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Source and location mechanism for lode gold deposits hosted in metamorphic rocks in northeastern Hunan, China

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Journal of Central South University of Technology 2001年第2期8卷 108-113页

作者： LIU Liang ming,PENG sheng lin,YANG Qun zhou (College of Resources, Environment and Civil Engineering, Central South University, Changsha 410083, China) 1. College of Resources Environment and Civil Engineering Central South University 410083 Changsha China

For understanding the source and location mechanism of lode gold deposits hosted in metamorphic rocks in northeastern Hunan, the authors analyzed the REE (rare earth elements) in ores and their host rocks, metallogenic elements in host rocks near and distant from the ore bodies, and characteristics of ore controlling structures, and deduced their genetic implication. Their geochemical features of REE and metallogenic elements suggest that they are formed by mobilization of dispersed metallogenic materials in Lengjiaxi Group of Middle Proterozoic during deformation and metamorphism process, mainly in Wulingian period. From the attributes of ore controlling structures and regularity of location of gold metallization, it is concluded that the location of gold deposits is closely related to reverse shearing. Ore forming fluids are focused on the secondary faults and extension fractures of reverse shear zones of nearly EW strike by stress driven diffusion and seismic pumping.

关键词： lode gold deposit location fluid focus seismic pump northeastern Hunan

Sensitivity of Interstitial combined Chemotherapy against Glioma

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医学信息（手术学分册） 2006年第4期19卷 6-8页

作者： WANG Ming-sheng lin Jian-ying zhou Guo-sheng ZHANG Xin-zhong The First Affiliated Hospital of Xinxiang Medical University Weihui 453100Henan P. R. China

Objective To investigate the inhibitory effects of combination chemotherapy of Carboplatin(CBP) ,Teniposide (Vm-26) ,Methasquin(MTX),and Nimodipine(NIM) on glioma,and to explore the sensitivity of glioma cells to different treatment regimens so as to provide some clues for clinical usage of interstitial combination chemotherapy. Methods MTT assay and 3H-TdR incorporation assay were performed to evaluate the inhibitory effects upon the proliferation of glioma cells,and to compare the sensitivity of glioma cells to administration of CBP,Vm-26, MTX, and NIM with that of the administration of CBP + NIM, Vm-26 + NIM, MTX + NIM, CBP + Vm-26 + MTX, or CBP + Vm-26 + MTX + NIM respectively. Results The inhibition rate of CBP + Vm-26 + MTX + NIM combination administration against glioma cells was 96.64%,which was higher than that of CBP + NIM (69.03%), Vm-26 + NIM (71.53%), MTX + NIM (52. 75% ), CBP + Vm-26 + MTX(78.59%)(P＜0.01),and the dosage of CBP,Vm-26,and MTX was declined to 1/10 ～ 1/100 that of respective use of CBP,Vm-26,and MTX. Conclusions The curative effects of combination administration of CBP,Vm-26, MTX, and NIM was much better than that of respective administration,suggesting a higher inhibition rate and a lower dosage use.

关键词： glioma combination administration interstitial chemotherapy

M_(12)作用在396个点上的SPBIB设计的分类

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数学学报（中文版） 2016年第3期59卷 377-384页

作者：田德路周胜林广东第二师范学院数学系广州510303 华南理工大学数学学院广州510640

研究Mathieu群M_(12)作用在396个点上所构成的对称的部分平衡不完全区组设计(即SPBIB设计)的分类情况.首先,证明了以M_(12)作为自同构群的非平凡的2-(396,k,λ)对称设计是不存在的.然后,得到了同构意义下的3个点数为396且区组长度为80的... 详细信息

研究Mathieu群M_(12)作用在396个点上所构成的对称的部分平衡不完全区组设计(即SPBIB设计)的分类情况.首先,证明了以M_(12)作为自同构群的非平凡的2-(396,k,λ)对称设计是不存在的.然后,得到了同构意义下的3个点数为396且区组长度为80的SPBIB设计.最后,给出了396个点上以M_(12)作为自同构群的SPBIB设计的完全分类.

关键词： SPBIB设计对称设计群作用结合方案

Assessment of 188Re marked anti MHC class II antibody by peripheral blood mononuclear cells stimulated by donor alloantigen

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Chinese Medical Journal 2011年第16期124卷 2512-2516页

作者： DING Guo-ping CAO Li-ping LIU Jie LIU Da-ren QUE Ri-sheng ZHU lin-hua zhou Yi-ming MAO Ke-jie HU Jun-an Department of Surgery Second Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou Zhejiang 310009China

Background Previous studies showed that anti MHC-II monoclone antibody （MAb） only had partial inhibiting effect of alloreactive mixed lymphocyte reaction （MLR） in vitro and it was unsteady and non-persistent. The aim of this research was to determine whether radioactive isotope 188Re marked MHC-II antibody could benefit the allograft acceptance in transplantation as compared to normal MHC-II antibody. Methods 188Re was incorporated to 2E9/13F（ab＇）2 which is against swine MHC class II antigen （MAb-~88Re）. Porcine peripheral blood mononuclear （PBMC） cells were examined for proliferation and cytokine mRNA expression after stimulation with MHC-II MAb or MAb-188Re. Results The proliferative response of recipient PBMCs in mixed lymphocyte reaction （MLR） to donor alloantigen showed that the stimulation index of MAb-188Re group was significantly lower than the MHC-II MAb group and control （P 〈0.05）. mRNA expression of interleukin 2, interferon y and tumor necrosis factor a （type 1 cytokines） was lower in MAb-188Re group than the MHC-II MAb group, while interleukin 10 （type 2 cytokines） was higher in MAb-~aSRe group in the first 24 hours. Conclusion MAb-188Re could help the graft acceptance by inhibiting T cell proliferation, lowering the expression of type 1 cytokines and elevating the type 2 cytokines produced by PBMC.

关键词： MHC class H antibody dendritic cells cytokine 188Re, acute rejection

PREDICTION OF LOCATION OF HIDDEN ORE DEPOSITS IN THE AGED ORE FIELDS: AN EXAMPLE FROM FENGHUANGSHAN ORE FIELD, TONGlinG, CHINA

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Geotectonica et Metallogenia 2001年第1期25卷 132-139页

作者： LIU Liang ming, PENG sheng lin, YIANG Qun zhou, SHAO Yong jun and WANG Zhi qiang (Institute of Diwa Theory and Metallogeny, Central South University, Changsha 410083, China) Institute of Diwa Theory and Metallogeny Central South UniversityChangsha 410083China

This paper discusses the strategy for successfully predicting the location of potential hidden ore bodies in aged ore field, and presents the result of location prediction of hidden ore bodies in Fenghuangshan ore field, Tongling. Innovative conceptual targeting procedures based on a genetic understanding of mineralization systems, carefully geological investigation and correct deduction, together with new geochemical and geophysical technology and integrating of comprehensive information are all very important for the successful prediction. In the aged Fenghuangshan ore field, through researching by application of the metallogenic theory of polygenetic compound ore deposits and triple frequency induced polarization method and exploration tectono geochemical method, we predicted location and quality of hidden ore bodies. According to the prediction, hidden high quality Cu Au ore bodies of skarn type and porphyry type have been discovered.

关键词： Location prediction of hidden ore deposits aged ore field polygenetic compound ore deposits Fenghuangshan Tongling

复合添加剂对锌在KOH溶液中电化学行为的影响

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电源技术 2009年第12期33卷 1108-1111页

作者：蔡增鑫林胜舟王贵生周合兵李伟善华南师范大学化学与环境学院广东广州510006 广东高校电化学储能与发电技术重点实验室广东广州510631 华南理工大学材料科学与工程学院广东广州510641

采用失重法、电化学方法、扫描电镜等方法研究了咪唑、聚乙二醇400及由两者组成的复合添加剂对锌在3mol/LKOH溶液中的电化学行为的影响。结果表明:单一添加剂及其组合均具有一定的缓蚀作用,但与单一添加剂相比,由咪唑和聚乙二醇400组成... 详细信息

采用失重法、电化学方法、扫描电镜等方法研究了咪唑、聚乙二醇400及由两者组成的复合添加剂对锌在3mol/LKOH溶液中的电化学行为的影响。结果表明:单一添加剂及其组合均具有一定的缓蚀作用,但与单一添加剂相比,由咪唑和聚乙二醇400组成的复合添加剂缓蚀效果明显更好,这是由于咪唑和聚乙二醇400之间产生了协同作用所致,这种协同作用表现在有咪唑存在的情况下,聚乙二醇400更容易吸附在锌电极的表面,此外,两者能发挥自身的优势,弥补对方在结构上的不足,提高缓蚀效果。

关键词：添加剂锌缓蚀电化学行为

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五水硫酸铜催化合成乙酸正丙酯的研究

应用化工 2014年第12期43卷 2249-2251页

作者：陈玉林圣洲福建师范大学福清分校海洋与生化工程学院福建福清350300

采用五水硫酸铜催化合成乙酸正丙酯，研究不同反应时间、五水硫酸铜用量、乙酸和正丙醇摩尔比对乙酸正丙酯产率的影响。结果表明，最佳的工艺条件为：催化剂用量为2.5 g，醇酸摩尔比为2：1，反应时间为2.5 h。在此条件下，收率可达78.64... 详细信息

采用五水硫酸铜催化合成乙酸正丙酯，研究不同反应时间、五水硫酸铜用量、乙酸和正丙醇摩尔比对乙酸正丙酯产率的影响。结果表明，最佳的工艺条件为：催化剂用量为2.5 g，醇酸摩尔比为2：1，反应时间为2.5 h。在此条件下，收率可达78.64%，转化率为87.83%。产品为无色透明液体，具有淡淡的果香味，30℃下测得其折光率为1.3839，沸程为98.5~101.6℃，纯度为82.36%。

关键词：乙酸正丙酯五水硫酸铜正交实验产率

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen lin Zhong Luji Huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 1-26页

作者： Wei zhou Xiaogang Zhu Qing-Long Han lin Li Xiao Chen sheng Wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

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