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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong lily Song William Wagstaff Rex C.Haydon Hue H.luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He lewis l.shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and lRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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大质量弹丸高速侵彻混凝土质量侵蚀试验研究

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振动与冲击 2024年第12期43卷 148-155页

作者：董凯江坤王浩王健姜春雷史律南京理工大学能源与动力工程学院南京210094

动能弹在高速侵彻混凝土目标时产生的质量侵蚀是引起侵彻效率降低的重要原因,该文开展了质量约为20 kg、直径为100 mm的高硬度弹丸以近1.0 km/s的速度侵彻C40混凝土的试验研究,对弹丸侵蚀参数和头部卵型段的变化进行了详细的描述,并对... 详细信息

动能弹在高速侵彻混凝土目标时产生的质量侵蚀是引起侵彻效率降低的重要原因,该文开展了质量约为20 kg、直径为100 mm的高硬度弹丸以近1.0 km/s的速度侵彻C40混凝土的试验研究,对弹丸侵蚀参数和头部卵型段的变化进行了详细的描述,并对大质量弹丸的侵蚀机理进行了分析,通过计算得到了热熔侵蚀和切削侵蚀的占比。结果表明:在侵彻过程中,当不同质量弹丸以相同的初速撞击同等强度混凝土时,弹丸表面压力受弹丸质量影响,当高于某临界速度时,随着弹丸质量的增加而增大;弹丸侵彻混凝土时的质量侵蚀与弹丸质量有关,弹丸质量较小时侵蚀现象更明显。切削侵蚀占比随弹丸硬度提高而降低,提高弹丸材料硬度对降低大质量弹丸的质量侵蚀效果更加明显。

关键词：高速侵彻质量侵蚀热熔侵蚀切削侵蚀硬度

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Hua's Theorem on Five Almost Equal Prime Squares

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Acta Mathematica Sinica,English Series 2006年第3期22卷 907-916页

作者： Guang shi l Department of Mathematics Shandong University

In this paper we sharpen Hua＇s result by proving that each sufficiently large integer N congruent to 5 modulo 24 can be written as N=p1^2＋p2^2＋p3^2＋p4^2＋p5^2,with │pj-√N/5│≤U=N^1/2-1/28＋ε,where pj are primes.

关键词： Additive theory of prime numbers Circle method iterative method

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考虑残余应力影响的桥式起重机多轴疲劳寿命评估

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科学技术与工程 2024年第25期24卷 10768-10775页

作者：张广辉孙淼吕世宁李仕华高有山太原科技大学机械工程学院太原030024 太原重工股份有限公司制造部太原030024

桥式起重机桥架结构是典型的焊接结构,在日常服役时主梁焊缝区域经常出现疲劳裂纹。为保证起重机的服役安全,基于多尺度有限元分析方法建立危险裂纹区域的多级子模型;在二级子模型上建立热-结构耦合焊接有限元模型并模拟分析了焊接的全... 详细信息

桥式起重机桥架结构是典型的焊接结构,在日常服役时主梁焊缝区域经常出现疲劳裂纹。为保证起重机的服役安全,基于多尺度有限元分析方法建立危险裂纹区域的多级子模型;在二级子模型上建立热-结构耦合焊接有限元模型并模拟分析了焊接的全过程,通过模拟焊后热处理分析对残余应力的影响;结合多轴临界面法构建了以应变幅值作为多轴损伤参量的疲劳分析方法,评估了危险裂纹区域的疲劳性能。结果表明:所提方法将结构整体疲劳问题转化成局部焊接位置的疲劳问题,不仅增加了计算效率,还能考虑疲劳细节处更多的影响因素,为起重机焊缝部位的疲劳寿命评估和延寿提供了一定的参考。

关键词：疲劳裂纹多级子模型焊后热处理残余应力多轴临界面法

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Monotone Chains in Modulus of Two Classes of Dirichlet Coefficients

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Acta Mathematica Sinica,English Series 2023年第6期39卷 1101-1114页

作者： Guang shi lü Qiang MA School of Mathematics Shandong UniversityJi'nan 250100P.R.China

let f1,...,fkand g1,...,qkbe non-CM newforms of square-free *** byλ_(sym)jf_(i)(n)the coefficients of the Dirichlet expansion of l(sym^(j)f_(i),s)andν1,...,νkthe distinct positive integers such thatλ_(sym)jf_(i)(νi)≠*** this paper,we obtain that there exist infinitely many positive integers m such that 0let expansion of l(sym^(j1)f×sym^(j2)g,s),we have a similar result.

关键词： Dirichlet coefficients Sato-Tate conjecture

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A vacuum nano-casting route to magnetite cores/mesoporous silica shell composites

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Nano-Micro letters 2009年第1期1卷 27-29页

作者： l.M.Guo J.l.shi State Key laboratory of High Performance and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Science

Hollow mesoporous silica spheres with magnetite cores(HMSMC) have been fabricated by Vacuum Nano-casting Route. The amount of magnetite cores and saturation magnetization value can be easily adjusted by changing the concentration of iron nitrate solution used in the synthesis procedure. Furthermore, the as-prepared HMSMCs still maintain narrow mesopore distribution, high surface area and large pore volume after the hollow cores of hollow mesoporous silica spheres were filled with magnetite particles. Specially, when the saturation magnetization value of as-prepared HMSMCs reaches 22.0 emu/g, the surface area and pore volume of corresponding HMSMCs are 149 m^2/g and 0.19 cm^3/g, respectively, and the pore size is 2.30 nm. The corresponding samples are characterized by X-ray diffraction, N_2 sorption isotherms, transmission electron microscopy and vibrating-sample magnetometer.

关键词： Hollow mesoporous silica spheres Magnetite cores Vacuum nano-casting

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A NEW METHOD TO DETERMINE THE R-CURVE OF CERAMICS-FRACTURE GRATING METHOD

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Acta Mechanica Solida Sinica 1996年第1期9卷 81-87页

作者： shi, l Dai, Fl Jiang, Xl TSING HUA UNIV DEPT ENGN MECHBEIJING 100084PEOPLES R CHINA

The etching technique of the single-lined zero-thickness specimen grating is applied to the surface of the SiC fiber toughening Si3N4 ceramic composite specimen. The position of the crack and the crack length during the process of crack extension when the load is applied and gradually increased can be determined by recording the output voltage value of the Wheatstone bridge in which the ceramic specimen with the fracture grating on is located. The crack-growth-resistance(R-curve) of this material is thus obtained.

关键词： fiber toughening ceramic composite zero thickness specimen grating etching crack extension R-curve

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Microstructure and properties of pure iron/copper composite cladding layers on carbon steel

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International Journal of Minerals,Metallurgy and Materials 2016年第8期23卷 920-927页

作者： long Wan Yong-xian Huang shi-xiong lü Ti-fang Huang Zong-liang lü State Key laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin World Wide Welding Co. Ltd.

In the present study, pure iron/copper composite metal cladding was deposited onto carbon steel by tungsten inert gas welding. The study focused on interfacial morphological, microstructural, and mechanical analyses of the composite cladding layers. Iron liquid–solid-phase zones were formed at copper/steel and iron interfaces because of the melting of the steel substrate and iron. Iron concentrated in the copper cladding layer was observed to exhibit belt, globule, and dendrite morphologies. The appearance of iron-rich globules indicated the occurrence of liquid phase separation（lPS） prior to solidification, and iron-rich dendrites crystallized without the occurrence of lPS. The maximum microhardness of the iron/steel interface was lower than that of the copper/steel interface because of the diffusion of elemental carbon. All samples fractured in the cladding layers. Because of a relatively lower strength of the copper layer, a short plateau region appeared when shear movement was from copper to iron.

关键词： tungsten inert gas welding metal cladding pure iron copper carbon steel interfacial properties

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半开式离心叶轮叶顶泄漏诱发流道流动堵塞特性研究

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中国农村水利水电 2024年第1期 79-85,93页

作者：朱俊桦金永鑫吕世杰成涛宋文武西华大学能源与动力工程学院四川成都610039 西华大学流体及动力机械教育部重点实验室四川成都610039

为探究半开式离心叶轮叶顶泄漏量诱发的流道中流动堵塞作用,采用大涡模拟对流场进行精确计算,基于流动堵塞预估模型对叶顶间隙0.5、1.0和1.5 mm的3种半开式离心叶轮在不同流量工况下的流动堵塞特性进行研究,发现在叶轮流道内存在流动堵... 详细信息

为探究半开式离心叶轮叶顶泄漏量诱发的流道中流动堵塞作用,采用大涡模拟对流场进行精确计算,基于流动堵塞预估模型对叶顶间隙0.5、1.0和1.5 mm的3种半开式离心叶轮在不同流量工况下的流动堵塞特性进行研究,发现在叶轮流道内存在流动堵塞峰值,且在3种叶顶间隙下均在截面2处,在经过截面2之后流动堵塞发生大幅度的减小,并在后面4个截面发生小幅度的波动;通过对不同叶顶间隙、不同流量工况下在叶轮尾缘处相对流动堵塞作用的分析,发现尾缘处的流动堵塞在不同叶顶间隙下,随流量的变化具有相同的趋势,相对流动堵塞均在1.0Q_(d)时达到最小值,在0.6Q_(d)时出现峰值;然而流动堵塞在相同流量下与叶顶间隙的关系不是单一的线性关系,且存在一个最优叶顶间隙在设计工况点达到最小的流动堵塞情况;同时通过对泄漏涡发展情况的观察,发现泄漏涡的破碎和位移会增大叶片尾缘处的流动堵塞;通过对叶片静压差的分析,发现运行流量对叶片载荷的影响不大,然而叶顶间隙的改变会大大影响叶片载荷,同时对叶片尾缘处的流动堵塞造成影响。

关键词：半开式离心叶轮大涡模拟流动堵塞预估模型叶顶间隙叶片载荷泄漏涡

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A STUDY OF DIRECTIONAlITY OF lATENT HARDENING BEHAVIOR IN AlUMINIUM SINGlE CRYSTAlS

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Acta Mechanica Solida Sinica 1996年第3期9卷 246-252页

作者： Wang, MZ shi, l li, CH Xiao, JM UNIV SCI & TECHNOl BEIJING DEPT MAT PHYSBEIJING 100083PEOPLES R CHINA

By defining the yield stress in a latent hardening test as the first deviation from the elastic straight line, the yielding and hardening behavior on a latent system in the positive and negative slip direction was studied in aluminium single crystals. It is shown that the yield stresses on both the positive and negative latent systems are about equal to or a little lower than the maximum resolved shear stress in the primary test, but much higher than that of the active system. The Influence of relative orientation and prestrain on latent hardening and initial work-hardening in the secondary test was also investigated, and it was found that there is a considerable effect on initial work-hardening, but none on latent hardening. With reasonable approximation, a hardening rule for single crystal could be proposed from the experimental results, that is, except for the yield stress on the system negative to the active system that is very low, hardening on the other systems is nearly the same as self-hardening.

关键词： latent hardening work-hardening Bauschinger effect aluminium single crystal plastic deformation

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