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China Ocean Engineering 2024年第4期38卷 557-571页

作者： DENG Rui HU Yu-xiao HUANG Si-chong SONG Zhi-jie WANG shi-gang WU Tie-cheng School of Ocean Engineering and Technology Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China

To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different *** lift forces are obtained by numerical calculations and validated by a model test in a towing *** factors that influence the force are the interceptor height,velocity,draft,and deadrise *** relationship between each factor and the induced lift force is investigated and *** found that the induced lift mainly depends on the interceptor height and advancing velocity,and is proportional to the square of the interceptor height and *** results also showed that the effects of the draft and deadrise angle are relatively less important,and the relationship between the induced lift and these two factors is generally *** on the results,a formula including the combined effect of all factors used to estimate the lift force induced by the interceptor is developed based on systematic *** proposed formula could be used to estimate the lift force induced by interceptors,especially under high-speed condition.

关键词： high-speed mono-hull ship interceptor lift force formula lift force towing tank test computational fluid dynamics

Chemical modification of barite for improving the performance of weighting materials for water-based drilling fluids

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Petroleum Science 2024年第1期21卷 551-566页

作者： Li-Li Yang Ze-Yu Liu shi-bo Wang Xian-Bo He Guan-Cheng Jiang jie Zhang MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and ProspectingChina University of Petroleum(Beijing)Changping DistrictBeijing102249China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

With increasing drilling depth and large dosage of weighting materials,drilling fluids with high solid content are characterized by poor stability,high viscosity,large water loss,and thick mud cake,easier leading to reservoir damage and wellbore *** this paper,micronized barite(MB)was modified(mMB)by grafting with hydrophilic polymer onto the surface through the free radical polymerization to displace conventional API barite *** suspension stability of water-based drilling fluids(WBDFs)weighted with API barite:mMB=2:1 in 600 g was significantly enhanced compared with that with API barite/WBDFs,exhibiting the static sag factor within 0.54 and the whole stability index of *** viscosity and yield point reached the minimum,with a reduction of more than 40%compared with API barite only at the same *** multi-stage filling and dense accumulation of weighting materials and clays,filtration loss was decreased,mud cake quality was improved,and simultaneously it had great reservoir protection performance,and the permeability recovery rate reached 87%.In addition,it also effectively improved the lubricity of *** sticking coefficient of mud cake was reduced by 53.4%,and the friction coefficient was ***,mMB can serve as a versatile additive to control the density,rheology,filtration,and stability of WBDFs weighted with API barite,thus regulating comprehensive performance and achieving reservoir protection *** work opened up a new path for the productive drilling of extremely deep and intricate wells by providing an efficient method for managing the performance of high-density WBDFs.

关键词： Drilling fluids Weighting materials Filtration control Reservoir protection Stability property

Room-temperature nitrogen-rich niobium nitride photodetector for terahertz detection

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Optoelectronics Letters 2024年第11期20卷 641-646页

作者： lu Xuehui LIU Binding CHI Chengzhu LIU Feng shi Wangzhou Department of Physics Mathematics & Science College Shanghai Normal University

A sensitive room-temperature metal-semiconductor-metal(MSM) structure is fabricated on high-resistivity silicon substrates(ρ>4 000 Ω·cm) for terahertz(THz) detection by utilizing the photoconductive effect.

关键词： A

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Additive manufacturing of NiTi lightweight porous structures bio-mimicking coral skeleton with enhanced mechanical properties and shape memory functions

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Science China(Technological Sciences) 2024年第8期67卷 2461-2474页

作者： LIU Xin GU DongDong YUAN luHao ZHANG Han SUN JianFeng CHEN WenXin WANG jie shi KeYu Jiangsu Provincial Research Center for Laser Additive Manufacturing of High-Performance Components College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China

Concerning the high demand for lightweight and multifunctional properties of engineering structures, the coral skeleton-inspired sheet-based(CSS) structure, which was a novel bio-mimicking coral skeleton wall-septa architecture with a unique ability to resist wave shocks was fabricated using NiTi alloy by laser powder bed fusion(LPBF) technology. The effects of laser energy density(LED) on surface morphologies, microstructures, phase transformation behavior, and mechanical properties of LPBFfabricated CSS structures were systematically investigated. The results indicated that the size deviation was predominantly governed by powder adhesion and step effect. NiTi CSS structures with LED of 71 J·mm~(-3)possessed superior compressive modulus(~400 MPa), ultimate strength(~13 MPa), and energy absorption efficiency(~69%). The compression fracture mechanism of the LPBF-fabricated NiTi CSS structures was revealed to be predominantly brittle fracture accompanied by ductile fracture. Furthermore, the Ni_4Ti_3 nanoprecipitates induced the precipitation strengthening effect, enabling better shape memory response at LED of 71 J·mm~(-3), with a recoverable strain of 3.63% and recovery ratio of 90.8%, after heating under a pre-strain of 4%. This study highlights the importance of a bionic design strategy for enhancing the mechanical properties of NiTi components and offers the possibility to tailor its functional properties.

关键词： bioinspired structures laser powder bed fusion NiTi shape memory alloy mechanical performance

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Colorectal Cancer Segmentation Algorithm Based on Deep Features from Enhanced CT Images

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Computers, Materials & Continua 2024年第8期80卷 2495-2510页

作者： shi Qiu Hongbing lu Jun Shu Ting Liang Tao Zhou School of Biomedical Engineering Fourth Military Medical UniversityXi’an710119China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an710032China Department of Radiology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China School of Computer Science and Engineering North Minzu UniversityYinchuan750030China

Colorectal cancer,a malignant lesion of the intestines,significantly affects human health and life,emphasizing the necessity of early detection and *** segmentation of colorectal cancer regions directly impacts subsequent staging,treatment methods,and prognostic *** colonoscopy is an effective method for detecting colorectal cancer,its data collection approach can cause patient *** address this,current research utilizes Computed Tomography(CT)imaging;however,conventional CT images only capture transient states,lacking sufficient representational capability to precisely locate colorectal *** study utilizes enhanced CT images,constructing a deep feature network from the arterial,portal venous,and delay phases to simulate the physician’s diagnostic process and achieve accurate cancer *** innovations include:1)Utilizing portal venous phase CT images to introduce a context-aware multi-scale aggregation module for preliminary shape extraction of colorectal cancer.2)Building an image sequence based on arterial and delay phases,transforming the cancer segmentation issue into an anomaly detection problem,establishing a pixel-pairing strategy,and proposing a colorectal cancer segmentation algorithm using a Siamese *** with 84 clinical cases of colorectal cancer enhanced CT data demonstrated an Area Overlap Measure of 0.90,significantly better than Fully Convolutional Networks(FCNs)at *** research will explore the relationship between conventional and enhanced CT to further reduce segmentation time and improve accuracy.

关键词： Colorectal cancer enhanced CT multi-scale siamese network segmentation

Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第6期30卷 565-578页

作者： Wen-Peng Wang Dan shi Duo Yun Jun Hu jie-Fu Wang Jia Liu Yan-Peng Yang Ming-Rui Li Jun-FengWang Da-lu Kong Department of Colorectal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Gastrointestinal Surgery Tianjin Nan Kai HospitalTianjin Medical UniversityTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM RepairInstitute of Integrative Medicine for Acute Abdominal DiseasesTianjin 300100China Department of Oncology The First Hospital of HohhotHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology Dazhou Central HospitalDazhou 635000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a deadly malignancy with limited treatment ***(DUBs)have been confirmed to play a crucial role in the development of malignant ***2 is a DUB involved in con-trolling protein deubiquitination and influencing critical cellular processes in *** To investigate the impact of JOSD2 on the progression of *** Bioinformatic analyses were employed to explore the expression,prognosis,and enriched pathways associated with JOSD2 in *** transduction was utilized to manipulate JOSD2 expression in ESCC cell lines(KYSE30 and RESULTS )Preliminary research indicated that JOSD2 was highly expressed in ESCC tissues,which was associated with poor *** analysis demonstrated that JOSD2 was upregulated in ESCC cell lines compared to normal esophageal ***2 knockdown inhibited ESCC cell activity,including proliferation and colony-forming ***,JOSD2 knockdown decreased the drug resistance and migration of ESCC cells,while JOSD2 overexpression enhanced these *** vivo xenograft assays further confirmed that JOSD2 promoted tumor proliferation and drug resistance in ***,JOSD2 appears to activate the MAPK/ERK and PI3K/AKT signaling *** spectrometry was used to identify crucial substrate proteins that interact with JOSD2,which identified the four primary proteins that bind to JOSD2,namely USP47,IGKV2D-29,HSP90AB1,and *** JOSD2 plays a crucial role in enhancing the proliferation,migration,and drug resistance of ESCC,suggesting that JOSD2 is a potential therapeutic target in ESCC.

关键词： Esophageal squamous cell carcinoma JOSD2 Ubiquitination Biomarker Targeted therapy Drug resistance

AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian Chen Pan Cao Chun-Xia shi lu-Yi Zhang lu-Wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

Synthesis and properties of single-crystal Ni-rich cathode materials in Li-ion batteries

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Transactions of Nonferrous Metals Society of China 2021年第4期31卷 1074-1086页

作者： shi-jie lu Yang LIU Zhen-jiang HE Yun-jiao LI Jun-chao ZHENG Jing MAO Ke-hua DAI School of Metallurgy and Environment Central South UniversityChangsha 410083China National Engineering Laboratory for High Efficiency Recovery of Refractory Nonferrous Metals Central South UniversityChangsha 410083China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China College of Chemistry Tianjin Normal UniversityTianjin 300387China

Single-crystal Ni-rich cathode material LiNi0.88Co0.09Al0.03O2(SC) was synthesized by a high-temperature solid-state calcination method. Physicochemical properties of primary and delithiated SC samples were investigated by X-ray diffractometry, X-ray photoelectron spectroscopy, and transmission electron microscopy. Electrochemical performance was characterized by long-term cycling, cyclic voltammetry, and in-situ impedance spectroscopy. The results indicated that high temperature rendered layered oxides to lose lithium/oxygen in the interior and exterior, and induced cationic disordering. Besides, the solid-phase synthesis process promoted phase transformation for electrode materials, causing the coexisting multi-phase in a single particle. High temperature can foster the growth of single particles, but it caused unstable structure of layered phase.

关键词： lithium-ion battery cathode material single-crystal electrochemical performance phase transformation

Enhanced ferroelectric and improved leakage of BFO-based thin films through increasing entropy strategy

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2263-2273页

作者： Dongfei lu Guoqiang Xi Hangren Li jie Tu Xiuqiao Liu Xudong Liu Jianjun Tian Linxing Zhang Institute for Advanced Materials Technology University of Science and Technology BeijingBeijing 100083China

BiFeO_(3)(BFO)has received considerable attention as a lead-free ferroelectric film due to its large theoretical remnant ***,BFO suffers from a large leakage current,resulting in poor ferroelectric ***,the sol-gel method was used to deposit a series of BFO-based thin films on fluorine-doped tin oxide substrates,and the effects of the substitution of the elements Co,Cu,Mn(B-site)and Sm,Eu,La(A-site)on the crystal structure,ferroelectricity,and leakage current of the BFO-based thin films were *** confirmed that lattice distortion by X-ray diffraction can be attributed to the substitution of individual elements in the BFO-based *** and Eu substitutions contribute to the lattice distortion in a pseudo-cubic structure,while La is biased toward *** force microscopy confirmed that reversible switching of ferroelectric domains by nearly 180°can be realized through the prepared *** ferroelectric hysteresis loops showed that the order for the polarization contribution is as follows:Cu>Co>Mn(B-site),Sm>La>Eu(A-site).The current density voltage curves indicated that the order for leakage contribution is as follows:Mn

关键词： increasing entropy synergistic ferroelectric film remnant polarization leakage current

Machine learning for prediction of retained austenite fraction and optimization of processing in quenched and partitioned steels

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Journal of Iron and Steel Research International 2024年第8期31卷 2002-2013页

作者： Shuai Wang jie Li Li-yang Zeng Xun-wei Zuo Nai-lu Chen Yong-hua Rongg Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The metastable retained austenite(RA)plays a significant role in the excellent mechanical performance of quenching and partitioning(Q&P)steels,while the volume fraction of RA(V_(RA))is challengeable to directly predict due to the complicated relationships between the chemical composition and process(like quenching temperature(Qr)).A Gaussian process regression model in machine learning was developed to predict V_(RA),and the model accuracy was further improved by introducing a metallurgical parameter of martensite fraction(fo)to accurately predict V_(RA) in Q&P *** developed machine learning model combined with Bayesian global optimization can serve as another selection strategy for the quenching temperature,and this strategy is very effcient as it found the"optimum"Qr with the maximum V_(RA) using only seven consecutive *** benchmark experiment also reveals that the developed machine learning model predicts V_(RA) more accurately than the popular constrained carbon equilibrium thermodynamic model,even better than a thermo-kinetic quenching-partitioning-tempering-local equilibrium model.

关键词： Q&P steel Retained austenite fraction Machine learning Quenching temperature Gaussian process regression model