregulated and 171 *** were predominantly enriched in epithelial cell proliferation,osteoblast differentiation,mesenchymal cell differentiation,nuclear division,and wound *** cellular components,DEGs are primarily involved in condensed chromosome,chromosomal region,actin cytoskeleton,and *** aspect of molecular functions,DEGs are mainly involved in glycosaminoglycan binding,integrin binding,nuclear steroid receptor activity,cytoskeletal motor activity,and steroid *** real-time polymerase chain reaction confirmed targeted transcript *** Our systematic investigation of the wide-ranging transcriptional pattern modulated by nsPEFs revealed the differential expression of 26

关键词： Nanosecond pulsed electric fields Whole transcriptome sequencing Mesenchymal stem cells Genetic response Stem cell engineering

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