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Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

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Neural Regeneration Research 2021年第10期16卷 2078-2085页

作者： Yan-Zhen Li Yuan-Jie Liu Wei Zhang shi-Fang luo Xin Zhou Gui-Qiong He Chongqing Key Laboratory of Neurobiology Chongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Galactophore Chongqing University Cancer HospitalChongqingChina

Postmenopausal women with Alzheimer’s disease exhibit dramatically reduced sensitivity to estrogen replacement therapy,which is though to be related to an estrogen receptor(ER)α/ERβratio imbalance arising from a significantly decreased level of ERs of the *** aim of our study was to investigate whether valproic acid(VPA)can enhance the beneficial effects of estrogen on cognitive function through restoration of ERαand ERβexpression in the *** removed the ovaries of female APP/PS1 mice to simulate the low estrogen levels present in postmenopausal women and then administered VPA(30 mg/kg,intraperitoneal injection,once daily),17β-estradiol(E2)(2.4μg,intraperitoneal injection,once daily),liquiritigenin(LG)(50μg/kg,intragastric infusion,once daily),VPA+E2,or VPA+LG for 4 successive *** with treatment with a single drug,treatment with VPA+E2 or VPA+LG significantly increased the level of glycogen synthase kinase 3β,increased the expression of estrogen receptorα,reduced the expression of small ubiquitin-like modifiers,and increased the level of estrogen receptorβ.This resulted in enhanced sensitivity to estrogen therapy,reduced amyloidβaggregation,reduced abnormal phosphorylation of the tau protein,reduced neuronal loss,increased dendritic spine and postsynaptic density,and significantly alleviated memory loss and learning impairment in Alzheimer’s *** study was approved by the Chongqing Medical University Animal Protection and Ethics Committee,China on March 6,2013.

关键词： 17β-estradiol amyloidβ dementia estrogen receptorα estrogen receptorβ glycogen synthase kinase-3β liquiritigenin menopause neuron loss tau

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The Probability Density Function Related to Shallow Cumulus Entrainment Rate and Its Influencing Factors in a Large-Eddy Simulation

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Advances in Atmospheric Sciences 2024年第1期41卷 173-187页

作者： Lei ZHU Chunsong LU Xiaoqi XU Xin HE Junjun LI shi luo Yuan WANG Fan WANG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)and Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science and TechnologyNanjing 210044China Nanjing Joint Institute for Atmospheric Sciences Nanjing 210019China College of Aviation Meteorology Civil Aviation Flight University of ChinaGuanghan 618307China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China Department of Geography Hong Kong Baptist UniversityHong Kong SAR 999077China

The process of entrainment-mixing between cumulus clouds and the ambient air is important for the development of cumulus *** obtaining the entrainment rate(λ)is particularly important for its parameterization within the overall cumulus parameterization *** this study,an improved bulk-plume method is proposed by solving the equations of two conserved variables simultaneously to calculateλof cumulus clouds in a large-eddy *** results demonstrate that the improved bulk-plume method is more reliable than the traditional bulk-plume method,becauseλ,as calculated from the improved method,falls within the range ofλvalues obtained from the traditional method using different conserved *** probability density functions ofλfor all data,different times,and different heights can be well-fitted by a log-normal distribution,which supports the assumed stochastic entrainment process in previous *** analysis demonstrate that the relationship betweenλand the vertical velocity is better than other thermodynamic/dynamical properties;thus,the vertical velocity is recommended as the primary influencing factor for the parameterization ofλin the *** results of this study enhance the theoretical understanding ofλand its influencing factors and shed new light on the development ofλparameterization.

关键词： large-eddy simulation cumulus clouds entrainment rate probability density functions spatial and temporal distribution

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Effect of Gd content on hot-tearing susceptibility of Mg-6Zn-xGd casting alloys

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China Foundry 2022年第2期19卷 131-139页

作者： He Qin Guang-yu Yang Xun-wei Zheng shi-feng luo Tong Bai Wan-qi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China Dongfeng Nissan Aeolus Xiangyang Automobile Co. Ltd.Xiangyang 441100HubeiChina

The hot-tearing susceptibility(HTS)of Mg-6Zn-xGd(x=0.5,1,2,3,4,6)alloys was evaluated using a constrained rod casting(CRC)*** results show that the HTS curve follows a typical"Λ"shape with the increase of Gd *** Mg-6Zn-2Gd alloy has the highest while Mg-6Zn-6Gd alloy has the lowest HTS *** hot-tearing behavior characteristics of Mg-6Zn-xGd alloys were further studied through a multifunctional hot-tearing test *** to the dendrite contact point inferred from the stress curve,the Clyne-Davies criterion was modified and found to be accurate in predicting the HTS of Mg-6Zn-xGd *** observation reveals that the grain size and the volume of eutectic liquid are the two key factors affecting HTS of Mg-6Zn-xGd *** large grain with columnar structure can easily promote initiation and propagation of hot-tearing due to the poor feeding and coordinating deformation capability,which have a harmful effect on HTS.A higher volume fraction of eutectic phase can refill the cracking and provide continuous feeding channels by dendrite bridge and thicker liquid film,thus increase the hot-tearing resistance.

关键词： Mg-Zn-Gd alloy hot-tearing susceptibility modified Clyne-Davies model microstructure

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Functional connectivity changes during migraine treatment with electroacupuncture at Shuaigu(GB8)

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Journal of Integrative Medicine 2022年第3期20卷 237-243页

作者： Xiang-yu Wei shi-lei luo Hui Chen Shan-shan Liu Zhi-gang Gong Song-hua Zhan Department of Radiology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Acupuncture&Moxibustion Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To investigate the changes in the functional connectivity(FC)in the right insula between migraine without aura(MWoA)and healthy controls by using resting-state functional magnetic resonance imaging(rs-fMRI),and to observe the instant alteration of FC in MWoA during electroacupuncture(EA)stimulation at Shuaigu(GB8).Methods:A total of 30 patients with MWoA(PM group)and 30 healthy controls(HC group)underwent rs-fMRI *** PM group underwent a second rs-fMRI scan while receiving EA at *** right insula subregions,including the ventral anterior insula(vAI),dorsal anterior insula(dAI)and posterior insula(PI),were selected as the seed points for FC ***:Aberrant FC,including dAI with right postcentral gyrus,PI with left precuneus,was found among PM before EA(PMa),PM during EA(PMb)and ***,decreased FC between dAI and the right postcentral gyrus was found in the PMa compared to the HC and *** FC between the PI and left precuneus was found in the PMa compared to the HC and *** analysis showed that the FC value of the right postcentral gyrus in PMa was negatively correlated with the scores of Hamilton Rating Scale for Depression and Hamilton Rating Scale for *** FC value of the left precuneus in PMa was positively correlated with the visual analogue scale ***:The alteration of FC between the right insula subregions and multiple brain regions may be an important index for *** at GB8 was able to adjust the FC between the right insula subregions and parietal lobe,namely,the right dAI and right postcentral gyrus,and the right PI and left precuneus,thereby rendering an instant effect in the management of MWoA.

关键词： Functional status Migraine Electroacupuncture Shuaigu(GB8) Functional magnetic resonance imaging

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Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma

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Acta Pharmaceutica Sinica B 2019年第3期9卷 575-589页

作者： Xi Cao Ying Hu shi luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan University

Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma.

关键词： Na■ve neutrophils membrane Celastrol PEG-PLGA nanoparticle Pancreatic carcinoma Inflammation

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Targeted puncture of left branch of intrahepatic portal vein in transjugular intrahepatic portosystemic shunt to reduce hepatic encephalopathy

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World Journal of Gastroenterology 2019年第9期25卷 1088-1099页

作者： shi-Hua luo Jian-Guo Chu He Huang Guo-Rui Zhao Ke-Chun Yao Department of Radiology Zhongnan Hospital of Wuhan University Department of Radiology Air Force Medical Center of PLA Department of Interventional Radiology Henan Provincial Infectious Disease Hospital Department of Ultrasound Air Force Medical Center of PLA

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS) is currently used for the treatment of complications of portal hypertension. The incidence of hepatic encephalopathy(HE) remains a problem in TIPS placement. It has been reported that the right branch mainly receives superior mesenteric venous blood while the left branch mainly receives blood from the splenic vein. We hypothesized that targeted puncture of the left portal vein would divert the non-nutritive blood from the splenic vein into the TIPS shunt; therefore, targeted puncture of the left branch of the intrahepatic portal vein during TIPS may reduce the risk of *** To evaluate the influence of targeted puncture of left branch of portal vein in TIPS on *** A retrospective analysis of 1244 patients with portal-hypertension-related complications of refractory ascites or variceal bleeding who underwent TIPS from January 2000 to January 2013 was performed. Patients were divided into group A(targeting left branch of portal vein, n = 937) and group B(targeting right branch of portal vein, n = 307). TIPS-related HE and clinical outcomes were *** The symptoms of ascites and variceal bleeding disappeared within a short *** the endpoint of follow-up, recurrent bleeding and ascites did not differ significantly between groups A and B(P = 0.278, P = 0.561, respectively).Incidence of HE differed significantly between groups A and B at 1 mo(14.94% vs36.80%, χ~2 = 4.839, P = 0.028), 3 mo(12.48% vs 34.20%, χ~2 = 5.054, P = 0.025), 6 mo(10.03% vs 32.24%, χ~2 = 6.560, P = 0.010), 9 mo(9.17% vs 31.27%, χ~2 = 5.357, P =0.021), and 12 mo(8.21% vs 28.01, χ~2 = 3.848, P = 0.051). There were no significant differences between groups A and B at 3 years(6.61% vs 7.16%, χ~2 = 1.204, P =0.272) and 5 years(5.01% vs 6.18%, χ~2 = 0.072, P = 0.562). The total survival rate did not differ between groups A and B(χ~2 = 0.226, P = 0.634, log-rank test).CONCLUSION Targeted puncture of the left branch of the i

关键词： Portal hypertension Transjugular intrahepatic portosystemic shunt Portal vein branch Hepatic encephalopathy

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Electrochemical polymerization of 2,6-pyridinediamine and characterization of the resulting polymer

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Chinese Chemical Letters 2012年第11期23卷 1311-1314页

作者： shi Ping luo Qing Xin Liu Zhong Liu Ai Juan Xie Yong Kong Xin Dai Institute of Petrochemical Technology Changzhou UniversityChangzhou 213164China Science and Technology Department Changzhou College of Information TechnologyChangzhou 213164China

Electrochemical synthesis of poly（2,6-pyridinediamine）（PPa） in aqueous sodium hydroxide solution has been carried out by using cyclic voltammetry for the first time. The scanning electron microscopy （SEM） revealed the interpenetrating network structure of the as-prepared PPa film, which makes it possible that anions can be doped into the polymer in the oxidation process, and vice versa in the reduction process. The results from FT-IR spectrum provided a possible polymerization mechanism of 2,6- pyridinediamine.

关键词： 2,6-Pyridinediamine Electrochemical polymerization Cyclic voltammetry SEM b'T-IR

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Creep property and microstructural evolution of DD11 alloy under high temperature and low stress

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Rare Metals 2024年第2期43卷 810-816页

作者： Yan-Fei Liu Jiang-Bo Sha Yun-Song Zhao Chen-Guang Liu Yuan-Yuan Guo Jian Zhang Yu-shi luo School of Materials Science and Engineering Beihang UniversityBeijing100191China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing100095China

In this paper,the interrupted and ruptured creep tests were carried out in a novel second generation single crystal superalloy named DD11 at 1100℃/130 *** alloy exhibited typical creep curve including primary,steady,and tertiary three creep *** microstructural evolution at different stages of the creep were analyzed by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The results show that theγ′phases transform into rafted structure at the early stage of the steady creep and keep stable during the steady creep *** the creep goes on,the rafted structure further coarsens and the topological inversion *** addition,at the primary creep,the dislocations mainly move in theγmatrix and pile up in theγ/γ′interface since the matrix channels widen *** formation of the regular interfacial dislocation networks occurs at the early stage of the steady *** the low stress,the dominated deformation mechanism during steady creep stage is the climbing of the〈010〉type edge ***,the effect of the deformation mechanism on creep property was discussed in detail.

关键词： DD11 alloy Creep property Interrupted creep test Rafted structure Deformation mechanism

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Elliptical Galaxies with Emission Lines from the Sloan Digital Sky Survey

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 15-24页

作者： Ying-He Zhao Qiu-Sheng Gu Zhi-Xin Peng Lei shi Xin-Lian luo Qiu-He Peng Department of Astronomy Nanjing University Nanjing 210093

As part of a study of star formation history along the Hubble sequence, we present here the results for 11 elliptical galaxies with strong nebular emission lines. After removing the dilution from the underlying old stellar populations by use of stellar population synthesis model, we derive the accurate fluxes of all the emission lines in these objects, which are then classified, using emission line ratios, into one Seyfert 2, six LINERs and four HII galaxies. We also identify one HII galaxy （A1216＋04） as a hitherto unknown Wolf-Rayet galaxy from the presence of the WolfRayet broad bump at 4650A. We propose that the star-forming activities in elliptical galaxies are triggered by either galaxy-galaxy interaction or the merging of a small satellite/a massive star cluster, as has been suggested by recent numerical simulations.

关键词： Galaxies: elliptical and lenticular cD Galaxies: starburst - Galaxies:individual: A1212+06 A1216+04 CGCG13-83 IC 225

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Conservation of Traditional Rice Varieties in a Globally Important Agricultural Heritage System (GIAHS):Rice-Fish Co-Culture

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Agricultural Sciences in China 2011年第5期10卷 754-761页

作者： XIE Jian WU Xuex WU Xue TANG Jian-jun ZHANG Jia-en luo shi-ming CHEN Xin College of Life Sciences Zhejiang Unmersity Hangzhou 310058 P.R.China Institute of Tropical and Subtropical Ecology South China Agricultural University Guangzhou 510642 P.R.China

The traditional rice-fish farming system is selected as a ＂globally important agricultural heritage system＂（GIAHS） by the Food and Agriculture Organization （FAO）,United Nations Development Programme （UNDP）,and Global Environment Facility （GEF）,*** Zhejiang Province of China,where the pilot site for this GIAHS farming system is located,we compared the use of traditional rice varieties in rice-fish co-culture and rice ***,we determined how traditional rice varieties were performed in this rice-fish *** 19% of the farmers who practiced rice monoculture planted traditional varieties while 52% of farmers who practiced rice-fish co-culture planted traditional *** varieties represented 13% of the total land cultivated under rice in the rice-fish system but only 2% in the rice monoculture *** the rice-fish system,yield was lower for traditional rice varieties than hybrid varieties but application of fertilizers and pesticides was also *** a field experiment in the rice-fish system without pesticides,rice planthopper numbers and sheath blight incidence were lower from three traditional varieties than one hybrid variety;yields were 8 to 32% lower from the traditional varieties than the *** results showed that traditional rice varieties can be preserved through conserving GIAHS rice-fish *** study also indicated that traditional rice varieties can survive in the rice-fish system because these varieties are helpful to the whole system and beneficial to the farmers.

关键词： hybrid rice varieties on-farm conservation rice monoculture traditional rice-fish farming

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