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径向井辅助前置液酸压裂缝扩展数值模拟

中国石油大学学报（自然科学版） 2024年第3期48卷 101-110页

作者：齐宁甘俊冲章泽辉刘毅龙申玉洋刘练中国石油大学(华东)石油工程学院山东青岛266580 中国石油长庆油田分公司天然气评价项目部陕西西安710018 中国石油化工股份有限公司西北油田分公司新疆乌鲁木齐830011

基于扩展有限元及双尺度连续模型理论建立径向井辅助前置液酸压裂缝扩展模型,引入偏离系数作为量化评价指标,分析各因素对裂缝形态的影响,并利用灰色关联分析方法明确主控因素。结果表明:径向井对前置液酸压裂缝扩展具有显著引导作用,... 详细信息

基于扩展有限元及双尺度连续模型理论建立径向井辅助前置液酸压裂缝扩展模型,引入偏离系数作为量化评价指标,分析各因素对裂缝形态的影响,并利用灰色关联分析方法明确主控因素。结果表明:径向井对前置液酸压裂缝扩展具有显著引导作用,裂缝优先沿径向井方向起裂并扩展一定距离,而后逐渐偏向最大水平主应力方向;径向井方位角、水平地应力差和地层弹性模量越小,径向井长度越长,偏离系数越小,径向井引导效果越好,其中水平地应力差为主控因素;当径向井方位角为15°时,前置液酸压裂缝沿着径向井方向扩展14.32 m后偏向最大水平主应力方向,径向井的引导效果最好,偏离系数为0.005。

关键词：径向井前置液酸压裂缝扩展扩展有限元双尺度模型

基于二代测序检测结直肠癌中PIK3CA基因突变及其与预后的相关性分析

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中华病理学杂志 2024年第7期53卷 716-721页

作者：彭潇张鑫卢宏霞申璐璐高宁昝丽坤山西医科大学第二临床医学院太原030001 山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院结直肠外科太原030013 山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院消化内科太原030013 山西省肿瘤医院中国医学科学院肿瘤医院山西医院山西医科大学附属肿瘤医院病理科太原030013

目的探索PIK3CA在结直肠癌中的突变情况,分析PIK3CA与结直肠癌患者临床病理特征的关系,评估PIK3CA在指导临床治疗及预后评估中的价值。方法收集山西省肿瘤医院2018—2021年病理确诊为结直肠癌的石蜡样本128例,从中提取DNA,采用二代测序... 详细信息

目的探索PIK3CA在结直肠癌中的突变情况,分析PIK3CA与结直肠癌患者临床病理特征的关系,评估PIK3CA在指导临床治疗及预后评估中的价值。方法收集山西省肿瘤医院2018—2021年病理确诊为结直肠癌的石蜡样本128例,从中提取DNA,采用二代测序方法检测PIK3CA突变,回顾性分析其与结直肠癌患者临床病理特征的关系以及对预后的影响。结果128例结直肠癌样本中,男性75例,女性53例;患者年龄为32~86岁,中位年龄为61.5岁;PIK3CA突变的有27例(21.09%)。PIK3CA突变的结直肠癌易发生在男性患者(P=0.007),与肿瘤部位(P=0.032)、肿瘤大小(P=0.029)和TP53野生型(P=0.001)相关,且PIK3CA常见位点突变多出现在肿瘤突变负荷≥10 Muts/Mb的肿瘤中(P=0.031)。生存分析显示,PIK3CA突变对患者的生存预后无显著影响,但该类患者术后加用靶向抗血管生成药物治疗效果较差。结论PIK3CA突变是结直肠癌中较为常见的突变,在结直肠癌的发生发展过程中起到了重要作用。PIK3CA突变可能会导致结直肠癌抗血管生成药物的耐药性产生,但其对患者生存预后的影响还有待进一步研究。

关键词：结直肠肿瘤序列分析,DNA 肿瘤治疗方案 PIK3CA

EFFECT OF ELECTROSTATIC RESISTANCE ON THE SHUTTLE OF MICRORESONATOR

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Chinese Journal of Mechanical Engineering 2008年第5期21卷 55-58页

作者： shen Xuejin HOU Licheng School of Mechatronical Engineering and Automation Shanghai University Shanghai 200072 China

To improve the performance and reliability of microelectromechanical system＇s devices, it is necessary to understand the effect of friction which exists in the majority of microelectromechanical systems （MEMS） with a large ratio of surface area to their volume. The model of electrostatic tangential force of the shuttle in laterally driven comb microresonator is established based on the rule of energy conservation. The effects of microscale, surface roughness, applied voltage, and micro asperities or dents or holes formed in fabrication are investigated, and the electrostatic resistance between two charged moving plates is analyzed. The analytic results are coincident well with those of ANSYS simulation. It is found that the electrostatic resistance becomes high as the increase of the ratio of the shuttle width to the gap between moving plates and the relative surface roughness or the increment of the applied voltage.

关键词： Microresonator Microtribology Electrostatic resistance Surface roughness

Insight into the in vivo fate of intravenous herpetrione amorphous nanosuspensions by aggregation-caused quenching probes

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Chinese Chemical Letters 2022年第11期33卷 4948-4951页

作者： Lingyu Hang Chengying shen Baode shen Hailong Yuan Department of Pharmacy Air Force Medical CenterPLABeijing 100142China College of Pharmacy Jiangxi University of Chinese MedicineNanchang 330004China Department of Pharmacy Jiangxi Provincial People's HospitalNanchang 330006China

Intravenous nanosuspensions are attracted growing attention as a viable strategy for development of intravenous formulations of poorly water-soluble ***,only few information about the biological fate of intravenous nanosuspensions is currently known,especially amorphous nanosuspensions are not reported *** this study,the in vivo fate of herpetrione(HPE)amorphous nanosuspensions following intravenous administration was explored by using an aggregation-caused quenching(ACQ)probe and HPLC *** ACQ probe is physically embedded into HPE nanoparticles via anti-solvent method to form HPE hybrid nanosuspensions(HPE-HNSs)for ***-HNSs emit strong and stable fluorescence,but fluorescence quenches immediately upon the dissolution of HPE-HNSs,confirming the selfdiscrimination of *** intravenous administration of HPE-HNSs,integral HPE-HNSs and HPE show similar degradation and biodistribution,with rapid clearance from blood circulation and obvious accumulation in liver and *** to the slower dissolution and enhanced recognition by reticuloendothelial system,450 nm HPE-HNSs accumulate more in liver,lung and spleen than that of 200 nm *** results demonstrate that integral HPE-HNSs determine the in vivo performance of *** study provides insight into the in vivo fate of intravenous amorphous nanosuspensions.

关键词： Amorphous nanosuspensions Herpetrione In vivo fate Intravenous delivery Aggregation-caused quenching

葡萄籽原花青素对高精料育肥绵羊肝脏炎症反应、抗氧化功能的影响及代谢组学分析

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动物营养学报 2024年第7期36卷 4447-4461页

作者：牟春堂谢蕴哲申玉萍张建新郝小燕山西农业大学动物科学学院晋中030801

本试验旨在研究葡萄籽原花青素(GSPs)对高精料育肥绵羊肝脏形态结构、肝脏功能、抗氧化功能及炎症反应的影响,通过非靶向代谢组学分析肝脏代谢变化。试验选取48只日龄、体重[(22.75±1.20)kg]相近的杜寒F1代杂交公羔羊,随机分为4组,每... 详细信息

本试验旨在研究葡萄籽原花青素(GSPs)对高精料育肥绵羊肝脏形态结构、肝脏功能、抗氧化功能及炎症反应的影响,通过非靶向代谢组学分析肝脏代谢变化。试验选取48只日龄、体重[(22.75±1.20)kg]相近的杜寒F1代杂交公羔羊,随机分为4组,每组12只羊。基础饲粮精粗比为70∶30,对照组饲喂基础饲粮,各试验组在饲喂基础饲粮的同时分别再每天补饲10(LGSPs组)、20(MGSPs组)、40 mg/kg BW GSPs(HGSPs组)。试验羊单栏饲养,自由采食、饮水,GSPs于每次晨饲前单独混合于100 g基础饲粮中饲喂。试验期60 d,其中预试期15 d。结果表明:1)对照组绵羊肝细胞肿胀、空泡化严重,各GSPs添加组肝脏组织损伤均有不同程度缓解。2)随着GSPs添加水平的提高,绵羊血清总蛋白和白蛋白含量线性升高(P<0.05),血清天冬氨酸转氨酶和谷丙转氨酶活性线性降低(P<0.05);肝脏组织总抗氧化能力(T-AOC)呈二次曲线变化,谷胱甘肽过氧化物酶(GSH-Px)活性线性升高,丙二醛(MDA)含量线性降低(P<0.05);肝脏组织中髓过氧化物酶(MPO)活性线性降低,炎症因子白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)含量线性降低(P<0.05)。与对照组相比,MGSPs和HGSPs组血清脂多糖(LPS)和脂多糖结合蛋白(LBP)含量显著降低(P<0.05)。3)随着GSPs添加水平的提高,肝脏组织中甘油三酯、总胆固醇和低密度脂蛋白胆固醇含量线性降低(P<0.05)。4)非靶向代谢组学结果表明,MGSPs组与对照组间共有99种差异代谢物,其中67种脂类物质。99种差异代谢产物中71种显著上调,28种显著下调。共有差异代谢物富集在癌症中的胆碱代谢、甘油磷脂代谢、逆行内源性大麻素信号、自噬-其他/动物等潜在靶向通路。综上所述,GSPs可以提高高精料饲粮条件下绵羊肝脏抗氧化功能,降低炎症因子含量,并可能通过调节肝脏脂质代谢、胆碱代谢及肝细胞自噬共同应答肝脏炎性反应和氧化应激,缓解炎性损伤。

关键词：葡萄籽原花青素高精料绵羊肝脏功能代谢组

Gradient Estimates for p-Laplacian Lichnerowicz Equation on Noncompact Metric Measure Space

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Chinese Annals of Mathematics,Series B 2020年第3期41卷 397-406页

作者： Liang ZHAO Ming shen Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Mathematics and Computer Science Fuzhou UniversityFuzhou 350116China

In this paper, the authors obtain the gradient estimates for positive solutions to the weighted p-Laplacian Lichnerowicz equation △p,fu + cuσ= 0 on noncompact smooth metric measure space, where c is a nonnegative constant, and p, σ(1 < p≤2, σ≤p-1) are real constants. Moreover, by the gradient estimate, they can get the corresponding Liouville theorem and Harnack inequality.

关键词： p-Laplacian Positive solutions Liouville theorem

Learning Semantic Concepts from Noisy Media Collection for Automatic Image Annotation

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Chinese Journal of Electronics 2015年第4期24卷 790-794页

作者： TIAN Feng shen Xukun School of Computer and Information Technology Northeast Petroleum University State Key Laboratory of Virtual Reality Technology and Systems Beihang University

Along with the explosive growth of images, automatic image annotation has attracted great interest of various research communities. However, despite the great progress achieved in the past two decades, automatic annotation is still an important open problem in computer vision, and can hardly achieve satisfactory performance in real-world environment. In this paper, we address the problem of annotation when noise is interfering with the dataset. A semantic neighborhood learning model on noisy media collection is proposed. Missing labels are replenished, and semantic balanced neighborhood is construct. The model allows the integration of multiple label metric learning and local nonnegative sparse *** construct semantic consistent neighborhood for each sample, thus corresponding neighbors have higher global similarity, partial correlation, conceptual similarity along with semantic balance. Meanwhile, an iterative denoising method is also proposed. The method proposed makes a marked improvement as compared to the current state-ofthe-art.

关键词： Image annotation Noisy media collection Semantic neighborhood

A Pricing Model for Big Personal Data

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Tsinghua Science and Technology 2016年第5期21卷 482-490页

作者： Yuncheng shen Bing Guo Yan shen Xuliang Duan Xiangqian Dong Hong Zhang College of Computer Science Sichuan University Chengdu 610065 China College of Information Science and Technology Zhaotong University Zhaotong 657000 China School of Control Engineering Chengdu University of Information Technology Chengdu 610225 China

Big Personal Data is growing explosively. Consequently, an increasing number of internet users are drowning in a sea of data. Big Personal Data has enormous commercial value; it is a new kind of data asset. An urgent problem has thus arisen in the data market： How to price Big Personal Data fairly and reasonably. This paper proposes a pricing model for Big Personal Data based on tuple granularity, with the help of comparative analysis of existing data pricing models and strategies. This model is put forward to implement positive rating and reverse pricing for Big Personal Data by investigating data attributes that affect data value, and analyzing how the value of data tuples varies with information entropy, weight value, data reference index, cost, and other factors. The model can be adjusted dynamically according to these parameters. With increases in data scale, reductions in its cost,and improvements in its quality, Big Personal Data users can thereby obtain greater benefits.

关键词： data tuple Big Personal Data positive grading reverse pricing pricing model

基于生命周期碳排放和总拥有成本的公交车队更新优化

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Journal of Southeast University(English Edition) 2024年第2期40卷 185-192页

作者：沈金星刘沁鑫郑长江刘坤马昌喜河海大学土木与交通学院南京210098 兰州交通大学交通与运输学院兰州730070

为探索电能和氢能源作为常规公交替代燃料的优势和潜力,确定公交车队更新时序的优化方案,从生命周期的角度综合考虑碳排放和总拥有成本的影响,提出了一种混合整数规划模型.基于柴油、天然气、油电混合、纯电动和氢燃料电池5种动力类型... 详细信息

为探索电能和氢能源作为常规公交替代燃料的优势和潜力,确定公交车队更新时序的优化方案,从生命周期的角度综合考虑碳排放和总拥有成本的影响,提出了一种混合整数规划模型.基于柴油、天然气、油电混合、纯电动和氢燃料电池5种动力类型公交的运营数据,分析了电力结构、制氢方式、车辆购置成本和氢能源使用成本的不确定性对车队更新方案的影响.结果表明:电动公交车是当前公交车队更新的最佳选择;在现有的车辆技术水平和制氢方式情景下,不宜选择氢燃料电池公交;在蓝氢或绿氢得到大规模商业化之前,不建议通过财政补贴的方式全面推广氢燃料电池公交;采用该方法可以在不同情景和预期目标下确定公交车队的更新优化方案,促进绿色可持续发展.

关键词：公交车队更新生命周期碳排放总拥有成本混合整数规划替代燃料电动公交氢燃料电池公交