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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi shi Yuang zhang Haibin Xu Xuesong zhang jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： Ji-Kui Wang Di zhang jin-Feng Wang Wan-Lin Lu jing-Yuan Wang shi-Feng Liang Ran Liu jing-Xin Jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

房地产行业税收风险释放对当地财源建设的影响——以福州市为例

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福建商学院学报 2017年第3期 25-31页

作者：黄丽微石德金张和明福建农林大学管理学院福建福州350002

房地产业行业已然成为拉动经济增长和财政增收的支柱产业。运用VAR向量自回归模型探讨该行业税收风险对福州市财源建设的影响,研究结果表明,财政收入、房地产税收风险和房地产价格陷入了不断反复"循环":当财政收入下降时,政府会运用救... 详细信息

房地产业行业已然成为拉动经济增长和财政增收的支柱产业。运用VAR向量自回归模型探讨该行业税收风险对福州市财源建设的影响,研究结果表明,财政收入、房地产税收风险和房地产价格陷入了不断反复"循环":当财政收入下降时,政府会运用救市措施,房地产税收风险增加;房地产税收风险增加后,政府会平抑房地产过热,房地产价格下降;房价下降之后政府财政收入也会跟着减少。

关键词：房地产业税收财政收入

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu jin jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

Fault-tolerant control of an open-winding brushless doublyfed wind power generator system with dual three-level converter

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Frontiers in Energy 2023年第1期17卷 149-164页

作者： shi jin Long shi Sul ADEMI Yue zhang Fengge zhang School of Electrical Engineering Shenyang University of TechnologyShenyang 110870China Warwick Manufacturing Group University of WarwickCoventry CV47ALWarwickUK School of Electrical Engineering Shandong UniversityJinan 250061China

To improve the fault redundancy capability for the high reliability requirement of a brushless doubly-fed generation system applied to large offshore wind farms,the control winding of a brushless doubly-fed reluctance generator is designed as an open-winding ***,the two ends of the control winding are connected via dual three-phase converters for the emerging open-winding ***,a novel fault-tolerant control strategy based on the direct power control scheme is brought to focus in this *** on the direct power control(DPC)strategy,the post-fault voltage vector selection method is explained in detail according to the fault types of the dual *** fault-tolerant control strategy proposed enables the open-winding brushless doubly-fed reluctance generator(BDFRG)system to operate normally in one,two,or three switches fault of the converter,simultaneously achieving power tracking *** presented results verify the feasibility and validity of the scheme proposed.

关键词： open-winding brushless doubly-fed reluctance generator(BDFRG) direct power control faulttolerant control multi-level converter wind power

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SiOC低介电常数介质吸湿机理的理论研究

上海交通大学学报 2007年第S2期41卷 9-11页

作者：孙亮朱莲薛原丁士进张卫复旦大学微电子学系上海200433

利用密度泛函理论(DFT)系统研究了掺碳的SiO2低κ互连介质(SiOC)的吸湿问题.比较了Si-CH3和Si-CH2-Si这两种反应位与H2O的反应,研究发现—CH3更加容易与水反应而脱离SiOC薄膜.还研究了多个水分子吸附于Si-CH3反应位情况下的吸水反应.当S... 详细信息

利用密度泛函理论(DFT)系统研究了掺碳的SiO2低κ互连介质(SiOC)的吸湿问题.比较了Si-CH3和Si-CH2-Si这两种反应位与H2O的反应,研究发现—CH3更加容易与水反应而脱离SiOC薄膜.还研究了多个水分子吸附于Si-CH3反应位情况下的吸水反应.当SiOC薄膜表面吸附多个水分子,并且水分子以二聚物形式存在时,吸水反应的势垒明显降低.

关键词： SiOC 密度泛函理论吸水反应

Grant-Free Random Access in Pilot-Reused Multicell Massive MIMO Systems with Backoff Mechanisms

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China Communications 2023年第9期20卷 185-195页

作者： Qi zhang Jun zhang shi jin Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China

Grant-free random access(RA)is attractive for future network due to the minimized access *** this paper,we investigate the grantfree RA in multicell massive multiple-input multipleoutput(MIMO)systems with pilot *** backoff mechanism,user equipments(UEs)in each cell are randomly activated,and active UEs randomly select orthogonal pilots from a predefined pilot pool,which results in a random pilot contamination among *** the help of indicators that capture the uncertainties of UE activation and pilot selection,we derive a closed-form approximation of the spectral efficiency per cell after averaging over the channel fading as well as UEs’random *** on the analysis,the optimal backoff parameter and pilot length that maximize the spectral efficiency can be *** find that the backoff mechanism is necessary for the system with large number of UEs,as it can bring significant gains on the spectral ***,as UE number grows,more backoff time is needed.

关键词： backoff mechanism grant-free RA multicell massive MIMO

基于残差U-net网络的地震资料分辨率提高方法

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中国海洋大学学报（自然科学版） 2025年第1期55卷 140-148页

作者：董博艺张进中国海洋大学海洋地球科学学院山东青岛266100 青岛海洋科技中心海洋矿产资源评价与探测技术功能实验室山东青岛266237 中国海洋大学海底科学与探测技术教育部重点实验室山东青岛266100

高分辨率地震资料处理是获取高品质地震资料、实现薄储层良好地震地质解释的关键。传统提高地震分辨率的方法应用条件苛刻,关键参数求取复杂,在实际应用中受到诸多限制。深度学习中的U-net网络以纯数据驱动的优势,可学习低分辨率地震记... 详细信息

高分辨率地震资料处理是获取高品质地震资料、实现薄储层良好地震地质解释的关键。传统提高地震分辨率的方法应用条件苛刻,关键参数求取复杂,在实际应用中受到诸多限制。深度学习中的U-net网络以纯数据驱动的优势,可学习低分辨率地震记录到高分辨率标签的非线性关系,实现地震资料的高分辨率处理。本文设计了残差U-net网络结构,同时提出了基于概率密度函数控制的同分布反射系数集生成方法,将测井反射系数的概率密度函数作为一种先验约束信息融入训练样本,不仅保证了足够的同分布样本来训练网络,还确保了训练样本更符合工区实际情况,以此提高模型预测的准确性。模型测试和实际资料应用结果表明,本文提出的方法能够有效应用于地震资料分辨率的提高,同时拓宽频带。

关键词：提高分辨率 U-net 残差结构同分布