检索结果-南通市图书馆

Nuclear Science and Techniques 2017年第7期28卷 73-78页

作者： sheng-ying zhao Hui-Yin Wu Bi-Tao Hu Hui-Rong Qi Yi Zhang School of Nuclear Science and Technology Lanzhou University Lanzhou 730000 China State Key Laboratory of Particle Detection and Electronics Beijing 100049 China

In this work,a new hybrid MPGD consisting of two GEM foils and a metallic mesh was *** on the simulation studies,this design can significantly reduce the rise time of signal and has a better performance in respect of particle identification compared with the triple GEM *** gain with various voltages setting was computed in order to provide us references for future *** simulation results also show that the time and space resolution compared to the triple GEM detector are also *** time and space resolution of hybrid detector with Ar/CO_2(70/30) and Ar/isobutane(95/5) were investigated for various drift electric field *** new hybrid detector shows excellent potential for both fundamental research and imaging applications.

关键词：时间分辨率混合概率放电模拟仿真结果基础研究空间分辨率

Analysis of ice slurry production by direct contact heat transfer of air and water solution

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 583-588页

作者： Xue-jun ZHANG Ke-qing ZHENG Ling-shi WANG Wei WANG Min JIANG sheng-ying zhao Institute of Refrigeration and Cryogenics Zhejiang University School of Information and Electrical Engineering Zhejiang University City College

In this paper, a novel system using direct contact heat transfer between air and water solution was proposed to generate ice slurry. The heat transfer process and the system performance were studied; energy efficiency coefficients of 0.038, 0.053, and 0.064 were obtained using different solutions. An empirical relationship between the volumetric heat transfer coefficient U v and the main parameters was obtained by fitting the experimental data. The U v calculated from the empirical formula agreed with the experimental U v quite well with a relative error of less than 15%. Based on the empirical formula, a laboratory-scale direct contact ice slurry generator was then constructed, with practical application in mind. If the air flow rate is fixed at 200 m 3 /h, the ice production rate will be 0.091 kg/min. The experimental results also showed that the cold energy consumption of the air compressor accounted for more than half of the total amount. To improve the system energy efficiency coefficient, it is necessary to increase the air pipes insulation and the solution's thermal capacity, and also it is appropriate to utilize the free cold energy of liquefied natural gas (LNG).

关键词： Ice slurry Generator Air and water solution Direct contact Volumetric heat transfer coefficient Liquefied naturalgas (LNG)

Sensing Escherichia coli O157:H7 via frequency shift through a self-assembled monolayer based QCM immunosensor

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 121-131页

作者： Li-jiang WANG Chun-sheng WU zhao-ying HU Yuan-fan ZHANG Rong LI Ping WANG Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China

By means of the specific immuno-recognition and ultra-sensitive mass detection, a quartz crystal microbalance (QCM) biosensor for Escherichia coli O157:H7 detection was developed in this work. As a suitable surfactant, 16-mercaptohexadecanoic acid (MHDA) was introduced onto the Au surface of QCM, and then self-assembled with N-hydroxysuccinimide (NHS) raster as a reactive intermediate to provide an active interface for the specific antibody immobilization. The binding of target bacteria with the immobilized antibodies decreased the sensor’s resonant frequency, and the frequency shift was correlated to the bacterial concentration. The stepwise assembly of the immunosensor was characterized by means of the electrochemical techniques. Using the immersion-dry-immersion procedure, this QCM biosensor could detect 2.0×102 colony forming units (CFU)/ml E. coli O157:H7. In order to reduce the fabrication time, a polyelectrolyte layer-by-layer self-assembly (LBL-SA) method was adopted for fast construction. Finally, the reproducibility of this biosensor was discussed.

关键词： Biosensor Escherichia coli O157:H7 Immunosensor Layer-by-layer self-assembly (LBL-SA) Quartz crystalmicrobalance (QCM)

Acoustic impedance characteristics of linear compressors

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第7期14卷 494-503页

作者： Zhi-hua GAN Long-yi WANG sheng-ying zhao Yu-jing SONG Wei-wei WANG Yi-nong WU Institute of Cryogenics and Refrigeration Zhejiang University School of Information and Electrical Engineering Zhejiang University City College Shanghai Institute of Technical Physics Chinese Academy of Sciences

The acoustic field of a linear compressor serves to deliver the compression work to the load, such as the connected cold head of a cryocooler; it plays an equivalently important role as the electrical and mechanical parts, especially in the impedance match issue. This paper studies the acoustic impedance characteristics of a linear compressor. The parameters including the current, the piston displacement, the pressure amplitude, the electrical power dissipation, the power factor, the pressure-volumetric (PV) power delivered, and the efficiency are theoretically and experimentally investigated. Different from previous theoretical studies, optimization for the operations away from the resonance is also included. More general optimization results imply relevance between thermoacoustic engines and linear compressors. The predicted results are validated by the experiments performed on a linear compressor with an adjustable resistive-capacitive (RC) acoustic load. The comparisons between the calculations and the measurements are presented and analyzed. The results provide deeper insight into the mechanism of the linear compressor and the impedance match in a cryocooler system.

关键词： Linear compressor Acoustic impedance Resistive-capacitive (RC) load

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： Jing-Jing Yang ying-Xin Liu Yan-Fang Wang Bi-ying Ge ying Wang Qing-Shan Wang sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong sheng-Ming Yin Jie zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第4期30卷 367-380页

作者： Yan-Min Chen Wen-Qian Yang Cheng-Wei Gu ying-ying Fan Yu-Zhen Liu Bao-sheng zhao Department of Thoracic Surgery The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina Department of Oncology The Affiliated HospitalHenan Polytechnic UniversityJiaozuo 454000Henan ProvinceChina Life Science Research Center The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina

BACKGROUND L-type calcium channels are the only protein channels sensitive to calcium channel blockers,and are expressed in various cancer *** Cancer Genome Atlas database shows that the mRNA levels of multiple L-type calcium channel subunits in esophageal squamous cell carcinoma tumor tissue are significantly higher than those in normal esophageal epithelial ***,we hypothesized that amlodipine,a long-acting dihydropyridine L-type calcium channel blocker,may inhibit the occurrence and development of esophageal cancer(EC).AIM To investigate the inhibitory effects of amlodipine on EC through endoplasmic reticulum(ER)*** Cav1.3 protein expression levels in 50 pairs of EC tissues and corresponding paracancerous tissues were ***,the inhibitory effects of amlodipine on proliferation and migration of EC cells in vitro were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide and Transwell *** vivo experiments were performed using murine xenograft *** elucidate the underlying mechanisms,in vitro cell studies were performed to confirm that ER stress plays a role in inhibition proliferation and migration of EC cells treated with *** The expression level of Cav1.3 in esophageal carcinoma was 1.6 times higher than that in paracancerous *** treatment decreased the viability of esophageal carcinoma cells in a dose-and time-dependent *** vivo animal experiments also clearly indicated that amlodipine inhibited the growth of EC tumors in ***,amlodipine reduces the migration of tumor cells by inhibiting epithelial-mesenchymal transition(EMT).Mechanistic studies have demonstrated that amlodipine induces ER stress-mediated apoptosis and suppresses ***,amlodipine-induced autophagy was characterized by an increase in autophagy lysosomes and the accumulation of light chain 3B *** combination of amlodipine with the ER stress inhibitor 4-p

关键词： L-type calcium channel Amlodipine Esophageal cancer Autophagy Endoplasmic reticulum stress

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 2994-3006页

作者： ying Li Yi-Han zhao Lu-Lu zhao Peng-Fei Wang ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(LIBs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of Li~+limits its practical *** this work,C-Sb composite was constructed as anode material of LIBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)Li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)Li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： Li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

Recursive Projected Filter Algorithm with Binary-Valued Observations

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第5期37卷 1832-1860页

作者： ZHANG Xiaoyan WANG ying XUE Wenchao zhao Yanlong Key Laboratory of Systems and Control Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

This paper focuses on the state estimate for a class of systems with both process noise and measurement noise under binary-valued observations, in which the Gaussian assumption on the predicted density of the state is not required. A recursive projected filter algorithm with time-varying thresholds is constructed to estimate the state under binary-valued observations. The time-varying thresholds are designed as the prediction value of the measurement, which can provide more information about the system state. The convergence property is established with some suitable stability,boundedness and observability conditions. In particular, the estimation error between state and estimate is proved to be asymptotically bounded in the mean-square sense, whose upper bound is related to the variance of process noise. Finally, the theoretical results are demonstrated via numerical examples of first-order and high-order systems.

关键词： Binary-valued observations convergence recursive filter time-varying thresholds

Tunable Phase Structure of Side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第10期42卷 1459-1469,I0009页

作者： Wen-Huan Yao Lan-sheng Liu Jie zhao Yan-Xia Wang An-Zhi Ma Zheng-Rui Ma Lan-ying Zhang Ruo-Chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Institute of Advanced Materials&Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(SCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMS)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these SCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers Self-assembly Phase structure Chiral molar ratio

Tethered spinal cord syndrome with symptomatic onset in adulthood

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第21期122卷 2669-2671页

作者： HE Shi-sheng zhao ying-chuan SHI Zhi-cai LIMing HOU Tie-sheng ZHANG Ye WU Yun-gang Orthopedics Department Changhai Hospital Second Military Medical University Shanghai 200433 China

Tethered spinal cord syndrome （TCS） is a condition of overstretching or compression of the caudal part of the spinal cord caused by various spinal lesions, such as a tight filum terminale or an intraspinal lipoma.l-9 Though it is a well-recognized cause of neurological deterioration in childhood, its symptomatic onset in adulthood is uncommon. Eleven cases of TCS are presented here. In addition, their related clinical features, surgical procedures and outcomes are investigated.

关键词： tethered spinal cord syndrome adult