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Design of a novel hybrid quantum deep neural network in INEQR images classification

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Chinese Physics B 2024年第6期33卷 230-238页

作者：王爽王柯涵程涛赵润盛马鸿洋郭帅 School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China School of Sciences Qingdao University of TechnologyQingdao 266033China

We redesign the parameterized quantum circuit in the quantum deep neural network, construct a three-layer structure as the hidden layer, and then use classical optimization algorithms to train the parameterized quantum circuit, thereby propose a novel hybrid quantum deep neural network(HQDNN) used for image classification. After bilinear interpolation reduces the original image to a suitable size, an improved novel enhanced quantum representation(INEQR) is used to encode it into quantum states as the input of the HQDNN. Multi-layer parameterized quantum circuits are used as the main structure to implement feature extraction and classification. The output results of parameterized quantum circuits are converted into classical data through quantum measurements and then optimized on a classical computer. To verify the performance of the HQDNN, we conduct binary classification and three classification experiments on the MNIST(Modified National Institute of Standards and Technology) data set. In the first binary classification, the accuracy of 0 and 4 exceeds98%. Then we compare the performance of three classification with other algorithms, the results on two datasets show that the classification accuracy is higher than that of quantum deep neural network and general quantum convolutional neural network.

关键词： quantum computing image classification quantum–classical hybrid neural network quantum image representation interpolation

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU sheng Hui HU Dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong tao Yong XU Song tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-tao Zhang Peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-sheng Zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age:Findings from the Ma’anshan Birth Cohort Study

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Environment & Health 2024年第9期2卷 651-660页

作者： Baolin Wang Feifei Han Peng Ding Juan Tong Kaiyong Liu Shuangqin Yan sheng Wang Guanjun Chen Xiaoyan Wu Kun Huang Menglong Geng Fangbiao tao School of Public Health Anhui Medical UniversityHefei 230032 AnhuiChina Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032 AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032 AnhuiChina Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course Anhui Medical UniversityHefei 230032 AnhuiChina Ma’anshan Maternal and Child Healthcare(MCH)Center Ma’anshan 243011China The Center for Scientific Research of Anhui Medical University Anhui Medical UniversityHefei 230032 AnhuiChina

ABSTRACT:Antibiotic exposure during pregnancy may affect the neurodevelopment of children,but biomonitoring-based population studies on this class of new pollutants are *** conducted a prospective birth cohort study of 2860 mother−child pairs,measured the urinary concentrations of 41 antibiotics and their two metabolites over three trimesters,and assessed children’s autism spectrum disorder(ASD)symptoms at 3 years of *** examined the associations between prenatal antibiotic exposure and children’s ASD *** least absolute shrinkage and selection operator regression screened for Tetracycline and Ofloxacin as important predictors of ASD *** Poisson regression models revealed that maternal Tetracycline exposure throughout pregnancy increased the risk of ASD symptoms(RR:1.66,95%CI:1.14,2.40).Maternal Tetracycline exposure during the first(RR:1.74,95%CI:1.13,2.68)and third trimesters(RR:1.86,95%CI:1.16,3.00)increased the risk of ASD symptoms in boys,and Ofloxacin exposure during the first trimester(RR:1.47,95%CI:1.07,2.02)increased the risk of ASD symptoms in *** dose-dependent relationships between prenatal antibiotic exposure and ASD symptoms were validated by restricted cubic *** exposure to Tetracycline and Ofloxacin may increase the risk of ASD symptoms in children,and the first and third trimesters might be the key windows.

关键词： Antibiotics Biomonitoring Urine biomarkers Prenatal exposure Autism Birth cohort

X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan Wan-Qing liao tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

A comprehensive review of recent advances in chronic pancreatitis

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Journal of Pancreatology 2024年第1期7卷 45-52页

作者： sheng-Han Mao Wen-Bin Zou Xiao-Tong Mao Zhao-Shen Li Zhuan liao Department of Gastroenterology Changhai HospitalThe Naval Medical UniversityShanghaiChina Shanghai Institute of Pancreatic Diseases ShanghaiChina

Chronic pancreatitis(CP)is a multifaceted disorder influenced by environmental and genetic factors,with smoking and alcohol consumption being major *** developments encompass the advent of innovative transgenic models and the identification of susceptibility genes,shedding light on the genetic aspect of *** pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction,inflammatory reactions,and *** research delves into understanding these molecular ***,a pivotal symptom of CP,has been increasingly studied to develop effective therapeutic *** advancements,including endoscopic ultrasound,radiomics,and blood-based markers,have shown potential in enhancing early CP ***,recent clinical trials have optimized treatment approaches,such as pancreatic stone fragmentation,stent placement,and decision-making between endoscopic and surgical *** therapies,including chemical pancreatectomy and gene therapy,present promising opportunities for improved CP management.

关键词： Chronic pancreatitis Diagnosis Endoscopy Etiology Mechanism Surgery

视觉语言模型引导的文本知识嵌入的小样本增量学习

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软件学报 2024年第5期35卷 2101-2119页

作者：姚涵涛余璐徐常胜多模态人工智能系统全国重点实验室(中国科学院自动化研究所) 北京100190 中国科学院大学人工智能学院北京100049 天津理工大学计算机科学与工程学院天津300384

真实场景往往面临数据稀缺和数据动态变化的问题,小样本增量学习的目的是利用少量数据推理数据知识并减缓模型对于旧知识的灾难性遗忘.已有的小样本增量学习的算法(CEC和FACT等)主要是利用视觉特征来调整特征编码器或者分类器,实现模型... 详细信息

真实场景往往面临数据稀缺和数据动态变化的问题,小样本增量学习的目的是利用少量数据推理数据知识并减缓模型对于旧知识的灾难性遗忘.已有的小样本增量学习的算法(CEC和FACT等)主要是利用视觉特征来调整特征编码器或者分类器,实现模型对于新数据的迁移和旧数据的抗遗忘.但是少量数据的视觉特征往往难以建模一个类别的完整特征分布,导致上述算法的泛化能力较弱.相比于视觉特征,图像类别描述的文本特征具有较好的泛化性和抗遗忘性.因此,在视觉语言模型的基础上,研究基于文本知识嵌入的小样本增量学习,通过在视觉特征中嵌入具有抗遗忘能力的文本特征,实现小样本增量学习中新旧类别数据的有效学习.具体而言,在基础学习阶段,利用视觉语言模型抽取图像的预训练视觉特征和类别的文本描述,并通过文本编码器实现预训练视觉特征到文本空间的映射.进一步利用视觉编码器融合学习到的文本特征和预训练视觉特征抽象具有高辨别能力的视觉特征.在增量学习阶段,提出类别空间引导的抗遗忘学习,利用旧数据的类别空间编码和新数据特征微调视觉编码器和文本编码器,实现新数据知识学习的同时复习旧知识.在4个数据集(CIFAR-100,CUB-200,Car-196和mini Image Net)上验证算法的有效性,证明基于视觉语言模型文本知识嵌入可以在视觉特征的基础上进一步提升小样本增量学习的鲁棒性.

关键词：小样本增量学习视觉语言模型文本知识嵌入类别空间引导的抗遗忘学习

Apple polyphenol phloretin inhibits type II glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

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Food Science and Human Wellness 2024年

作者： Han-sheng Chang Tzu-Chun Cheng Shih-Hsin Tu Pei-Han liao Yu-Ching Lee Chi-Tang Ho Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science & Technology， College of Life Sciences， China Medical University Institute of Biochemistry and Molecular Biology， College of Life Sciences， China Medical University Department of Surgery， School of Medicine， College of Medicine， Taipei Medical University Research Center of Cancer Translational Medicine， Taipei Medical University Department of Food Science， Rutgers University New Jersey， USA Institute of Food Sciences and Technology， Taiwan University

This study presents novel findings on the potential of phloretin， an apple polyphenol， to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity， significantly reducing cancer cell glucose uptake. We confirmed the overexpression of GLUT1 and GLUT2 mRNA in paired human breast tumor tissues， with GLUT2 overexpression associated explicitly with poorer survival rates in breast cancer patients. Treatment with phloretin was observed to increase the interaction between GLUT2 and HER2 proteins， attenuate glycolysis， and enhance the binding affinity of anti-HER2 antibody drugs to target human breast cancer cells. Furthermore， the efficacy of the combination therapy involving phloretin and antibody drugs was reaffirmed in a cell-derived xenograft (CDX) tumor animal model， particularly in suppressing the growth of Trastuzumab-resistant HER2+ breast cancer. These significant findings suggest that targeting GLUT2 activity with phloretin in combination with anti-HER2 antibody drugs may help mitigate the development of drug-resistant breast cancer， offering valuable insights for enhancing tumor treatment strategies and contributing to developing more effective therapies.

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Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng CUI Yao-Ming MA Yan WANG Jian-sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-Bo TANG Chao-Yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk