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Nano Research 2023年第2期16卷 2719-2727页

作者： Yifei Zhou Biao Huang shi-hui chen Shu-Lin Liu Mingxi Zhang Ran Cui College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Centre for Analytical SciencesCollege of ChemistryNankai UniversityTianjin 300071China

The long-wavelength region of the near-infrared-IIb(NIR-IIb,1,500–1,700 nm)imaging window has become an ideal window for in vivo imaging due to the suppressed photon scattering and near-zero autofluorescence of biological ***,it is necessary to develop fluorescent probes with excellent fluorescence performance and stability for NIR-IIb fluorescence *** this work,zinc-doped silver telluride quantum dots(Zn:Ag_(2)Te QDs)with bright fluorescence in the NIR-IIb window were *** introduction of Zn dopants inhibited crystal defects and reduced non-radiative ***,the quantum yield and fluorescence lifetime of Zn:Ag_(2)Te QDs were significantly *** addition,Zn-doping increased the number of ligands on the surface of QDs,thus enhancing the colloidal stability of Zn:Ag_(2)Te ***,the PEGylated Zn:Ag_(2)Te QDs with high absolute quantum yield realized noninvasive imaging of cerebral vascular of mouse with high resolution able to distinguish blood capillary,which could be utilized to monitor the brain condition of mice after traumatic brain injury.

关键词： near-infrared-IIb(NIR-IIb)window silver telluride quantum dots fluorescence in vivo imaging

Imaging-guided precision oncotherapy mediated by nanoprobes: From seeing to curing

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Chinese Chemical Letters 2024年第1期35卷 116-128页

作者： Jie Zheng shi-hui chen Biao Huang Mingxi Zhang Quan Yuan Ran Cui College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Jiangxia Laboratory Wuhan 430200China

Malignant tumors are the main diseases threatening human life. Using precise theranostics to diagnose and cure tumors has emerged as a new method to improve patient survival. Based on the current development of precise tumor imaging, image-guided tumor therapy has received widespread attention because it is beneficial for developing precise treatment of tumors, has the potential to improve the efficacy of tumor therapy and reduce the incidence of adverse side effects. Nanoprobes, which are nanomaterial functionalized with specific biomolecules, have intrigued intense interest due to their great potential in monitoring biorecognition and biodetection evens. Benefiting from the unique advantages of nanomaterials, including the easy surface functionalization, the unique imaging performances, and the high drug loading capacity, nanoprobes have become a powerful tool to simultaneously realize tumor precise imaging, diagnosis, and therapy. This review introduces the non-invasive tumor precise imaging and highlights the recent advances of image-guided oncotherapy mediated by nanoprobes in anti-tumor drug delivery, tumor precise surgical navigation, chemodynamic therapy, and phototherapy. Finally, a perspective on the challenge and future direction of nanoprobes in imaging-guided tumor theranostics is also discussed.

关键词： Precise theranostics Imaging-guided Tumor surgical navigation Chemodynamic therapy Phototherapy Nanoprobes

Study of Composite Hardcoat Anodizing of Aluminum Alloy 6063 and Its Friction Behaviors

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材料热处理学报 2004年第05B期25卷 1146-1148页

作者： LIUshi-yong ZHANGhui-chen GAOXue-min LIUWei shiYa-qin InstituteofMetafandTechnology DalianMaritimeUniversity Datian116026 China

A composite hard-anodized coating containing micro PTFE (polytetrafluoroethylene) particles on aluminum alloy 6063 was produced by adding micro PTFE particles into the traditional hardcoat anodizing solution. The size of the PTFE particles is around 2 v- m in diameter and the content of the PTFE particles in the composite coating is within 2%-3% by area percentage. Thickness of the composite coating can reach up to 70 v m after one hour’s anodizing. Surface hardness of the composite coating is between 400-480 HVo.i- The average friction coefficient of the composite coating against steel under dry friction test is 0.11, which is 17% lower than that obtained by traditional hardcoat anodizing.

关键词： 6063铝合金硬盖阳极氧化复合涂层 PTEE 摩擦系数

Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model

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World Journal of Gastroenterology 2012年第35期18卷 4934-4943页

作者： Wei-Hong Gong Wen-Xia Zheng Jun Wang shi-hui chen Bo Pang Xia-Min Hu Xiao-Lu Cao Department of Pharma-cology College of Medicine Wuhan University of Science andTechnology Wuhan 430065 Hubei Province China

AIM:To investigate the correlation of hyperlipemia(HL) and acute cerebral ischemia/reperfusion(I/R) injury on liver damage and its ***:Rats were divided into 4 groups:control,HL,I/R and HL+I/*** the induction of HL via a high-fat diet for 18 wk,middle cerebral artery occlusion was followed by 24 h of reperfusion to capture I/*** alanine transaminase(ALT) and aspartate aminotransferase(AST) were analyzed as part of liver function tests and liver damage was further assessed by histological *** apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) *** expression of genes related to apoptosis(caspase-3,bcl-2) was assayed by immunohistochemistry and Western *** tumor necrosis factor-(TNF-),interleukin-1(IL-1) and liver mitochondrial superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA) and Ca 2+ levels were measured to determine inflammatory and oxidative/antioxidative status *** hydroxylase activity of the cytochrome P450 2E1(CYP2E1)-containing enzyme was measured with aniline as the substrate,and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting ***:HL alone induced by high-fat diet for 18 wk resulted in liver damage,indicated by histopathological analysis,and a considerable increase in serum ALT(25.13 ± 16.90 vs 9.56 ± 1.99,P < 0.01) and AST levels(18.01 ± 10.00 vs 11.33 ± 4.17,P < 0.05) compared with ***,HL alone induced hepatocyte apoptosis,which was determined by increased TUNEL-positive cells(4.47 ± 0.45 vs 1.5 ± 0.22,P < 0.01),higher caspase-3 and lower bcl-2 ***,compared with those in control,HL or I/R groups,massive increases of serum ALT(93.62 ± 24.00 vs 9.56 ± 1.99,25.13 ± 16.90 or 12.93 ± 6.14,P < 0.01) and AST(82.32 ± 26.92 vs 11.33 ± 4.17,18.01 ± 10.00 or 14.00 ± 6.19,P < 0.01) levels in HL+I/R group were

关键词： Hyperlipidemia High-fat diet Cerebral isch-emia/reperfusion Liver damage Hepatocyte apoptosis Cytochrome P450 2E1

Quantum dots boost large-view NIR-II imaging with high fidelity for fluorescence-guided tumor surgery

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Chinese Chemical Letters 2024年第12期35卷 525-530页

作者： Biao Huang Tao Tang Fushou Liu shi-hui chen Zhi-Ling Zhang Mingxi Zhang Ran Cui College of Chemistry and Molecular Sciences Wuhan University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology

Owing to the high spatiotemporal resolution,the second near-infrared (NIR-II) imaging window can provide high imaging contrast with diminished tissue autofluorescence and suppressed photon scattering to pinpoint the locations for tumor *** to the unique optical properties and excellent fluorescence performance,quantum dots (QDs) are regarded as ideal nanoprobes for fluorescence-guided surgery(FGS).Moreover,QDs can be excited by a variety of light sources owing to the continuous and wide absorption ***,light-emitting diode (LED) was used as the excitation source of QDs-based nanoprobes to realize FGS of tumor with high *** the LED light could irradiate a large region with consistent light intensity,signal distortion at the edge of imaging field was *** signal intensity of the view edges under LED excitation can be improved by about 5 times compared to laser ***,more micro-vessels and smaller tumors (Vtumor<5 mm2) could be detected,thus providing more precise guidance for tumor resection surgery.

关键词： Fluorescence-guided surgery Light-emitting diode NIR-II imaging Quantum dots Tumor imaging

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai chen Xu Feng Yuan shi Xin-Lin Li Zheng-Rong shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

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OAS1基因多态性与脊柱结核的关联性分析

西安交通大学学报（医学版） 2018年第5期39卷 729-732页

作者：张庭史晨辉高立华南方医科大学附属南海医院广东佛山528200 石河子大学医学院第一附属医院骨科中心新疆石河子832002

目的研究寡腺苷酸合成酶1(OAS1)基因多态性与脊柱结核的关系。方法纳入113个脊柱结核患者作为实验组,114个健康人作为对照组,所有纳入者均为汉族。采用等位基因频率和基因模型来计算OAS1基因多态性和脊柱结核之间的联系。基因分型采用iM... 详细信息

目的研究寡腺苷酸合成酶1(OAS1)基因多态性与脊柱结核的关系。方法纳入113个脊柱结核患者作为实验组,114个健康人作为对照组,所有纳入者均为汉族。采用等位基因频率和基因模型来计算OAS1基因多态性和脊柱结核之间的联系。基因分型采用iMLDR方法。结果与rs1131454AA基因型比较,AG对于脊柱结核来说是保护因素(OR=0.532,95%CI:0.354~0.801,P=0.003)。同时rs1131454GG基因型与AA比较也是脊柱结核保护性因素(OR=0.788,95%CI:0.660~0.940,P=0.008)。结论在汉族人中,OAS1基因多态性与脊柱结核是相关联的,但需要在规模较大的、多中心和其他民族中进一步验证。

关键词： OAS1基因脊柱结核基因多态性易感性

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储藏期间粳稻谷脂肪酸值的影响因素研究

粮食与油脂 2017年第6期30卷 32-34页

作者：孟晶戴辉秦施奇陈慧菲上海科茂粮油食品质量检测有限公司上海200333

对上海地区粮库储藏的稻谷样品的水分、发芽率、直链淀粉、蛋白质、碱消值、脂肪酸值进行了约2年的跟踪分析,通过一系列检测数据揭示有关因素对粳稻谷脂肪酸值变动的影响和作用机理。

关键词：粳稻谷脂肪酸值因素

基于驾驶员类型分析的智能车辆交叉口行为决策

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北京理工大学学报 2016年第9期36卷 917-922页

作者：宋威龙熊光明王诗源陈慧岩北京理工大学机械与车辆学院北京100081

提出一种基于车辆行为交互的两阶段智能车辆交叉口行为决策方法.第一阶段通过基于模糊逻辑的驾驶员激进程度判别模型,判断交叉口其他车辆的驾驶员类型;第二阶段通过驾驶员激进程度与碰撞到达时间(TTC)进行行为决策.使用Prescan和Matlab/... 详细信息

提出一种基于车辆行为交互的两阶段智能车辆交叉口行为决策方法.第一阶段通过基于模糊逻辑的驾驶员激进程度判别模型,判断交叉口其他车辆的驾驶员类型;第二阶段通过驾驶员激进程度与碰撞到达时间(TTC)进行行为决策.使用Prescan和Matlab/Simulink进行交叉口联合仿真.结果表明,该方法可以使智能车辆安全有效通过有其他车辆通行的交叉路口.

关键词：智能车辆驾驶员类型行为决策交叉口

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing Dong Dong chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy