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Clinical characteristics and outcomes of psoriasis patients with COVID-19: A retrospective, multicenter cohort study in China

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中华医学杂志(英文版) 2024年第14期137卷 1736-1743页

作者： Liu Yanhua Xu Zhongrui Zhou Jian Chen Aijun Zhang Junling Kang Xiaojing Jiang Xian Lyu Chengzhi shi chunrui shi Yuling Liu Xiaoming Li Fuqiu Yang Bin Huang Yongmei Yu Chen Wang Gang Department of Dermatology Xijing Hospital Fourth Military Medical University Xi’an Shaanxi China Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang China Department of Dermatology West China Hospital Sichuan University Chengdu Sichuan China Department of Psoriasis Dalian Dermatosis Hospital Dalian Liaoning China Department of Dermatology The First Hospital of Lanzhou University Lanzhou Gansu China Skin Disease Hospital of Tongji University Shanghai China Department of Dermatology The University of Hong Kong-Shenzhen Hospital Shenzhen Guangdong China Department of Dermatology The Second Hospital of Jilin University Changchun Jilin China Department of Dermatology Dermatology Hospital of Southern Medical University Guangzhou Guangdong China Department of Dermatology Xining First People’s Hospital Xining Qinghai China

Background: Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on psoriasis patients. The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 ***: A retrospective, multicenter study was conducted between March and May 2023. Univariable and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019 (COVID-19)-related psoriasis outcomes. The study included 2371 psoriasis patients from 12 clinical centers, with 2049 of them having been infected with ***: Among the infected groups, lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments (22.3% [236/1058]vs. 39.8% [92/231]vs. 37.5% [140/373],P <0.001). Psoriasis progression with lesions (adjusted odds ratio [OR] = 8.197, 95% confidence interval [95% CI] = 5.685–11.820, compared to no lesions), hypertension (adjusted OR = 1.582, 95% CI = 1.068–2.343), traditional systemic (adjusted OR = 1.887, 95% CI= 1.263–2.818), and nonsystemic treatment (adjusted OR= 1.602, 95% CI= 1.117–2.297) were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection, but not biologics (adjusted OR = 0.931, 95% CI = 0.680–1.274, compared to no treatment), according to multivariable logistic regression ***: A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic treatments. Significant risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.

关键词： COVID-19 SARS-CoV-2 Psoriasis Treatment Biologics

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高频超声在寻常痤疮中的应用进展

实用皮肤病学杂志 2024年第3期17卷 167-171页

作者：杨贝张炜阳石春蕊兰州大学第一临床医学院兰州730030 兰州大学第一医院超声科兰州大学第一医院皮肤科

寻常痤疮是一种累及毛囊皮脂腺的慢性炎症性损容性皮肤病,以往的诊治多依靠皮肤科医师视诊、触诊及个人经验,检查设备参与较少。近年来,随着皮肤成像技术的进步和高频率超声探头的发展,无创、便捷、客观、量化、动态的皮肤高频超声检测... 详细信息

寻常痤疮是一种累及毛囊皮脂腺的慢性炎症性损容性皮肤病,以往的诊治多依靠皮肤科医师视诊、触诊及个人经验,检查设备参与较少。近年来,随着皮肤成像技术的进步和高频率超声探头的发展,无创、便捷、客观、量化、动态的皮肤高频超声检测成为了可能。其不仅可应用于正常皮肤测量,还可应用于皮肤医学美容和多种皮肤疾病的诊疗。本文主要就高频超声在寻常痤疮和痤疮瘢痕的形态特征观察、疾病严重度评估、治疗方案指导、治疗监测及疗效评价等方面的应用进展作一综述。

关键词：寻常痤疮高频超声瘢痕严重度评估疗效评价

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张掖地区气象因素对痤疮门诊就诊量的影响

中国社会医学杂志 2024年第4期41卷 465-470页

作者：吴岳石春蕊张剑虹武奕董继元韩磊兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院皮肤性病科甘肃兰州730000 兰州大学公共卫生学院甘肃兰州730000 河西学院附属张掖人民医院皮肤性病科甘肃张掖734099

目的研究甘肃省张掖地区气象因素对痤疮门诊就诊人数的影响,为痤疮防控提供理论依据。方法收集2015-2019年张掖地区某三甲医院6305例痤疮门诊患者日就诊数据及同时期气象资料,运用分布滞后非线性模型分析气象因素和痤疮门诊就诊人数的关... 详细信息

目的研究甘肃省张掖地区气象因素对痤疮门诊就诊人数的影响,为痤疮防控提供理论依据。方法收集2015-2019年张掖地区某三甲医院6305例痤疮门诊患者日就诊数据及同时期气象资料,运用分布滞后非线性模型分析气象因素和痤疮门诊就诊人数的关系,并按不同性别、年龄进行分层分析。结果张掖地区气象因素对痤疮门诊就诊人数的影响是非线性的,且存在滞后效应。低温(-10.7℃)的危害发生早,高温(24.9℃)的危害时间久,两者单日滞后最大相对危险度(RR)分别为1.031(95%CI:1.001~1.061)、1.076(95%CI:1.037~1.120);低温和高温均在累积滞后21天时效应值最大,RR分别为1.806(95%CI:1.576~2.071)、1.755(95%CI:1.493~2.062);低温和高温对男性及19~<35岁人群影响较大。低湿度(22%)的保护效应(RR<1)在累积滞后21天时效应最强RR=0.564(95%CI:0.449~0.709);低湿度对女性及19~<35岁人群的保护效应最显著。结论低温和高温均增加张掖地区痤疮门诊就诊风险,男性及19~<35岁人群更敏感。低湿度主要保护女性及19~<35岁人群。

关键词：气象因素气温相对湿度痤疮分布滞后非线性模型

Review of the Therapeutic Advance of Acne Treatment

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Journal of Biosciences and Medicines 2022年第6期10卷 66-78页

作者： Noha Saleh Gholais chunrui shi The First Clinical Medical College Lanzhou University Lanzhou China Department of Dermatology The First Hospital of Lanzhou University Lanzhou China

Acne vulgaris is among the most frequent chronic skin disorders in adolescents, characterized by inflammation of the pilosebaceous unit. The psychological distress due to the disfiguring is the main problem that affects the quality of life for patients suffering from acne. Drugs for the treatment of acne are one of the main contents of drug research on common skin diseases. Acne treatment has remained relatively unaltered over the last years. Still, in conjunction with the increase of bacterial resistance to antibiotics throughout the world, there is a global trend away from antibiotic monotherapy treatment. This review discussed the currently used treatment options and evaluated the issues and evidence supporting their usage for patients with acne, including drug therapy with topical, oral, hormonal therapy, and so on. Drug therapy is the most common method in the clinic. Due to the multifactorial etiology of acne vulgaris, most drugs cannot meet the treatment requirements. Therefore, the screening and development of excellent drugs are one of the key targets for treating acne in the future.

关键词： Acne Therapeutic Advance Oral Topical Therapy

In vitro antifungal effect of Zanthoxylum bungeanum volatile oil to Candida isolates

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In vitro antifungal effect of Zanthoxylum bungeanum volatile...

钛（Ⅳ）-氯磺酚S-N-苯甲酰苯基羟肟酸三元配合物及其分析应用

International Forum 2003 Academic Conference of Dermatology of the Integration of TCM with Western Medicine

作者： shi chunrui, Luo Zhicheng, Wu Sanmao, et al Department of Dermatology, the Second Affiliated Hospital, Lanzhou Medical College, Lanzhou 730030, China

Objective:To investigate the in vitro antifungal effect of Zanthoxylumbungeamum volatile oil to Candida isolates. Methods:The minimum inhibitory concentrations (MICs) of Zanthoxy-lum bungeanum volatile oil, with fluco... 详细信息

关键词： Zanthoxylum bungeanum volatile oil antifungal susceptibility Candida Minimum inhibitory concentration

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分析化学 1989年第6期 533-535页

作者：杨志斌占春瑞史安农江西大学化学系87届江西大学化学系毕业生南昌

本文研究了钛（Ⅳ）一氯—磺酚S—N—苯甲酰苯基羟肟酸三元混配配合物的形成条件,提出了一个快速简便的分光光度法,用于测定硅酸盐矿物中的微量钛。Ti（Ⅳ）量在0—20μg/25ml符合比尔定律,λ=660nm,ε=1.98×***-1。

关键词：钛氯磺酚 S N-苯甲酰苯基羟肟酸分光光度法

光电技术在红斑毛细血管扩张型玫瑰痤疮治疗中的应用

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激光生物学报 2022年第4期31卷 303-310页

作者：杨贝石春蕊兰州大学第一临床医学院兰州730030 兰州大学第一医院皮肤病与性病科兰州730030

玫瑰痤疮是一种主要累及面中部的慢性炎症性损容性皮肤病,确切的病因及发病机制尚未完全阐明,临床治疗棘手。尽管以往的局部外用药物和系统口服药物治疗对红斑毛细血管扩张型玫瑰痤疮(ETR)有一定的效果,但用药周期长、起效慢且容易反弹... 详细信息

玫瑰痤疮是一种主要累及面中部的慢性炎症性损容性皮肤病,确切的病因及发病机制尚未完全阐明,临床治疗棘手。尽管以往的局部外用药物和系统口服药物治疗对红斑毛细血管扩张型玫瑰痤疮(ETR)有一定的效果,但用药周期长、起效慢且容易反弹复发,特别是对潮红、灼热等主观症状改善不明显,患者的依从性差,满意度低,易存在焦虑抑郁等心理问题。近年来,随着脉冲染料激光、强脉冲光、Nd:YAG激光、KTP激光、Pro-Yellow激光、光生物调节疗法等多种光电技术广泛应用于临床,ETR的治疗方案选择性更广了,整体治疗效果得到了提升,医患双方的满意度也较前有所提高。本文对目前多种光电技术在ETR治疗中的应用进展作一综述。

关键词：玫瑰痤疮红斑血管扩张激光光生物调节

慢性自发性荨麻疹患者外周血Treg细胞比例和白细胞介素17A、27水平及意义

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中华皮肤科杂志 2017年第12期50卷 916-919页

作者：王亚婷石春蕊武奕师蓓熊潇周兰霞兰州大学第一临床医学院兰州大学第一医院皮肤性病科 730000

目的探讨外周血中CD4＋CD25＋CD127low调节性T（Treg）细胞、白细胞介素17A（IL？17A）和IL？27在慢性自发性荨麻疹发病机制中的作用。方法收集37例慢性自发性荨麻疹患者和40例健康对照外周血标本。采用流式细胞仪检测外周血中CD4＋C... 详细信息

目的探讨外周血中CD4＋CD25＋CD127low调节性T（Treg）细胞、白细胞介素17A（IL？17A）和IL？27在慢性自发性荨麻疹发病机制中的作用。方法收集37例慢性自发性荨麻疹患者和40例健康对照外周血标本。采用流式细胞仪检测外周血中CD4＋CD25＋CD127low Treg细胞比例，酶联免疫吸附试验（ELISA）检测血清中IL？17A和IL？27水平。结果慢性自发性荨麻疹患者外周血中CD4＋CD25＋CD127low Treg细胞比例（5.99% ± 2.72%）明显低于健康对照组（9.07% ± 3.44 %，t = 4.325，P 〈 0.01），IL？27水平［（20.54 ± 7.65）ng/L］亦低于健康对照组［（26.63 ± 9.72） ng/L，t = 3.039，P = 0.003］，IL？17A表达水平与健康对照组差异无统计学意义（P = 0.529）。慢性自发性荨麻疹患者IL？17A表达水平与CD4＋CD25＋CD127low Treg细胞比例呈负相关（r = -0.359，P = 0.029），IL？17A、IL？27、CD4＋CD25＋CD127 low Treg细胞比例与UAS评分均无显著相关性（r值分别为-0.076、-0.083、-0.053，均P 〉 0.05）。结论慢性自发性荨麻疹患者外周血中可能存在Th17/Treg细胞失衡，且IL？27可能参与慢性自发性荨麻疹的发病过程。

关键词：荨麻疹白细胞介素 17 T淋巴细胞调节性白细胞介素 27

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二期梅毒误诊为荨麻疹性血管炎1例

中国皮肤性病学杂志 2019年第7期33卷 849-850页

作者：白瑶石春蕊刘昱彤武奕白瑛骆志成兰州大学第一医院皮肤科甘肃兰州730000 兰州大学第二医院皮肤科甘肃兰州730000

患者女,20岁,全身出现水肿性红斑伴痒10 d,加重4 d。拟诊“荨麻疹性血管炎”,行梅毒血清学检查:TPPA(+),RPR(+)1:32;皮损组织病理示:角化过度,上皮突存在,棘层肥厚,基底膜完整,真皮浅层及小血管周围可见淋巴细胞及浆细胞浸润。诊断:二... 详细信息

患者女,20岁,全身出现水肿性红斑伴痒10 d,加重4 d。拟诊“荨麻疹性血管炎”,行梅毒血清学检查:TPPA(+),RPR(+)1:32;皮损组织病理示:角化过度,上皮突存在,棘层肥厚,基底膜完整,真皮浅层及小血管周围可见淋巴细胞及浆细胞浸润。诊断:二期梅毒。给予苄星青霉素240万U驱梅治疗,连用3周。患者皮损已消退,目前在随访中。

关键词：二期梅毒荨麻疹性血管炎误诊