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Immobilization of urease in metal–organic frameworks via biomimetic mineralization and its application in urea degradation

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2173-2180页

作者： Xiao Liang Qing Li zhiyuan shi Shaowei Bai Quanshun Li Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

Enzyme immobilization has been accepted as an efficient technique for improving the stability and recyclability of ***,biomimetic mineralization strategy was employed to achieve the immobilization of urease in a type of metal–organic frameworks(zeolite imidazolate framework-8,ZIF-8),and the immobilized enzyme urease@ZIF-8 was systematically evaluated for its structure,activity,stability and recyclability,using the hydrolysis of urea as a *** entrapment of urease was found to be realized in a synchronous manner with the formation of ZIF-8 *** loading of urease in ZIF-8 was measured to be ca.10.6%through the bicinchoninic acid(BCA)protein *** encapsulated urease could efficiently maintain its native conformation,which endowed the immobilized urease with excellent activity and stability,even in harsh conditions(e.g.,in the presence of trypsin,acidic or alkali conditions,or at high temperature).Further,urease@ZIF-8 exhibited good recyclability during the degradation of urea,in which it could keep 58.86%of initial activity after being used for 5 ***,biomimetic mineralization could be potentially utilized as a promising method to prepare immobilized ureases with superior activity,stability and recyclability,thereby facilitating the construction of efficient catalysts for industrial biocatalysis and biosensing.

关键词： Urease Metal–organic frameworks Immobilization Biomimetic mineralization Stability Recyclability

Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Nano Research 2019年第12期12卷 3037-3043页

作者： Nian Liu Yiyue shi Jingru Guo Hai Li Qiang Wang Menglin Song zhiyuan shi Le He Xinhui Su Jin Xie Xiaolian Sun State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 210009China Institute of Biological and Medical Imaging Helmholtz Zentrum Miinchen and Technische Universitat MiinchenNeuherberg 85764Germany State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Nuclear Medicine Zhongshan Hospital Xiamen UniversityXiamen 361004China Department of Chemistry Bio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia 30602USA

Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical *** 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I *** 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in *** to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h ***,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 *** radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for *** with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in *** more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.

关键词： radioiodination tyrosine based carbon dots single photon emissionrenal clearance

The Mechanochemical Release of Naphthalimide Fluorophores fromβ-Carbonate andβ-Carbamate Disulfide-Centered Polymers

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CCS Chemistry 2021年第11期3卷 2333-2344页

作者： zhiyuan shi Qingchuan Song Robert Göstl Andreas Herrmann DWI—Leibniz Institute for Interactive Materials Aachen 52056 Institute of Technical and Macromolecular Chemistry RWTH Aachen UniversityAachen 52074 Department I of Internal Medicine University Hospital of CologneCologne 50937 Zernike Institute for Advanced Materials University of Groningen9747 AG Groningen

The covalent attachment of cargo molecules(e.g.,drugs and fluorophores)inβ-position to a disulfide moiety through carbamate and carbonate bonds finds many applications in responsive release ***,we showed that the combination of this release process with polymer mechanochemistry-induced disulfide scission enabled the remote-controlled release of small molecule drugs and fluorophores from their inactive parent macromolecules using *** nature of the linker bond largely governed the subsequent release kinetics,an aspect that has not been investigated so *** compare the differences,we here employ disulfide-centered polymers releasing either hydroxyl-or amino-naphthalimides from their respectiveβ-carbonate or-carbamate linkers by forceinduced intramolecular 5-exo-trig *** present the synthesis,characterization,and cell imaging evaluation of three naphthalimides featuring colorimetric and green fluorescence turn-on upon release,allowing monitoring of the release *** believe that the insights gained from these experiments would advance the tailoring of release rates for force-induced pharmacotherapy.

关键词： mechanochemistry polymers drug delivery bioimaging sonopharmacology

NUMERICAL SIMULATION ON DEFORMATION CHARACTERISTICS OF AS WIRE BY CASTEX

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Chinese Journal of Mechanical Engineering 2001年第1期14卷 5-8,17页

作者： shi zhiyuan Wang Wanjun Wang Xinhua Metallurgical Engineering School,Beijing University of Science and Technology Wen Jinglin Northeastern University 北京科技大学冶金学院北京东北大学辽宁

Castex(continuous cast and extrusion)is a latest metallurgical technology Making of AS wire(aluminum clad steel wire) by Castex is an advanced bonding technology of bimetal In order to study the deformation character of AS wire the numerical simulation is performed with FE method From the simulation result the following conclusions are obtained:① The simulation is carried out sequentially in three zones:initial extrusion,cavity filling and bonding ② In the first zone the shearing deformation governs the whole zone,while in that of cavity filling, the deformation mainly concentrates on transition arc of the concave mould In addition, in the last zone, the dominant deformation lies at the boundary of concave mould, surface of steel wire and entry of sizing band Due to the movement of steel wire, the direction of shear stress on its surface is opposite to that on the boundary of concave die

关键词： Castex AS wire FE method Elasto plastic Deformation characteristic

Experiment Study on Castex Process of AS Wire

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Journal of University of Science and Technology Beijing 2001年第1期8卷 22-24页

作者： zhiyuan shi Wanjun Wang Jinglin Wen Xinhua Wang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China School of Materials and Metallurgy,Northeastern University, Shenyang 110006, China Univ Sci & Technol Beijing Met Sch Beijing 100083 Peoples R China Northeastern Univ Sch Met & Mat Shenyang 110006 Peoples R China

In order to optimize the Castex process of AS wire, the systematic experiments have been done for different process parameters with self-made DZJ-II 350 Castex machine. The parameters, such as casting temperature of aluminum, flow of cooling water, extrusion ratio and the gap between the surface of wheel and that of the mould, have been mainly studied. The results show that with the increase of casting temperature or rotating speed of wheel the measured length of liquid metal zone increases too. However, the length of liquid metal zone decreases with the increase of the flow of cooling water. Moreover, the relationship between the extrusion ratio and the extrusion power is studied.

关键词： Castex AS wire parameter length of liquid metal zone

民法典时代国有自然资源使用权的体系设计与规则完善

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法学论坛 2022年第6期37卷 136-147页

作者：施志源福建师范大学法学院福建福州350117

自然资源作为特殊的“物”,与民法存在着天然的密切的关联性。当前,应在《民法典》确定的自然资源权利制度框架下,处理好民法典与自然资源单行法的分工与衔接,进一步整合各个自然资源单行法的零散规定,科学设计自然资源使用权的体系。... 详细信息

自然资源作为特殊的“物”,与民法存在着天然的密切的关联性。当前,应在《民法典》确定的自然资源权利制度框架下,处理好民法典与自然资源单行法的分工与衔接,进一步整合各个自然资源单行法的零散规定,科学设计自然资源使用权的体系。就具体规则的立法完善而言,应当规范表达自然资源开发利用权利术语,并完善自然资源使用权的权利义务规则、权利存续期限规则和权利继承规则。

关键词：民法典自然资源使用权体系设计

自然资源领域生态综合执法的改革路径及其制度完善

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中国特色社会主义研究 2020年第3期 88-96页

作者：施志源福建师范大学法学院

深化自然资源领域的生态综合执法改革是不断推进生态文明法治建设的内在要求。尽管各地已经探索出了"污染防治+资源保护+生态保护""污染防治+生态保护""污染防治+陆地生态保护"等改革模式,但仍然存在执法职权范围的边界界定不清、综合... 详细信息

深化自然资源领域的生态综合执法改革是不断推进生态文明法治建设的内在要求。尽管各地已经探索出了"污染防治+资源保护+生态保护""污染防治+生态保护""污染防治+陆地生态保护"等改革模式,但仍然存在执法职权范围的边界界定不清、综合执法与专业执法的分合把握不准、执法信息共享机制不畅、陆海生态执法的统筹推进不力等诸多现实难题。完善自然资源领域的生态综合执法制度需要进一步厘清执法权责边界、规范组建执法队伍、形成各部门协同推进自然资源领域执法改革的格局,并加强自然资源领域生态综合执法的陆海统筹与立法保障。

关键词：自然资源生态综合执法协同推进陆海统筹

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自然资源资产有偿使用的改革难点与规则完善

中国特色社会主义研究 2019年第2期 86-91页

作者：施志源福建师范大学法学院

全民所有自然资源资产有偿使用制度改革面临着改革如何避免"一刀切"、如何计算自然资源的资产价值、如何确定有偿使用的范围以及如何发挥政府与市场各自作用等难题。为顺利推进改革,在实践层面应当有效落实"资源有价、使用有偿"的准则和... 详细信息

全民所有自然资源资产有偿使用制度改革面临着改革如何避免"一刀切"、如何计算自然资源的资产价值、如何确定有偿使用的范围以及如何发挥政府与市场各自作用等难题。为顺利推进改革,在实践层面应当有效落实"资源有价、使用有偿"的准则和"资源有限、使用有序"的准则;在制度保障层面应当加大自然资源资产有偿使用的立法力度,完善与自然资源资产有偿使用相关的政府管制规则、市场化规则、高效利用规则和绿色使用规则。

关键词：全民所有自然资源资产有偿使用权利行使规则完善制度改革

Phase calibration for integrated optical phased arrays using artificial neural network with resolved phase ambiguity

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Photonics Research 2022年第2期10卷 347-356页

作者： Lemeng Leng Zhaobang Zeng Guihan Wu Zhongzhi Lin Xiang Ji zhiyuan shi Wei Jiang College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China Key Laboratory of Intelligent Optical Sensing and Manipulation Ministry of EducationNanjing UniversityNanjing 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing UniversityNanjing 210093China National Laboratory of Solid-State Microstructures Nanjing 210093China

Phase calibration for optical phased arrays(OPAs) is a key process to compensate for the phase deviation and retrieve the initial working state. Conventional calibration approaches based on iterative optimization algorithms are tedious and time-consuming. The essential difficulty of such a problem is to inversely solve for the phase error distribution among OPA elements from the far-field pattern of an OPA. Deep-learning-based technology might offer an alternative approach without explicitly knowing the inverse solution. However, we find that the phase ambiguities, including conjugate ambiguity and periodic ambiguity, severely deter the accuracy and efficacy of deep-learning-based calibration. Device-physics-based analysis reveals the causes of the phase ambiguities, which can be resolved by creating a tailored artificial neural network with phase-masked far-field patterns in a conjugate pair and constructing a periodic continuity-preserving loss function. Through the ambiguity-resolved neural network, we can extract phase error distribution in an OPA and calibrate the device in a rapid, noniterative manner from the measured far-field patterns. The proposed approach is experimentally verified. Pure main-beam profiles with >12 dB sidelobe suppression ratios are observed. This approach can help overcome a crucial bottleneck for the further advance of OPAs in a variety of applications such as lidar.

关键词： resolved conjugate inverse