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Corrigendum to “Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)” [Genes & Diseases 4 (2017) 229–239]

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Genes & Diseases 2023年第2期10卷 624-626页

作者： Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L. Shi Leonardo Oliveira Jennifer Moriatis Wolf sherwin Ho Aravind Athiviraham H.M. Tsai Tong-Chuan He Wei Huang Department of Orthopedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of radiology The University of ChicagoChicagoIL 60637USA

The authors regret having image assembly errors in Figure 1A and Figure ***,in Figure 1A,the images for"C3H10T1/2",""BMP2"and"Sox9"were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same *** Figure 3A,the images for"Col2a1"and"β-actin"were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time.

关键词： Smad7 Figure BMP2

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湍流的hp型谱元隐式大涡模拟

湍流的hp型谱元隐式大涡模拟

Aokang Anti-dumping Win ＂Positive Precedent＂

第十一届全国流体力学学术会议

作者：徐辉 Pierre Sagaut Spencer J.sherwin 上海交通大学航空航天学院 Department of Aeronautics Imperial College London Aix-Marseille Université CNRSCentrale Marseille

基于高精度hp型谱元法,实施典型壁湍流问题隐式大涡模拟,隐式大涡模型基于正则化谱粘性消去法构建。针对壁湍流的流动特性,讨论了平均流动、雷诺应力、流动的各向异性特征及能谱。与典型的实验及数值模拟的基准结果相比较而言,上述物理... 详细信息

基于高精度hp型谱元法,实施典型壁湍流问题隐式大涡模拟,隐式大涡模型基于正则化谱粘性消去法构建。针对壁湍流的流动特性,讨论了平均流动、雷诺应力、流动的各向异性特征及能谱。与典型的实验及数值模拟的基准结果相比较而言,上述物理量与基准解具有良好的吻合。结果表明,基于正则化的谱粘性消去法所构建的物理模型无关的隐式大涡模型能够取得与经典模型相一致的结果,能够对具有大尺度分离的壁湍流问题实施良好的模拟。

关键词：壁湍流 hp型谱元法隐式大涡模拟

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China's Foreign Trade 2012年第12期 90-90页

作者： sherwin Liu

By winning a lawsuit on November 18 against the European Union＇s anti-dumping duties after a six-year battle,Chinese shoemaking giant Aokang Group Co., Ltd has encouraged more domestic manufacturers to challenge such... 详细信息

关键词：反倾销税奥康提起诉讼中国

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可压缩性及分离泡拓扑形状对转捩的影响

可压缩性及分离泡拓扑形状对转捩的影响

Time spent outdoors and myopia:establishing an evidence base

第十一届全国流体力学学术会议

作者：徐辉 Shahid Mughal Spencer J.sherwin 上海交通大学航空航天学院 Department of Aeronautics Imperial College London Department of Mathematics Imperial College London

本文研究了可压缩性对T-S波诱导层流-湍流转捩的影响作用,同时探讨了壁面缺陷诱导分离泡拓扑形状对流动稳定性及转捩的影响机制。文中考虑了两类壁面缺陷(凹陷和凸包)及两类缺陷诱导分离涡的拓扑特征。基于全局稳定性分析,研究了两类缺... 详细信息

本文研究了可压缩性对T-S波诱导层流-湍流转捩的影响作用,同时探讨了壁面缺陷诱导分离泡拓扑形状对流动稳定性及转捩的影响机制。文中考虑了两类壁面缺陷(凹陷和凸包)及两类缺陷诱导分离涡的拓扑特征。基于全局稳定性分析,研究了两类缺陷诱导分离涡对转捩的影响机制。研究表明,w针对可压缩性及分离泡对转捩影响作用的研究对流动控制具有一定的意义。

关键词：可压缩性分离泡转捩

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Eye Science 2015年第4期30卷 143-146页

作者： Enis D.Kocak Justin C.sherwin The Alfred Hospital royal Victorian Eye and Ear Hospital Lions Eye Institute University of Western AustraliaCentre for Ophthalmology and Visual Science

Myopia is a highly prevalent refractive error in Asia(1).Although mild myopia does not have serious ocular ramifications,pathological myopia is associated with the development of various ocular pathologies that can lead to irreversible visual loss or blindness(2).The prevalence of visual impairment attributable to pathologic myopia is 0.2-1.4% in Asian populations(3).Over the past few generations,the prevalence of myopia has increased significantly(4).In urbanized areas of East

关键词：近视眼基础证据户外时间视力障碍折射误差眼部疾病

The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine

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Genes & Diseases 2019年第3期6卷 201-223页

作者： Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He russell r·reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA rosalind Franklin University Chicago Medical SchoolNorth ChicagoIL 60064USA SIr Program Illinois Math and Science Academy(IMSA)AuroraIL 60506USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL60208USA The Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL60616USA

Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological *** roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ *** of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP *** it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other *** effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of ***,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and *** review aims to summarize our current understanding of BMP9 across biology and the body.

关键词： Adipogenesis Bone morphogenetic proteins(BMPs) BMP9/GDF2 Mesenchymal stem cells(MSCs) Metabolism Osteogenesis regenerative medicine Tumorigenesis

LPKp-人胰岛素基因逆转录病毒载体的构建与鉴定

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军医进修学院学报 2009年第4期30卷 537-539页

作者：王雪岷 ripps ME Krause DS sherwin rS 解放军总医院内分泌科北京100853 美国耶鲁大学医学院内分泌学系美国耶鲁大学医学院实验室医学系

目的构建肝型丙酮酸激酶启动子(LPKp)与人胰岛素基因(hINSg)逆转录病毒表达载体并鉴定。方法1)母本pMDN-SIN及父本p54质粒扩增、纯化、酶切鉴定;2)取相关片段构建pM54载体并扩增、纯化、鉴定;3)脂质体法转染pM54进入pT67等细胞系,p54等... 详细信息

目的构建肝型丙酮酸激酶启动子(LPKp)与人胰岛素基因(hINSg)逆转录病毒表达载体并鉴定。方法1)母本pMDN-SIN及父本p54质粒扩增、纯化、酶切鉴定;2)取相关片段构建pM54载体并扩增、纯化、鉴定;3)脂质体法转染pM54进入pT67等细胞系,p54等质粒做对照基因;4)用转染后细胞上清液感染3T3细胞;5)ELISA法检测转染、感染后上清液INS含量鉴定质粒。结果酶切鉴定质粒大小与预期相符;ELISA法检测转染、感染上清液中均含较高水平INS。对照结果均阴性。结论LPKp-hINSg逆转录病毒表达载体pM54构建成功。实验为基因治疗或基因结合干细胞治疗糖尿病的进一步相关研究奠定了基础。

关键词：启动子胰岛素逆转录病毒载体

Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering

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Genes & Diseases 2015年第4期2卷 307-327页

作者： Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed rex C.Haydon Hue H.Luu richard Kang Michael J.Lee sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Department of Orthopaedic Surgery and rehabilitation Medicine The University of Chicago Medical CenterChicagoIL 60637USA Department of Orthopaedic Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of Bioengineering Chongqing UniversityChongqingChina

Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular *** surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous ***,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue *** include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling *** and epigenetic regulation of chondrogenesis will also be *** in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering.

关键词： BMPs Cartilage Cell signaling Chondrogenesis FGF regenerative medicine

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