Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis:a 2-year follow-up study

作     者：Jiangyi Zhu Yongquan Shi Xinmin Zhou Zengshan Li Xiaofeng Huang Zheyi Han Jianhong Wang Ruian Wang Jie Ding Kaichun Wu Ying Han Daiming Fan 

作者机构：State Key Laboratory of Cancer BiologyInstitute of Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi’an 710032China Department of PathologyXijing HospitalFourth Military Medical UniversityXi’an 710032China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2013年第7卷第2期

页      面：255-263页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81070326,30971339) Science&Technology Innovation Project of Shaanxi(Grant No.2011KTCL03-09) 

主　　题：primary biliary cirrhosis ursodeoxycholic acid Chinese biochemical response therapeutic efficacy 

摘      要：The efficacy of ursodeoxycholic acid(UDCA)on long-term outcome of primary biliary cirrhosis(PBC)has been less documented in Chinese *** aimed to assess the therapeutic effect of UDCA on Chinese patients with *** the present study,67 patients with PBC were treated with UDCA(13–15 mg∙kg^(-1)∙day^(-1))and followed up for 2 years to evaluate the changes of symptoms,laboratory values and histological *** the results indicated,fatigue and pruritus were obviously improved by UDCA,particularly in patients with mild or moderate *** alkaline phosphatase andγ-glutamyl transpetidase levels significantly declined at year 2 comparing to baseline values,with the most profound effects achieved in patients at stage *** levels of alanine aminotransferase and aspartate aminotransferase significantly decreased whereas serum bilirubin and immunoglobulin M levels exhibited no significant *** feature was stable in patients at stages 1–2 but still progressed in patients at stages 3–*** biochemical response of patients at stage 2 was much better than that of patients at stages 3–*** data suggest that,when treated in earlier stage,patients in long-term administration of UDCA can gain favorable results not only on symptoms and biochemical responses but also on *** is also indicated that later histological stage,bad biochemical response and severe symptom may be indicators of poor prognosis for UDCA therapy.