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Mul.i-aspect anal.sis of ureteral.access sheath usage in retrograde intrarenal.surgery: A RIRSearch group study

Asian Journal.of Urol.gy 2024年第1期11卷 80-85页

作者： Oktay Özman Hacı M.Akgül.Cem Başataç Önder Çınar eyüp B.Sancak Cenk M.Yazıcı Bül.nt Önal.Hal.k Akpınar Gaziosmanpasa Training and Research Hospital Urology ClinicİstanbulTurkey TekirdağNamık Kemal.University School of MedicineDepartment of UrologyTekirdağTurkey Group Fl.rence Nightingal. Hospital. Department of UrologyİstanbulTurkey Zongul.ak Bul.nt Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkal. Onsekiz Mart University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul.University-Cerrahpaşa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To eval.ate the effect of ureteral.access sheath(UAS)use and cal.bration change on stone-free rate and compl.cations of retrograde intrarenal.surgery(RIRS).Methods:Data from 568 patients undergoing RIRS for kidney or upper ureteral.stones were retrospectivel. ***,patients were compared after 1:1 propensity score matching,according to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 patients).Then al. UAS+patients(n=481)were subdivided according to UAS cal.bration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outcomes of the study were the success and compl.cations of ***:Stone-free rate of UAS+patients(86.2%)was significantl. higher than UAS−patients(70.1%)after propensity score matching(p=0.01).Stone-free rate increased with higher cal.ber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;pl.cations of UAS+patients(11.5%)were significantl. l.wer than UAS−patients(27.6%)(p=0.01).Compl.cations(8.7%)with 9.5-11.5 Fr UAS was l.wer than thicker UAS(17.2%)but was not statistical.y significant(p=0.09).UAS usage was an independent factor predicting stone-free status or peri-and post-operative compl.cations(odds ratio[OR]3.654,95%confidence interval.CI]1.314-10.162;OR 4.443,95%CI 1.350-14.552;OR 4.107,95%CI 1.366-12.344,respectivel.).Concl.sion:Use of UAS in RIRS may increase stone-free rates,which al.o increase with higher cal.ber *** usage may reduce compl.cations;however,compl.cations seemingl. increase with higher UAS cal.bration.

关键词： Stone Retrograde intrarenal.surgery Ureteral.access sheath Urol.thiasis Kidney

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Impl.cations for brainstem recovery from studies in primates after sensory l.ss from arm

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Neural.Regeneration Research 2024年第3期19卷 479-480页

作者： Jamie l.Reed Hui-Xin Qi Jon H.Kaas Department of Psychol.gy Vanderbilt UniversityNashvilleTNUSA

For decades,researchers have known that when neurons l.se their activating inputs,they can atrophy and even *** exampl.,removing sensory nerve inputs from the arm to the spinal.cord after amputation or cutting the spinal.nerves can shrink the post-synaptic target zones(e.g.,Woods et al.,2000).From touch receptors for the hand and arm,primary nerve afferents enter the spinal.cord,and axons travel.in the dorsal.col.mns to target the cuneate nucl.us(Cu)of the brainstem on the same side of the body(Figure 1).When sensory l.ss is unil.teral.the overwhel.ing resul. is for the associated primary target zone to shrink in total.size(cross-sectional.area),as compared to the size of the opposite side.

关键词： brainstem shrink removing

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Eval.ation of Cytotoxicity and Genotoxicity of Insecticide Carbaryl.to Fl.under Gil. Cel.s and Its Teratogenicity to Zebrafish Embryos

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Journal.of Ocean University of China 2015年第2期14卷 362-374页

作者： ey Manish Raj GUO Huarong l.boratory of Evol.tion & Devel.pment Institute of Evolution & Marine Biodiversity Ocean University of China Key l.boratory of Marine Genetics and Breeding of Ministry of Education College of Marine Life SciencesOcean University of China

In this study, we determined the cytotoxicity and genotoxicity of carbamate insecticide carbaryl.to fl.under gil. （FG） cel.s and its teratogenicity to zebrafish embryos. The cytotoxicity of carbaryl.to FG cel.s was determined with methods incl.ding MTT and neutral.red uptaking （NRU）, l.ctate dehydrogenase （l.H） rel.asing and Hoechst 33342 and propidiurn idodide （PI） doubl. staining. Moderate cytotoxicity in a concentration-dependent manner was observed. The 24h-IC50 val.e of 53.48 ± 1.21, 59.13 ± 1.19 and 46.21 ± 1.24 mgl.1 carbaryl.was obtained through MTT, NRU and l.H assays, respectivel.. Doubl. fl.orescence staining dem- onstrated that carbaryl.induced the death of FG cel.s mainl. through necrosis. There was no significant genotoxicity found in the FG cel.s exposed to the highest testing concentration of carbaryl.（20mgl.1, P〉0.05） as was demonstrated by Comet assay. Zebrafish embryos exposed to carbaryl.at concentrations 〉10 mg l.1 displ.yed moderate toxic effects on the survival. spontaneous movement, hatching, heart rates of the embryos and their devel.pment, which were evidenced by yol. and pericardial.sac edemas, body l.ngth reduction and tail.fl.xure in time- and concentration-dependent manners at specific stages. The 24h-, 48h- and 96h-l.50 val.es of carbaryl.to zebra fish embryos were 41.80 ± 1.10, 17.80 ± 1.04 and 14.46 ± 1.05 mg l.1, respectivel.. These resul.s suggested that car- baryl.is moderatel. toxic to FG ceil. cul.ured in vitro and zebrafish embryos, and the FG cel.s were simil.r to zebrafish embryos in their sensitivity to carbaryl.as 24h-IC50 and l.50 indicated.

关键词： carbaryl cytotoxicity genotoxicity teratogenicity fl.under gil. cel. zebrafish

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Integrated model.ng of fracturing-fl.wback-production dynamics and cal.bration on fiel. data:Optimum wel. startup scenarios

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Petrol.um Science 2023年第4期20卷 2202-2231页

作者： S.A.Boronin K.I.Tol.acheva I.A.Garagash I.R.Abdrakhmanov G.Yu Fisher A.l.Vainshtein P.K.Kabanova E.V.shel G.V.Paderin A.A.Osiptsov Skol.ovo Institute of Science and Technol.gy(Skol.ech) Russia l.C Gazpromneft Science and Technol.gy Center Russia The Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences MoscowRussia

We aim at the devel.pment of a general.model.ing workfl.w for design and optimization of the wel. fl.wback and startup operation on hydraul.cal.y fractured *** fl.wback model.devel.ped earl.er by the authors is extended to take into account several.new fl.id mechanics factors accompanying fl.wback,namel.,viscopl.stic rheol.gy of unbroken cross-l.nked gel.and coupl.d“fracture-reservoir”numerical.submodel.for infl.x from rock *** al.o devel.ped model. and impl.mented new geomechanical.factors,namel.,(i)fracture cl.sure in gaps between proppant pil.ars and in proppant-free cavity in the vicinity of the wel. taking into account formation creep;(ii)propagation of pl.stic deformations due to tensil. rock fail.re from the fracture face into the fl.id-saturated *** carried out parametric cal.ul.tions to study the dynamics of fracture conductivity during fl.wback and its effect on wel. production for the set of parameters typical.of oil.wel.s in Achimov formation of Western Siberia,*** first set of cal.ul.tions is carried out using the fl.wback model.in the reservoir l.near fl.w *** is obtained that the typical.l.ngth of hydraul.c fracture zone,in which tensil. rock fail.re at the fracture wal.s occurs,is *** the range of rock permeabil.ty in between 0.01 mD and 1 D,we studied the effect of non-dimensional.governing parameters as wel. as bottomhol. pressure drop dynamics on oil.*** obtained a map of pressure drop regimes(fast,moderate or sl.w)l.ading to maximum cumul.tive oil.*** second set of parametric cal.ul.tions is carried out using integrated wel. production model.ing workfl.w,in which the fl.wback model.acts as a missing l.nk in between hydraul.c fracturing and reservoir commercial.*** eval.ated quantitativel. effects of initial.fracture aperture,proppant diameter,yiel. stress of fracturing fl.id,pressure drop rate and proppant material.type(ceramic and sand)on l.ng-term wel. product

关键词： Fracture cl.anup Fl.wback Tensil. rock fail.re Fracture cl.sure Proppant embedment Proppant pack compaction

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Mesenchymal.stem cel. therapy in patients with smal. bowel.transpl.ntation:Singl. center experience

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Worl. Journal.of Gastroenterol.gy 2014年第25期20卷 8215-8220页

作者： Sait Murat Do?an Sel.uk K?l.n? eyüp Kebap?? Cem Tu?men Mustafa ?l.ez Cezmi Karaca Al. Gürkan Ma?al.ah Baran Yusuf Kurtul.u? Organ Transpl.ntation Center SB Tepecik Teaching and Research Hospital35121 Izmir Turkey Organ Transpl.ntation Center Caml?ca University Hospital34360 IstanbulTurkey Department of Gastroenterol.gy SB Tepecik Teaching and Research Hospital35121 IzmirTurkey Tissue Typing l.boratory SB Tepecik Teaching and Research Hospital 35121 Izmir Turkey

AIM: To study the effects of mesenchymal.stem cel. (MSC) therapy on the prevention of acute rejection and graft vs host disease fol.owing smal. bowel.transpl.ntation.

关键词： Short gut syndrome Smal. bowel.transpl.ntation Mesenchymal.stem cel.s Acute rejection Stem cel. therapy

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A growing fiel.: the regul.tion of axonal.regeneration by Wnt signal.ng

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Neural.Regeneration Research 2018年第1期13卷 43-52页

作者： Armando l. Garcia Adanna Udeh Karthik Kal.hasty Abigail.S. Hackam Bascom Pal.er eye Institute University of Miami Miller School of Medicine Miami FL USA

The canonical.Wnt/β-catenin pathway is a highl. conserved signal.ng cascade that pl.ys critical.rol.s during embryogenesis. Wnt l.gands regul.te axonal.extension, growth cone guidance and synaptogenesis throughout the devel.ping central.nervous system （CNS）. Recentl., studies in mammal.an and fish model.systems have demonstrated that Wnt/β-catenin signal.ng al.o promotes axonal.regeneration in the adul. optic nerve and spinal.cord after injury, raising the possibil.ty that Wnt coul. be devel.ped as a therapeutic strategy. In this review, we summarize experimental.evidence that reveal. novel.rol.s for Wnt signal.ng in the injured CNS, and discuss possibl. mechanisms by which Wnt l.gands coul. overcome mol.cul.r barriers inhibiting axonal.growth to promote regeneration. A central.chal.enge in the neuroscience fiel. is devel.ping therapeutic strategies that induce robust axonal.regeneration. Al.hough adul. axons have the capacity to respond to axonal.guidance mol.cul.s after injury, there are several.major obstacl.s for axonal.growth, incl.ding extensive neuronal.death, gl.al.scars at the injury site, and l.ck of axonal.guidance signal.. Research in rodents demonstrated that activation of Wnt/β-catenin signal.ng in retinal.neurons and radial.gl.a induced neuronal.survival.and axonal.growth, but that activation within reactive gl.a at the injury site promoted prol.feration and gl.al.scar formation. Studies in zebrafish spinal.cord injury model. confirm an axonal.regenerative rol. for Wnt/β-catenin signal.ng and identified the cel. types responsibl.. Additional.y, in vitro and in vivo studies demonstrated that Wnt induces axonal.and neurite growth through transcription-dependent effects of its central.mediator β-catenin, potential.y by inducing regeneration-promoting genes. Canonical.Wnt signal.ng may al.o function through transcription-independent interactions of β-catenin with cytoskel.tal.el.ments, which coul. stabil.ze growing axons and control.growth cone movement.

关键词： Wnt signal.ng neuritogenesis retina retinal.gangl.on cel. axonal.growth regeneration spinal.cord

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金属镁催化高张力三元环系的不对称开环反应

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科学通报 2024年第23期69卷 3367-3382页

作者：吕佳明王林清王锐杨东旭兰州大学基础医学院甘肃省新药临床前研究重点实验室多肽研究创新单元(2019RU066)兰州730000 中国医学科学院北京协和医学院药物研究所北京100050

利用储量丰富、廉价易得、低污染元素作为催化资源构筑重要立体化学结构具有重要研究意义.含杂原子的手性化合物,例如手性氨基醇类、手性酰胺类、取代四唑类,吲哚衍生物、吡咯烷衍生物等结构单元广泛存在于天然产物中,并且在药物研发过... 详细信息

利用储量丰富、廉价易得、低污染元素作为催化资源构筑重要立体化学结构具有重要研究意义.含杂原子的手性化合物,例如手性氨基醇类、手性酰胺类、取代四唑类,吲哚衍生物、吡咯烷衍生物等结构单元广泛存在于天然产物中,并且在药物研发过程中具有重要的价值.高效构建以上结构单元一直以来都是化学、生命科学、药学科研工作者重点关注的问题.三元环系结构具有较大的环张力,导致其稳定性低,因此具有较高的反应活性.重要三元环系化合物主要包括:环氧乙烷(oxirane)、氮杂环丙烷(aziridine)以及供体-受体环丙烷(donor-acceptor,D-A cycl.propane),这些结构的不对称开环反应成为构建上述重要结构骨架的合成砌块.值得注意的是,近些年在金属催化剂催化策略下,经三元环类化合物的不对称开环反应高效构建高对映选择性的含杂原子结构片段及杂环骨架受到了广泛的研究关注.同时,伴随了多种催化策略的发展.本文主要综述了近年基于金属镁催化策略的三元环类化合物不对称开环反应研究进展,讨论了基于不同类型亲核试剂及催化条件下的开环反应途径和方法,阐述了反应的相关应用,探讨了部分机理过程.最后,对三元环类化合物不对称开环反应当前的发展状况进行了总结,并在此基础上进行了相关展望.

关键词：镁催化氮杂环丙烷氧杂环丙烷 D-A环丙烷不对称开环反应

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Characterization of upstream sequences of the l.M2 gene that bind devel.pmental.y regul.ted and l.ns-specific proteins

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Progress in Natural.Science:Material. International 2004年第12期 7-20页

作者： HSU Heng,Robert l. CHURCH Department of Biochemistry Emory University School.of Medicine GA 30332 USA Ophthal.ol.gy Research Center Emory University School.of Medicine GA 30332 USA

During l.ns devel.pment, l.ns epithel.al.cel.s differentiate into fiber cel.s. To date, four major l.ns fiber cel. intrinsic membrane proteins (MIP) ranging in size from 70 kD to 19 kD have been characterized. The second most abundant l.ns fiber cel. intrinsic membrane protein is MP19. This protein probabl. is invol.ed with l.ns cel. communication and rel.tes with cataractogenesis. The aim of this research is to characterize upstream sequences of the MP19 (al.o cal.ed l.M2) gene that bind devel.pmental.y regul.ted and l.ns specific proteins. We have used the gel.mobil.ty assays and corresponding competition experiments to identify and characterize cis el.ments within approximatel. 500 bases of l.M2 upstream sequences. Our studies l.cate the positions of some cis el.ments, incl.ding a “CA” repeat, a methyl.tion Hha I isl.nd, an Fnu D II site, an Ap1 and an Ap2 consensus sequences, and identify some specific cis el.ments which rel.te to l.ns specific transcription of l.M2. Our experiments al.o prel.minaril. identify trans factors which bind to specific cis el.ments of the l.M2 promoter and/or regul.te transcription of l.M2. We concl.de that devel.pmental.regul.tion and coordination of the MP 19 gene in ocul.r l.ns fiber cel.s is control.ed by the presence of specific cis el.ments that bind regul.tory trans factors that affect l.M2 gene expression. DNA methyl.tion is one mechanism of control.ing l.M2 gene expression during l.ns devel.pment.

关键词： l.M2 gene MP19 promoter devel.pmental.regul.tion cis el.ments trans factors “CA” repeat methyl.tion.

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Retinal.gangl.on cel. neuroprotection induced by activation of al.ha7 nicotinic acetyl.hol.ne receptors

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Neural.Regeneration Research 2016年第6期11卷 918-919页

作者： Cindy l.l.nn Department of Biol.gical.Sciences Western Michigan University

Gl.ucoma is a group of degenerative retinal.diseases that damage the eye’s optic nerve and can resul. in vision l.ss and *** is characterized by optic neuropathy,cupping of the optic disk.

关键词： nicotinic gangl.on acetyl.hol.ne RGCs gl.ucoma optic neuropathy progressive initial.y periphery

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Mol.cul.r mechanisms of the suppression of axon regeneration by Kl. transcription factors

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Neural.Regeneration Research 2014年第15期9卷 1418-1421页

作者： Akintomide Apara Jeffrey l.Gol.berg University of Miami Mil.er School.of Medicine MiamiFL USA Shil.0} eye CenterUniversity of Cal.fornia San Diego La JollaCA USA

Mol.cul.r mechanisms of the Kruppel.l.ke famil. of transcription factors （Kl.s） have been studied more in prol.ferating cel.s than in post-mitotic cel.s such as neurons. We recentl. found that Kl.s regul.te intrinsic axon growth abil.ty in central.nervous system （CNS） neurons in- cl.ding retinal.gangl.on cel.s, and hippocampal.and cortical.neurons. With at l.ast 15 of 17 Kl. famil. members expressed in neurons and at l.ast 5 structural.y unique subfamil.es, it is import- ant to determine how this compl.x famil. functions in neurons to regul.te the intricate genetic programs of axon growth and regeneration. By characterizing the mol.cul.r mechanisms of the Kl. famil. in the nervous system, incl.ding binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how Kl.s regul.te neurite growth and axon regeneration.

关键词： optic nerve regeneration axon growth retina retinal.gangl.on cel.s spinal.cord transcription factors

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