检索结果-南通市图书馆

Hepatocellular carcinoma-derived exosomal miRNA-761 regulates the tumor microenvironment by targeting the SOCS2/JAK2/STAT3 pathway

引用

World Journal of Emergency Medicine 2022年第5期13卷 379-385页

作者： Xiao-hu Zhou Hao Xu Chang Xu Ying-cai Yan lin-shi Zhang Qiang Sun Wei-lin Wang Yan-jun shi Department of Hepatobiliary and Pancreatic Surgery the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Exosomes and exosomal microRNAs have been implicated in tumor occurrence and *** previous study showed that microRNA-761(miR-761)is overexpressed in hepatocellular carcinoma(HCC)tissues and that its inhibition affects mitochondrial function and inhibits HCC *** mechanism by which exosomal miR-761 modulates the tumor microenvironment has not been ***:Exosomal miR-761 was detected in six cell *** counting kit-8(CCK-8)and transwell migration assays were performed to determine the function of exosomal miR-761 in HCC *** luciferase reporter assay was used to analyze miR-761 target genes in normal fi broblasts(NFs).The inhibitors AZD1480 and C188-9 were employed to determine the role of the Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)signaling pathway in the transformation of cancer-associated fi broblasts(CAFs).RESULTS:In this study,we characterized the mechanism by which miR-761 reprogrammed the tumor *** found that HCC-derived exosomal miR-761 was taken up by ***,HCC exosomes aff ected the tumor microenvironment by activating NFs via suppressor of cytokine signaling 2(SOCS2)and the JAK2/STAT3 signaling ***:These results demonstrated that exosomal miR-761 modulated the tumor microenvironment via SOCS2/JAK2/STAT3 pathway-dependent activation of *** fi ndings may inspire new strategies for HCC prevention and therapy.

关键词： Exosomes Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)signaling pathway microRNA-761 Suppressor of cytokine signaling 2 Tumor microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficient Synthesis of 2,6-Diphenyl-4-arylpyrylium Tetrafluoroborate

引用

Chinese Chemical Letters 2002年第7期13卷 605-606页

作者： Shrong shi lin Cheng Yong LI Xuan WANG Department of Chemistry Peking UniversityBeijing 100871

Four pyrylium salts, (2,6-diphenyl-4-arylpyrylium tetrafluoroborate, aryl = C6H5, 4-MeO C6H4, 4-Me2NC6H4, 4-NO2C6H4) were synthesized efficiently and economically from acetophenone and substituted chalcones in the pre... 详细信息

关键词： Diphenyl-4-arylpyrylium tetrafluoroborate chalcone acetophenone borontrifuo- ride.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel Chiral Polyoxometalate:First Arginine Based Anderson-type Complex

引用

Chemical Research in Chinese Universities 2012年第3期28卷 375-378页

作者： lin shi-wei WU Qiong WANG En-bo Key Laboratory of Polyoxometalate Science Ministry of EducationFaculty of ChemistryNortheast Normal UniversityChangchun 130024P.R.China Department of Chemistry Changchun Normal UniversityChangchun 130032P.R.China Department of Chemistry Science&Technology Kunming UniversityKunming 650214P.R.China

A novel chiral polyoxometalate（POM）, {[Na（Arg）2]NaH}[AIMo6（OH）6O18].6H2O（1,Arg=L-arginine）has been synthesized by the reaction between Na3[A1Mo6（OH）6O18].8H2O and Arg in aqueous solution and was structu- rally characterized by single-crystal X-ray diffraction, elemental analyses and UV-Vis spectrometry. Compound 1 was an example of Arg based Anderson-type complex. Photocatalytic analysis indicates that compound 1 presents cata- lytic activity for photodegradation of rhodamine-B（RhB） under UV irradiation.

关键词： Polyoxometalate Anderson-type Chiral Arginine Photocatalysis property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A theoretical model for the estimation of maximum impact force from a rockfall based on contact theory

引用

Journal of Mountain Science 2018年第2期15卷 430-443页

作者： ZHANG shi-lin YANG Xing-guo ZHOU Jia-wen State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University College of Water Resource and Hydropower Sichuan University

Rockfall poses a great threat to buildings and personal security. To understand the dynamic characteristics of rockfalls is a prerequisite for disaster prevention and assessment. Models for rockfalls in different forms are established based on the theory of rigid body motion. The equivalent velocity considering the rotational effect is determined by the energy ratio. Besides, considering plastic deformation and nonlinear hardening, the maximum impact force is estimated based on the Hertz contact theory. Then, a case study is carried out to illustrate the applicability of the model and sensitive analyses on some affecting parameters are also made. Calculation results show that the maximum impact force increases with the increasing of incident velocity, angle and slope gradient reflected by the changing of energy ratio. Moreover, the model for the estimation of maximum impact force is validated by two different scales of experiments and compared with other theoretical models. Simulated maximum impact forces agree well with the experiments.

关键词： RockfaU Motion characteristics Contacttheory Maximum impact force

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

引用

Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang shi-lin Huang Nan-nan Chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anorectal Malignant Melanoma：Diagnosis and Treatment of 42 Cases

引用

Chinese Journal of Cancer Research 2010年第3期22卷 176-180页

作者： Xiao-bin Li lin shi Shuang-min Zhang Department of General Surgery Peking Union Medical College Hospital Peking UnionMedical College Chinese Academy of Medical Sciences Beijing 100730 China Department of General Surgery Haidian Hospital Beijing 100080 China

Objective：Anorectal malignant melanoma（AMM） is a rare and aggressive malignant tumor,and its treatment still *** study was to investigate and summarize our experience on diagnosis,treatment and misdiagnosis of ***：From August 1980 to December 2009,42 patients with AMM were treated in our *** clinical data of those patients were retrospectively analyzed,including the major symptoms,treatment and *** immunophenotyping analyses using antibodies to S-100 protein,HMB-45 reactive antigen and vimentin were performed in 22 ***：The major complaints among the 42 cases were hematochezia（23/42,55.0%）,anal masses（12/42,28.6%）,changes in stool character（4/42,9.5%）,and anal tenesmus or pain（3/42,7.1%）.The misdiagnosis rate was 62%（26/42）,the most common misdiagnosis consisted of hemorrhoid（9/26,34.6%）,polyps（11/26,42.3%） and rectal cancer（6/26,23.1%）.28 cases underwent abdominoperineal resection,10 underwent local wide excision,3 underwent palliative operation,and 1 with no *** surgery,15 patients underwent radiotherapy,21 underwent chemotherapy and 8 were treated with both.22 cases deceased within 1 year,11 within 2 years,5 within 3 years and 1 within 4 *** median survival time was 11 months,with the longest of 45 *** immunohistochemical findings revealed that the S-100 protein was present in all 22 cases（100%）,HMB-45 was stained in 19 of 22（86.4%） and vimentin in 21 of 22（95.5%）.Conclusion：AMM is a rare disease with a poor prognosis and with an aptitude of being *** is the most common *** staining is conducive to the diagnosis of *** is the major treatment,the operation type should be individualized.

关键词： Anorectal Melanoma Diagnosis Treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure and Mechanical Properties of High Manganese TRIP Steel

引用

Journal of Iron and Steel Research International 2012年第4期19卷 57-62页

作者： ZHAO Jin-long XI Yan shi Wen LI lin College of Material Science and Engineering Shanghai University Shanghai 200072 China

Microstructure evolution and mechanical properties of newly designed 0.1C-6Mn-0.5Si-1Al TRIP-aided steels under different annealing conditions and the effects of matrix microstructure before intercritical annealing on the final microstructure were studied by means of X-ray diffraction（XRD）,scanning electron microcopy（SEM）,dilatometric simulation,optical microstructure（OM） and tensile testing in this *** experimental results indicate that the TRIP steel with Mn of 6% could form a considerable amount of retained austenite with good TRIP effect after a simple intercritical annealing treatment,and the matrix microstructure before intercritical annealing treatment can greatly affect the final *** original microstructure of the ferritic matrix steel was eliminated,while annealed martensite was remained from the martensite matrix steel under the same intercritical annealing conditions

关键词： high manganese TRIP steel intercritical annealing microstructure mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bone marrow-derived mesenchymal stem cell transplantation attenuates overexpression of inflammatory mediators in rat brain after cardiopulmonary resuscitation

引用

Neural Regeneration Research 2020年第2期15卷 324-331页

作者： Qing-Ming lin Xia-Hong Tang shi-Rong lin Ben-Dun Chen Feng Chen Institute of Fujian Emergency Medicine Clinical College of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFujian Provincial Emergency CenterFuzhouFujian ProvinceChina

Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain unclear. This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cell treatment on expression profiles of multiple cytokines in the brain after cardiac arrest and cardiopulmonary resuscitation. Cardiac arrest was induced in rats by asphyxia and cardiopulmonary resuscitation was initiated 6 minutes after cardiac arrest. One hour after successful cardiopulmonary resuscitation, rats were injected with either phosphate-buffered saline(control) or 1 × 10~6 bone marrow-derived mesenchymal stem cells via the tail vein. Serum S100 B levels were measured by enzyme-linked immunosorbent assay and neurological deficit scores were evaluated to assess brain damage at 3 days after cardiopulmonary resuscitation. Serum S100 B levels were remarkably decreased and neurological deficit scores were obviously improved in the mesenchymal stem cell group compared with the phosphate-buffered saline group. Brains were isolated from the rats and expression levels of 90 proteins were determined using a RayBio Rat Antibody Array, to investigate the cytokine profiles. Brain levels of the inflammatory mediators tumor necrosis factor-α, interferon-γ, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, macrophage inflammatory protein-3α, macrophage-derived chemokine, and matrix metalloproteinase-2 were decreased ≥ 1.5-fold, while levels of the anti-inflammatory factor interleukin-10 were increased ≥ 1.5-fold in the mesenchymal stem cell group compared with the control group. Donor mesenchymal stem cells were detected by immunofluorescence to determine their distribution in the damaged brain, and were primarily observed in the cerebral cortex. These results indicate that bone marrow-derived mesenchymal stem cell transplantation attenuates brai

关键词： antibody array asphyxia brain damage cardiac arrest cardiopulmonary resuscitation global cerebral ischemia inflammatory mediator mesenchymal stem cell neurological deficit score S100B

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

QCD Axial Anomaly Enhances theηη'Decay of the Hybrid Candidateη1(1855)

引用

Chinese Physics Letters 2022年第5期39卷 29-35页

作者： Hua-Xing Chen Niu Su shi-lin Zhu School of Physics Southeast UniversityNanjing 210094China School of Physics and Center of High Energy Physics Peking UniversityBeijing 100871China

We study the hybrid mesons with the exotic quantum number I^(G)J^(PG)=0+1-+and investigate their decays into theηη’,a1(1260)π,f1(1285)η,f1(1420)η,K*(892)■,K1(1270)■,and K1(1400)■*** is found that the QCD axial anomaly enhances the decay width of theηη’channel although this mode is strongly suppressed by the small p-wave phase *** results support the interpretation of theη1(1855)recently observed by BESⅢas the ssg hybrid meson of I^(G)J^(PC)=0^(+)1^(-+).The QCD axial anomaly ensures theηη’decay mode to be a characteristic signal of the hybrid nature of theη1(1855).

关键词： BESⅢ QCD mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Group tracking control of second-order multi-agent systems 36

Group tracking control of second-order multi-agent systems

引用

第36届中国控制会议

作者： lin shi Qing Cui Dongmei Xie Department of Mathematics Tianjin University

ISBN: (纸本)9781538629185

This paper focuses on studying the group consensus tracking issue of discrete time second-order multi-agent systems（MASs） under directed fixed and Markovian switching topologies, respectively. For MASs with m leaders, we first introduce a method to divide the whole MASs into m subgroups. Based on the subgroup-divided method, the condensation directed graph G of the communication topology of the whole MASs becomes a directed acyclic graph（DAG）. Then, for MASs with fixed/Markovian switching topology, some sufficient/necessary and sufficient group consensus tracking criteria are established.

关键词： Multi-agent systems(MASs) subgroup-divided method group tracking Markovian switching topologies

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：