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Biogenesis of Rab14-positive Endosome Buds at Golgi-endosome Contacts by the RhoBTB3-SHIP164-Vps26B Complex

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Current Medical Science 2024年第4期44卷 864-866页

作者： jing-ru WANG Jun-yao ZHANG wei-Ke JI Department of Biochemistry and Molecular Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Cell Architecture Research Center Huazhong University of Science and TechnologyWuhan430030China State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and TechnologyWuhan430030China shenzhen Bay Laboratory Shenzhen518132China

As one of the basic processes of cellular activity,endocytosis sorting determines the fate of many proteins on the endosomal membranes,thus affecting a variety of important cellular processes,such as nutrient uptake,c... 详细信息

关键词： homeostasis endo sorting

Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

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Genes & Diseases 2024年第2期11卷 952-963页

作者： Zhenhao Zhang Doudou jing Baijun Xuan Zhicai Zhang wei Wu Zengwu Shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Osteosarcoma is the most common primary malignancy of bones and primarily occurs in adolescents and young ***,a second smaller peak of osteosarcoma incidence was reported in the elderly aged more than *** patients with osteosarcoma exhibit different characteristics compared to young patients,which usually results in a poor *** mechanism underlying osteosarcoma development in elderly patients is intriguing and of significant value in clinical *** cells can accelerate tumor progression by metabolic *** research has shown that methylmalonic acid(MMA)was significantly up-regulated in the serum of older individuals and played a central role in the development of aggressive *** found that the significant accumulation of MMA in elderly patients imparted proliferative potential to osteosarcoma *** expression of MAFB was excessively up-regulated in osteosarcoma specimens and was further enhanced in response to MMA accumulation as the patient ***,we first confirmed a novel molecular mechanism between cellular senescence and cancer,in which the MMA-driven transcriptional reprogramming of the MAFB-NOTCH3 axis accelerated osteosarcoma progression via the activation of PI3K-AKT ***,the down-regulation of the MAFB-NOTCH3 axis increased the sensitivity and effect of AKT inhibitors in osteosarcoma through significant inhibition of AKT *** conclusion,we confirmed that MAFB is a novel age-dependent biomarker for osteosarcoma,and targeting the MAFB-NOTCH3 axis in combination with AKT inhibition can serve as a novel therapeutic strategy for elderly patients with osteosarcoma in experimental and clinical trials.

关键词： Cellular senescence Elderly patients MAFB-NOTCH3axis Methylmalonic acid Osteosarcoma PI3K-AKTpathway

Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-Chen Zhang Chun-Mei Lai Bang-Yue Luo jing-wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China college of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

Recent progress in ternary mixed matrix membranes for CO_(2) separation

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Green Energy & Environment 2024年第5期9卷 831-858页

作者： Zikang Qin Yulei Ma jing wei Hongfang Guo Bangda Wang jing Deng Chunhai Yi Nanwen Li Shouliang Yi Yi Deng Wentao Du Jian shen Wenju Jiang Lu Yao Lin Yang Zhongde Dai college of Architecture and Environment Sichuan UniversityChengdu610065China college of Carbon Neutrality Future Technology Sichuan UniversityChengdu610065China National Engineering Research Centre for Flue Gas Desulfurization Chengdu610065China Carbon Neutral Technology Innovation Center of Sichuan Chengdu610065China School of Chemical Biological and Materials EngineeringUniversity of OklahomaNormanOK73019USA Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China US DOE Natl Energy Technol Lab626 Cochrans Mill RdPittsburghPA 15236USA DongFang Boiler Co. Ltd.China Clean Combustion and Flue Gas Purification Key Laboratory of Sichuan Province Chengdu611731China college of Environment and Resources Xiangtan UniversityXiangtan411105China

Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousﬁllers,making them an effective alternative to conventional polymer ***,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsﬁllers and the polymer matrix,currently limit the gas sep-aration performance of *** phase MMMs(consisting of aﬁller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation *** review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanoﬁllers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy *** on this separation data,the challenges of ternary MMMs are also ***,future directions for ternary MMMs are proposed.

关键词： CO_(2) separation Mixed matrix membranes Ternary phase

Advancements in heterojunction,cocatalyst,defect and morphology engineering of semiconductor oxide photocatalysts

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Journal of Materiomics 2024年第2期10卷 315-338页

作者： Guojing Wang Shasha Lv Yuanhua shen wei Li Linhan Lin Zhengcao Li State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials(MOE)School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Key Laboratory of Beam Technology and Material Modification Ministry of EducationCollege of Nuclear Science and TechnologyBeijing Normal UniversityBeijing100875China School of Physical Science and Technology Lanzhou UniversityLanzhou730000China Department of Engineering Physics Tsinghua UniversityBeijing100084China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing100084China

Photocatalytic technology has emerged as a crucial avenue for harnessing solar energy,presenting itself as a viable solution to address the current energy crisis and environmental *** past 50 years have witnessed significant progress and breakthroughs in scientific research on photocatalytic *** paper provides a comprehensive review of the mechanism of photocatalytic technology and methods to improve the photocatalytic efficiency of semiconductor photocatalysts,such as TiO 2 and *** this paper,common modification methods are divided into four categories:heterojunction con-struction,cocatalysts,defects,and morphological *** origin and development of photo-catalysts in each category are briefly summarized;moreover,the latest progress in each type of modification is discussed.S-scheme heterojunctions retain the high reduction and oxidation capacity of photogenerated electrons and holes by sacrificing half of the photogenerated carriers,showing excellent performance in photocatalysis and great application *** challenges associated with current modification schemes are *** is growing interest in quantitative and atomic-level modu-lation as attractive approaches to tackling these *** the electronic spin state and internal field is important for minimizing photogenerated carrier recombination in *** review will inspire researchers and promote the application of photocatalytic technology.

关键词： Photocatalytic activity Modification Heterostructure Thermal annealing Ion irradiation

Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

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Biomedical and Environmental Sciences 2024年第1期37卷 3-18页

作者： LIANG Yu Jian RONG Jia Hui WANG Xue Xiu CAI Jian sheng QIN Li Dong LIU Qiu Mei TANG Xu MO Xiao Ting wei Yan Fei LIN Yin Xia huang shen xiang LUO Ting Yu GOU Ruo Yu CAO Jie jing huang Chu Wu LU Yu Fu QIN Jian ZHANG Zhi Yong Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P<0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P<0.001)when each quartile of the mixture of the seven metals was *** kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength *** the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression

Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu wei Qiu-Man Xu wei Shang Qing Li jing-sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

Protein tyrosine phosphatase non-receptor Ⅱ:A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3913-3931页

作者： Hui-Yuan Li Yi-Ming jing Xue shen Ming-Yue Tang Hong-Hong shen Xin-wei Li Zi-Shu Wang Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina

BACKGROUND The incidence of primary liver cancer is increasing year by *** 2022 alone,more than 900000 people were diagnosed with liver cancer worldwide,with hepatocellular carcinoma(HCC)accounting for 75%-85%of *** is the most common primary liver *** has the highest incidence and mortality rate of HCC in the world,and it is one of the malignant tumors that seriously threaten the health of Chinese *** onset of liver cancer is occult,the early cases lack typical clinical symptoms,and most of the patients are already in the middle and late stage when ***,it is very important to find new markers for the early detection and diagnosis of liver cancer,improve the therapeutic effect,and improve the prognosis of *** tyrosine phosphatase non-receptor 2(PTPN2)has been shown to be associated with colorectal cancer,triple-negative breast cancer,non-small cell lung cancer,and prostate cancer,but its biological role and function in tumors remain to be further *** To combine the results of relevant data obtained from The Cancer Genome Atlas(TCGA)to provide the first in-depth analysis of the biological role of PTPN2 in *** The expression of PTPN2 in HCC was first analyzed based on the TCGA database,and the findings were then verified by immunohistochemical staining,quantitative real-time polymerase chain reaction(qRT-PCR),and *** value of PTPN2 in predicting the survival of patients with HCC was assessed by analyzing the relationship between PTPN2 expression in HCC tissues and clinicopathological ***,the potential of PTPN2 affecting immune escape of liver cancer was evaluated by tumor immune dysfunction and exclusion and immunohistochemical *** The results of immunohistochemical staining,qRT-PCR,and immunoblotting in combination with TCGA database analysis showed that PTPN2 was highly expressed and associated with a poor prognosis in HCC *** Encyclopedia of Ge

关键词： Protein tyrosine phosphatase non-receptor 2 Hepatocellular carcinoma Immune evasion Biomarker Immunotherapy Prognosis

A novel method for producing benzene polycarboxylic acids by electrochemical oxidation of Zhaotong lignite in aqueous NaCl solution

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Carbon Resources Conversion 2024年第2期7卷 88-94页

作者： Ze-Zheng Li wei-Jia Jiang Yu-Gao Wang Zhi-Lei Wang Jun shen Xian-Yong wei college of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024ShanxiChina School of Basic Medicine Shanxi University of Chinese MedicineJinzhong 030619China Institute of Environmental Science Shanxi UniversityTaiyuan 030031China Shanxi Huayang New Material Technology Group Co. Ltd.YangquanShanxi 045000China Key Laboratory of Coal Processing and Efficient Utilization Ministry of EducationChina University of Mining&TechnologyXuzhou 221116JiangsuChina

The development of a coal-based synthetic route to produce benzene polycarboxylic acids(BPCAs)is of great importance for the highly efficient utilization of *** this paper,aqueous NaCl^(-)electrolytic system was used to oxidize Zhaotong lignite to prepare *** electrochemical oxidation of lignite in aqueous NaCl solution could produce more BPCAs than that in aqueous NaOH *** aqueous NaCl electrolytic system could in-suit produce a stable OCl^(-),which was synthesized by the combination reaction between Cl_(2)and OH􀀀generated in the anode or cathode,*** in-suit produced OCl^(-)would degrade the organic structures of the lignite dispersing in the electrolyte to generate *** formation of BPCAs could be greatly affected by current density,electrolysis time and the addition amount of NaCl in the electrolytic system,which resulted from that the factors played an important role in the generation of OCl^(-).The coal related model compounds including anthracene and phenanthrene were used to investigate the electrochemical oxidation mechanism of the *** results indicated that the aromatic ring structures in the lignite were attacked by O_(2)•^(-)from the OCl^(-)to afford BPCAs.

关键词： Lignite Benzene polycarboxylic acids Electrochemical oxidation Aqueous NaCl electrolytic system Coal related model compounds