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足球的基本形态及其价值属性

天津体育学院学报 1999年第3期14卷 1-4页

作者：张德胜施俊咸宁师范高等专科学校·教务处

从体育本体的角度切入,将体育分为Play, Gam e, Sports, Sport 四个层面,对不同层面上的足球的不同表现形态及其价值属性,进行哲学与美学、历史与文化分析。

关键词：体育足球价值属性体育美学体育文化

WORKING PRINCIPLE AND DESIGN OF A LINEAR ULTRASONIC MOTOR WITH RING-TYPE STATOR

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WORKING PRINCIPLE AND DESIGN OF A LINEAR ULTRASONIC MOTOR WI...

DESIGN AND ANALYSIS OF A CYLINDRICAL STANDING WAVE ULTRASONIC MOTOR USING CANTILEVER AND SANDWICH TYPE TRANSDUCERS

2015全国压电和声波理论及器件技术研讨会

作者： Ji-peng YAN Ying-xiang LIU sheng-jun shi Xiu-hua NI Huai-yin XIONG State Key Laboratory of Robotics and System Harbin Institute of Technology Shanghai Radio Equipment Research Institute

This paper presents a new idea for constructing ring-type linear ultrasonic *** stator of proposed motor contains two driving feet,sixteen pieces of piezoelectric ceramic plates and three rings-inner ring,middle ring and outer *** proposed ultrasonic motor forms elliptical movements on the driving feet by the superposition of stretching and bending vibration of the metal *** paper presents the working principle of proposed *** using FEM method,the proposed motor is designed and *** adjusting the structure parameters,the resonance frequencies of two working modes were tuned to be *** by transient analysis,the elliptical motion trajectories of nodes on the driving feet are obtained and verify the theoretical feasibility.

关键词： Ultrasonic motor Linear driving Ring-type Axial bending mode Radial stretching mode

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DESIGN AND ANALYSIS OF A CYLINDRICAL STANDING WAVE ULTRASONI...

Anti-depression effect of Xiao-yao-san series prescriptions with plasma NMR metabolomics

第三届全国压电和声波理论及器件技术研讨会

作者： Ying-xiang LIU,Wei-shan CHEN,jun-kao LIU,sheng-jun shi State Key Laboratory of Robotics and System,Harbin Institute of Technology, 92 West Dazhi Street,Harbin,Heilongjiang Province,China

A cylindrical standing wave ultrasonic motor using cantilever and sandwich type transducers was proposed in this paper. There are four pairs of cantilevers outside the cylindrical stator,and four PZT ceramics are set between each pair of *** PZT ceramics together with a pair of cantilevers compose a longitudinal *** bending mode of cylindrical stator is excited by the longitudinal vibration of PZT ***,linear simple harmonic motions are achieved at the particle on the *** the frictional force between rotor and stator is the driving force to realize the rotational motion of *** PZT ceramics work with d mode,which have high electromechanical coupling efficiency and could improve the output *** working principle of proposed motor was *** cylinder and longitudinal transducer were designed with *** sensitive parameters of resonant frequency of transducers and cylinder were gained with modal *** longitudinal resonant frequency of transducers and bending resonant frequency of cylinder were degenerated,and the motion trajectories of nodes on the teeth were *** results of this study could be useful in the development of this new type of ultrasonic motor.

关键词： Ultrasonic motor cylindrical cantilever type longitudinal transducer FEM

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Anti-depression effect of Xiao-yao-san series prescriptions ...

Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

中国药理学会第十一次全国学术会议

作者： TIAN jun-sheng,shi Bi-yun,GUO Xiao-qing,QIN Xue-mei (Modern Research Center for Traditional Chinese Medicine of Shanxi University,Shanxi 030006,China)

OBJECTIVE To discriminate the anti-depression effect of Xiao-yao-san series prescriptions on forced swimming test (FST) rat model with *** The forced swimming test rat model was used to evaluate the action of antidepressant and the rat plasma was collected ***-yao-san(XY),Dan-zhi-xiao-yao-san(DZ) and Chai-hu-shu-gan-san (CH) formula were extracted with aqueous solution,and the final concentration was 46.3,48.9 and 7.9 g·kg(the total amount of crude drug),respectively.54 rats were divided into 6 groups *** saline,velafaxin and Xiao-yao-san series extractions were orally treated to the rat groups for 2 weeks.A metabonomics method was used to evaluate the pathogenesis of depression and the mechanism of Xiao-yao-san *** samples were prepared and measured using NMR,and the data were processed with Microsoft Excel or analyzed by SIMCA-P *** importance in projection statistics and loading plot were used to screen relative *** Significant difference was observed between the FST group and control group,which was an illustration that the pharmacological model was duplicated *** effect of Xiao-yao-san was similar to that of positive drug venlafaxin,while the effect of Dan-zhi-xiao-yao-san and Chai-hu-shu-gan-san is not as good as *** with the control group,significant changes were observed in lactate,thrronine,Glu,choline,glucose in serum of positive and Xiao-yao-san *** The NMR analysis suggested that Xiao-yao-san prescription was of significant anti-depression effect which is better than the effect of Dan-zhi-xiao-yao-san and *** forced swimming test rat model is a mature model to evaluate the pathogenesis of depression and to discriminate the anti-depression effect of Xiao-yao-san series prescriptions.

关键词： Xiaoyaosan series prescriptions depression metabonomics NMR mechanism

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Science China Life Sciences 2025年

作者： shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng jun Xu Department of Cell Biology School of Basic Medical Sciences Peking University Stem Cell Research Center Peking University Health Science Center Peking University Academy of Advanced Interdisciplinary Studies Peking University BeiCell Therapeutics School of Life Sciences Center for Bioinformatics Center for Statistical Science Peking University MOE Engineering Research Center of Regenerative Medicine School of Basic Medical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Human primed pluripotent stem cells are capable of generating all the embryonic ***,their extraembryonic trophectoderm potentials are *** remains unclear how to expand their developmental potential to trophectoderm *** we show that transient treatment with a cocktail of small molecule epigenetic modulators imparts trophectoderm lineage potentials to human primed pluripotent stem cells while preserving their embryonic *** chemically treated cells can generate trophectoderm-like cells and downstream trophoblast stem cells,diverging into syncytiotrophoblast and extravillous trophoblast *** and CUT&Tag analyses reveal that these induced cells share transcriptional profiles with in vivo trophectoderm and cytotrophoblast,and exhibit reduced H3K27me3 modification at gene loci specific to trophoblast lineages compared with primed pluripotent *** exploration highlighted the critical roles of epigenetic modulators HDAC2,EZH1/2,and KDM5s in the activation of trophoblast lineage *** findings demonstrate that transient epigenetic resetting activates unrestricted lineage potential in human primed pluripotent stem cells,and offer new mechanistic insights into human trophoblast lineage specification and in vitro models for studying placental development and related disorders.

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风力机翼型同相对厚度条件下的气动性能模拟分析

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水电能源科学 2011年第3期29卷 185-187页

作者：王军盛杰施璐邹方茂华中科技大学能源与动力工程学院湖北武汉430074

针对翼型气动性能优劣将直接影响风力机使用过程中的效率问题,选取3种具有相同相对厚度(相对厚度为21%)而形状不同的常用风力机翼型NACA0021、NACA63421和S809进行二维建模和网格划分,对比3种翼型形状上的差异,并利用Fluent取雷诺数为5.... 详细信息

针对翼型气动性能优劣将直接影响风力机使用过程中的效率问题,选取3种具有相同相对厚度(相对厚度为21%)而形状不同的常用风力机翼型NACA0021、NACA63421和S809进行二维建模和网格划分,对比3种翼型形状上的差异,并利用Fluent取雷诺数为5.5×105时对其空气动力学性能进行数值模拟和分析,获得了不同攻角下3种翼型的升阻力系数和升阻比,并与试验数据进行对比验证。结果表明,3种风力机翼型中,在相同相对厚度、较低雷诺数条件下,具备一定弯度的风力机翼型NACA63421的气动性能优于其他2种,为风力机叶片翼型选型与改型设计提供了参考。

关键词：风力机翼型相对厚度数值模拟气动性能

(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis

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World Journal of Gastroenterology 2007年第8期13卷 1162-1169页

作者： Bao-He Zhu, Wen-Hua Zhan, Zheng-Rong Li, Zhao Wang, Yu-Long He, jun-sheng Peng, shi-Rong Cai, Jin-Ping Ma, Chang-Hua Zhang, Department of Gastrointestinal & Pancreatic Surgery, First Affiliated Hospital, Sun Yat-Sen University Gastric Center of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China Department of Gastrointestinal & Pancreatic Surgery First Affiliated Hospital Sun Yat-Sen University Gastric Center of Sun Yat-Sen University Guangzhou 510080 Guangdong Province China. wenhuazhanwcwk@***

AIM： To investigate the effect of （-）-epigallocatechin-3-gallate （EGCG） on growth of gastric cancer and its possible mechanism. METHODS： Heterotopic tumors were induced by subcutaneously injection of SGC-7901 cells in nude mice. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Vascular endothelial growth factor （VEGF） protein level and activation of signal transducer and activator of transcription 3 （Star3） were examined by Western blotting. VEGF mRNA expression was determined by RT-PCR and VEGF release in tumor culture medium by ELISA. VEGF-induced cell proliferation was studied by MTT assay, cell migration by gelatin modified Boyden chamber （Transwell） and in vitro angiogenesis by endothelial tube formation in Matrigel. RESULTS： Intraperitoneal injection of EGCG inhibited the growth of gastric cancer by 60.4%. MVD in tumor tissues treated with EGCG was markedly reduced. EGCG treatment reduced VEGF protein level in vitro and in vivo. Secretion and mRNA expression of VEGF in tumor cells were also suppressed by EGCG in a dose-dependent manner. This inhibitory effect was associated with reduced activation of Star3, but EGCG treatment did not change the total Star3 expression. EGCG also inhibited VEGF-induced endothelial cell proliferation, migration and tube formation. CONCLUSION： EGCG inhibits the growth of gastric cancer by reducing VEGF production and angiogenesis, and is a promising candidate for anti-angiogenic treatment of gastric cancer.

关键词： Epigallocatechin-3-gallate Angiogenesis Migration Tube formation Vascular endothelial growth factor Signal transducer and activator of transcription 3 Gastric cancer

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COD测定方法的发展与研究动态

四川环境 2005年第1期24卷 40-43页

作者：唐圣钧石磊赵由才同济大学污染控制与资源化研究国家重点实验室上海200092

本文较为全面地论述了COD测定方法的发展与研究现状。在论述了国标中COD标准方法不足之处的基础上,本文就标准方法的众多改进措施分类进行了比较与探讨,包括消解方法的改进、替代催化剂的研究以及氯离子干扰的消除,然后介绍了相关系数... 详细信息

本文较为全面地论述了COD测定方法的发展与研究现状。在论述了国标中COD标准方法不足之处的基础上,本文就标准方法的众多改进措施分类进行了比较与探讨,包括消解方法的改进、替代催化剂的研究以及氯离子干扰的消除,然后介绍了相关系数法、电化学法、分光光度法和流动注射法等COD测定替代技术。本文认为,研究试剂用量少、无污染的绿色COD测定方法具有重要而积极的意义,而研究适应性强、运行可靠、性价比高的COD在线监测仪则是COD监测的发展趋势。

关键词：化学需氧量(COD) 测定方法改进研究动态绿色

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening