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Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation

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Signal Transduction and Targeted Therapy 2017年第1期2卷 294-302页

作者： Sha Xu Cai-Xia Liu Wei Xu Lei Huang Jian-Yuan zhao shi-min zhao The Obstetrics&Gynecology Hospital of Fudan University School of Life SciencesShanghaiP.R.China Institute of Biomedical Science Fudan UniversityShanghaiP.R.China Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengduP.R.China

The underlying anticancer effects of butyrate,an end-product of the intestinal microbial fermentation of dietary fiber,remain ***,we report that butyrate promotes cancer cell apoptosis by acting as a SIRT3 *** inhibits SIRT3 both in cultured cells and in ***-induced PDHA1 hyperacetylation relieves the inhibitory phosphorylation of PDHA1 at serine 293,thereby activating an influx of glycolytic intermediates into the tricarboxylic acid(TCA)cycle and reversing the Warburg ***,butyrate-induced hyperacetylation inactivates complex I of the electron transfer chain and prevents the utilization of TCA cycle *** metabolic stresses promote apoptosis in hyperglycolytic cancer cells,such as HCT116p53^(−/−)***3 deacetylates both PDHA1 and complex *** ablation of Sirt3 in mouse hepatocytes abrogated the ability of butyrate to induce *** results identify a butyrate-mediated anti-tumor mechanism and indicate that the combined activation of PDC and inhibition of complex I is a novel tumor treatment strategy.

关键词： SIRT3 HCT116 inhibiting

Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis

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Signal Transduction and Targeted Therapy 2021年第3期6卷 875-887页

作者： Sha Xu Hui Tao Wei Cao Li Cao Yan Lin shi-min zhao Wei Xu Jing Cao Jian-Yuan zhao Zhongshan Hospital of Fudan University Obstetrics&Gynecology Hospital of Fudan UniversityState Key Lab of Genetic EngineeringSchool of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCand Institutes of Biomedical SciencesFudan University200438 ShanghaiChina Collaborative Innovation Center for Biotherapy West China HospitalSichuan University610041 ChengduChina Department of Cardiothoracic Surgery Second Hospital of Anhui Medical Universityand Cardiovascular Research CenterAnhui Medical University230601 HefeiChina Department of Anatomy and Neuroscience Research Institute School of Basic Medical SciencesZhengzhou University450001 ZhengzhouChina

In addition to their use in relieving the symptoms of various diseases,ketogenic diets(KDs)have also been adopted by healthy individuals to prevent being ***,we reported that prolonged KD exposure induced cardiac *** rats,KD or frequent deep fasting decreased mitochondrial biogenesis,reduced cell respiration,and increased cardiomyocyte apoptosis and cardiac ***,increased levels of the ketone body β-hydroxybutyrate(β-OHB),an HDAC2 inhibitor,promoted histone acetylation of the Sirt7 promoter and activated Sirt7 *** in turn inhibited the transcription of mitochondrial ribosome-encoding genes and mitochondrial biogenesis,leading to cardiomyocyte apoptosis and cardiac fibrosis.

关键词： cardiac inhibited diseases

The Physiologic/Pathologic Significance of Lactate

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The Physiologic/Pathologic Significance of Lactate

Measurement of the ^(27)Al(n,2n)^(26)Al Cross Section Using Accelerator Mass Spectrometry

第四届中国生物物理学会代谢生物学分会学术研讨会

作者： shi-min zhao

＜正＞Lactate is one of the most mysterious metabolites of life because it produces no subsequent metabolite but prevails from physiological processes such as exercise, stem cell maintenance, embryonic development, and T cell proliferation to pathological processes such as cancer development. However, the precise physiological and pathological significance of lactate signaling remains unclear, largely because a lactyltransferase is yet to be identified. We （Cell Metabolism, 2018） and others （Nature,2019） have reported that lactate is a protein modifier,

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Chinese Physics Letters 1998年第1期15卷 8-9页

作者： zhao Qiang LU Xiang-yang GUO Zhi-yu shi zhao-min WANG Jian-jun LIU Ke-xin LI Bin LI Kun CHEN Jia-er LU Han-lin Institute of Heavy Ion Physics Peking UniversityBeijing 100871 China Institute of Atomic Energy Beijing 102413

The ^(27)Al(n,2n)^(26)Al cross section is of great interest for the waste disposal assessment of fusion reactor materials and fusion *** the technique of accelerator mass spectrometry,we have measured the ^(26)Al/^(27)Al ratio of Al2O3 powder samples which were irradiated by a neutron *** neutron reaction cross section for ^(27)Al(n,2n)^(26)Al in the energy range of 14.8-14.9MeV are deduced.

关键词： irradiated

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong min Wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan shi-min zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

Measurement of ^(64)Zn(n,γ) ^(65)Zn Cross Section

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Chinese journal of nuclear physics 1995年第4期17卷 342-344页

作者： Chen Jin-xiang shi zhao-min Tang Guo-you Zhang Guo-hui,Institute of Heavy Ion Physics, Peking University, Beijing 100871Lu Han-lin,zhao Wen-rong and Yu Wei-xiang, China Institute of Atomic Energy, P. O. Box 275(3), Beijing 102413 北京大学重离子物理所北京中国原子能科学院北京

Cross sections of 64（n,γ）（65）Zn reaction are measured in the energy range from 156to 1150 keV by the activation technique. The activities of the products are counted with a highresolution HPGe γ-ray spectrometer. The neutron fluence is determined by （197）Au（n,γ）（198）Aucross section. Experimental activation cross sections are given for the first time. The errors ofthe measured results are 5%-8%.

关键词： Cross section Activation technique Zinc

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基于数字地图辅助修正的岸上目标跟踪算法

火力与指挥控制 2013年第12期38卷 28-30页

作者：石章松董银文石钊铭海军工程大学武汉430033 海军装备部重庆局重庆610100

以大口径舰炮武器系统对岸上目标的火力支援打击为研究背景,研究了电视侦察弹使用过程完成对岸上目标定位和跟踪预测的数据处理流程,分析了图像传输时延、图像配准误差以及目标运动的不确定性等因素对岸上运动目标跟踪的影响,依据岸上... 详细信息

以大口径舰炮武器系统对岸上目标的火力支援打击为研究背景,研究了电视侦察弹使用过程完成对岸上目标定位和跟踪预测的数据处理流程,分析了图像传输时延、图像配准误差以及目标运动的不确定性等因素对岸上运动目标跟踪的影响,依据岸上目标运动易受地形的限制,提出了利用数字地图提供的道路信息来修正电视侦察图像定位量测值的修正方法,然后提出了不确定区域与道路是否相交的判别方法,采用基于singer运动模型的Kalman滤波算法来实现岸上运动目标的跟踪与预测。仿真结果表明,该方法可以改善岸上运动目标的跟踪性能,具有一定的应用参考价值。

关键词：电视侦察弹数字地图地上目标跟踪

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao shi Ying zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Perovskite solar cells