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Signaling pathways involved in ischemic stroke:molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy 2022年第8期7卷 2733-2761页

作者： Chuan Qin Sheng Yang Yun-Hui Chu Hang Zhang Xiao-Wei Pang Lian Chen Luo-Qi Zhou Man Chen dai-shi Tian Wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Ischemic stroke is caused primarily by an interruption in cerebral blood flow,which induces severe neural injuries,and is one of the leading causes of death and disability ***,it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the *** recent years,efforts have been made to understand the pathophysiology of ischemic stroke,including cellular excitotoxicity,oxidative stress,cell death processes,and *** the meantime,a plethora of signaling pathways,either detrimental or neuroprotective,are also highly involved in the forementioned *** pathways are closely intertwined and form a complex signaling ***,these signaling pathways reveal therapeutic potential,as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic *** this review,we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate *** approaches targeting these signaling pathways,which are associated with the pathophysiology mentioned above,are also ***,clinical trials regarding ischemic stroke,which potentially target the pathophysiology and the signaling pathways involved,are summarized in ***,this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke,and summarize the therapeutic approaches targeted various pathophysiology,with particular reference to clinical trials and future prospects for treating ischemic stroke.

关键词： therapeutic injuries protective

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Dual Functions of Microglia in Ischemic Stroke

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Neuroscience Bulletin 2019年第5期35卷 921-933页

作者： Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu dai-shi Tian Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurology Mayo Clinic Rochester MN 55905 USA

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit.

关键词： Microglia Inflammation Ischemic stroke Signaling pathways

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Treatment of infant postrenal acute renal failure followingobstruction due to upper urinary calculi

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Frontiers of Medicine 2010年第1期4卷 127-130页

作者： Hui-Xia ZHOU Zhi-Chun FENG Hao MENG Xiao-Guang ZHOU Shuang LI Jun WANG shi-Xi dai Department of Urology Bayi Children’s HospitalGeneral Hospital of Beijing Military RegionBeijing 100700China Department of Urology Wuhan Children’s HospitalWuhan 430030China

The surgical emergency treatments and cura-tive effects of postrenal acute renal failure following obstruction due to upper urinary calculi in infants were *** the 13 infants with postrenal acute renal failure following obstruction due to upper urinary calculi,11 received retrograded catheterizations of the ureter with semi-rigid ureteroscopy(F 6.8),and two received open *** results showed that only one infant had anuresis and continuous reduction of hemoglobin 5 h after the open ureterolithotomy and received exploration via excision and peritoneal dialysis,and the remaining 12 patients well recovered in this *** renal function of all the patients was restored without postoperative *** is concluded that the retrograded catheterization of the ureter with ureteroscopy is a minimally invasive,safe and effective therapy for postrenal acute renal failure following obstruction due to upper urinary calculi in *** those infants whose urethras are thin and small,the open ureterolithotomy is a suitable *** patients with bleeding tendency need to be corrected prior to the open ureterotomy to remove obstructions.

关键词： infant acute renal failure postrenal uretero-scopy

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A sensitivity analysis of factors affecting in geologic CO_(2) storage in the Ordos Basin and its contribution to carbon neutrality

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China Geology 2022年第3期5卷 359-371页

作者： shi-xin dai Yan-jiao Dong Feng Wang Zhen-han Xing Pan Hu Fu Yang School of Earth Sciences and Geospatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China China Railway Times Architectural Design Institute Co.Ltd. Wuhu 241000China Key Laboratory of Coal Resources Exploration and Comprehensive Utilization Ministry of Natural ResourcesXi’an 710021China

To accelerate the achievement of China’s carbon neutrality goal and to study the factors affecting the geologic CO_(2)storage in the Ordos Basin,China’s National Key R&D Programs propose to select the Chang 6 oil reservoir of the Yanchang Formation in the Ordos Basin as the target reservoir to conduct the geologic carbon capture and storage(CCS)of 100000 t per *** applying the basic theories of disciplines such as seepage mechanics,multiphase fluid mechanics,and computational fluid mechanics and quantifying the amounts of CO_(2)captured in gas and dissolved forms,this study investigated the effects of seven factors that influence the CO_(2)storage capacity of reservoirs,namely reservoir porosity,horizontal permeability,temperature,formation stress,the ratio of vertical to horizontal permeability,capillary pressure,and residual gas *** results show that the sensitivity of the factors affecting the gas capture capacity of CO_(2)decreases in the order of formation stress,temperature,residual gas saturation,horizontal permeability,and ***,the sensitivity of the factors affecting the dissolution capture capacity of CO_(2)decreases in the order of formation stress,residual gas saturation,temperature,horizontal permeability,and *** sensitivity of the influencing factors can serve as the basis for carrying out a reasonable assessment of sites for future CO_(2)storage areas and for optimizing the design of existing CO_(2)storage *** sensitivity analysis of the influencing factors will provide basic data and technical support for implementing geologic CO_(2)storage and will assist in improving geologic CO_(2)storage technologies to achieve China’s carbon neutralization goal.

关键词： eologic CO_(2)storage Influencing factors Sensitivity analysis Carbon neutrality Oil and gas exploration engineering Ordos Basin China

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火山岩地层裂缝地震波场特征研究

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地球物理学进展 2017年第1期32卷 120-127页

作者：戴世立中国石油大庆油田有限责任公司勘探开发研究院大庆163712

火山岩地层裂缝发育、裂缝发育程度是制约产能关键因素.裂缝是怎样影响地层横向的地震成像效果,并具有什么独特的地球物理反射特征,是人们一直关注的重点.本文设计不同类型含裂缝地质模型,结合不同岩性实验室测试参数将地质模型转化为... 详细信息

火山岩地层裂缝发育、裂缝发育程度是制约产能关键因素.裂缝是怎样影响地层横向的地震成像效果,并具有什么独特的地球物理反射特征,是人们一直关注的重点.本文设计不同类型含裂缝地质模型,结合不同岩性实验室测试参数将地质模型转化为地球物理模型,采用计算精度高的交错网格高阶有限差分法,开展不同裂缝模型地震波场特征正演模拟研究,对比分析含裂缝和不含裂缝地层波场传播的特征和成像剖面特征,以及含裂缝和不含裂缝全弹性波场的频率域特征变化,指导火山岩地层中裂缝的识别和预测.研究表明,含裂缝地层产生强散射波场,裂缝散射波振幅与裂缝数量、速度差有关;发育裂缝的火山机构,散射波场与其他波场(如反射波场、透射波场等)叠加、干涉相互作用,造成波前面出现断断续续的现象,在成像地震剖面上裂缝形成断续反射,且火山岩地层中裂缝散射波主频高于地层反射波的,裂缝发育地层具有高频段振幅明显增强的特征.

关键词：火山岩裂缝地震波场正演模拟

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浅论钱伟长学术思想中的人文精神

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上海大学学报（社会科学版） 2006年第1期13卷 13-20页

作者：戴世强上海大学应用数学和力学研究所上海200072

通过简要回顾钱伟长先生的治学生涯和学术成就,力图具体地探索他的学术思想中的人文精神。着重阐明:他一贯主张自然科学与社会科学的密切结合,在自然科学研究中不断借鉴、融合人文科学的先进思路,坚持爱国敬业、勤奋进取、锐意创新、求... 详细信息

通过简要回顾钱伟长先生的治学生涯和学术成就,力图具体地探索他的学术思想中的人文精神。着重阐明:他一贯主张自然科学与社会科学的密切结合,在自然科学研究中不断借鉴、融合人文科学的先进思路,坚持爱国敬业、勤奋进取、锐意创新、求真务实、广闻博览、融会贯通,在提携后进过程中,力主通才教育和学术民主。分析表明,钱伟长学术思想中的这种人文精神源自我国先哲深邃的学术思想和德国哥廷根学派优良的学术传统。

关键词：学术思想人文精神自然科学社会科学治学方法

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Downregulation of metabotropic glutamate receptors mGluR5 and glutamate transporter EAAC1 in the myenteric plexus of the diabetic rat ileum

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Journal of Nanjing Medical University 2008年第6期22卷 356-361页

作者： Yanhua Bai Jun Zhang Hongyang shi Fei dai Department of Gastroenterology Second Hospital of Xi' an Jiaotong University Xi' an 710004 Shanxi Province China

Objective： To study the morphologic abnormalities of the myenteric plexus in diabetic rats and to explore the mechanism of their effect on gastrointestinal motility. Methods： Forty rats were randomly divided into a diabetic group and a control group, Gastric emptying and small intestine transit rates were measured and histologic and molecular changes in glutamatergic nerves in the ileal myenteric plexus were observed, mGluR5 receptor and EAAC1 transporter changes in the diabetic rats were studied using fluorescence immunohistochemistry and RT-PCR. Results：Eighteen weeks after the establishment of the diabetic rats model, gastric emptying and small intestine transit rates were found to be significantly delayed in the diabetic group when compared with the control group. The density of glutamatergic ganglia and neurons in the ileal myenterie plexus were significantly decreased in the diabetic group when compared with control group（P 〈 0.05） and the mGluR5 receptors and EAAC1 transporters were downregulated in the diabetic rats（P 〈 0.05）. Conclusion： Decreased glutamatergic enteric ganglia and neurons and decreased mGluR5 receptors and EAAC1 transporters in the intestinal myenteric plexus is one of the mechanisms of diabetic gastroenteropathy in rats.

关键词： Glutamate mGluR5 EAAC 1 Enteric Nervous System Diabetic gastroenteropathy

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Variable angle spectroscopic ellipsometry and its applications in determining optical constants of chalcogenide glasses in infrared

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Chinese Physics B 2018年第6期27卷 454-460页

作者： Ning-Ning Wei Zhen Yang Hong-Bo Pan Fan Zhang Yong-Xing Liu Rong-Ping Wang Xiang Shen shi-Xun dai Qiu-Hua Nie Laboratory of Infrared Material and Devices Advanced Technology Research InstituteNingbo UniversityNingbo 315211China Key Laboratory of Photoelectric Materials and Devices of Zhejiang Province Ningbo 315211China

The principle of variable angle spectroscopic ellipsometry（VASE） and the data analysis models, as well as the applications of VASE in the characterization of chalcogenide bulk glasses and thin films are reviewed. By going through the literature and summarizing the application scopes of various analysis models, it is found that a combination of various models, rather than any single data analysis model, is ideal to characterize the optical constants of the chalcogenide bulk glasses and thin films over a wider wavelength range. While the reliable optical data in the mid-and far-infrared region are limited, the VASE is flexible and reliable to solve the issues, making it promising to characterize the optical properties of chalcogenide glasses.

关键词： chalcogenide glasses/thin films VASE optical constants infrared

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Finite-Time Formation Control of Mobile Robots Under Limited Sensing Range

Finite-Time Formation Control of Mobile Robots Under Limited...

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第30届中国控制与决策会议

作者： shi-Lu dai Xin Chen Shude He School of Automation Science and Engineering South China University of Technology

This paper addresses the finite-time decentralized platoon formation control problem for a platoon of mobile robots. Under the limited sensing range, the control objective is to ensure the robotic platoon follow the virtual leader and to guarantee each robot satisfies the distance and bearing angle constraints such that it could detect its predecessor and avoid collision with its predecessor. To guarantee non-violation of the constraints, novel tan-type barrier Lyapunov functions are employed, and the boundary functions are taken as time-varying exponential functions to provide transient performances of formation errors. Based on backstepping procedure, barrier Lyapunov functions, and Lyapunov synthesis, the decentralized formation controllers are designed, where the finite-time control is incorporated with the control design technique to achieve finite time convergence of the formation errors with guaranteed prescribed *** proposed formation control is decentralized in the sense that each robot calculates its control signals based only on its predecessor’s information. Simulation results illustrate the performance of the proposed formation controller.

关键词： Finite-time formation control Mobile robots Barrier Lyapunov functions Prescribed performance

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Performance-Guaranteed Control of an Autonomous Underwater Vehicle Subject to Time-Varying Disturbances

Performance-Guaranteed Control of an Autonomous Underwater V...

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第30届中国控制与决策会议

作者： shi-Lu dai Yungen Peng Shude He School of Automation Science and Engineering South China University of Technology

This paper present a control design technique of asymptotic trajectory tracking with guaranteed transient performance for an autonomous underwater vehicle（AUV） subject to external time-varying disturbances. To achieve the asymptotic convergence of output tracking errors, the robust integral of the sign of the error（RISE） feedback method is employed to compensate for the effect of the external disturbances. In the previous RISE-based control scheme, the upper bounds of the external disturbances and their derivatives are often required to be known a priori, while this requirement is relaxed by adaptive tuning gain of the error sign term. To further provide the transient performance of the tracking errors, the prescribed performance control technique is introduced to guarantee that the convergence rate of the tracking error is faster than a prescribed speed and the overshoot of the tracking error is less than a predefined value. Based on backstepping procedure, prescribed performance control, and Lyapunov synthesis, a RISE-based controller is designed to achieve asymptotic convergence of the tracking errors with guaranteed prescribed performance. The effectiveness of the proposed control strategy is demonstrated through numerical simulation.

关键词： Asymptotic tracking Autonomous underwater vehicle(AUV) Adaptive tuning gain Prescribed performance

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