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M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals

World Journal of Gastroenterology 2020年第21期26卷 2864-2876页

作者： shereen a saleh Mohamed M Salama Marwan M Alhusseini Ghada A Mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11341Egypt

BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient ***-invasive techniques to assess liver fibrosis are becoming ***,serum Mac-2 binding protein glycosylation isomer(M2BPGi)was identified as a non-invasive marker of liver *** To investigate the diagnostic accuracy of M2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with *** From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort *** 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,*** measured serum M2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSM)at baseline and 12 weeks after the end of *** M2BPGi levels were measured using enzyme-linked immunosorbent *** All patients achieved sustained virologic response(SVR12)(100%).Serum M2BPGi levels,LSM,FIB-4 score and PAPAS index decreased significantly at SVR12(P<0.05).Serum M2BPGi levels correlated positively with LSM at baseline and SVR12(P<0.001).At baseline,compared with the FIB-4 score and PAPAS index,M2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,P<0.001),patients with grade F2 from grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.763,P<0.001).At SVR12,M2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,P<0.001),patients with grade F3 from grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grad

关键词： Hepatitis C virus Liver fibrosis Human Mac-2 binding protein Antiviral agents Sustained virologic response Elastography

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Bacterial infections post-living-donor liver transplantation in Egyptian hepatitis C virus-cirrhotic patients: A singlecenter study

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World Journal of Hepatology 2017年第20期9卷 896-904页

作者： Mohamed F Montasser Nadia A Abdelkader Sara M Abdelhakam Hany Dabbous Iman F Montasser Yasmine M Massoud Waleed Abdelmoaty shereen a saleh Mohamed Bahaa Hany Said Mahmoud El-Meteini Department of Tropical Medicine Faculty of Medicine Ain Shams University Department of Internal Medicine Faculty of Medicine Ain Shams University Department of Hepatobiliary Surgery Ain Shams Center for Organ Transplant Faculty of Medicine Ain Shams University

AIM To determine risk factors, causative organisms and antimicrobial resistance of bacterial infections following living-donor liver transplantation(LDLT) in cirrhotic *** This prospective study included 45 patients with hepatitis C virus-related end-stage liver disease who underwent LDLT at Ain Shams Center for Organ Transplant, Cairo, Egypt from January 2014 to November 2015. Patients were followed-up for the first 3 mo after LDLT for detection of bacterial infections. All patients were examined for the possible risk factors suggestive of acquiring infection pre-, intra-and post-operatively. Positive cultures based on clinical suspicion and patterns of antimicrobial resistance were identified. RESULTS Thirty-three patients(73.3%) suffered from bacterial infections; 21 of them had a single infection episode, and 12 had repeated infection episodes. Bile was the most common site for both single and repeated episodes of infection(28.6% and 27.8%, respectively). The most common isolated organisms were gramnegative bacteria. Acinetobacter baumannii was the most common organism isolated from both single and repeated infection episodes(19% and 33.3%, respectively), followed by Escherichia coli for repeated infections(11.1%), and Pseudomonas aeruginosa for single infections(19%). Levofloxacin showed high sensitivity against repeated infection episodes(P = 0.03). Klebsiella, Acinetobacter and Pseudomonas were multi-drug resistant(MDR). Pre-transplant hepatocellular carcinoma(HCC) and duration of drain insertion(in days) were independent risk factors for the occurrence of repeated infection episodes(P = 0.024).CONCLUSION MDR gram-negative bacterial infections are common post-LDLT. Pre-transplant HCC and duration of drain insertion were independent risk factors for the occurrence of repeated infection episodes.

关键词： Living-donor liver transplantation Bacterial infection Multi-drug resistance Hepatitis C virus Liver cirrhosis

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Impact of biliary complications on quality of life in live-donor liver transplant recipients

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World Journal of Hepatology 2021年第10期13卷 1405-1416页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim shereen a saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Despite significant advancements in liver transplantation(LT)surgical procedures and perioperative care,post-LT biliary complications(BCs)remain a significant source of morbidity,mortality,and graft *** addition,data are conflicting regarding the health-related quality of life(HRQoL)of LT ***,the success of LT should be considered in terms of both the survival and recovery of *** To assess the impact of BCs on the HRQoL of live-donor LT recipients(LDLT-Rs).METHODS We retrospectively analysed data for 25 LDLT-Rs who developed BCs post-LT between January 2011 and December 2016 at our *** Short Form 12 version 2(SF 12v2)health survey was used to assess their *** also included 25 LDLT-Rs without any post-LT complications as a control *** The scores for HRQoL of LDLT-Rs who developed BCs were significantly higher than the norm-based scores in the domains of physical functioning(P=0.003),role-physical(P<0.001),bodily pain(P=0.003),general health(P=0.004),social functioning(P=0.005),role-emotional(P<0.001),and mental health(P<0.001).No significant difference between the two groups regarding vitality was detected(P=1.000).The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains(P<0.001)and the mental(P<0.001)and physical(P=0.0002)component summary *** The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.

关键词： Live-donor liver transplantation Quality of life The Short Form 12 version 2 Cirrhosis Biliary complications Mental health

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Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients

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World Journal of Hepatology 2016年第30期8卷 1279-1286页

作者： Mahmoud A Osman Moataz M Sayed Khaled A Mansour shereen a saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud Department of Internal Medicine Hepatology and Gastroenterology Faculty of Medicine Ain Shams University Department of Tropical Medicine Faculty of Medicine Ain Shams University Department of Hepatobiliary Surgery Faculty of Medicine Ain Shams University Department of Community Environmental and Occupational Medicine Faculty of Medicine Ain Shams University Department of Internal Medicine Hepatology and Gastroenterology National Research Center Department of Neuropsychiatry Faculty of Medicine Ain Shams University

AIMTo evaluate the reversibility of minimal hepatic encephalopathy (MHE) following liver transplantation (LT) in Egyptian cirrhotic patients. METHODSThis prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty age- and sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A (TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score (PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTSBefore LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls (P P P P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score CONCLUSIONReversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score

关键词： Liver transplantation Model for end-stage liver disease score Psychometric tests Minimal hepatic encephalopathy Cirrhosis

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Biliary complications in recipients of living donor liver transplantation:A single-centre study

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World Journal of Hepatology 2021年第12期13卷 2081-2103页

作者： Reginia Nabil Guirguis Ehab Hasan Nashaat Azza Emam Yassin Wesam Ahmed Ibrahim shereen a saleh Mohamed Bahaa Mahmoud El-Meteini Mohamed Fathy Hany Mansour Dabbous Iman Fawzy Montasser Manar Salah Ghada Abdelrahman Mohamed Gastroenterology and Hepatology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11591Egypt Department of General Surgery Faculty of MedicineAin Shams UniversityCairo 11591Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11591Egypt

BACKGROUND Biliary complications(BCs)after liver transplantation(LT)remain a considerable cause of morbidity,mortality,increased cost,and graft *** To investigate the impact of BCs on chronic graft rejection,graft failure and *** From 2011 to 2016,215 adult recipients underwent right-lobe living-donor liver transplantation(RT-LDLT)at our *** excluded 46 recipients who met the exclusion criteria,and 169 recipients were included in the final ***’and recipients’demographic data,clinical data,operative details and postoperative course information were *** also reviewed the management and outcomes of *** were followed for at least 12 mo post-LT until December 2017 or graft or patient *** The overall incidence rate of BCs including biliary leakage,biliary infection and biliary stricture was 57.4%.Twenty-seven(16%)patients experienced chronic graft *** failure developed in 20(11.8%)patients.A total of 28(16.6%)deaths occurred during *** were a risk factor for the occurrence of chronic graft rejection and failure;however,mortality was determined by recurrent hepatitis C virus *** Biliary complications after RT-LDLT represent an independent risk factor for chronic graft rejection and graft failure;nonetheless,effective management of these complications can improve patient and graft survival.

关键词： Biliary complications Living donor liver transplantation Retrospective analysis Bile leak Biliary stricture Risk factors Mortality Graft rejection

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Prospective Assessment of the Rockall Risk Scoring System in Egyptian Patients with Upper Gastrointestinal Bleeding

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Open Journal of Gastroenterology 2015年第6期5卷 66-76页

作者： Mohga A. Reda Iman F. Montasser shereen A. saleh Azza M. Hassan Alaa Eldein I. Ewis Department of Tropical Medicine Faculty of Medicine Ain Shams University Cairo Egypt Department of Internal Medicine Faculty of Medicine Ain Shams University Cairo Egypt Department of Community Environmental and Occupational Medicine Faculty of Medicine Ain Shams University Cairo Egypt Department of Tropical Medicine Theodor Bilharz Research Institute Cairo Egypt

Background: One of the major challenges in managing acute upper gastrointestinal bleeding involves the identification of patients who are at high risk of rebleeding and death;conversely, the identification of patients who are suitable for early discharge and outpatient endoscopy is also important for effective resource. The use of Rockall system has been shown to represent accurate and valid predictor of rebleeding and death. The aim of this prospective study was to evaluate validity of Rockall score for prediction of rebleeding and mortality in Egyptian patients with upper gastrointestinal bleeding. Patients and Methods: 50 patients presented with upper GI bleeding were subjected to detailed clinical, laboratory, sonographic and endoscopic examination together with Rockall score calculation. Results: According to the findings of upper GI endoscopy patients were further subdivided into two subgroups as follows: Group 1 (n = 32): Patients with portal hypertension manifested by variceal bleeding and/or portal hypertensive gastropathy;and Group 2 (n = 18): other causes of acute upper gastrointestinal bleeding (peptic ulcer disease, Mallory Weiss syndrome…). Clinical condition of the patients was assessed after 48 hours and mortality was recorded. Rockall score was the highest in mortality group, and higher in rebleeding group than stable group (P < 0.01). Rockall score was higher in Child C than Child B and Child A among hepatic patients (P < 0.01). The cutoff value of Rockall score = 3.5 was the best for prediction of rebleeding with sensitivity 100%, specificity 53%, while the cutoff value = 6.5 was the best for prediction of mortality with sensitivity 100% and 93.5% specificity. Conclusion: Rockall score is clinically useful in prediction of rebleeding and mortality in patients with upper gastrointestinal bleeding. It can accurately differentiate between patients with stable condition that could be discharged from hospital and those who require hospitalization and t

关键词： Upper Gastrointestinal Bleeding Rockall Score Portal Hypertension

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Comparison between FIB-4 Index and Fibroscan as Marker of Fibrosis in Chronic HCV Infection in Egyptian Patients

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Open Journal of Gastroenterology 2014年第12期4卷 383-391页

作者： Noha A. El Nakeeb Amir Helmy shereen A. saleh Heba M. Abdellah Mostafa H. Abdel Aleem Dina Elshennawy Internal Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt Tropical Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt

The FIB-4 index is a simple and noninvasive algorithm consisting to evaluate liver fibrosis in chronic HCV infection. Aim: To evaluate the utility of FIB-4 index as a noninvasive marker to assess liver fibrosis in chronic HCV infection in comparison to transient elastography. Patients and Methods: We studied 30 patients having chronic HCV infection based on clinical features, laboratory tests, diagnostics images, Fibroscan and FIB-4 score. According to the results of Fibroscan, the 30 patients were classified into two groups in order to obtain a cutoff value to exclude patient with significant fibrosis: group Ia: 7 patients with no or mild liver fibrosis (F0-F1) and group Ib: 23 pa-tients with significant fibrosis or cirrhosis (F2-F3-F4). Group IIa: 17 patients with no or significant fibrosis (F0-F1-F2-F3) and group IIb (F4): 13 patients with cirrhosis (F4). Results: The mean of FIB-4 index increased with the increase of the fibrosis score. FIB-4 index proved to be sensitive and specific in differentiation between patients with no or mild fibrosis (F0-F1) and patients with significant fibrosis or cirrhosis (F2-F3-F4) with the best cutoff value at 1.61. It also proved to be sensitive and specific in differentiation between patients with no or significant fibrosis (F0-F1-F2-F3) and patients with cirrhosis (F4) with cutoff value at 1.88. Conclusion: The FIB-4 index enabled the correct identification of extreme types of fibrosis. Using these cutoffs (1.61 - 1.88), 87% of patients fell outside these ranges and could thus avoid liverbiopsy with an overall accuracy of 70%.

关键词： Chronic HCV Infection Transient Elastography FIB-4 Liver Fibrosis Liver Cirrhosis

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Blockchain for secure and decentralized artificial intelligence in cybersecurity: A comprehensive review

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BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第3期5卷 184-208页

作者： saleh, Ahmed M. Shamsan Univ Tabuk Dept Informat Technol Tabuk 47512 Saudi Arabia

As the use of artificial intelligence (AI) grows within the field of cybersecurity, so does the demand for secure and decentralized AI systems to protect against potential cyber threats. Blockchain technology has emerged as the ideal approach for increasing both the security and privacy of AI systems since it provides decentralized and immutable data storage. This systematic literature review focuses on the integration of blockchain technology with decentralized AI within cybersecurity. It provides a comprehensive taxonomy of blockchain technology and decentralized AI for cybersecurity, serving as the starting point for the study. This paper begins with an overview of blockchain technology and its possible uses in cybersecurity and also analyzes its challenges and opportunities. Decentralized AI is also covered in the study, along with its potential advantages and difficulties in decentralized AI cybersecurity. Building on that foundation, this study provides convincing findings highlighting the beneficial relationships between blockchain technology and decentralized AI for cybersecurity, contributing to a nuanced comprehension of their integration. Moreover, it offers real-world uses of blockchain-enabled, decentralized AI to discuss its usefulness in tackling cybersecurity concerns. Finally, this paper discusses future research directions for blockchain-enabled decentralized AI in cybersecurity, including potential applications and implications of this technology in the field, emphasizing the potential of blockchain-enabled decentralized AI in cybersecurity to enhance security, privacy, and trust in AI systems.

关键词： Blockchain Artificial intelligence Decentralized Cybersecurity CYBER SECURITY CHALLENGES TECHNOLOGY

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Advanced Nanocomposite Arabic Gum Polyacrylic Acid Hydrogels for Flexible Supercapacitors

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Journal of Renewable Materials 2024年第7期12卷 1219-1236页

作者： Borhan Albiss Asala saleh Nanotechnology Institute Jordan University of Science and TechnologyP.O.Box 3030Irbid22110Jordan

In this work,the fabrication and characterization of the nanocomposite hydrogel,as a solid electrode in electro-chemical cell and gel electrolyte material using Indium titanium oxide/polyethylene terephthalate(ITO/PET)ﬂex-ible substrate for double-layer supercapacitors have been *** nanocomposite hydrogel composed of Arabic gum(AG),Acrylic acid(AA),reduced graphene oxide(RGO),and silver nanoparticles(AgNPs)was fab-ricated via a physical cross-linked polymerization reaction,in which the ascorbic acid was used as a reducing agent to generate AgNPs and to convert Graphene oxide(GO)to RGO during the polymerization *** morphology and structural characteristics of nanocomposite hydrogel were investigated using atomic force microscopy(AFM),scanning electron microscope(SEM),Fourier transfer infrared(FTIR),and X-rayﬂuores-cence(XRF).Additionally,the effect of RGO and AgNPs on hydrogel stability was assessed through Thermogra-vimetric analysis(TGA)and differential scanning calorimetry(DSC),while its mechanical properties were studied using the nanoindentation *** impedance spectroscopy(EIS),and cyclic voltammetry(CV)were also conducted to study the electrochemical properties of the prepared *** effects of AgNPs,RGO,and water content were all considered in the study of supercapacitor *** microstructural tests showed that the nanocomposite hydrogel has a relatively high swelling rate,which has a crucial effect on the ***,the effects of increasing AgNP concentration and water content in the hydrogel matrix showed a signiﬁcant improvement in its electrochemical performance,compared with that for Arabic gum poly acrylic acid(AGPAA)hydrogel itself,were the speciﬁc capacitance exhibited a signiﬁcant enhancement,convert-ing from a low value to a substantially higher capacitance ***,when the nanocomposite hydrogel was used as the working electrode in an electrochemical cell with a hydrochloric acid

关键词： Supercapacitor energy harvesting nanocomposite hydrogel reduced graphene oxide

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The necessity to expand mycorrhizal boundaries:Including the fungal endophytes that possess key mycorrhizal criteria

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Pedosphere 2024年第2期34卷 520-523页

作者： Khalil KARIMAN Zed RENGEL Rodica PENA saleh RAHIMLOU Mark TIBBETT UWA School of Agriculture and Environment The University of Western AustraliaPerth WA 6009Australia Department of Sustainable Land Management&Soil Research Centre School of AgriculturePolicy and DevelopmentUniversity of ReadingReading RG66ARUK Department of Ecology and Evolutionary Biology University of MichiganAnn Arbor MI 48109USA

Dear editor,This letter aims to urge the necessity to expand the boundaries of mycorrhizal symbiosis to include certain root fungal *** conventional classification of mycorrhizal associations emphasizes specialized fu... 详细信息

关键词： editor specialized interface

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