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女性压力性尿失禁患者运动康复的研究进展

中华现代护理杂志 2024年第12期30卷 1665-1670页

作者：陈聪史蕾耿连霞胡晓炜薛英玲李建红陈军肖河北医科大学第二医院人事处石家庄050051 河北医科大学第二医院泌尿外科石家庄050051 河北省曲周县医院外三科邯郸057250 河北省邯郸市第一医院外五科邯郸056002

盆底肌训练(PFMT)是女性压力性尿失禁(SUI)患者非手术治疗的一线干预措施,但由于盆底肌肉生理位置的特殊性,导致13%~53%的患者在初次就诊后无法正确进行PFMT。鉴于此,国内外学者提出一些其他的运动康复方法且取得良好的临床效果。本文... 详细信息

盆底肌训练(PFMT)是女性压力性尿失禁(SUI)患者非手术治疗的一线干预措施,但由于盆底肌肉生理位置的特殊性,导致13%~53%的患者在初次就诊后无法正确进行PFMT。鉴于此,国内外学者提出一些其他的运动康复方法且取得良好的临床效果。本文对女性SUI患者运动康复方法进行综述,包括PFMT、核心肌群训练、普拉提、瑜伽、身体活动等,以期医务人员为女性SUI患者制订科学可行的运动康复方案提供参考。

关键词：综述康复护理压力性尿失禁盆底肌训练运动康复

盐酸丙卡特罗颗粒治疗儿童喘息性疾病的效果观察

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华夏医学 2024年第1期37卷 106-110页

作者：谢磊刘川玉陈山林石桂俏秦坤清唐建红桂林医学院第二附属医院桂林541199 桂林医学院药学院桂林541199 桂林医学院附属医院桂林541001

目的观察盐酸丙卡特罗颗粒治疗儿童喘息性疾病的临床效果。方法90例喘息性疾病患儿依据不同的给药方案分为3组,每组30例。对照组采用常规药物治疗,丙卡特罗组为常规药物加盐酸丙卡特罗颗粒治疗,氨溴特罗组为常规药物加氨溴特罗口服液治... 详细信息

目的观察盐酸丙卡特罗颗粒治疗儿童喘息性疾病的临床效果。方法90例喘息性疾病患儿依据不同的给药方案分为3组,每组30例。对照组采用常规药物治疗,丙卡特罗组为常规药物加盐酸丙卡特罗颗粒治疗,氨溴特罗组为常规药物加氨溴特罗口服液治疗。观察各组临床症状好转时间、不良反应发生率、复发住院和门诊就诊次数。结果丙卡特罗组的咳嗽好转时间、喘息好转时间、肺部哮鸣音好转时间均短于氨溴特罗组和对照组,差异具有统计学意义(P0.05);丙卡特罗组1年内因喘息性疾病3次及以上门诊就诊发生率低于氨溴特罗组和对照组(P<0.05)。结论盐酸丙卡特罗颗粒治疗儿童喘息性疾病的临疗效果较好,安全性高,能减少疾病复发率。

关键词：盐酸丙卡特罗颗粒氨溴特罗口服液儿童喘息性疾病

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis:a 2-year follow-up study

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Frontiers of Medicine 2013年第2期7卷 255-263页

作者： Jiangyi Zhu Yongquan shi Xinmin Zhou Zengshan Li Xiaofeng Huang Zheyi Han jianhong Wang Ruian Wang Jie Ding Kaichun Wu Ying Han Daiming Fan State Key Laboratory of Cancer Biology Institute of Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Pathology Xijing HospitalFourth Military Medical UniversityXi’an 710032China

The efficacy of ursodeoxycholic acid(UDCA)on long-term outcome of primary biliary cirrhosis(PBC)has been less documented in Chinese *** aimed to assess the therapeutic effect of UDCA on Chinese patients with *** the present study,67 patients with PBC were treated with UDCA(13–15 mg∙kg^(-1)∙day^(-1))and followed up for 2 years to evaluate the changes of symptoms,laboratory values and histological *** the results indicated,fatigue and pruritus were obviously improved by UDCA,particularly in patients with mild or moderate *** alkaline phosphatase andγ-glutamyl transpetidase levels significantly declined at year 2 comparing to baseline values,with the most profound effects achieved in patients at stage *** levels of alanine aminotransferase and aspartate aminotransferase significantly decreased whereas serum bilirubin and immunoglobulin M levels exhibited no significant *** feature was stable in patients at stages 1–2 but still progressed in patients at stages 3–*** biochemical response of patients at stage 2 was much better than that of patients at stages 3–*** data suggest that,when treated in earlier stage,patients in long-term administration of UDCA can gain favorable results not only on symptoms and biochemical responses but also on *** is also indicated that later histological stage,bad biochemical response and severe symptom may be indicators of poor prognosis for UDCA therapy.

关键词： primary biliary cirrhosis ursodeoxycholic acid Chinese biochemical response therapeutic efficacy

血清KL-6、PTX3、HBP水平与老年重症肺炎合并呼吸衰竭患者预后的相关性

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检验医学与临床 2024年第16期21卷 2380-2384,2389页

作者：宋秉睿王建洪史丽娜李有亮李欣岳树春河北省张家口市第一医院重症医学科河北张家口075000 河北省沧州市青县中医医院重症医学科河北沧州062650

目的探讨血清涎液化糖链抗原(KL-6)、正五聚蛋白3(PTX3)、肝素结合蛋白(HBP)与老年重症肺炎合并呼吸衰竭患者预后的相关性。方法选取2021年12月至2023年5月在张家口市第一医院重症医学科就诊的老年重症肺炎合并呼吸衰竭患者372例作为研... 详细信息

目的探讨血清涎液化糖链抗原(KL-6)、正五聚蛋白3(PTX3)、肝素结合蛋白(HBP)与老年重症肺炎合并呼吸衰竭患者预后的相关性。方法选取2021年12月至2023年5月在张家口市第一医院重症医学科就诊的老年重症肺炎合并呼吸衰竭患者372例作为研究对象,根据患者28 d后转归状况分为死亡组和生存组。采用酶联免疫吸附试验检测血清KL-6、PTX3、HBP水平;采用Pearson相关分析KL-6、PTX3、HBP水平与白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平及急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分的相关性;采用多因素Logistic回归分析老年重症肺炎合并呼吸衰竭患者预后的影响因素;绘制受试者工作特征(ROC)曲线分析血清KL-6、PTX3、HBP对老年重症肺炎合并呼吸衰竭患者预后的预测价值。结果随访28 d后,372例患者中生存312例(生存组),死亡60例(死亡组)。生存组患者血清KL-6、PTX3、HBP水平显著低于死亡组(P<0.05);两组患者ICU住院时间、机械通气时间、中性粒细胞计数、WBC、氧合指数(PaO_(2)/FiO_(2))、APACHEⅡ评分及血清PCT、CRP、白细胞介素-10水平比较,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,血清KL-6、PTX3、HBP水平与WBC、APACHEⅡ评分及血清PCT、CRP水平均呈正相关(P<0.05)。多因素Logistic回归分析结果显示,血清KL-6、PTX3、HBP、WBC、PCT、CRP水平是老年重症肺炎合并呼吸衰竭患者死亡的影响因素(P<0.05)。KL-6、PTX3、HBP联合预测老年重症肺炎合并呼吸衰竭患者死亡的曲线下面积(AUC)显著高于各指标单项检测的AUC(Z_(联合***-6)=4.590,P<0.001;Z_(联合***3)=3.823,P=0.001;Z_(联合***)=5.471,P<0.001)。结论老年重症肺炎合并呼吸衰竭患者血清KL-6、PTX3、HBP水平较高,且与患者预后关系密切,故KL-6、PTX3、HBP在评估老年重症肺炎合并呼吸衰竭患者的预后中具有重要作用。

关键词： Ⅱ型肺泡细胞表面抗原正五聚蛋白3 肝素结合蛋白老年重症肺炎呼吸衰竭预后

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The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum

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Food Production, Processing and Nutrition 2021年第1期3卷 326-334页

作者： Xin Liu Xin Fang Shuang Wang Deliang Wu Tao Gao Yin-Won Lee Sherif Ramzy Mohamed Fang Ji jianhong Xu Jianrong shi Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and QualityMinistry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation(Nanjing)Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and NutritionJiangsu Academy of Agricultural SciencesNanjing 210014JiangsuChina School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina School of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Department of Food Toxicology and Contaminant National Research Centre of EgyptGiza 12411Egypt

Production of the Fusarium toxin deoxynivalenol(DON)is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium *** this study,we found that the antioxidant methyl gallate(MG)displays inhibitory effects against mycelial growth,conidial formation and germination,and DON biosynthesis in *** in a dose-dependent *** with 0.05%(w/v)MG resulted in an abnormal swollen conidial *** expression of the TRI genes involved in DON biosynthesis was significantly reduced,and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated ***-Seq analysis of MG-treated *** showed that 0.5%(w/v)MG inhibited DON production by possibly altering membrane functions and oxidoreductase *** with the observations that MG treatment decreases catalase,POD and SOD activity in *** results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative *** together,the current study revealed the potential of MG in inhibiting mycotoxins in ***.

关键词： Fusarium graminearum Antioxidant methyl gallate Deoxynivalenol production Mechanism of action

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江苏省某地级市社会办医现状分析与对策研究

江苏卫生事业管理 2021年第4期32卷 414-418页

作者：周珏何涛施建红倪登峰南通市第一人民医院行政办公室南通市第一人民医院医患沟通办公室江苏南通226001

目的:分析江苏省某地级市社会办医的现状,探讨该市社会办医发展趋势。方法:依据该地级市卫健委发布的有关统计数据,从社会办医机构数、床位数、职工人数、诊疗人次、出院人数、床位使用率、床位周转率等方面进行分析和探讨。结果:截止至... 详细信息

目的:分析江苏省某地级市社会办医的现状,探讨该市社会办医发展趋势。方法:依据该地级市卫健委发布的有关统计数据,从社会办医机构数、床位数、职工人数、诊疗人次、出院人数、床位使用率、床位周转率等方面进行分析和探讨。结果:截止至2018年底,该地级市社会办医疗机构1 739家,占全市医疗机构的46.05%,实有床位占比31.99%,在岗职工占比29.96%,工作量虽逐年上升,但明显低于公办医疗机构,床位使用率及周转率较低,平均住院日呈上升趋势。结论:该市近几年社会办医发展势头良好,可通过精进拓宽特色服务、健全优化人才机制、保障完善政策落实,破解社会办医能力瓶颈、人力瓶颈、政策瓶颈,加快社会办医向好发展步伐,助力区域卫生健康事业平衡持续发展。

关键词：社会办医医疗机构研究对策

基于器官系统的专业学位硕士研究生规范化培训案例设计与编写实践

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中华医学教育探索杂志 2024年第7期23卷 1004-1008页

作者：周庆季秋虹沈剑虹唐东吉云兰陆玉华施炜南通大学附属医院教育培训处南通226001 南通大学附属医院神经内科南通226001 南通大学附属医院神经外科南通226001 南通大学附属医院院长室南通226001

本研究结合基于器官系统的规范化培训案例教学改革,成立包括基础医学、临床医学、人文医学等教学专家一体化的教学案例编写团队,通过集体备课研讨,采用非虚构综合情境编写手法,以器官系统为基础,胜任力培养为导向,结合分层递进培养模式... 详细信息

本研究结合基于器官系统的规范化培训案例教学改革,成立包括基础医学、临床医学、人文医学等教学专家一体化的教学案例编写团队,通过集体备课研讨,采用非虚构综合情境编写手法,以器官系统为基础,胜任力培养为导向,结合分层递进培养模式,编写真实案例基础上的研究生教学案例,为通过基于器官系统的案例教学,分层递进地培养和提升研究生胜任力培养质量奠定良好基础。

关键词：器官系统案例专业学位研究生规范化培训

Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development

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National Science Review 2019年第3期6卷 480-493页

作者： Lei shi Xin Luo Jin Jiang Yongchang Chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi shi Martin Styner jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Primate Research Center Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translation Medicine Kunming University of Science and Technology Department of Psychiatry University of North CarolinaChapel Hill Department of Computer Science University of North CarolinaChapel Hill Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of Sciences Department of Medical Imaging the First Affiliated Hospital of Kunming Medical University Department of Minimally Invasive Neurosurgery the First Affiliated Hospital of Kunming Medical University

Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation, resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys, similar to the known evolutionary change of developmental delay(neoteny) in humans. Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes, providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys. More importantly, the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task. The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits.

关键词： human evolution brain development MCPH1 transgenic monkey neoteny cognition

Risk factors for anastomotic leakage after gastrectomy for Siewert type Ⅱ/Ⅲ adenocarcinoma of the esophagogastric junction:a retrospective case-control study

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Journal of Bio-X Research 2021年第2期4卷 71-76页

作者： Yibo Li Yinan shi Jun You Wenqing Hu Yingying Xu Haotang Wei Masanobu Abe Jiajia Cheng Liang Zong jianhong Dong Department of Gastrointestinal Surgery Shanxi Cancer HospitalShanxi Medical UniversityTaiyuan Department of Gastrointestinal Surgery The First Affiliated Hospital of Xiamen UniversityXiamenFujian Province Department of Gastrointestinal Surgery Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhiShanxi Province Department of General Surgery Yizhen People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhouJiangsu Province Department of Gastrointestinal Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina Division for Health Service Promotion University of Tokyo HospitalTokyoJapan Department of Central Lab Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhiShanxi ProvinceChina

Objective:To identify risk factors for anastomotic leakage after gastrectomy in patients with Siewert type II/III adenocarcinoma(AEG)of the esophagogastric ***:This was a retrospective case-control study of 903 patients with Siewert type II/III AEG treated from January 2012 to January 2015 at the Shanxi Cancer Hospital in *** patients underwent gastrectomy,and their clinical characteristics were analyzed to identify associations with anastomotic *** risk factors were identified by binary logistic *** 2-year disease-free survival was calculated and compared between patients with anastomotic leakage and control *** study was approved by the Institutional Review Board of Shanxi Medical University(approval No.2014-09-39)on September 19,***:Out of the 903 patients were included in the study,80(8.86%,80/903)experienced anastomotic *** mortality rate attributed to anastomotic leakage was 8.75%(7/80).Logistic regression analysis revealed that preoperative hypoalbuminemia(odds ratio(OR)=3.249,95%confidence interval(CI):1.569-6.725,P=0.002),type of reconstruction(OR=1.795,95%CI:1.026-3.142,P=0.040),and combined organ resection(OR=1.807,95%CI:1.069-3.055,P=0.027)were independent risk factors for anastomotic ***:Preoperative hypoalbuminemia,type of reconstruction,and combined organ resection were identified as risk factors for anastomotic leakage in patients undergoing gastrectomy for Siewert type Ⅱ/Ⅲ AEG.

关键词： adenocarcinoma of the esophagogastric junction anastomotic leakage gastrectomy logistic regression analysis Siewert typeⅡ/Ⅲ