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Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang yan Li Li-chao Sun Xiao-yu Liu Nan Gao sheng-tao yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its ***:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ *** was intraperitoneally injected 2 h before *** data(blood pressure and heart rate) were *** intestinal microcirculation data of the rats were analyzed via microcirculation ***-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the *** analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in *** expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western ***:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory ***,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small ***:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

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Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-lnduced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells

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Chinese Medical Journal 2018年第8期131卷 950-955页

作者： Guo-Qiang Zhang Yong-Kang tao Yong-Ping Bai sheng-tao yan Shui-Ping Zhao Department of Emergency China-Japan Friendship Hospital Beijing 100029 China Department of Geriatric Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Cardiology The Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Background：Oxidized low-density lipoprotein （ox-LDL）-induced oxidative stress and endothelial apoptosis are essential for atherosclerosis. Our previous study has shown that ox-LDL-induced apoptosis is mediated by the protein kinase RNA-like endoplasmic reticulum kinase （PERK）/eukaryotic translation initiation factor 2α-subunit （eIF2α）/CCAAT/enhancer-binding protein homologous protein （CHOP） endoplasmic reticulum （ER） stress pathway in endothelial cells. Statins are cholesterol-lowering drugs that exert pleiotropic effects including suppression of oxidative stress. This study aimed to explore the roles of simvastatin on ox-LDL-induced ER stress and apoptosis in endothelial ***：Human umbilical vein endothelial cells （HUVECs） were treated with simvastatin （0.1, 0.5, or 2.5 μmol/L） or DEVD-CHO （selective inhibitor of caspase-3, 100 μmol/L） for 1 h before the addition of ox-LDL （100 μg/ml） and then incubated for 24 h, and untreated cells were used as a control group. Apoptosis, expression of PERK, phosphorylation of eIF2α, CHOP mRNA level, and caspase-3 activity were measured. Comparisons among multiple groups were performed with one-way analysis of variance （ANOVA） followed by post hoc pairwise comparisons using Tukey’s tests. A value of P 〈 0.05 was considered statistically ***：Exposure of HUVECs to ox-LDL resulted in a significant increase in apoptosis （31.9% vs. 4.9%, P 〈 0.05）. Simvastatin （0.1, 0.5, and 2.5 μmol/L） led to a suppression of ox-LDL-induced apoptosis （28.0%, 24.7%, and 13.8%, F = 15.039, all P 〈 0.05, compared with control group）. Ox-LDL significantly increased the expression of PERK （499.5%, P 〈 0.05） and phosphorylation of eIF2α （451.6%, P 〈 0.05）, if both of which in the control groups were considered as 100%. Simvastatin treatment （0.1, 0.5, and 2.5 μmol/L） blunted ox-LDL-induced expression of PERK （407.8%, 339.1%, and 187.5%, F = 10.121, all P 〈 0.05, compared with control group） and phosphorylation of eIF2α （407.8%, 339.

关键词： Apoptosis Endoplasmic Reticulum Stress Endothelial Cells Oxidized Low-Density Lipoprotein Simvastatin

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Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study

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World Journal of Emergency Medicine 2022年第5期13卷 355-360页

作者： Fei Shao Xian Shi Shu-hua Huo Qing-yu Liu Ji-xue Shi Jian Kang Ping Gong sheng-tao yan Guo-xing Wang Li-jie Qin Fei Wang Ke Feng Feng-ying Chen Yong-jie Yin tao Ma yan Li yang Wu Hao Cui Chang-xiao Yu Song yang Wei Gan Sai Wang Liu-ye-zi Du Ming-chen Zhao Zi-ren Tang Shen Zhao Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Medicine Hebei Yanda HospitalLangfang 065201China Department of Emergency Medicine Beijing Huairou HospitalBeijing 101400China Department of Emergency Medicine the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Emergency Medicine the Second Affi liated Hospital of Shandong First Medical UniversityTai’an 271000China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China Department of Emergency Medicine Henan Provincial People’s HospitalZhengzhou 450003China Department of Emergency Medicine Beijing Tsinghua Changung HospitalBeijing 102218China Department of Emergency Medicine General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Emergency Medicine the Affi liated Hospital of Inner Mongolia Medical UniversityHohhot 010050China Department of Emergency Medicine the Second Hospital of Jilin UniversityChangchun 130021China Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Department of Emergency Medicine the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Big Data Research Goodwill Hessian Health Technology Co.Ltd.Beijing 100085China School of Public Health Peking UniversityBeijing 100083China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing 100020China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:This study aimed to establish an eff ective nomogram to predict the survival of heat stroke(HS)based on risk ***:This was a retrospective,observational multicenter cohort *** analyzed patients diagnosed with HS,who were treated between May 1 and September 30,2018 at 15 tertiary hospitals from 11 cities in Northern ***:Among the 175 patients,32 patients(18.29%)died before hospital *** the univariate analysis,mechanical ventilation,initial mean arterial pressure<70 mmHg,maximum heart rate,lab results on day 1(white blood cell count,alanine aminotransferase,creatinine),and Glasgow admission prediction score were included in multivariate *** Cox regression showed that invasive ventilation,initial mean arterial pressure<70 mmHg(1 mmHg=0.133 kPa),and Glasgow admission prediction score were independent risk factors for *** nomogram was established for predicting 7-d and 14-d survival in the training *** nomogram exhibited a concordance index(C-index)of 0.880(95%confidence interval[95%CI]0.831-0.930)by bootstrapping validation(B=1,000).Furthermore,the nomogram performed better when predicting 14-d survival,compared to 7-d *** prognostic index cut-off value was set at 2.085,according to the operating characteristic curve for overall survival *** model showed good calibration ability in the internal and external validation ***:A novel nomogram,integrated with prognostic factors,was proposed;it was highly predictive of the survival in HS patients.

关键词： Heat stroke Nomogram Survival Prognosis

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The renaissance of oxo synthesis: heterogeneous Rh-catalyzed hydroformylation

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Science China Chemistry 2025年

作者： tao yan Zhi Cao State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences National Energy Center for Coal to Clean Fuels Synfuels China Technology Co. Ltd.

Hydroformylation could convert olefins and syngas （mixture of H2and CO） into aldehydes with a great atomic *** transformation serves as one of the most prominent processes in modern chemical industry, as it provides over 10million tons of aldehydes as feedstock for our daily essential products such as plasticizers, paints, solvents, and pharmaceuticals. This process generally requires efficient yet robust catalyst to realize decent efficacy. Compared with metals such as Co, Ru, and Pd, rhodium （Rh）-based catalysts stand out due to its superior activity even under mild reaction conditions, and dominate over 70%of global hydroformylation processes.

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu tao Wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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基于透明质酸的刺激响应纳米给药系统的研究进展

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中国新药与临床杂志 2021年第5期40卷 330-335页

作者：陶胜岩王梅翟光喜山东大学药学院药剂学教研室山东济南250012 山东第一医科大学附属省立医院科教处山东济南250021

透明质酸(HA)因具有良好的生物相容性、生物可降解性、非免疫原性及可作为肿瘤细胞表面过表达CD44受体的配体的特点,在抗肿瘤纳米给药载体中得到广泛应用。纳米给药载体与CD44受体结合富集于肿瘤细胞表面后,以HA为配体的纳米给药载体在... 详细信息

透明质酸(HA)因具有良好的生物相容性、生物可降解性、非免疫原性及可作为肿瘤细胞表面过表达CD44受体的配体的特点,在抗肿瘤纳米给药载体中得到广泛应用。纳米给药载体与CD44受体结合富集于肿瘤细胞表面后,以HA为配体的纳米给药载体在外源性刺激物(如加热升温、施加外部磁场、近红外光照射等)的作用下,纳米药物载体释放药物,实现肿瘤的靶向给药;而当药物载体被内吞入肿瘤细胞后,在肿瘤内环境的pH值、氧化还原电位、酶等内源性刺激物的作用下药物载体裂解释放出抗癌药物。双重或多重刺激响应的纳米给药载体能够更好的控制药物传递和释放,具有良好的癌症靶向治疗潜力。

关键词：透明质酸刺激响应性聚合物药物载体肿瘤靶向

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang Li-Shuo Zheng Yu-tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

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中枢神经系统感染患儿抗菌药物应用分析

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食品与药品 2011年第7期13卷 271-274页

作者：王梅陶胜岩张强山东大学附属省立医院药剂科山东济南250021 山东博士伦福瑞达制药有限公司山东济南250101

目的了解我院近年儿科中枢神经系统感染的发病情况及抗菌药物应用的情况。方法回顾调查分析儿科2008～2009年度中枢神经系统感染出院331例的病例,统计患儿年龄、病原学、抗菌药物种类、用量用法、用药时间等。结果我院中枢神经系统感染... 详细信息

目的了解我院近年儿科中枢神经系统感染的发病情况及抗菌药物应用的情况。方法回顾调查分析儿科2008～2009年度中枢神经系统感染出院331例的病例,统计患儿年龄、病原学、抗菌药物种类、用量用法、用药时间等。结果我院中枢神经系统感染患儿以病毒感染最为常见。抗菌药物主要应用三代头孢菌素、青霉素类。结论我院中枢神经系统感染患儿抗菌药物应用基本合理,需要采取措施进一步提高病原菌送检率。

关键词：儿童中枢神经系统感染抗感染药

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灼烧温度对单一稀土氧化物粒度、比表面积和形貌的影响(Ⅰ)

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中国稀土学报 2001年第4期19卷 378-380页

作者：张亚文严铮洸廖春生贾江涛严纯华北京大学稀土材料化学及应用国家重点实验室北京100871

分别以稀土元素Y ,Pr ,Nd ,Sm ,Eu ,Tb ,Dy ,Er和Lu的草酸盐为前体原料 ,固定灼烧时间为 3h ,在 80 0～ 15 0 0℃范围内不同灼烧温度下制备了系列单一稀土氧化物。利用Coulter计数法、比表面积分析仪和扫描电镜研究了灼烧温度对稀土氧... 详细信息

分别以稀土元素Y ,Pr ,Nd ,Sm ,Eu ,Tb ,Dy ,Er和Lu的草酸盐为前体原料 ,固定灼烧时间为 3h ,在 80 0～ 15 0 0℃范围内不同灼烧温度下制备了系列单一稀土氧化物。利用Coulter计数法、比表面积分析仪和扫描电镜研究了灼烧温度对稀土氧化物的粒度、比表面积和形貌的影响。结果表明 ,各稀土氧化物的中位粒径和团聚程度随灼烧温度升高而增大 ,而比表面积则逐渐减小。

关键词：稀土稀土氧化物灼烧温度粒度比表面积形貌热分解制备

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： yan LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN sheng XIN yanG MANZHAO OUyanG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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