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Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

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Journal of Integrative Plant Biology 2006年第10期48卷 1244-1249页

作者： li-Wen Jing shi-hua Chen Xiao-li Guo Hui Zhang Yan-Xiu Zhao Key Laboratory of Plant Stress Research College of Life Sciences Shandong Normal University Jinan 250014 China

Ablotlc stress, such as salt, drought and extreme temperature, can result in enhanced production of reactive oxygen species （ROS）. Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase （SOD）, ascorbate peroxldaae （APX）, catalaae （CAT）, glutathione peroxldaae （GPX） and peroxiredoxina （Prxa）. In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. located at chloroplast. Overexpression of SsPrxQ In Arabidopsis leads to an increase In salt and low-temperature tolerance.

关键词： overexpression peroxiredoxin Q salt and low-temperature tolerance suaeda salsa subcellular localization

Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, Yi-Chun CHEN, Ping-Tao GUAN, hua-shi li, Ying-Xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release

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Science China Chemistry 2018年第7期61卷 806-811页

作者： Guoming huang Rui liu Yuehua Hu shi-hua li Ying Wu Yuan Qiu Jingying li huang-Hao Yang College of Biological Science and Engineering Fuzhou University Key Laboratory for Analytical Science of Food Safety and Biology Ministry of Education State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and *** this work,we report a p H-responsive theranostic nanoplatform based on Fe OOH clusters loaded mesoporous silica nanoparticles(Fe@MSNs).The as-synthesized Fe@MSNs possess activatable T_1magnetic resonance imaging(MRI)performance that can respond to the acidic microenvironment of solid tumor to turn on T_1singals by releasing paramagnetic Fe^(3+)*** Fe@MSNs are biocompatible without appreciable ***,the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid *** believe that this novel p H-responsive theranostic nanoplatform holds great promise in cancer treatment.

关键词： mesoporous silica nanoparticles magnetic resonance imaging pH-response cancer diagnosis cancer therapy

Long-term lamivudine for chronic hepatitis B and cirrhosis: A real-life cohort study

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World Journal of Gastroenterology 2015年第46期21卷 13087-13094页

作者： Ming-hua Su Ai-lian Lu shi-hua li Shao-hua Zhong Bao-Jian Wang Xiao-li Wu Yan-Yan Mo Peng liang Zhi-Hong liu Rong Xie li-Xia He Wu-Dao Fu Jian-Ning Jiang Department of Infectious Disease The First Affiliated Hospital of Guangxi Medical University

AIM: To investigate clinical outcomes of chronic hepatitis B(CHB) and liver cirrhosis(LC) patients under whole-course management with lamivudine(LAM). METHODS: This was a retrospective-prospective cohort study based on two nonrandom cohorts of Chinese patients(LAM group and history control group). Two hundred thirty-eight patients with LAM treatment for at least 12 mo under whole-course management were included in the LAM group. The management measures included regular follow-up and timely adjustment of the therapeutic regimen according to drug-resistance and relapse. Two hundred thirtyeight patients with CHB or LC without any antiviral treatment and with follow-up over 12 mo were included in the history control group. The LAM and control group patients were 1:1 matched by propensity score method to ensure both patients were similar in general datum,sex,age,E antigen,and diagnosis. The incidence rates of endpoint events [LC,hepatocellular carcinoma(HCC),and death] were compared between the LAM and control ***: Hepatitis B virus-DNA limit in LAM and control groups were 89.1% vs 18.5%(P liver endpoint criteria were 52.4% and 69.8%,respectively. Six CHB patients in the LAM group developed LC compared to 47 patients in the control group; the three-,and five-year cumulative rates of CHB at baseline of LAM were lower than those of the control group: 0.7% vs 12.0% and 1.8% vs 23.8%(P line of LAM was lower than that of the control gr

关键词： Hepatitis B virus Lamivudine Management liver cirr

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting liu Wei huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao shi-hua li Xiao-Jiang li Wei-li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Super Hybrid Rice Breeding in China：Achievements and Prospects

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Journal of Integrative Plant Biology 2007年第6期49卷 805-810页

作者： shi-hua Cheng li-Yong Cao Jie-Yun Zhuang Shen-Guang Chen Xiao-Deng Zhan Ye-Yang Fan De-Feng Zhu Shao-Kai Min State Key Laboratory of Rice Biology/National Center for Rice Improvement China National Rice Research Institute Hangzhou 310006 China

Hybrid rice has contributed greatly to the self-sufficiency of food supply In China. To meet the future demand for rice production, a national program on super rice breeding was established In China In 1996. The corresponding targets, breeding strategies and most significant advances are reviewed In this paper. New plant type models have been modified to adjust to various rice growing regions. In recognition of the Importance of applying parents with Intermediate subspecies differentiation In Increasing F1 yield, medium type parental lines were selected from populations derived from Inter-subspecies crosses with the assistance of DNA markers for subspecies differentiation. Results also indicate that a substantial increase of blomass Is the basis for further enhancement of the grain yield potential, and amelioration of leaf characteristics Is helpful In Increasing the photosynthetic rate. Thirty-four super hybrid rice varieties have been released commercially, growing In a total area of 13.5 million hm2 and producing 6.7 thousand million kg more rice In 1998-2005. Although remarkable progress has been made In super hybrid rice breeding In China, selections on the root system and Integration of more blotechnologlcal tools remain a great challenge.

关键词： biomass DNA marker harmonious plant type medium type parents super hybrid rice.

Mapping of Rice Fertility-Restoring Genes for ID-Type Cytoplasmic Male Sterility in a Restorer line R68

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Rice science 2008年第2期15卷 157-160页

作者： li liang-jie ZHOU Hai-peng ZHAN Xiao-deng CHENG shi-hua CAO li-yong State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement China National Rice Research Institute Hangzhou 310006 China

An F2 population derived from the cross Zhong 9A/R68 was used to map the fertility-restoring （Rf） gene for ID-type cytoplasmic male sterility （CMS）. Two bulks （a fertile bulk and a sterile bulk） were constructed by pooling equal amount of ten highly fertile lines and ten highly sterile lines, respectively. Four hundred and thirteen pairs of simple sequence repeat （SSR） primers, which evenly distributed on 12 chromosomes of rice, were selected for analyzing polymorphisms between the parents and between the two bulks. The primer RM283 on chromosome 1 and the primers RM5756, RM258, RM6100 and RM171 on chromosome 10 were found to be polymorphic between the parents and between the two bulks. These five SSR markers were linked to fertility-restoring genes. A total of 82 excessive sterile lines were selected from Zhong 9A/R68 F2 population to estimate the genetic distance between five SSR markers and fertility-restoring genes respectively. The results indicated that one Rf gene was linked to RM283 located on chromosome 1 at a distance of 6.7 cM, and the other Rfgene was mapped to the long arm of chromosome 10 flanked by RM258 and RM6100 at the distances of 8.0 cM and 2.4 cM, respectively.

关键词： rice cytoplasmic male sterility fertility-restoring gene gene mapping

Engineering of tungsten carbide nanoparticles for imaging-guided single 1,064 nm laser-activated dual-type photodynamic and photothermal therapy of cancer

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Nano Research 2018年第9期11卷 4859-4873页

作者： shi-hua li Wen Yang Yang liu Xiao-Rong Song Rui liu Guangliang Chen Chun-hua Lu huang-Hao Yang MOE Key Laboratory for Analytical Science of Food Safely and Biology State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University Fuzhou 350116 China College of Biological Science and Engineering Fuzhou University Fuzhou 350116 China Department of Radiology Fujian Medical University Union Hospital No. 29Xinquan Road Fuzhou 350001 China

The promising potential of photodynamic therapy （PDT） has fueled the development of minimally invasive therapeutic approaches for cancer therapy However, overcoming limitations in PDT efficacy in the hypoxic tumor environment and light penetration depth remains a challenge. We report the engineering of tungsten carbide nanopartides （W2C NPs） for 1,064 run laser-activated dual-type PDT and combined theranostics. The synthesized W2C NPs allow the robust generation of dual-type reactive oxygen species, including hydroxyl radicals （type I） and singlet oxygen （type II）, using only single 1,064 run laser activation, enabling effective PDT even in the hypoxic tumor environment. The W2C NPs also possess high photothermal performance under 1,064 nm laser irradiation, thus enabling synergistically enhanced cancer therapeutic efficacy of PDT and photothermal therapy. Additionally, the photoacoustic and X-ray computed tomography bioimaging properties of W2C NPs facilitate the integration of tumor diagnosis and therapy. The developed W2C based theranostic nanoagents increase the generation of reactive oxygen species in hypoxic tumors, improve the light penetration depth, and facilitate combined photothermal therapy and photoacoustic/computed tomography dual-mode bioimaging. These attributes could spur the exploration of transition metal carbides for advanced biomedical applications.

关键词： metal carbides tungsten carbide nanoparticles photodynamic therapy near-infrared window theranostics

低频强磁场屏蔽效能的测试方法与测试设备研制

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高电压技术 2010年第9期36卷 2272-2277页

作者：高成刘晓石立华周璧华解放军理工大学工程兵工程学院中国人民解放军96544部队

为了合理评估屏蔽体对低频强磁场的屏蔽效果,为工程中屏蔽室质量验收提供必要的检测手段,根据小环天线法测量电磁屏蔽室屏蔽效能的原理,提出了低频强磁场屏蔽效能测试系统的整体结构和设计方案,研制了以PIC16F73单片机为核心的低频大电... 详细信息

为了合理评估屏蔽体对低频强磁场的屏蔽效果,为工程中屏蔽室质量验收提供必要的检测手段,根据小环天线法测量电磁屏蔽室屏蔽效能的原理,提出了低频强磁场屏蔽效能测试系统的整体结构和设计方案,研制了以PIC16F73单片机为核心的低频大电流源,设计和制作了磁场发射、接收环天线,构建了低频强磁场屏蔽效能测试设备;采用研制的测试设备对屏蔽室进行了屏蔽效能实测。测试结果与理论值符合较好,表明测试设备能够满足实际测量的需要,同时验证了计算结果的可信性。

关键词：低频磁场低频大电流源屏蔽屏蔽效能测试设备小环天线单片机低阻抗磁场