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Promoting osteogenic differentiation in pre-osteoblasts and reducing tibial fracture healing time using functional nanofibers

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Nano Research 2018年第7期11卷 3658-3677页

作者： Gu cheng Jiajia Chen Qun Wang Xuewen Yang Yuet cheng Zhi Li Hu Tu Hongbing Deng Zubing Li The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology & Department of Oral and Maxillofacial Trauma and Plastic Surgery Wuhan University Stomatological Hospital Wuhan University Wuhan 430079 China Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology School of Resource and Environmental Science Wuhan University Wuhan 430079 China Department of Chemical and Biological Engineering Iowa State University Ames IA 50014 USA

Various composite materials are now used as artificial tissue substitutes, and are defining new frontiers in tissue engineering. In the present study, composite membranes based on silk fibroin （SF） were fabricated to form a synthetic periosteum. The fabricated membranes were physicochemically characterized by their morphology, porosity, biocompatibility, biodegradability, chemical structure, and mechanical properties. Following the addition of polycaprolactone （PCL） to the silk fibers, there was a 3-5-fold increase in the elongation at break compared with the pure silk membranes, and surface wettability was retained. The degradation time of the SF within the membranes was also prolonged by adding PCL. Compared with pure PCL membranes or plastic culture plates, the SF-based membranes significantly enhanced the cellular viability and osteogenic differentiation capability of MC3T3-E1 cells. Higher expression levels of osteogenic differentiation markers （runt-related transcription factor 2 （RUNX2）, alkaline phosphatase （ALP）, and osteopontin （OP）） further supported the use of the SF component in bone-related applications. A non-rigid internal fixation （non-RIF） fracture model that healed via endochondral bone formation was created, and fracture callus samples were collected to perform micro-computed tomography, histolog~ and immunohistochemistry analyses at 8 weeks after surgery. A smaller bone volume accompanied by a mineralized bony callus was observed in SF/PCL membrane-treated rats. Immunohistochemistry also indicated that the SF/PCL membrane-treated rats exhibited increased osteocalcin expression but reduced collagen type X expression. These findings could lead to an alternative strategy for treating comminuted fractures with enhanced intramembranous ossification and reduced endochondral ossification.

关键词： silk fibroin polycaprolactone scaffold bone tissue engineering

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Pure red cell aplasia caused by pegylated interferon-α-2a plus ribavirin in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2011年第16期17卷 2155-2158页

作者： cheng-Shyong Chang Hsuan-Yu Lin Fu-Lien Yu Chien-Yu Tsai sheng-Lei Yan Division of Hematology and Oncology Department of Internal MedicineChanghua Christian Hospital Graduate Institute of Nursing Chung Shan Medical University Division of Gastroenterology and Hepatology Department of Internal MedicineChang-Bing Show Chwan Memorial Hospital Department and Graduate Program of Bioindustrial Technology Dayeh University

Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia,reticulocytopenia and almost complete absence of erythroid precursors in bone *** pathophysiology of PRCA may be congenital or *** our knowledge,there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis *** report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis *** diagnosis of PRCA was confirmed by the typical findings of bone marrow *** possible etiologies of our case are also discussed in this paper.

关键词： Chronic hepatitis C Pegylated interferon-α2a Pure red cell aplasia Ribavirin

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The contribution of water molecules to the hydrogen evolution reaction

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Science China Chemistry 2022年第10期65卷 1854-1866页

作者： Chao cheng Mingming Deng Li Li Zidong Wei Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China The State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource UtilizationCollege of Chemistry and Chemical EngineeringChongqing UniversityChongqing 400044China

Traditionally,water molecules act as solvents in most chemical reactions,whereas they act as solvents and reactants in the alkaline electrolyte for the hydrogen evolution reaction(HER).It is well known that there is a current plateau in the linear potential–current dependence for HER in neutral or near-neutral electrolytes,showing that the HER is governed by the mass transport of reactive hydronium species at a given *** sharp rise in the current signal after the plateau at a slightly higher overpotential indicates that HER is supported by a new reactant,namely the water molecules rather than the limited hydronium ***,in combination with our own research experience in water electrolysis,we review the relevant literature in these years about the HER activity descriptor and mainly focus on the contribution of water molecules to the HER,including their dissociation,configuration,and composition in regulating the pH-dependent ***,we try to provide new insights into understanding the mechanism of the HER in terms of interfacial water enrichment,orientation,and configuration with the electric field strength of electrode/electrolyte interface and electrode compositions.

关键词： water electrolysis hydrogen evolution reaction interfacial water

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A novel subsidence monitoring technique based on space-surface bistatic differential interferometry using GNSS as transmitters

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Science China(Information Sciences) 2015年第6期58卷 68-83页

作者： ZENG Tao ZHANG Tian TIAN WeiMing HU cheng Beijing Key Laboratory of Embedded Real-time Information Processing Technology Radar Research Laboratory School of Information and ElectronicsBeijing Institute of Technology

Synthetic Aperture Radar Differential Interferometry(DIn SAR) technique is an effective tool with large coverage and high spatial accuracy for subsidence monitoring. Nevertheless, the temporal resolution is usually poor so that rapid deformation cannot be measured due to the long revisit time of radar *** SAR Differential Interferometry technique using Global Navigation Satellite System(GNSS) as illuminator has a shorter revisit time, whereas the measurement accuracy is constrained by low signal power, narrow bandwidth and atmospheric delay error. To cope with these problems, in this paper, we propose a novel subsidence monitoring technique based on Space-Surface bistatic Differential Interferometry(SS-DI) with GNSS transmitters, where two stations consist of a reference one and a measurement one that are deployed on the ground. First, we applied a space differential processing between two stations to cancel identical errors such as tropospheric and ionospheric errors etc. Then we used a long time coherent integration to improve the signal noise ratio. Subsequently, we also utilized a time differential processing to construct double differential equations with respect to unknown deformation variables. Finally, we solved the equations to obtain a highly accurate estimation of three dimension deformation. Furthermore, an SS-DI experiment using Beidou-2 as transmitters was carried out to validate the proposed method, where a high accuracy(0.01 mm) device was utilized to simulate subsidence deformation. The experimental results reveal that the proposed method has better performance of spatial measurement accuracy of 0.53 mm compared with differential GPS method.

关键词： differential interferometry subsidence monitoring Beidou-2/Compass-2 space-surface bistatic radar differential GPS

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Effect of chloride ions on 316L stainless steel in cyclic cooling water

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Acta Metallurgica Sinica(English Letters) 2010年第6期23卷 431-438页

作者： Zuojia LIU Xuequn cheng shengjie LU Xiaogang LI Key Laboratory of Corrosion and Protection (Mi-nistry of Education of China University of Science and Technology Beijing Beijing 100083 China Equipment and Power Department Shijiazhuang Refine N: Chemical Company Limited SINOPEC Shijiazhuang 050032 China

The effect of Cl^- on the 316L stainless steel in simulated cooling water has been studied using polarization curves, electrochemical impedance spectroscopy （EIS）, Mott- Schottky plot and scanning electron microscopy （SEM） techniques. Cl^- concentrations vary from 200 to 900 mg/L. Results reveal that the corrosion resistance increases with the decrease of Cl^- concentration in simulated cooling water. The increase of Cl^- concentration leads to the shift of the corrosion potential towards the positive direction. Mott-Schottky curves show that in the passive film, Cr2Oa and FeO at the inner layer exhibit P-type but Fe2O3 and CrOa （CrO4^2-） N-type semiconductive properties. The SEM/EDX data demonstrate that elements such as Fe, O, C, Si and Cl as well as the presence of calcium and aluminum are presented on the surface of the metal.

关键词： Polarization curve EIS Mott-Schottky plot SEM/EDX Simulated cyclic cooling water

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Antioxidant status following postprandial challenge of two different doses of tocopherols and tocotrienols

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Journal of Integrative Medicine 2020年第1期18卷 68-79页

作者： Syed Fairus Hwee Ming cheng Kalyana Sundram Malaysian Palm Oil Board Persiaran InstitusiBandar Baru Bangi43000 KajangSelangorMalaysia Faculty of Medicine University of Malaya50603 Kuala LumpurMalaysia Malaysian Palm Oil Council Jalan Perbandaran47301 Kelana JayaSelangorMalaysia

Objective:Tocotrienols(T3s)have been hypothesized to have greater antioxidant capacity than tocopherols(Ts)due to differences in biokinetics that affect their absorption and *** present trial compares the antioxidant effectiveness following postprandial challenge of two different doses ofα-T or palm T3-rich fraction(TRF)treatments and evaluates their dose-response effects on antioxidant ***:Ten healthy volunteers were given four different doses of vitamin E formulations(268 mgα-T,537 mgα-T,263 mg TRF or 526 mg TRF)in a cross-over postprandial *** was sampled at 0,2,4,5,6 and 8 hours after meal consumption and plasma antioxidant status including total glutathione,superoxide dismutase,malondialdehyde(MDA),ferric reducing antioxidant potential and trolox-equivalent antioxidant capacity,was ***:Supplementation with the different doses of eitherα-T or TRF did not significantly improve overall antioxidant *** was no significant difference in overall antioxidant status among treatments at the different doses ***,a significant dose-response effect was observed for plasma MDA throughout the 8-hour postprandial *** was significantly lower after the 537 mgα-T treatment,compared to the 268 mgα-T treatment;it was also lower after the 526 mg TRF treatment compared to the 263 mg TRF treatment(P<0.05).Conclusion:T3 andα-T demonstrated similar antioxidant capacity,despite markedly lower levels of T3 in blood and lipoproteins,compared toα-T.

关键词： Vitamin E Tocopherols Tocotrienols Antioxidants Postprandial

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Purification and characterization of anti-clotting protein component （ACPF-7221） from venom of Agkistrodon acutus

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Chinese Medical Journal 2009年第18期122卷 2169-2173页

作者： RUI Jing HUAI Jian-guo ZHANG Ye cheng dong-yun PAN Xue-bing Department of Surgery Yijishan Hospital Wannan Medical College Wuhu Anhui 241001 China Department of Oncology Yijishan Hospital Wannan Medical College Wuhu Anhui 241001 China

Background Snake venom contains a number of components with different pharmacological and biological activities, especially in cancer therapy, and has increasingly become a research focus. This study was designed to isolate and purify a novel anti-clotting protein component from the venom of Agkistrodon acutus, and to explore its physico-chemical properties and biological activity. Methods The venom of Agkistrodon was isolated and purified by ion-exchange chromatography on diethylaminoethyl （DEAE）-Sepharose Fast Flow, molecular sieve filtration through Sephadex G75, SP-Sepharose Fast Flow and molecular sieve filtration through Sephadex G50. We detected the activated partial thromboplastin time （APTT） of the eluant to select the anti-clotting protein component of interest. The molecular weight was determined by sodium dodecyl sulfate-polyacrylamid gel electrphoresis （SDS-PAGE） and liquid chromatography. Its protein content was detected by bicinchoninic acid （BCA）. Results SDS-PAGE vertical gel electrophoresis showed that the anticoagulant factor is a tripolymer composed of three proteins whose molecular weights are 25 KDa, 30 KDa and 50 KDa. The factor contains about 65% percent protein. Conclusions A novel anti-clotting protein component was purified by ion-exchange chromatography and molecular sieve filtration from the venom of Agkistrodon acutus and was found to be composed of three kinds of proteins.

关键词： Agkistrodon acutus anticoagulation purification high performance liquid chromatography

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东北严寒地区农村住宅热环境优化设计

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哈尔滨工业大学学报 2016年第10期48卷 183-188页

作者：甄蒙孙澄董琪哈尔滨工业大学建筑学院哈尔滨150006

为提高东北严寒地区农村住宅室内热舒适水平,并降低采暖能耗,通过实地测试、软件模拟对其重要影响因素进行了量化分析,并建立了采暖能耗预测模型.采用BES-01型温度采集记录器、De ST-h软件研究了体形系数、窗墙面积比、围护结构传热系... 详细信息

为提高东北严寒地区农村住宅室内热舒适水平,并降低采暖能耗,通过实地测试、软件模拟对其重要影响因素进行了量化分析,并建立了采暖能耗预测模型.采用BES-01型温度采集记录器、De ST-h软件研究了体形系数、窗墙面积比、围护结构传热系数、朝向、吸收系数、热惰性、附加阳光间、冰雪覆盖层等10项因素对农村住宅热环境的影响.实验结果表明:东北严寒地区农村住宅体形系数、窗墙面积比、围护结构传热系数与采暖能耗正相关,正南及南偏东为最佳朝向,吸收系数与采暖能耗负相关,附加阳光间能够有效改善室内热环境,冰雪覆盖层能够起到屋面保温作用,采暖能耗预测模型能够为农村居民建造节能住宅提供设计依据,研究能够引导并提升东北严寒地区农村住宅的节能设计水平.

关键词：东北严寒地区农村住宅采暖能耗预测模型

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The LGM refugia of deciduous oak and distribution development since the LGM in China

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Science China Earth Sciences 2023年第1期66卷 80-91页

作者： Qian HAO Hongyan LIU Ying cheng Zhaoliang SONG Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China College of Urban and Environmental Sciences Peking UniversityBeijing 100871China School of Geography and Tourism Shaanxi Normal UniversityXi’an 710119China

The distribution development of oak has significant effects on ecosystems and ***-term forest distribution studies can help to better understand the vegetation dynamics under climate change or human activities in the *** this study,we integrated different methods(i.e.,palaeoecology,phylogeography,and species distribution models)to investigate the likely locations of glacial refugia and the postglacial development of the main deciduous oak species(i.e.,Quercus variabilis,***,***,***,*** and ***).The results indicated that mountains such as the Changbai,Qinling,and Dabie Mountains acted as the refugia in northern and central China during the Last Glacial Maximum(LGM).The present Quercus in northern China could be the result of local dispersal during the postglacial period rather than only that of long-distance migration from south to *** was the main influencing factor for oak migration,while human activities did not show much influence on this widespread *** topography acted as a buffer and made the mountains act as refugia under a deteriorated *** with other main tree genera(e.g.,Pinus and Betula),the refugia locations and migration routes of deciduous oak species were different because of their physiological *** individual migration dynamics of these three genera need to be considered when modelling their dynamics.

关键词： Quercus Pollen analysis Species distribution model Chloroplast DNA Precipitation

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Machine Intelligence Research 2022年第1期19卷 24-37页

作者： Chun Yang Chang Liu Xu-cheng Yin Department of Computer Science and Technology University of Science and Technology BeijingBeijing 100083China

Various few-shot image classification methods indicate that transferring knowledge from other sources can improve the accuracy of the ***,most of these methods work with one single source or use only closely correlated knowledge *** this paper,we propose a novel weakly correlated knowledge integration(WCKI)framework to address these *** specifically,we propose a unified knowledge graph(UKG)to integrate knowledge transferred from different sources(i.e.,visual domain and textual domain).Moreover,a graph attention module is proposed to sample the subgraph from the UKG with low *** avoid explicitly aligning the visual features to the potentially biased and weakly correlated knowledge space,we sample a task-specific subgraph from UKG and append it as latent *** framework demonstrates significant improvements on multiple few-shot image classification datasets.

关键词： Computer vision pattern recognition knowledge refinement and reuse neural networks machine vision

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