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Plant-based,adjuvant-free,potent multivalent vaccines for avian influenza virus via Lactococcus surface display

Journal of Integrative Plant Biology 2021年第8期63卷 1505-1520页

作者： shi-jian song Gyeong-Im shin Jinyong Noh Jiho Lee Deok-Hwan Kim Gyeongryul Ryu Gyeongik Ahn Hyungmin Jeon Hai-Ping Diao Youngmin Park Min Gab Kim Woe-Yeon Kim Young-Jin Kim Eun-Ju Sohn Chang Seon song Inhwan Hwang Department of Life Science Pohang University of Science and TechnologyPohang37673 Korea College of Pharmacy and Research Institute of Pharmaceutical Science Gyeongsang National UniversityJinju660-701 Korea KCAV Inc. Gwangjin-gu05029 Korea Avian Disease Laboratory College of Veterinary MedicineKonkuk UniversitySeoul05029 Korea Division of Applied Life Science(BK21 PLUS) Institute of Agriculture&Life SciencesGyeongsang National UniversityJinju52828 Korea Bioapp Inc.Pohang Technopark ComplexPohang37668 Korea

Influenza epidemics frequently and unpredictably break out all over the world,and seriously affect the breeding industry and human *** and live attenuated viruses have been used as protective vaccines but exhibit high risks for *** vaccines enjoy high biosafety and specificity but have a few weak points compared to inactivated virus or live attenuated virus vaccines,especially in low *** this study,we developed a new subunit vaccine platform for a potent,adjuvant-free,and multivalent *** ectodomains of hemagglutinins(HAs)of influenza viruses were expressed in plants as trimers(tHAs)to mimic their native *** in plant extracts were directly used without purification for binding to inactivated Lactococcus(iLact)to produce iLact-tHAs,an antigen-carrying bacteria-like particle(BLP).tHAs BLP showed strong immune responses in mice and chickens without ***,simultaneous injection of two different antigens by two different formulas,t^(HAH5N6+H9N2) BLP or a combination of t^(HAH5N6) BLP and t^(HAH9N2) BLP,led to strong immune responses to both *** on these results,we propose combinations of plant-based antigen production and BLP-based delivery as a highly potent and cost-effective platform for multivalent vaccination for subunit vaccines.

关键词： bacteria-like particle(BLP) H5N6 H9N2 Lactococcus lactis multi-valent vaccine plant-based vaccine trimeric HA

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Exit options sustain altruistic punishment and decrease the second-order free-riders, but it is not a panacea

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Science China(Information Sciences) 2025年第1期68卷 278-291页

作者： Chen SHEN Zhao song Lei shi Jun TANIMOTO Zhen WANG Faculty of Engineering Sciences Kyushu University School of Statistics and Mathematics Yunnan University of Finance and Economics School of Computing Engineering and Digital Technologies Teesside University School of Artificial Intelligence OPtics and Electro Nics (iOPEN) Northwestern Polytechnical University

Why do humans punish free riders at their own expense? This behavior represents an evolutionary puzzle in human societies. This study explores the role of exit strategies in fostering altruistic punishment within evolutionary game theory. We extend the traditional prisoner's dilemma model by incorporating exiters, players who opt out for a small payoff while nullifying their opponent's payoff, and altruistic punishers who cooperate and punish non-cooperators. Our findings indicate that in well-mixed populations, exiters destabilize defection but do not promote altruistic punishment. In social networks, however,exiters enable altruistic punishment via cyclic dominance among altruistic punishers, defectors, and exiters. Notably, this cyclic dominance is sensitive to exit payoffs; adjustments can lead to cyclic dominance of non-punishing cooperators, defectors, and exiters, or to a bi-stable state between these two types of cyclic dominance. These results highlight the nuanced impact of exiters on altruistic punishment, emphasizing the need for careful incentivization of exit behavior. While exiters can support altruistic punishment in networked populations, their effectiveness is not a panacea and is highly sensitive to exit payoffs, indicating limits to the voluntary participation mechanism.

关键词： evolutionary game theory altruistic punishment coexistence cyclic dominance bi-stable

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Mutual-structure weighted guided image filtering for depth map restoration

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Optoelectronics Letters 2025年第1期21卷 51-56页

作者： LIU Zijian song jian CHEN Quanmin XU jiangtao Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology School of MicroelectronicsTianjin UniversityTianjin 300072China Spikesee Technology Co. Ltd.Beijing 100083China

Although guided image filtering(GIF) is known for preserving edges and fast computation,it may produce inaccurate outputs in depth map *** this paper,a novel confidence-weighted GIF called mutual-structure weighted GIF(MSWGIF) is proposed,which replaces the mean filtering strategy in GIF during handling overlapping *** confidence value is composed of a depth term and a mutual-structure term,where the depth term is utilized to protect the edges of the output,and the mutual-structure term helps to select accurate windows during the structure characteristics of the guidance image are transferred to the *** results show that MSWGIF reduces the root mean square error(RMSE) by an average of 12.37%,and the average growth rate of correlation(CORR) is 0.07% on ***,the average growth rate of structure similarity index measure(SSIM) is 0.34%.

关键词： filtering image mutual

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Systematic experimental investigation on pressure build-up characteristics of water-jet injection into a molten LBE pool

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Nuclear Science and Techniques 2025年第1期36卷 161-174页

作者： Hao-Ran Huang Zi-jian Deng song-Bai Cheng Jia-Yue Chen Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China College of Nuclear Science and Technology Harbin Engineering UniversityHarbin 150001China

In the scenario of a steam generator tube rupture accident in a lead-cooled fast reactor,secondary circuit subcooled water under high pressure is injected into an ordinary-pressure primary vessel,where a molten lead-based alloy(typically pure lead or lead-bismuth eutectic(LBE))is used as the *** clarify the pressure build-up characteristics under water-jet injection,this study conducted several experiments by injecting pressurized water into a molten LBE pool at Sun Yat-sen *** obtain a further understanding,several new experimental parameters were adopted,including the melt temperature,water subcooling,injection pressure,injection duration,and nozzle *** detailed analyses,it was found that the pressure and temperature during the water-melt interaction exhibited a consistent variation trend with our previous water-droplet injection mode LBE ***,the existence of a steam explosion was confirmed,which typically results in a much stronger pressure *** the non-explosion cases,increasing the injection pressure,melt-pool temperature,nozzle diameter,and water subcooling promoted pressure build-up in the melt ***,a limited enhancement effect was observed when increasing the injection duration,which may be owing to the continually rising pressure in the interaction vessel or the isolation effect of the generated steam *** of whether a steam explosion occurred,the calculated mechanical and kinetic energy conversion efficiencies of the melt were relatively small(not exceeding 4.1%and 0.7%,respectively).Moreover,the range of the conversion efficiency was similar to that of previous water-droplet experiments,although the upper limit of the jet mode was slightly lower.

关键词： Lead-cooled fast reactor Steam generator tube rupture accident Pressure build-up characteristics Experimental study Pressure water-jet injection

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钻井船入级符号分析

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船海工程 2018年第A2期47卷 65-67页

作者：石松建南通中远船务工程有限公司江苏南通226006

通过对比分析第六代和第七代钻井船典型代表船型的入级符号,深入了解钻井船相关的入级符号,为第七代钻井船实船和后续第八代钻井船的设计提供一定的参考。

关键词：第六代钻井船第七代钻井船入级符号

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Hierarchical porous carbon guided by constructing organic-inorganic interpenetrating polymer networks to facilitate performance of zinc hybrid supercapacitors

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Chinese Chemical Letters 2025年第1期36卷 561-567页

作者： Ting shi Ziyang song Yaokang Lv Dazhang Zhu Ling Miao Lihua Gan Mingxian Liu Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Customized design of well-defined cathode structures with abundant adsorption sites and rapid diffusion dynamics,holds great promise in filling capacity gap of carbonaceous cathodes towards high-performance Zn-ion hybrid supercapacitors(ZHC).Herein,we fabricate a series of dynamics-oriented hierarchical porous carbons derived from the unique organic-inorganic interpenetrating polymer *** interpenetrating polymer networks are obtained through physically knitting polyferric chloride(PFC)network into the highly crosslinked resorcinol-formaldehyde(RF)*** of covalent bonding,physical interpenetrating force in such RF-PFC networks efficiently relieves the RF skeleton shrinkage upon ***,the in-situ PFC network sacrifices as a structure-directing agent to suppress the macrophase separation,and correspondingly 3D hierarchical porous structure with plentiful ion-diffusion channels(pore volume of 1.35 cm^(3)/g)is generated in the representative HPC_(4) via nanospace occupation and swelling *** removal of Fe fillers leaves behind a large accessible specific surface area of 1550 m^(2)/g for enhanced Zn-ion *** used as the cathode for ZHC,HPC_(4) demonstrates a remarkable electrochemical performance with a specific capacity of 215.1 mAh/g at 0.5 A/g and a high Zn^(2+)ion diffusion coefficient of 11.1×10^(-18)cm^(2)/*** ZHC device yields 117.0 Wh/kg energy output at a power density of 272.1 W/kg,coupled with good cycle lifespan(100,000 cycles@10 A/g).This work inspires innovative insights to accelerate Zn diffusion dynamics by structure elaboration towards high-capacity cathode materials.

关键词： Carbonaceous cathode Interpenetrating polymer networks Zinc-ion hybrid supercapacitors Specific capacity Energy/power density

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N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: Design,structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2025年第2期36卷 256-261页

作者： jian song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang School of Basic Medical Sciences Zhengzhou University Children's Hospital Affiliated to Zhengzhou University Henan Children's Hospital Zhengzhou Children's Hospital School of Pharmaceutical Sciences Institute of Drug Discovery & Development Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education) Zhengzhou University State Key Laboratory of Esophageal Cancer Prevention & Treatment

In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization ***,13n （MY-1388） exhibited remarkable antiproliferative potency on fifteen human cancer cell lines,with half maximal inhibitory concentration (IC50)values ranging from 8 nmol/L to 48 nmol/***,13n effectively suppressed tubulin polymerization by targeting the colchicine-binding site (IC50=0.62μmol/L).13n also exhibited significant inhibition of cell colony formation,as well as displayed potent effects on inducing G2/M phase cell cycle arrest and promoting ***,13n exhibited enhanced and adequate liver microsomal stability in human and rat liver microsomes,and also exhibited a moderate half-life (T1/2=0.938 h) in ***,13n demonstrated effective antitumor effects in vivo in suppressing tumor growth in the MGC-803xenograft model (tumor growth inhibition （TGI） value was 76.4%at the dosage of 30 mg kg-1day-1)with a good safety ***,these results revealed that 13n represents a promising tubulin polymerization inhibitor that deserves further investigation for its efficacy in treating gastric cancers.

关键词： Antiproliferative activities CA-4 Colchicine binding site N-Benzyl arylamide Tubulin

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Insight into the activation of peroxymonosulfate by N-doped copper-based carbon for efficient degradation of organic pollutants:Synergy of nonradicals

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Chinese Chemical Letters 2025年第1期36卷 513-520页

作者： Mengmeng Ao jian Wei Chuan-Shu He Heng Zhang Zhaokun Xiong Yonghui song Bo Lai College of Environmental Sciences Liaoning UniversityShenyang 110036China State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

The contamination of water resources by phenolic compounds(PCs)presents a significant environmental hazard,necessitating the development of novel materials and methodologies for effective *** this study,a metallic copper-doped zeolitic imidazolate framework was pyrolyzed and designated as CuNC-20 for the activation of peroxymonosulfate(PMS)to degrade phenol(PE).Cu-NC-20 could effectively address the issue of metal agglomeration while simultaneously diminishing copper dissolution during the activation of PMS *** Cu-NC-20 catalyst exhibited a rapid degradation rate for PE across a broad pH range(3-9)and demonstrated high tolerance towards coexisting *** to scavenger experiments and electron paramagnetic resonance analysis,singlet oxygen(^(1)O_(2))and high-valent copperoxo(Cu(Ⅲ))were the predominant reactive oxygen species,indicating that the system was nonradicaldominated during the degradation *** quantitative structure-activity relationship(QSAR)between the oxidation rate constants of various substituted phenols and Hammett constants was *** indicated that the Cu-NC-20/PMS system had the optimal oxidation rate constant withσ^(-)correlation and exhibited a typical electrophilic reaction *** study provides a comprehensive understanding of the heterogeneous activation process for the selective removal of phenolic compounds.

关键词： N-doped copper-based carbon Phenolic compounds Peroxymonosulfate Nonradical pathway Quantitative structure-activity relationship(QSAR)

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Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer

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Oncology and Translational Medicine 2025年第1期11卷 5-9页

作者： Yeqin Wu Haitao song Huifang shi Gangping Wang Department of Pathology the Fourth Affiliated Hospital of Zhejiang University School of MedicineInternational School of Medicine Zhejiang UniversityInternational Institutes of Medicine Zhejiang UniversityYiwuChina Department of Oncology the Rizhao People’s HospitalRizhaoChina Central Laboratory the Rizhao People’s HospitalRizhaoChina

Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer *** has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment *** microRNAs(miRNAs)are involved in various cellular processes in ***,variations in the miRNA levels in TNBC may act as a dependable indicator for predicting the effectiveness and specificity of ***,the application of miRNAs for breast cancer therapy is primarily in the preclinical stage,with a focus on identifying highly specific and sensitive miRNAs that could offer new possibilities for early diagnosis,clinical treat-ment,and prognostic monitoring of TNBC.

关键词： Triple-negative breast cancer miRNA oncomiRs Tumorigenesis Prognosis Chemotherapy resistance

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应力框热应力数值模拟及变形分析

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铸造 2010年第1期59卷 38-41页

作者：李辉时建松张爱琴合肥工业大学材料科学与工程学院安徽合肥230009 佳木斯大学材料科学与工程学院黑龙江佳木斯154007

利用专业铸造模拟软件ProCAST,对HT250应力框铸件在3种不同浇注温度、3种不同落砂温度条件下进行了铸造过程温度场、应力场的计算机数值模拟,得到其残余应力分布和冷却过程变形情况。通过正交试验设计方法对残余应力和浇注温度、落砂温... 详细信息

利用专业铸造模拟软件ProCAST,对HT250应力框铸件在3种不同浇注温度、3种不同落砂温度条件下进行了铸造过程温度场、应力场的计算机数值模拟,得到其残余应力分布和冷却过程变形情况。通过正交试验设计方法对残余应力和浇注温度、落砂温度的关系进行分析,结果表明:落砂温度对残余应力的影响较大,落砂温度越高,残余应力越小,但铸件的变形越大;浇注温度对残余应力的影响没有规律,但浇注温度越高,铸件的最终变形越大。

关键词：应力框数值模拟正交试验残余应力变形落砂温度浇注温度

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