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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui Wang Shao-Wei Yang Fu-Bin Ma yi-Ke Zhao Shi-Nuo Zhao Zheng-Yu Xiong Dong cai Hai-Dong Shen Kai Zhu Qiu-Yu Zhang Yue-Ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

二十碳五烯酸和二十二碳六烯酸及其组合对斑马鱼阿尔茨海默病模型认知障碍的改善作用和机制

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中国药理学通报 2024年第4期40卷 701-709页

作者：黄城益邓淑怡宋采广东海洋大学食品科技学院广东湛江524088 广东海洋大学深圳研究院广东深圳518117

目的omega-3多不饱和脂肪酸二十碳五烯酸(eicosapentaenoic acid,EPA)和二十二碳六烯酸(docosahexaenoic acid,DHA)能够抑制M1型小胶质细胞的过度激活促炎细胞因子的释放和细胞凋亡,而EPA具有抗抑郁的作用。与EPA比较,DHA似对记忆的改... 详细信息

目的omega-3多不饱和脂肪酸二十碳五烯酸(eicosapentaenoic acid,EPA)和二十二碳六烯酸(docosahexaenoic acid,DHA)能够抑制M1型小胶质细胞的过度激活促炎细胞因子的释放和细胞凋亡,而EPA具有抗抑郁的作用。与EPA比较,DHA似对记忆的改善作用更强。由于两者在食物、衰老和疾病中的比值多变,其单一和最佳组合的功效不明,本实验拟利用AD模型比较研究EPA、DHA及最佳组合改善认知障碍及神经炎症的机制。方法Al 3+诱导斑马鱼AD模型,饲予EPA、DHA或EPA+DHA(1∶2),评估新物体识别和T迷宫奖赏的记忆,GC-MS检测躯体PUFAs浓度变化,qPCR检测脑内AChE、Axl、APP、Bace1、IL-6、TNF-α、CD11b、CD206、VDAC1、Caspase-3、Caspase-9和Bax的变化,ELISA试剂盒检测脑内Aβ的浓度。结果与模型组相比,EPA仅明显改善了斑马鱼的新物体识别能力,而DHA与EPA+DHA均恢复了新物体识别和T迷宫中的记忆。给予EPA、DHA和EPA+DHA均明显抑制了Aβ的蛋白浓度变化以及IL-6、CD206、Caspase-3、Caspase-9、Bax和AChE的mRNA表达,EPA和DHA均明显抑制了Bace1、APP和TNF-α的mRNA表达。DHA和EPA+DHA还明显降低了Axl和VDAC1的mRNA表达。结论EPA+DHA的组合对Al 3+诱导斑马鱼AD模型的记忆和认知障碍具有更好的改善作用,其作用机制可能通过抑制脑内细胞凋亡情况来改善记忆和认知障碍。

关键词： EPA DHA 阿尔茨海默病斑马鱼认知记忆神经炎症

Optimize Purcell filter design for reducing influence of fabrication variation

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Chinese Physics B 2024年第6期33卷 589-594页

作者：蔡晓周翼彪于文龙熊康林冯加贵 Gusu Laboratory of Materials Suzhou 215123China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China

To protect superconducting qubits and enable rapid readout, optimally designed Purcell filters are essential. To suppress the off-resonant driving of untargeted readout resonators, individual Purcell filters are used for each readout ***, achieving consistent frequency between a readout resonator and a Purcell filter is a significant challenge. A systematic computational analysis is conducted to investigate how fabrication variation affects filter performance, through focusing on the coupling capacitor structure and coplanar waveguide(CPW) transmission line specifications. The results indicate that the T-type enclosing capacitor(EC), which exhibits lower structural sensitivity, is more advantageous for achieving target capacitance than the C-type EC and the interdigital capacitor(IDC). By utilizing a large-sized CPW with the T-type EC structure, fluctuations in the effective coupling strength can be reduced to 10%, given typical micro-nanofabrication variances. The numerical simulations presented in this work minimize the influence of fabrication deviations, thereby significantly improving the reliability of Purcell filter designs.

关键词： superconducting circuit Purcell filter coplanar waveguide capacitor structure

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堰塞湖应急抢险技术综述

人民长江 2024年第4期55卷 2-8页

作者：蔡耀军徐轶长江勘测规划设计研究有限责任公司湖北武汉430010 国家大坝安全工程技术研究中心湖北武汉430010

壅水量大、短时间溃决的堰塞湖是威胁公共安全的重大自然灾害。受资料匮乏、交通不便或完全中断、环境险恶、处置窗口期短等多种因素制约,高风险堰塞湖应急抢险难度极大,是当今世界极具挑战的工程技术难题。对堰塞湖应急抢险技术进行归... 详细信息

壅水量大、短时间溃决的堰塞湖是威胁公共安全的重大自然灾害。受资料匮乏、交通不便或完全中断、环境险恶、处置窗口期短等多种因素制约,高风险堰塞湖应急抢险难度极大,是当今世界极具挑战的工程技术难题。对堰塞湖应急抢险技术进行归纳与总结,对于提高堰塞湖防灾减灾技术水平十分必要。从堰塞湖漫顶冲刷溃决机理、风险辨识方法、应急抢险技术及施工技术装备等方面综述了堰塞湖应急抢险技术,可以为今后堰塞湖灾害的应急抢险提供理论、方法和技术装备支撑,同时也指出了现有应急抢险技术研究中的不足和仍需进一步发展的方向,可对今后相关研究起到一定的借鉴意义。

关键词：堰塞湖应急抢险漫顶溃决机理风险辨识抢险装备

大兴安岭北部次生林演替过程中物种多样性的变化及其影响因子

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植物生态学报 2024年第3期48卷 349-363页

作者：牛一迪蔡体久东北林业大学林学院东北林业大学森林生态系统可持续经营教育部重点实验室哈尔滨150040

物种多样性是生物多样性的重要组成部分。森林演替过程中物种多样性的变化会直接影响生态系统功能和稳定性。因此,揭示森林演替过程中物种多样性变化及其与影响因子之间的关系,对于准确预测森林生态过程和生物多样性格局具有重要意义。... 详细信息

物种多样性是生物多样性的重要组成部分。森林演替过程中物种多样性的变化会直接影响生态系统功能和稳定性。因此,揭示森林演替过程中物种多样性变化及其与影响因子之间的关系,对于准确预测森林生态过程和生物多样性格局具有重要意义。该研究选择大兴安岭北部白桦(Betula platyphylla)林(演替前期)、白桦-兴安落叶松(Larix gmelinii)混交林(演替中期)和兴安落叶松林(演替后期)为研究对象,采用空间代替时间的研究方法,分析我国寒温带地区森林演替过程中物种多样性的变化规律及其与影响因子之间的关系。结果表明:(1)大兴安岭北部森林演替过程中物种丰富度和多样性呈显著增加趋势,演替初期Margalef丰富度指数和Shannon-Wiener多样性指数分别为2.42和2.69,演替末期则分别为5.90和3.43;而物种Pielou均匀度指数无显著差异。(2)随森林演替的进行,植物群落的相似性逐渐降低,差异性逐渐增强,Jaccard指数、Sorenson指数和Bray-Curtis指数均减小。(3)森林演替过程中土壤pH、有机质含量、全氮含量和全磷含量对物种多样性存在显著影响,其中全氮含量和全磷含量是演替前期和中期物种多样性的主要影响因子,土壤pH和有机质含量是影响演替后期物种多样性的主要因子。(4)随着演替的进行,林分空间结构对物种多样性的影响逐渐增强,角尺度和大小比数是影响物种多样性的主要空间结构因子。以上结果表明大兴安岭北部森林演替过程中土壤因子对物种多样性具有主导作用,而林分空间结构对森林演替过程中物种多样性的驱动作用也不容忽视。

关键词：大兴安岭次生演替物种多样性土壤性质林分结构

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Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang yin Lin Xiao-Qi Yuan Ren-Yuan Gao Xiao-cai Wu Wei-Wei Xu Tian-Qi Wu Kai Xia yi-Ran Jiao Lu yin Chun-Qiu Chen Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Due to the complexity and numerous comorbidities associated with Crohn’s disease(CD),the incidence of postoperative complications is high,significantly impacting the recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to either a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the training cohort,with model discrimination evaluated using the area under the curves(AUC).The validation cohort assessed the performance of the constructed *** Out of the 259 patients encompassed in the study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the logistic model was 0.916,significantly lower than the AUC of 0.965 for the RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminished preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the logistic model was *** for the surgical approach,the other three variables ranked among the top four important variables in the novel ML *** Both the nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the RF model showing more superiority.A preoperative CDAI of≥220,a di-minished preoperative serum albumin level,and an extended operation time might be the most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

Endoscopic polidocanol foam sclerobanding for the treatment of grade II-III internal hemorrhoids:A prospective,multi-center,randomized study

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World Journal of Gastroenterology 2024年第27期30卷 3326-3335页

作者： Chun-ying Qu Fei-Yu Zhang yi Zhang Ming-Ming Li Zheng-Hong Li Mei-Hong cai Lei-Ming Xu Feng Shen Wen Wang Wu-Lian Lin Feng-Yu Gao Hao Zhang Guang-Yu Chen Department of Gastroenterology&Endoscopy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina Department of Endoscopy Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014Shandong ProvinceChina Department of Endoscopy Baoshan People’s Hospital of Yunnan ProvinceBaoshan 678000Yunnan ProvinceChina Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural *** To evaluate satisfaction,long-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and *** This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary hospitals and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL *** patients were followed-up for 12 ***-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile *** One hundred and ninety-five patients were enrolled,with 98 in the EFSB *** was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12-month[2.0(1.0-3.0)vs 3.0(2.0-3.0),P<0.001]of *** prolapse recurrence rate was lower in the EFSB group at 12 months(11.2%vs 21.6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.843,95%CI:0.595-1.092,P<0.001)were negatively and independently associated with the VAS score 24 hours *** median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),P<0.001].CONCLUSION Cap-assisted EFSB provided long-term satisfaction and effective relief from the recurrence of prolapse and pain 24 hours post-procedure.

关键词： Internal hemorrhoids Endoscopic therapy Polidocanol foam Sclerotherapy Rubber band ligation Sclerobanding

Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao Zhang Yue-Bin Zhang Duo-Te cai Tao Pan Ken Chen yi Jin Wen-Juan Luo Zong-Wei Huang Qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm to<3 mm),moderate(≥3 mm to<10 mm),and severe(≥10 mm)was observed in 17,17,and 2 rats in the surgical group,respectively,while no dilation was observed in the control and sham surgical *** levels of alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

基于投票机制的暖通空调空气处理单元传感器故障诊断

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电子与信息学报 2024年第1期46卷 258-266页

作者：严颖蔡骏吴奇张欣杨溢南京信息工程大学自动化学院南京210044 南京信息工程大学大气环境与装备技术协同创新中心南京210044 中国民用航空飞行学院广汉618307 上海交通大学电子信息与电气工程学院上海200240 浙江大学电气工程学院杭州310027

现有暖通空调(HVAC)空气处理单元(AHU)的故障诊断研究往往是集中式的。少量的分布式方法大多需要求解大量耗时的优化问题,使得无法及时完成故障诊断。针对以上挑战,该文提出一种基于投票机制的分布式故障诊断方法。在该方法中,建立一个... 详细信息

现有暖通空调(HVAC)空气处理单元(AHU)的故障诊断研究往往是集中式的。少量的分布式方法大多需要求解大量耗时的优化问题,使得无法及时完成故障诊断。针对以上挑战,该文提出一种基于投票机制的分布式故障诊断方法。在该方法中,建立一个玻尔兹曼机来描述传感器网络,通过传感器之间的相互投票来确定玻尔兹曼机的边权值,基于边权值对玻尔兹曼机的状态也就是传感器的状态进行迭代,从而定位传感器的故障。设计了一种基于欧氏距离的投票策略确定投票值。开发了一种方法,通过在玻尔兹曼机中增加一个额外的节点来重置其权值矩阵,在将玻尔兹曼机对称化的同时,保持原来各传感器之间的投票关系,以保证玻尔兹曼机状态的迭代收敛。该方法不需要求解大量的优化问题,相较于当前的分布式方法计算量小。使用ASHRAE Project RP-1312提供的实际数据对所提方法进行验证。实验结果表明所提方法可以精确且高效地诊断出空气处理单元传感器的偏差故障和漂移故障。

关键词：故障诊断投票机制分布式传感器玻尔兹曼机

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中国特殊医学用途配方食品发展历程

临床儿科杂志 2024年第2期42卷 93-95页

作者：冯一蔡威上海交通大学医学院附属新华医院临床营养科上海交通大学医学院附属新华医院小儿外科上海市儿科医学研究所特医食品研究室上海市小儿消化与营养重点实验室上海200092

特殊医学用途配方食品(FSMP)又称特医食品,在中国的发展历程中,经历了从无到有,从引进到自主研发的转变。本文梳理了中国特医食品的发展脉络,探讨其在临床应用、产品种类、研发能力以及法规标准管理等方面的进展,我们也可以看到中国特... 详细信息

特殊医学用途配方食品(FSMP)又称特医食品,在中国的发展历程中,经历了从无到有,从引进到自主研发的转变。本文梳理了中国特医食品的发展脉络,探讨其在临床应用、产品种类、研发能力以及法规标准管理等方面的进展,我们也可以看到中国特医食品行业面临的挑战和机遇。随着国内外市场的不断扩大和技术的不断进步,特医食品将在临床营养治疗领域发挥越来越重要的作用。

关键词：特殊医学用途配方食品临床营养法规标准