Topiramate induced peripheral neuropathy:A case report and review of literature

作     者：Sherifa Ahmed Hamed 

作者机构：Department of Neurology and PsychiatryAssiut University Hospital 

出 版 物：《世界临床病例杂志》 (世界临床病例报告杂志(英文版))

年 卷 期：2017年第5卷第12期

页      面：446-452页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：Topiramate Peripheral neuropathy Sodium channel blockade Antiepileptic drugs 

摘      要：Drug-induced peripheral neuropathy had been rarely reported as an adverse effect of some antiepileptic drugs(AEDs) at high cumulative doses or even within the therapeutic drug doses or *** describe clinical and diagnostic features of a patient with peripheral neuropathy as an adverse effect of chronic topiramate(TPM) therapy.A 37-year-old woman was presented for the control of active epilepsy(2010).She was resistant to some AEDs as mono-or combined therapies(carbamazepine,sodium valproate,levetiracetam,oxcarbazepine and lamotrigine).She has the diagnosis of frontal lobe epilepsy with secondary generalization and has a brother,sister and son with active *** became seizure free on TPM(2013-2017) but is complaining of persistent distal lower extremities paresthesia in a stocking *** examination revealed presence of diminished Achilles tendon reflexes,stocking hypesthesia and delayed distal latencies,reduced conduction velocities and amplitudes of action potentials of posterior tibial and sural nerves,indicating demyelinating and axonal peripheral neuropathy of the lower *** exclusion of the possible causes of peripheral neuropathy,chronic TPM therapy is suggested as the most probable cause of patient s *** is the first case report of topiramate induced peripheral neuropathy in the literature.