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Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

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Cellular & Molecular Immunology 2023年第1期20卷 38-50页

作者： Miao-Hsi Hsieh Pei-Chi Chen Han-Yin Hsu Jui-Chang Liu Yu-sheng Ho Yuh Jyh Lin Chin-Wei Kuo Wen-Shuo Kuo Hui-Fang kao Shulhn-Der Wang Zhi-Gang Liu Lawrence Shih-Hsin Wu Jiu-Yao Wang Center for Allergy Immunologyand Microbiome(A.I.M.)China Medical University HospitalTaichungTaiwanChina Graduate Institute of Basic Medical Sciences College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Nursing National Tainan Junior College of NursingTainanTaiwanChina Graduate Institute of Biochemistry and Molecular Biology College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Department of Pediatrics National Cheng Kung University HospitalTainanTaiwanChina Division of Pulmonary Medicine Department of Internal MedicineNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainanTaiwanChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjingChina School of post-Baccalaureate Chinese Medicine China Medical UniversityTaichungTaiwanChina Department of Respirology and Allergy Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Allergy Immunologyand Rheumatology(AIR)China Medical University Children’s HospitalTaichungTaiwanChina

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.

关键词： Alveolar macrophages Chronic obstructive pulmonary diseases Surfactant protein D Lipid metabolism Ozone Cigarettes

白酒厂污泥与生活污泥有机组分的差异性及其淋溶迁移风险评估

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应用化工 2024年第3期53卷 583-587页

作者：唐显梅刘方朱健陈祖拥刘元生贵州大学资源与环境工程学院贵州贵阳550025 贵州喀斯特环境生态系统教育部野外科学观测研究站贵州贵阳550025

通过对白酒厂污泥和生活污泥中腐植酸、低分子有机酸的含量对比分析,探讨两种污泥中有机组分的差异性及其淋溶迁移的环境风险。结果表明,酒厂污泥中有机质和腐植酸(NaOH浸提)平均含量分别为428.2,342.47 g/kg,平均比生活污泥中的含量高4... 详细信息

通过对白酒厂污泥和生活污泥中腐植酸、低分子有机酸的含量对比分析,探讨两种污泥中有机组分的差异性及其淋溶迁移的环境风险。结果表明,酒厂污泥中有机质和腐植酸(NaOH浸提)平均含量分别为428.2,342.47 g/kg,平均比生活污泥中的含量高47.7%,62.6%。从污泥浸提(H 3po 4浸提)的低分子有机酸含量,白酒厂污泥中柠檬酸和苹果酸含量分别达3.90,0.88 g/kg,分别是生活污泥的10.00倍和1.83倍;而生活污泥中的草酸含量达3.74 g/kg,是白酒厂污泥的2.94倍。两种污泥的腐植酸均含有丰富的羟基、酚羟基,而白酒厂污泥的腐植酸还含有丰富的羧基。两种污泥的6次连续淋溶的实验表明,生活污泥的淋溶液中,COD、NH_(4)^(+)-N含量范围分别为121.5~380.5,1.83~10.67 mg/L,平均比酒厂污泥高出55.8%,27.2%;而白酒厂污泥的淋溶液中,TP含量范围为0.84~1.90 mg/L,平均比生活污泥淋溶液中的含量高28.1%,白酒厂污泥有机组分淋溶迁移对水环境的影响小于生活污泥。综上所述,白酒厂污泥的有机组分及腐植酸的资源化利用优于生活污泥。

关键词：污泥腐植酸低分子有机酸淋溶迁移

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On the initiation,movement and deposition of a large landslide in Maoxian County,China

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Journal of Mountain Science 2018年第6期15卷 1319-1330页

作者： pei xiang-jun guo bin cui sheng-hua wang dong-po xu qiang li tian-tao state key laboratory of geohazard prevention and geoenvironment protection chengdu university of technologyChengdu610059Chnia

At 5 am 24 th June 2017, a catastrophic landslide hit Xinmo Village, Maoxian County, Sichuan Province, China. The slide mass rushed down from an altitude of 3400 m and traveled 2700 m in a high velocity. The 13 million m^3 deposition buried the whole village and caused about 100 deaths. The source area of the landslide is located in a high steep slope, average slope angle is 40o and maximal angle is 65o. The strata are interbedded Triassic Zagunao Formation metamorphic sandstone and slate with the dip slope angle of 45°. Based on high-resolution satellite remote sensing image, UAV image, DEM data, and field investigation, failure mechanism, travel features, and deposit characteristics were analyzed. The results showed that this landslide was influenced by Songpinggou Fault zone. According to the topography before the failure, the landslide is located in the back scarp of an antecedent landslide induced by Diexi Earthquake in 1933. The bedding slope provided potential rupture surface. Historical seismic activities and long-term gravitational deformation caused rock mass accumulated damages. Weathering and precipitation weakened the rock mass and finally induced shearing and tension failure. A huge block detached from the top rock slope, pushed the past landslide deposits in the middle part, rushed out of the slope bottom in a high velocity and buried the Xinmo Village. The rapid movement entrained and brought the soil into the Songping Gully which recoiled with and bounced back from the opposite mountain.

关键词：山崩运动中国卫星遥感图象岩石质量地震活动高分辨率床上用品

Design and fabrication of broadband ultralow reflectivity black Si surfaces by laser micro/nanoprocessing

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Light(Science & Applications) 2014年第1期3卷 147-154页

作者： Jing Yang Fangfang Luo Tsung sheng kao Xiong Li Ghim Wei Ho Jinghua Teng Xiangang Luo Minghui Hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Institute of Materials Research and Engineering Agency for ScienceTechnology and ResearchSingapore 117602Singapore NUS Environmental Research Institute National University of SingaporeSingapore 117411Singapore State Key Laboratory of Optical Technologies for Microfabrication Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China

Light collection efficiency is an important factor that affects the performance of many optical and optoelectronic *** these devices,the high reflectivity of interfaces can hinder efficient light *** minimize unwanted reflection,anti-reflection surfaces can be fabricated by micro/*** this paper,we investigate the fabrication of broadband anti-reflection Si surfaces by laser micro/*** direct writing is applied to create microstructures on Si surfaces that reduce light reflection by light *** addition,laser interference lithography and metal assisted chemical etching are adopted to fabricate the Si nanowire *** anti-reflection performance is greatly improved by the high aspect ratio subwavelength structures,which create gradients of refractive index from the ambient air to the ***,by decoration of the Si nanowires with metallic nanoparticles,surface plasmon resonance can be used to further control the broadband reflections,reducing the reflection to below 1.0%across from 300 to 1200 *** average reflection of 0.8%is achieved.

关键词： anti-reflection broadband laser micro/nanoprocessing surface plasmons

A new radar stealth design excited by ^(210)po and ^(242)Cm

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Nuclear Science and Techniques 2022年第6期33卷 45-53页

作者： Jin-Jian Yuan Gui-Ping Meng Min Gu Run-sheng Huang School of Physics Nanjing UniversityNanjing 210093China

Open plasma stealth technology excited by radionuclides is known to have several problems:(1)owing to disturbance from airflow,the plasma distribution is unstable.(2)The plasma is highly dependent on the atmosphere;therefore,it is difficult to modulate in target stealth.(3)Concerns regarding radiation harassment prevent the application of this *** avoid these problems,an enclosed plasma stealth method is *** simulation on an infinite conducting plate,this method was found to effectively solve the above concerns,which may offer a new approach for the practical application of plasma stealth technology excited by radionuclides,especially for small-satellite stealth because of its lightweight and selfprovided plasma.

关键词： Radiation ionization αDecay particles Plasma film Radar stealth technology

安脑丸联合降血压药治疗原发性高血压病的经济学评价:一项基于决策树模型的研究

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中国中药杂志 2024年第6期49卷 1683-1689页

作者：陈子佳崔鑫韩晟乔萌付常宽王志飞谢雁鸣中国中医科学院中医临床基础医学研究所北京100700 北京大学医药管理国际研究中心北京100089

该研究旨在评价中国医疗环境下安脑丸联合降血压药治疗原发性高血压病的经济性。从卫生体系角度出发,运用TreeAge pro 2018构建模型对2种治疗方案进行成本⁃效果分析及敏感性分析。模拟模型干预时间为2周,成本参数源于药智网,效果参数基... 详细信息

该研究旨在评价中国医疗环境下安脑丸联合降血压药治疗原发性高血压病的经济性。从卫生体系角度出发,运用TreeAge pro 2018构建模型对2种治疗方案进行成本⁃效果分析及敏感性分析。模拟模型干预时间为2周,成本参数源于药智网,效果参数基于安脑丸加载随机对照试验(RCT)合并后的Meta分析,安脑丸组干预措施为安脑丸联合降血压药(硝苯地平控释片+氯沙坦钾片),对照组干预措施为降血压药(硝苯地平控释片+氯沙坦钾片)。基础分析显示,2组增量成本⁃效果比(ICER)为2678.67元,ICER小于2022年人均可支配收入的7.26%,即相比于单用降血压药,安脑丸联合降血压药每多治疗1例有效的原发性高血压病患者需多花费2678.67元。敏感性分析验证了基础分析结果的稳健性,概率敏感性分析显示,当患者的个人意愿支付价格高于2650元时,安脑丸组干预措施具有经济性的概率更高,与基础分析结果一致。结果表明,当个人意愿支付价格高于2650元时,原发性高血压病患者选用安脑丸联合降血压药比单用降血压药在改善有效率方面更具有经济性。

关键词：安脑丸原发性高血压病药物经济学成本⁃效果分析

Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome

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Chinese Journal of Integrative Medicine 2020年第7期26卷 519-526页

作者： Yung-Hsiang Chen Wen-Chi Chen kao-Sung Tsai po-Len Liu Ming-Yen Tsai Tzu-Chun Lin Shih-Chieh Yu Huey-Yi Chen Graduate Institute of Integrated Medicine College of MedicineResearch Center for Chinese Medicine and AcupunctureChinese Medicine Research CenterChina Medical UniversityTaichungTaiwanChina Departments of Medical Research Urologyand Obstetrics and GynecologyChina Medical University HospitalTaichungTaiwanChina Department of Psychology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Department of Applied Cosmetology Master Program of Cosmetic ScienceHungkuang UniversityTaiwanChina Department of Respiratory Therapy College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Chinese Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwanChina Department of Dermatology Chung Shan University HospitalInstitute of MedicineSchool of MedicineChung Shan Medical UniversityTaichungTaiwanChina Department of Neurology Kuang Tien General HospitalTaichungTaiwanChina

Objective:To investigate the efficacy of frankincense and myrrha in the treatment of acute interstitial cystitis/painful bladder syndrome(IC/PBS).Methods:The effects of frankincense and myrrha on the proliferation and migration of primary human urothelial cells(HUCs)were assessed in *** the animal study,48 virgin female rats were randomized into 4 groups(12 in each group):(1)control group(saline-injected control);(2)cyclophosphamide(CYP)group(intraperitoneal injected 150 mg/kg CYP);(3)CYP+pentosan polysulfate sodium group(orally received 50 mg/kg pentosan polysulfate sodium);and(4)CYP+frankincense and myrrha group[orally received frankincense(200 mg/kg)and myrrha(200 mg/kg)].Rats orally received pentosan polysulfate sodium or frankincense and myrrha on day 1,2,and *** experiments were performed on day *** and cystometry assessment behavior test were *** interval values were assessed in rats under ***,immunohistochemistry and Western blot were used to confirm the location and level,respectively,of cell junction-associated protein zonula occludens-2(ZO-2)***:Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control(Ppolysulfate and frankincense+myrrha groups compared with the CYP-induced acute IC/PBS group(P<0.05).Conclusion:frankincense and myrrha modulate urothelial wound healing,which ameliorates typical features of acute IC/PBS in rats.

关键词： frankincense myrrha acute interstitialcystitis painful bladder syndrome cell junction-associated protein

用于H_(2)po_(4)^(-)检测的比率型荧光探针合成及性能研究

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化学试剂 2024年第6期46卷 33-38页

作者：郭昌晟陈君霞刘忆茹卢钰盛董智云席福贵忻州师范学院化学系山西忻州034000

设计合成了一种基于吖啶-苯并咪唑鎓的大环受体ABIM,可作为H_(2)po_(4)^(-)的荧光比率传感器。借助荧光光谱研究了受体ABIM对H_(2)po_(4)^(-)的选择性识别,在大环受体ABIM的乙腈溶液中加入H_(2)po_(4)^(-)后,在426 nm处荧光发射明显“... 详细信息

设计合成了一种基于吖啶-苯并咪唑鎓的大环受体ABIM,可作为H_(2)po_(4)^(-)的荧光比率传感器。借助荧光光谱研究了受体ABIM对H_(2)po_(4)^(-)的选择性识别,在大环受体ABIM的乙腈溶液中加入H_(2)po_(4)^(-)后,在426 nm处荧光发射明显“关闭”,506 nm处荧光发射明显“打开”,溶液荧光颜色由蓝色变为蓝绿色,新的荧光发射峰可能是由于H_(2)po_(4)^(-)诱导两个受体中的吖啶环之间形成Excimer产生的。ABIM与H_(2)po_(4)^(-)以1∶1的化学计量比结合,结合常数为(7.13±0.48)×10^(6)L/mol,检出限为2.38×10-7 mol/L,最佳响应时间为2 min。回收实验表明,ABIM可应用于样品中H_(2)po_(4)^(-)的检测。

关键词：吖啶苯并咪唑鎓 H 2po-4 大环比率型荧光探针

Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： sheng Jia-Yun WANG Si-Qi LIU kao-Hua ZHU Bo ZHANG Qiao-Yan QIN Lu-Ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review