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Open Journal of Ecology 2014年第12期4卷 732-743页

作者： Eman Hashem Radwan sherifa shaker hamed Gaber Ahmed Saad Department of Zoology Faculty of Science Alexandria University Alexandria Egypt Department of Zoology Faculty of Science Damnhour University El Behara Egypt Department of Zoology College of Science King Saud University Saudi Arabia KSA Department of Biology College of Medicine Dammam University Saudi Arabia KSA

The date clam, Lithophaga lithophaga is a popular edible bivalve. It was collected from three different locations (Abo-Quir, Miami and El-Mex) along the coast of Alexandria-Egypt to determine the effect of two heavy metals as copper (Cu) and cadmium (Cd). The three organs were selected: gill, mantle and digestive gland. The enzymatic change is correlated with the concentration of metals. The present results suggest that Miami water is less polluted with Cu and Cd as compared to the two other locations. The physicochemical parameters are not significant among the three locations. Water of Abu-Quir and El-Max may be hazardous to bivalves. The order of levels of Cu and Cd was: gill > digestive gland > mantle. The present study illustrated that, in Abu Quir, there was a high positive correlation between Cd and Succinate dehydrogenase (SDH) as r = 0.969 whereas Cu and SDH as r = -0.91.

关键词： Lithophaga lithophaga Heavy Metals Cu Enzyme Activities

Impact of Selected Environmental Pollutants on the Ultrastructure of the Gills in <i>Pinctada radiata</i>from Coastal Zones, Egypt

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Open Journal of Ecology 2014年第14期4卷 907-917页

作者： sherifa shaker hamed Eman Hashem Radwan Gaber Ahmed Saad Department of Zoology College of Science King Saud University Saudi Arabia KSA Department of Zoology Faculty of Science Alexandria University Alexandria Egypt Department of Zoology Faculty of Science Damnhour University El Behara Egypt Department of Biology College of Medicine Dammam University Saudi Arabia KSA

There has been an increasing interest in marine oysters (order: Petridae) in recent years because their numbers are declining in many parts of the world and also because they are used as monitors of pollution. The present study describes the microscopic structure of gills as viewed by light and electron microscopy in two locations selected in Alexandria coast, Eastern Harbor (E.H.) and El Asafra. The specimens in the E.H. represent the presence of extracellular mineralized granules.

关键词： Gill Bivalve Transmission Electron Microscope Pinctada radiata

Idiopathic steno-occlusive disease with bilateral internal carotid artery occlusion:A Case Report

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World Journal of Clinical Cases 2023年第13期11卷 3076-3085页

作者： sherifa Ahmed hamed Hosam Abozaid Yousef Department of Neurology and Psychiatry Assiut UniversityFaculty of MedicineAssiut 71516AssiutEgypt Department of Radiology Assiut UniversityFaculty of MedicineAssiut 71516AssiutEgypt

BACKGROUND Moyamoya disease(MMD)is a rare cause of acute stroke and transient ischemic attacks in *** described clinical,diagnostic features and follow-ups of a young child with acute *** SUMMARY We report a 4-year-old girl with left hemiparesis after an acute ischemic *** history was also significant for repeated left or right focal motor seizures,generalized tonic-clonic convulsions and transient ischemic *** magnetic resonance imaging and computed tomography(CT)of the brain and magnetic resonance angiography,CT angiography and venography on the cerebral vessels revealed evidence of bilateral fronto-parietal ischemic infarctions,occlusion of the right and left internal carotid arteries started at its bifurcation and non-visualization of right and left anterior and middle cerebral *** was evidence of progression in angiography manifested as development of collaterals from the basal perforating vessels,increase in the extent of large intracranial arterial stenosis/occlusion and extensive collateral circulation with predominance from the posterior *** and neurological evaluation and comprehensive laboratory investigations excluded an obvious comorbid disease or risk factor for the child’s *** diagnosis of MMD was highly suggested as a cause of the child’s steno-occlusive *** was treated symptomatically with levetiracetam,an antiepileptic *** was prescribed for secondary *** clinical manifestations were improved during the three years of *** surgery was *** Up to our knowledge,this is the first report for MMD in a child in our *** clinical improvement and the stabilization of the child’s condition over the 3 years of follow-up could be attributed to the rapid and extensive recruitment of collaterals and absence of risk factors or *** surgery is highly recommended.

关键词： Steno-occlusive disease Moyamoya disease Internal carotid artery Collateral circulation Neovascularization Case report

Peripartum depression and its predictors:A longitudinal observational hospital-based study

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World Journal of Psychiatry 2022年第8期12卷 1061-1075页

作者： sherifa Ahmed hamed Mohamed Elwasify Mohamed Abdelhafez Mohamed Fawzy Department of Neurology and Psychiatry Assiut University HospitalAssiut 71516Egypt Department of Psychiatry Mansoura UniversityMansoura 11001Egypt Department of Obstetrics and Gynecology Mansoura UniversityMansoura 11001Egypt

BACKGROUND Depression is a common problem in women in childbearing years due to burdens of motherhood and building a *** studies estimate the prevalence of antepartum depression compared to those in the postpartum *** To estimate the prevalence and the severities of peripartum depression and major depressive disorder and their *** This is a longitudinal observation *** included 200 women scoring≥13 with the Edinburgh Postpartum Depression Scale,indicating presence of symptoms of *** had a gestational age of≥6 wk and did follow-ups until the 10^(th) week to 12^(th) weeks *** of women's reactions to life circumstances and stressors during the current pregnancy were gathered from answers to questions of the designed unstructured clinical *** of depression,anxiety,and parenting stress were determined by the Beck Depression Inventory,State-Trait Anxiety Inventory for Adults,and Parenting Stress Index-Short Form,*** interviewing was done to confirm the diagnosis of major *** the levels of triiodothronine(T3),thyroxine(T4),and thyroid stimulating hormone(TSH)was done in both antepartum and postpartum *** Out of 968(mean age=27.35±6.42 years),20.66%(n=200)of the patients had clinically significant symptoms of depression and 7.44%had major *** premenstrual dysphoria,post-abortive depression,and depression unrelated to pregnancy and were reported in 43%,8%,and 4.5%of the patients,*** stressors were reported in 15.5%of the *** anxiety and parenting stress were reported in 90.5%and 65%of the patients,*** T3,T4,and TSH levels did not significantly differ from reference *** analysis showed that anxiety trait was a predictor for antepartum(standardized regression coefficients=0.514,t=8.507,P=0.001)and postpartum(standardized regression coefficients=0.573,t=0.04

关键词： Peripartum depression Antepartum depression Postpartum depression Anxiety Edinburgh postpartum depression scale Parenting stress

Evaluation of chronic idiopathic tinnitus and its psychosocial triggers

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World Journal of Clinical Cases 2023年第14期11卷 3211-3223页

作者： sherifa Ahmed hamed Fadia Ahmed Attiah Mohamed Fawzy Mohamed Azzam Department of Neurology and Psychiatry Assiut UniversityFaculty of MedicineAssiut 71516Egypt Department of Otolaryngology Assiut UniversityFaculty of MedicineAssiut 71516Egypt

BACKGROUND The tinnitus susceptibility patterns in relation to different psychological and life stressors are unknown in different *** To determine the comorbid psychosocial factors and behaviors associated with tinnitus and the predictors for the increase in its *** Participants were 230 adults(males=70;females=160;mean age=38.6±3.3).They underwent audiograms,speech discrimination and masking testing,and neuropsychiatric *** used for assessment included tinnitus handicap inventory,depression anxiety stress scale 21(DASS-21),perceived stress scale(PSS),and insomnia severity index(ISI).RESULTS Patients had mean duration of tinnitus of 11.5±2.5 *** had intact hearing perception at 250-8000 Hz and 95(41.3%)had aggravation of tinnitus loudness by masking *** tinnitus was reported in 77%(n=177).The majority had clinically significant insomnia(81.3%),somatic symptoms(75%)other than tinnitus and perceived moderate(46.1%)and high(44.3%)stress to *** severe/extremely severe symptoms of depression,anxiety and stress were reported in 17.4%,35.7%and 44.3%,*** with decompensated type had significantly higher scores for ISI(P=0.001)and DASS-21(depression=0.02,anxiety=0.01,stress=0.001)compared to those with compensated *** interviewing showed that 35.7%had non-specific anxiety disorder,17.4%had major depression,and 19.6%fulfilled the criteria of somatization *** analysis showed that the only independent predictors for tinnitus severity were the duration of tinnitus[odd ratios(OR)=0.832,95%CI:0.640-1.158;P=0.001]and PSS(OR=0.835,95%CI:0.540-1.125;P=0.001)*** To the best of our knowledge,this is the first study in our culture to evaluate the causal relationship between psychological factors and tinnitus onset,severity and *** could be the earliest and dominant somatic symptom induced by life stressors and psychological vulnerabilitie

关键词： Chronic tinnitus Idiopathic Stress Anxiety Insomnia Somatization Psychosocial factors

Cerebrolysin as a nerve growth factor for treatment of acquired peripheral nervous system diseases

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Neural Regeneration Research 2011年第18期6卷 1415-1420页

作者： sherifa Ahmad hamed Department of Neurology and Psychiatry Assiut University Hospital

Cerebrolysin is a drug consisting of low-molecular-weight neurotrophic peptides and free amino acids. Cerebrolysin has been shown to ameliorate the effects of oxidative stress, reduce apoptosis, and promote neuronal growth in several degenerative and acquired central nervous system insults, including dementias, stroke, and traumatic injuries. Little is known about its therapeutic efficacy in peripheral nervous system diseases. In this study, we clinically evaluated the effects of cerebrolysin on peripheral nervous system lesions. We evaluated the clinical efficacy of cerebrolysin in six patients with the following conditions who failed to respond to conventional therapies：（1） atonic bladder due to inflammatory radiculitis; （2） paraplegia due to inflammatory radiculoneuropathy; （3） post-traumatic brachial plexopathy; （4） compressive radial nerve injury; （5） post-traumatic facial nerve paralysis; and （6） diabetic ophthalmoplegia. Our results showed that cerebrolysin was more associated with rapid neurological recovery after various peripheral nerve lesions than other therapies including steroids and supportive therapies such as vitamins and antioxidants. The present results support the therapeutic efficacy of cerebrolysin in the treatment of acquired peripheral nervous system diseases.

关键词： cerebrolysin neurotrophic effect neuroprotection peripheral nervous system

Vestibular function for children with insulin dependent diabetes using cervical vestibular evoked myogenic potentials testing

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World Journal of Clinical Pediatrics 2022年第1期11卷 61-70页

作者： sherifa Ahmed hamed Kotb Abbas Metwalley Hekma Saad Farghaly Amira Mohamed Oseily Department of Neurology and Psychiatry Assiut University HospitalsAssiut 71516Egypt Department of Pediatrics Assiut University HospitalsAssiut 71516Egypt Department of ENT(Auditory Unit) Assiut University HospitalsAssiut 71516Egypt

BACKGROUND Healthy vestibular system adjusts balance during static and dynamic *** is important for normal development(standing up and walking).Vestipulopathies(central and peripheral)are common complications of diabetes in adult *** studies are scare in children with type 1 diabetes(T1D).AIM To assess saccular function of otolith organ in children with T1D and predictors for its *** Cervical vestibular evoked myogenic potential(cVEMP)was used for objective *** The study included 40 patients(boys=15;girls=25).Patients had mean age of 13.63±1.50 years,duration of diabetes of 5.62±2.80 years,frequent attacks of diabetic ketoacidosis(55%)and hypoglycemia(30%),hyperlipidemia(20%),hypertension(12.5%)and peripheral neuropathy(40%).Dizziness was found in 10%.Compared to healthy children(n=25),patients had prolonged cVEMP P1 and N1 latencies and reduced P1-N1 *** cVEMP abnormalities were found in 60%(vs 25%for unilateral abnormalities).Higher frequencies and severe vestibulopathies were found with chronic diabetes of>5 years,hemoglobin A1c values>7%,frequent diabetic ketoacidosis and hypoglycemic attacks and presence of *** analyses showed that predictors for prolonged P1 latencies and reduced P1-N1 amplitudes were only chronic diabetes(>5 years){odds ratio(OR)=2.80[95%confidence interval(CI):1.80–5.33],P=0.01;OR=3.42(95%CI:2.82–6.81)}and its severity(hemoglobin A1c>7%)[OR=3.05(95%CI:2.55–6.82),P=0.01;OR=4.20(95%CI:3.55–8.50),P=0.001].CONCLUSION Dysfunction or injury of the saccular macula and its pathways is prevalent in children with *** glycemic control is important to prevent diabetes related vestipulopathies.

关键词： Children Type 1 diabetes Otilith organ Cervical vestibular evoked myogenic potential

Evaluation of children and adults with post-COVID-19 persistent smell,taste and trigeminal chemosensory disorders:A hospital based study

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World Journal of Clinical Pediatrics 2023年第3期12卷 133-150页

作者： sherifa Ahmed hamed Eman Bahaa Kamal-Eldeen Mohamed Azzam Abdel-Razek Ahmed Department of Neurology and Psychiatry Assiut UniversityFaculty of MedicineAssiut 71516Egypt Department of Pediatrics Assiut UniversityFaculty of MedicineAssiut 71516Egypt Department of ENT Assiut UniversityFaculty of MedicineAssiut 71516Egypt

BACKGROUND Smell disorders are the most frequent persistent coronavirus disease 2019(COVID-19)*** To describe the patterns and characteristics of persistent smell and taste disorders in Egyptian *** Assessment was done to 185 patients(adults=150,age:31.41±8.63 years;children=35;age:15.66±1.63 years).Otolaryngology and neuropsychiatric evaluations were *** included:A clinical questionnaire(for smell and taste);sniffin'odor,taste and flavor identification tests and the Questionnaire of Olfactory Disorders-Negative Statements(sQOD-NS).RESULTS Duration of disorders was 11.53±3.97 ms(6-24 ms).Parosmia(n=119;64.32%)was developed months after anosmia(3.05±1.87 ms).Objective testing showed anosmia in all,ageusia and flavor loss in 20%(n=37)and loss of nasal and oral trigeminal sensations in 18%(n=33)and 20%(n=37),*** had low scoring of sQOD-NS(11.41±3.66).There were no specific differences in other demographics and clinical variables which could distinguish post-COVID-19 smell and taste disorders in children from *** The course of small and taste disorders are supportive of the nasal and oral neuronal ***-COVID-19 taste and trigeminal disorders were less frequent compared to smell ***-COVID-19 flavor disorders were solely dependent on taste and not smell *** were no demographics,clinical variables at onset or specific profile of these disorders in children compared to adults.

关键词： Post-COVID-19 complications Anosmia Ageusia Trigeminal sensory loss Parosmia Quality of life

Topiramate induced peripheral neuropathy:A case report and review of literature

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世界临床病例杂志 2017年第12期5卷 446-452页

作者： sherifa Ahmed hamed Department of Neurology and Psychiatry Assiut University Hospital

Drug-induced peripheral neuropathy had been rarely reported as an adverse effect of some antiepileptic drugs(AEDs) at high cumulative doses or even within the therapeutic drug doses or *** describe clinical and diagnostic features of a patient with peripheral neuropathy as an adverse effect of chronic topiramate(TPM) therapy.A 37-year-old woman was presented for the control of active epilepsy(2010).She was resistant to some AEDs as mono-or combined therapies(carbamazepine,sodium valproate,levetiracetam,oxcarbazepine and lamotrigine).She has the diagnosis of frontal lobe epilepsy with secondary generalization and has a brother,sister and son with active *** became seizure free on TPM(2013-2017) but is complaining of persistent distal lower extremities paresthesia in a stocking *** examination revealed presence of diminished Achilles tendon reflexes,stocking hypesthesia and delayed distal latencies,reduced conduction velocities and amplitudes of action potentials of posterior tibial and sural nerves,indicating demyelinating and axonal peripheral neuropathy of the lower *** exclusion of the possible causes of peripheral neuropathy,chronic TPM therapy is suggested as the most probable cause of patient's *** is the first case report of topiramate induced peripheral neuropathy in the literature.

关键词： Topiramate Peripheral neuropathy Sodium channel blockade Antiepileptic drugs

Outcome of non surgical hepatic decompression procedures in Egyptian patients with Budd-Chiari

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世界胃肠病学杂志：英文版 2011年第7期17卷 906-913页

作者： Ahmed Eldorry Eman Barakat Heba Abdella Sara Abdelhakam Mohamed shaker Amr hamed Mohammad Sakr Department of Radiodi-agnosis and Interventional Radiology Faculty of Medicine AinShams University Department of Tropical Medicine Faculty of Medicine Ain Shams University

AIM: To evaluate outcome of patients with Budd-Chiari syndrome after balloon angioplasty ± stenting or transjugular intrahepatic portosystemic shunt (TIPS). METHODS: Twenty five patients with Budd-Chiari syndrome admitted to Ain Shams University Hospitals, Tropical Medicine Department were included. Twelve patients (48%) with short segment occlusion were candidates for angioplasty; with stenting in ten cases and without stenting in two. Thirteen patients (52%) had Transjugular Intrahepatic Portosystemic Shunt. Patients were followed up for 12-32 mo. RESULTS: Patency rate in patients who underwent angioplasty ± stenting was 83.3% at one year and at end of follow up. The need of revision was 41.6% with one year survival of 100%, dropped to 91.6% at end of follow up. In patients who had Transjugular Intrahepatic Portosystemic Shunt, patency rate was 92.3% at one year, dropped to 84.6% at end of follow up. The need of revision was 38.4% with one year and end of follow up survival of 100%. Patients with patent shunts showed marked improvement compared to those with occluded shunts. CONCLUSION: Morbidity and mortality following angioplasty ± stenting and TIPS are low with satisfactory outcome. Proper patient selection and management of shunt dysfunction are crucial in improvement.

关键词：患者血管成形术肝程序减压埃及手术 TIPS