检索结果-南通市图书馆

Mechanism of apoptosis induced by Mcl-1 inhibitor UMI-77 on gallbladder carcinoma GBC-SD cells

在线全文

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2019年第1期6卷 1-6页

作者： shengbin zhang Baoqin Liu Changcheng Dong Bing Li Department of Hepatobiliary Surgery Baogang HospitalBaotouInner MongoliaChina

Objective:To investigate the mechanism of apoptosis induced by myeloid cell leukemia-1(Mcl-1)inhibitor UMI-77 on gallbladder carcinoma GBC-SD ***:GBC-SD cells were treated with different concentrations of ***-SD cell proliferation and apoptosis were detected by MTT assay and Annexin V/*** expressions of Mcl-1,Bcl-2,Bcl-xL,Bax,Bak,cleaved-caspase 9,cleaved-caspase 3 and cleaved-PARP proteins in GBC-SD cells treated with UMI-77 were detected by Western ***:The results of MTT showed that different concentrations of UMI-77 had different inhibitory effects on cell proliferation of GBC-SD cells in a dose-dependent and time-dependent *** V/PI results showed that the apoptosis rate was increasing gradually with the increase of UMI-77 concentration in a dose-dependent *** blotting results showed that the expression of anti-apoptotic protein Mcl-1 was significantly decreased(p<0.05),and the expressions of Bax and Bak proteins were significantly increased respectively(p<0.05),but there were no significant changes in the expressions of Bcl-2 and Bcl-xL proteins,and the expression levels of cleaved-caspase 9,cleaved-caspase 3 and cleaved-PARP proteins were significantly increased(p<0.05)in 24 h after GBC-SD cells were treated with 10μmol/L of ***:Mcl-1 inhibitor UMI-77 can induce the apoptosis of GBC-SD cells in a dose-dependent manner through the caspase-mediated endogenous apoptosis ***,Mcl-1 may become a new therapeutic target in the research on gallbladder cancer.

关键词： Mcl-1 inhibitor UMI-77 Gallbladder carcinoma Apoptosis

Survey data analysis of the related risk factors of echinococcosis in Inner Mongolia of China and Mongolia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2019年第1期6卷 17-25页

作者： shengbin zhang Zhelin Yun Erdengsuhe E Baoqin Liu Department of Hepatobiliary Surgery Baogang HospitalBaotouInner MongoliaChina Mongolian Hospital ErenhotChina

Objective:The aim of the study is to analyze the risk factors of hepatic echinococcosis in mass epidemiological studies in Inner Mongolia of China and Mongolia and provide a basis for related authorities to make appropriate preventive ***:Eight areas in Inner Mongolia and Zamyn-Üüd region of Mongolia were selected as epidemiological *** distributing epidemiological questionnaires to local residents and performing serological examinations and abdominal ultrasound examinations,the data results were collected and analyzed to obtain the risk ***:In this research,there were 7,373 cases of valid data in the area of Inner Mongolia and 1,500 cases in the area of *** mean age of the whole survey samples was 52.86±13.90,and the ratio of the female(58.35%)was much higher than that of the male(41.65%).Both univariate analysis and multivariate analysis in this study showed that the female(14.7%)had a higher risk of hepatic echinococcosis than the male(10.9%).From the perspective of profession,children,educators and medical personnel had a lower incidence,herdsmen had the highest positive rate of the disease(15.8%).Living in pastoral areas,having been to pastoral areas,eating uncooked food and drinking unboiled water,raising dogs and surrounding activities of foxes and voles can also increase the risk of ***:Our findings demonstrate that the most important risk factor of hepatic echinoccosis is unhealthy lifestyles and customs in farmers and *** is possible to provide a basis for related authorities to make effective protective measures aiming at hepatic echinococcosis.

关键词： Hepatic echinococcosis Epidemiological study Inner Mongolia of China Mongolia

Analysis of diagnosis and treatment of heterotopic pancreas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2015年第2期2卷 23-28页

作者： Shipeng Song Rui Liu shengbin zhang Tianyong Zhao Jin Zhao Zhijian zhang The Third Affiliated Hospital of Inner Mongolia Medical University HohhotChina

A case of heterotopic pancreas in the Third Affiliated Hospital of Inner Mongolia Medical University was recorded and analyzed on the basis of diagnosis,physical examination and *** of gastrointestinal stromal tumor(GIST)is very common since it is a rare *** this paper aims to enhance the doctors’awareness of GIST during clinical practice.

关键词： Heterotopic pancreas Diagnosis Treatment

Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2018年第3期5卷 13-17页

作者： Xiaoming Zou Zhelin Yun shengbin zhang Jin Zhao Bing Li Department of General Surgery The Third Affiliated Hospital of Inner Mongolia Medical UniversityBaotouChina

Objective: To analyze Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy and inves-tigate the relationship between the major risk factors and Clavien-Dindo classification of complications. Methods: The retrospective case-control study was adopted. The clinical data of 200 patients who underwent pancreatico-duodenectomy at the Third Affiliated Hospital of Inner Mongolia Medical University from January 2010 to June 2015 were collected. The patients underwent Whipple procedure or pylorus-preserving pancreaticoduodenectomy according to the tumor site. Observation indicators included: (1) postoperative complications using Clavien-Dindo classification;(2) univariate and multivariate analyses: patients' basic information, surgery-related factors, pancreas-related factors;(3) relationship between independent risk factors and Clavien-Dindo classification of complications after pancreaticoduodenectomy. The chi-square test was applied to univariate analysis and categorical data. The comparison between groups was done by using independent samples nonparametric test (Kolmogorov-Smirnov Z), and multivariate analysis was done by using Logistic regression model. Results: (1) Postoperative complications: Of 200 patients, 122 underwent Whipple procedure and 78 underwent pylorus-preserving pancreaticoduodenectomy, including 6 cases combined with vascular reconstructions and 1 case with RFA of liver tumors. Ninety-eight patients had postoperative complications, including 41 patients with no less than 2 types of complications. After surgery, pancreatic fistula was detected in 80 patients, including 42 cases with grade A, 28 cases with grade B and 10 cases with grade C;incisional infection in 29 patients;gastric retention in 24 patients;intra-abdominal infection in 16 patients;intra-abdominal hemorrhage in 10 patients, including 8 patients receiving interventional treatment;biliary leakage in 7 patients and unplanned reoperation in 2 patients. Th

关键词： Pancreatic diseases Pancreaticoduodenectomy Surgical procedures Post-operative complications Risk factors Clavien-Dindo classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

歧路上的辩证逻辑

河南社会科学 2006年第6期14卷 62-65页

作者：张盛彬皖西学院安徽六安237012

中国的辩证逻辑研究在苏联哲学问题编辑部《逻辑问题讨论总结》误导下,抛弃了形式逻辑,只研究认识过程中的辩证思维阶段,走上了歧途。恩格斯的“辩证逻辑”,是“辩证的逻辑”的误译。辩证逻辑不仅名不正,言也不顺:研究对象和研究方法都... 详细信息

中国的辩证逻辑研究在苏联哲学问题编辑部《逻辑问题讨论总结》误导下,抛弃了形式逻辑,只研究认识过程中的辩证思维阶段,走上了歧途。恩格斯的“辩证逻辑”,是“辩证的逻辑”的误译。辩证逻辑不仅名不正,言也不顺:研究对象和研究方法都偏离了黑格尔奠基的大方向。

关键词：思辨逻辑认识论逻辑辩证逻辑形而上学的逻辑

Perioperative treatment of liver transplantation

在线全文

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2014年第1期1卷 12-18页

作者： shengbin zhang Rui Liu Shipeng Song Weiqing Wang Jin Zhao Xiaoshi Dong The Third Affiliated Hospital of Inner Mongolia Medical University HohhotChina

A case of liver transplantation in the department of general surgery of the third affiliated hospital of Inner Mongolia medical school was collected and analyzed on the basis of diagnosis,physical examination and *** transplantation was very complicated,accompanied by various postoperative *** this paper aims to share experience of perioperative management of liver transplantation among physicians.

关键词： Liver transplantation Perioperative treatment Perioperative management

基于UMBmark算法的移动机器人定位试验研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代电子技术 2018年第3期41卷 80-83,87页

作者：张胜宾赵祚喜广东交通职业技术学院汽车与工程机械学院广东广州510642 华南农业大学工程学院广东广州510642

测程法是使用最广泛的移动机器人自主定位方法,具有短时定位精度较高,成本低廉的特点,缺点是无界的误差累积。在光滑规则的地面上运动时,系统误差是测程法的主要来源。为了提高移动机器人自主定位的精度,国内外专家尝试了多种改进方法,... 详细信息

测程法是使用最广泛的移动机器人自主定位方法,具有短时定位精度较高,成本低廉的特点,缺点是无界的误差累积。在光滑规则的地面上运动时,系统误差是测程法的主要来源。为了提高移动机器人自主定位的精度,国内外专家尝试了多种改进方法,其中,UMBmark校核算法是使用最广泛的方法之一。概述了UMBmark校核方法"双向正方形路径试验"及其简化模型,利用Pioneer3-AT差动轮式移动机器人完成了UMBmark校核试验。结果表明,UMBmark校核算法使得Pioneer3-AT机器人自主定位的精度和稳定性均有较大提高。

关键词：移动机器人定位测程法 UMBmark算法系统误差校核试验

在线全文

学校读者我要写书评

暂无评论

基于不同衬底的五氧化二钒薄膜光电特性

光学学报 2016年第4期36卷 321-328页

作者：张圣斌左敦稳卢文壮左杨平南京航空航天大学机电学院江苏南京210016

利用射频磁控溅射方法,在红外石英、蓝宝石和光学单晶金刚石上制备了氧化钒薄膜,然后对其结构与厚度、表面形貌、电学及光学性能进行了表征。实验结果表明,制备出的薄膜均为单一组分的V_2O_5薄膜,在(001)面有明显的择优取向,单晶金刚石... 详细信息

利用射频磁控溅射方法,在红外石英、蓝宝石和光学单晶金刚石上制备了氧化钒薄膜,然后对其结构与厚度、表面形貌、电学及光学性能进行了表征。实验结果表明,制备出的薄膜均为单一组分的V_2O_5薄膜,在(001)面有明显的择优取向,单晶金刚石衬底的薄膜结晶度和表面形貌最好;电学性能方面,金刚石衬底的薄膜相变温度最低经历的温度范围也最小,电学突变性能最为优异;光学性能方面,蓝宝石和金刚石衬底的薄膜光关闭时间均非常短,低于2.5 ms,回复时间在30 ms左右;单晶金刚石衬底的薄膜相变前后透射率比值为10.3,表现出了非常显著的光学突变性能。

关键词：薄膜 V2O5薄膜衬底单晶金刚石电学性能光学突变性能

基于能量效率的HEV多模式控制策略及判据研究

在线全文

学校读者我要写书评

暂无评论

汽车技术 2017年第12期 28-33页

作者：郭海龙张永栋张胜宾广东交通职业技术学院广州510650 华南理工大学广州510641

以某款混联式HEV为研究对象,建立了车辆动力系统仿真模型及整车能量控制策略优化模型。对比不同需求驱动转矩下的整车能量转换效率发现,在电池剩余电量及车速相同条件下,随着驾驶人需求驱动转矩的增加,HEV能量转换效率呈现"凸抛物线"规... 详细信息

以某款混联式HEV为研究对象,建立了车辆动力系统仿真模型及整车能量控制策略优化模型。对比不同需求驱动转矩下的整车能量转换效率发现,在电池剩余电量及车速相同条件下,随着驾驶人需求驱动转矩的增加,HEV能量转换效率呈现"凸抛物线"规律。基于该规律,形成了HEV能量控制策略动力性、平衡性和经济性控制规则的划分判据。

关键词：混联式 HEV 多模式能量控制策略遗传粒子群算法需求驱动转矩能量转换效率