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《药品标准管理办法》解读与思考

中国药房 2024年第7期35卷 783-786页

作者：赵梦遐孙丽娜徐丹柴文江学孔毛志海贺盛亮湖北科技学院医学部公共卫生与健康学院湖北咸宁437100 湖北省药品监督管理局审评中心武汉430071 咸宁市咸安区公共检验检测中心湖北咸宁437000 湖北省药品监督管理局咸宁分局湖北咸宁437100 真奥金银花药业有限公司湖北咸宁437000

2023年7月,国家药品监督管理局发布《药品标准管理办法》(以下简称《办法》)。本文就《办法》的主要内容进行解读,分析其存在的不足为:《办法》现有条文中对药品标准代号和药品标准信息化建设目标未明确。建议国家药品监督管理部门及时... 详细信息

2023年7月,国家药品监督管理局发布《药品标准管理办法》(以下简称《办法》)。本文就《办法》的主要内容进行解读,分析其存在的不足为:《办法》现有条文中对药品标准代号和药品标准信息化建设目标未明确。建议国家药品监督管理部门及时向标准化主管部门申请药品标准代号“YB”字母的确权,并将药品标准代号、编号规则在下一轮《办法》修正时写入条文,同时明确药品标准信息化体系建设目标;按用户界面层、计算处理层、数据存储层的基本框架搭建国家药品标准数据共享平台,免费向社会公开数字化药品标准,提供查阅和下载服务。

关键词：药品标准管理办法药品标准代号药品注册标准信息化解读

Optimization of jamming formation of USV offboard active decoy clusters based on an improved PSO algorithm

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Defence Technology（防务技术） 2024年第2期32卷 529-540页

作者： Zhaodong Wu Yasong Luo shengliang Hu College of Weapons Engineering PLA Naval University of EngineeringWuhan430033China

Offboard active decoys(OADs)can effectively jam monopulse ***,for missiles approaching from a particular direction and distance,the OAD should be placed at a specific location,posing high requirements for timing and *** improve the response speed and jamming effect,a cluster of OADs based on an unmanned surface vehicle(USV)is *** formation of the cluster determines the effectiveness of ***,based on the mechanism of OAD jamming,critical conditions are identified,and a method for assessing the jamming effect is ***,for the optimization of the cluster formation,a mathematical model is built,and a multi-tribe adaptive particle swarm optimization algorithm based on mutation strategy and Metropolis criterion(3M-APSO)is ***,the formation optimization problem is solved and analyzed using the 3M-APSO algorithm under specific *** results show that the improved algorithm has a faster convergence rate and superior performance as compared to the standard Adaptive-PSO *** with a single OAD,the optimal formation of USV-OAD cluster effectively fills the blind area and maximizes the use of jamming resources.

关键词： Electronic countermeasure Offboard active decoy USV cluster Jamming formation optimization Improved PSO algorithm

Coupling effect on the thermal hazard assessment of hazardous chemical materials via calorimetric technologies and simulation approaches

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Defence Technology（防务技术） 2024年第2期32卷 644-654页

作者： Yabei Xu Jiankun Shao Wei Wang shengliang Xu Dongping Chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang 441003China

The coupling effect of heat absorption and release exists in the thermal decomposition of a few chemical ***,the impact of the above coupling on thermal hazard assessment is not considered in the literature *** this work,nitroguanidine(NQ)and 1,3,5-trinitro-1,3,5-triazine(RDX)are selected as representative materials to explore the influence of the coupling effect on the thermal hazard assessment of chemical *** linear heating experiments of NQ and RDX are carried out by a microcalorimeter and synchronous thermal *** thermal decomposition curves are decoupled by advanced thermokinetics *** thermal decomposition and kinetic parameters before and after decoupling are *** results of TG experiment show that both NQ and RDX began to lose mass during the endothermic *** endothermic melting and exothermic decomposition of NQ and RDX are coupled within this *** coupling effect has different degrees of influence on its initial decomposition temperature and safety *** with the parameters in the coupling state,the initial decomposition temperature and adiabatic induction period after decoupling *** self-accelerating decomposition temperature increases,and internal thermal runaway time *** the thermal hazard assessment of chemical materials with coupling effects,the calculated parameters after decoupling should be taken as an important safety index。

关键词： Calorimetric technologies Kinetics Thermal hazard Phase transformation Thermal decomposition

Enhanced nitrite electroreduction to ammonia via interfacial dual-site adsorption

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Journal of Energy Chemistry 2024年第9期96卷 328-335页

作者： Xiaokang Chen shengliang Zhai Yi Tan Le Su Dong Zhai Wei-Qiao Deng Hao Wu Institute of Frontier Chemistry School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266071ShandongChina College of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031ShanxiChina Suzhou Research Institute of Shandong University Suzhou 215123JiangsuChina

The nitrite(NO_(2)^(−))to ammonia(NH3)electroreduction reaction(NO_(2)^(−)RR)would be impeded by sluggish proton-coupled electron transfer kinetics and competitive hydrogen evolution reaction(heR).A key to improving the NH3 selectivity is to facilitate adsorption and activation of NO_(2)^(−),which is generally undesirable in unitary *** this work,an efficient NO_(2)^(−)RR catalyst is constructed by cooperating Pd with In2O3,in which NO_(2)^(−)could adsorb on interfacial dual-site through“Pd–N–O–In”linkage,leading to strengthened NO_(2)^(−)adsorption and easier N=O bond cleavage than that on unitary Pd or ***,the Pd/In_(2)O_(3)composite exhibits moderate H^(*)adsorption,which may facilitate protonation kinetics while inhibiting competitive *** a result,it exhibits a fairly high NH_(3)yield rate of 622.76 mmol h^(−1)g^(−1)cat with a Faradaic efficiency(FE)of 95.72%,good selectivity of 91.96%,and cycling stability towards the NO_(2)^(−)RR,surpassing unitary In_(2)O_(3)and Pd/C ***,computed results indicate that NH_(3)production on Pd/In_(2)O_(3)follows the deoxidation to hydrogenation *** work highlights the significance of H^(*)and NO_(2)^(−)adsorption modulation and N=O activation in NO_(2)^(−)RR electrochemistry by creating synergy between a mediocre catalyst with an appropriate cooperator.

关键词： Dual-site adsorption Nitrite electroreduction Ammonia Pd Hydrogenation

Performance analysis of the tight combination of GPS, BDS, GALILEO, and QzsS mixed frequencies signals

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Geodesy and Geodynamics 2024年第4期15卷 366-378页

作者： Yu Han Fangjun Qin Xugang Lian shengliang Wang Leiyuan Qian Wenhua Huang College of Electrical Engineering Naval University of EngineeringWuhan 430033China College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Satellite Navigation System and Equipment Technology Shijiazhuang 050081China State Key Laboratoryof Geodesy and Earth'sDynamics Innovation AcademyforPrecision Measurement Scienceand Technology Chinese Academy of SciencesWuhan 430077China China Energy Engineering Group Shanxi Electric Power Engineering CO.LTD. Taiyuan 030001China

With the gradual development and modernization of satellite navigation systems,using observation information from multi-GNss has become one of the hot-spot issues in recent ***-system loose combinations form double-difference observation equations within their respective systems,and the positioning effect is ***,the interchangeability and compatible interoperability between global navigation satellite systems(GNSS)cannot be truly *** the same time,when the number of visible satellites decreases abruptly,the positioning performance deteriorates *** paper focuses on the GNsS multi-system tight combination relative positioning technique,gives a mathe-matical model of multi-system tight combination relative positioning considering differential inter-system bias(DISB),and analyzes the time-varying characteristics of DISB at overlapping and non-overlapping frequencies among GPS/Galileo,GPS/BDS,and GPS/QZSS in terms of receiver brand,tem-perature,and receiver *** GNsS tight combination relative positioning performance is verified by static data from Curtin University and dynamic data measured at Taiyuan University of *** results show that compared with loose combination,the ambiguity-fixed rate increases from 62.18%to 97.60%for static data and from 74.97%to 99.53%for dynamic data when the elevation mask angle is 50°,resulting in a significant improvement in positioning performance.

关键词： GNSS Mix frequencies Redundancy Tightcombination Differential inter-system bias

A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

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Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun‑sing Lee shengliang Li Xiao‑Hong Zhang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

Dunhuang and Exchanges and Mutual Learning Among Civilizations

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中国新闻发布(英文版) 2024年第Z1期 44-45页

作者： Zhao shengliang the Communist Party of China Committee of Dunhuang Academy

In 138 BCE and 119 BCE, Emperor Wu of the Han Dynasty(206 BCE–24 CE) dispatched envoy Zhang Qian to the Western Regions twice, establishing the “Silk Road” between the East and West. For thousands of years, the Silk Road has facilitated political, economic, and cultural exchanges between the East and West and has had a far-reaching impact on the development of the civilizations of China, India, and Central Asian countries.

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继往开来砥砺前行——敦煌研究院八十年

敦煌研究 2024年第4期 5-12页

作者：赵声良敦煌研究院

敦煌研究院已有八十周年历史，自1944年国立敦煌艺术研究所成立，1950年改名为敦煌文物研究所，1984年扩建为敦煌研究院。经过几代人的不懈努力，在文物保护、学术研究、文化弘扬以及科学管理方面全面发展，取得了丰硕的成果。在文物保... 详细信息

敦煌研究院已有八十周年历史，自1944年国立敦煌艺术研究所成立，1950年改名为敦煌文物研究所，1984年扩建为敦煌研究院。经过几代人的不懈努力，在文物保护、学术研究、文化弘扬以及科学管理方面全面发展，取得了丰硕的成果。在文物保护领域，不断提高科技保护水平，并率先发展文物数字化技术；在敦煌学研究领域，以敦煌石窟考古、石窟艺术、敦煌文献研究为中心，加强丝绸之路与多元文化、古代民族文化等方面研究，取得了一系列成果。不断加强国内外学术交流与合作，并在世界范围内传播弘扬敦煌文化。

关键词：敦煌研究院保护研究弘扬管理

High-Value-Added Utilization of Turpentine:Screening of Anti-Influenza Virus Agents fromβ-Pinene Derivatives

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Journal of Renewable Materials 2024年第1期12卷 45-56页

作者： Yiwen Li Hongyan Si Peng Wang Hai Luo Minggui Shen Xiaoping Rao Zhanqian Song Shibin Shang Zongde Wang shengliang Liao East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration Camphor Engineering Research Center of National Forestry and Grassland AdministrationCollege of ForestryJiangxi Agricultural UniversityNanchang330045China Institute of Chemical Industry of Forestry Products China Academy of ForestryNational Engineering Laboratory for Biomass Chemical UtilizationKey and Open Laboratory of Forest Chemical EngineeringState Forestry AdministrationKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing210042China College of Chemical Engineering Huaqiao UniversityXiamen361021China

Turpentine is a renewable and resourceful forest *** deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread *** study aimed to synthesize 40 derivatives ofβ-pinene,including nopinone,3-cyanopyridines of nopinone,myrtanyl acid,myrtanyl acylthioureas,and myrtanyl *** assessed the antiviral activities of theseβ-pinene derivatives against influenza virus A/Puerto Rico/8/34(H1N1)using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ***β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 *** results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration(IC50)value of 47.6μmol/*** the compounds,4e,4i,and 4l demonstrated therapeutic effects against cellular infection,with compound 4e displaying the most potent therapeutic effect(IC50=17.5μmol/L),comparable to the positive control *** findings indicated that certainβ-pinene derivatives exhibited in vitro antiviral activity against the H1N1 influenza A virus,warranting further investigation as potential anti-influenza agents.

关键词： Antiviral activity β-pinene derivative 3-cyanopyridine influenza virus