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Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting liu Wei huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao shi-hua li Xiao-Jiang li Wei-li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

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Contact Model of Revolute Joint with Clearance Based on Fractal Theory

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Chinese Journal of Mechanical Engineering 2018年第6期31卷 34-44页

作者： shi-hua li Xue-Yan Han Jun-Qi Wang Jing Sun Fu-Juan li Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan University

The contact sti ness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the energy loss that necessarily occurs during the impact process should be considered com?prehensively. To study the normal contact force of a revolute joint with clearance more accurately in the case of dry friction, a nonlinear sti ness coe cient model considering the surface roughness was established based on fractal theory, which considers the elastic, elastic?plastic, and plastic deformations of the asperities of the contact surface during the contact process. On this basis, a modified nonlinear spring damping model was established based on the Lankarani–Nikravesh contact force model. The laws influencing the surface roughness, recovery coe cient, initial velocity, and clearance size on the impact force were revealed, and were compared with the Lankarani–Nikravesh model and a hybrid model using MATLAB. The maximum impact force was obtained using a modified contact force model under di erent initial velocities, di erent clearances, and di erent degrees of surface roughness, and the calculated results were then compared with the experiment results. This study indicates that the modified model can be used more widely than other models, and is suitable for both large and small clearances. In particular, the modified model is more accurate when calculating the contact force of a revolute joint with a small clearance.

关键词： Fractal theory Modified contact model Surface roughness Lankarani–Nikravesh model

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Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

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Journal of Integrative Plant Biology 2006年第10期48卷 1244-1249页

作者： li-Wen Jing shi-hua Chen Xiao-li Guo Hui Zhang Yan-Xiu Zhao Key Laboratory of Plant Stress Research College of Life Sciences Shandong Normal University Jinan 250014 China

Ablotlc stress, such as salt, drought and extreme temperature, can result in enhanced production of reactive oxygen species （ROS）. Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase （SOD）, ascorbate peroxldaae （APX）, catalaae （CAT）, glutathione peroxldaae （GPX） and peroxiredoxina （Prxa）. In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. located at chloroplast. Overexpression of SsPrxQ In Arabidopsis leads to an increase In salt and low-temperature tolerance.

关键词： overexpression peroxiredoxin Q salt and low-temperature tolerance suaeda salsa subcellular localization

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Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, Yi-Chun CHEN, Ping-Tao GUAN, hua-shi li, Ying-Xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

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FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release

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Science China Chemistry 2018年第7期61卷 806-811页

作者： Guoming huang Rui liu Yuehua Hu shi-hua li Ying Wu Yuan Qiu Jingying li huang-Hao Yang College of Biological Science and Engineering Fuzhou University Key Laboratory for Analytical Science of Food Safety and Biology Ministry of Education State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and *** this work,we report a p H-responsive theranostic nanoplatform based on Fe OOH clusters loaded mesoporous silica nanoparticles(Fe@MSNs).The as-synthesized Fe@MSNs possess activatable T_1magnetic resonance imaging(MRI)performance that can respond to the acidic microenvironment of solid tumor to turn on T_1singals by releasing paramagnetic Fe^(3+)*** Fe@MSNs are biocompatible without appreciable ***,the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid *** believe that this novel p H-responsive theranostic nanoplatform holds great promise in cancer treatment.

关键词： mesoporous silica nanoparticles magnetic resonance imaging pH-response cancer diagnosis cancer therapy

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Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 29-40页

作者： Xi li Zhongyang Zhang hua shi Feifan Zhou Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan University Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

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Influence of rare earth oxides on microstructure and mechanical properties of nickel-based superalloys fabricated by high energy beam processing:A review

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Journal of Rare Earths 2024年第9期42卷 1629-1645,I0001页

作者： lianjie Bi hua Yan Peilei Zhang Haichuan shi Zhiyuan li Ruidi li School of Materials Science and Engineering Shanghai University of Engineering ScienceShanghai201620China College of Agricultural Science and Engineering Hohai UniversityNanjing211100China Department of Mechanics and Maritime Science Chalmers University of TechnologyGothenburSE41296Sweden State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

In this paper,the effects of rare earth oxides on the micro structure and mechanical properties of nickelbased superalloys prepared by high-energy beam processing technology were critically *** focus is on the optimal amount of rare earth oxides that can produce ideal *** attention was paid to their main strengthening mechanisms,including solid solution strengthening mainly in the form of solid solution dissolved in the nickel-based alloy and improving the microstructure of the alloy by grain refinement or fine grain strengthening produced by homogenizing the distribution phase.Y_(2)O_(3),La_(2)O_(3) and CeO_(2) rare earth oxides can also improve the fluidity of the alloy molten pool and reduce the segregation of alloying *** advantages can significantly improve the mechanical properties of the ***,this paper outlines the future research directions of rare earth oxides,aiming to expand their application potential.

关键词： Rare earths High energy beam Nickel-based superalloys Microstructure Mechanical properties

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A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo li Tingxia Zhou Ziwang Zhang Wen shi Yexiang Tong Jianxin shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

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Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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动物学研究 2024年第2期 242页

作者： Xiu-Sheng Chen Rui Han Yan-Ting liu Wei huang Qi Wang Xin Xiong Ying Zhang Jian-Guo Zhao shi-hua li Xiao-Jiang li Wei-li Yang

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On the Performances of Estimating Stellar Atmospheric Parameters from CSST Broad-band Photometry

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Research in Astronomy and Astrophysics 2024年第4期24卷 161-173页

作者： Rui-Feng shi Yang huang Xin-Yi li hua-Wei Zhang School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China South-Western Institute for Astronomy Research Yunnan UniversityKunming 650500China CAS Key Lab of Optical Astronomy Key Laboratory of Space Astronomy and TechnologyNational Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Deriving atmospheric parameters of a large sample of stars is of vital importance to understand the formation and evolution of the Milky *** surveys,especially those with near-ultraviolet filters,can offer accurate measurements of stellar parameters,with the precision comparable to that from low/medium resolution *** this study,we explore the capability of measuring stellar atmospheric parameters from Chinese Space Station Telescope(CSST)broad-band photometry(particularly in the near-ultraviolet bands),based on synthetic colors derived from model *** find that colors from the optical and near-ultraviolet filter systems adopted by CSST show significant sensitivities to the stellar atmospheric parameters,especially the *** to our mock data tests,the precision of the photometric metallicity is quite high,with typical values of0.17 and 0.20 dex for dwarf and giant stars,*** precision of the effective temperature estimated from broad-band colors are within 50 K.

关键词： methods:data analysis stars:abundances surveys

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