Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors

作     者：Akintomide Apara Jeffrey L.Goldberg 

作者机构：University of Miami Miller School of MedicineMiamiFL USA Shiley Eye CenterUniversity of California San DiegoLa JollaCA USA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第15期

页      面：1418-1421页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：the National Eye Institute(EY022129 to JLG P30-EY022589 to UCSD) the DOD(W81XWH-12-1-0254 to JLG) an unrestricted grant from Research to Prevent Blindness,Inc 

主　　题：optic nerve regeneration axon growth retina retinal ganglion cells spinal cord transcription factors 

摘      要：Molecular mechanisms of the Kruppel-like family of transcription factors （KLFs） have been studied more in proliferating cells than in post-mitotic cells such as neurons. We recently found that KLFs regulate intrinsic axon growth ability in central nervous system （CNS） neurons in- cluding retinal ganglion cells, and hippocampal and cortical neurons. With at least 15 of 17 KLF family members expressed in neurons and at least 5 structurally unique subfamilies, it is import- ant to determine how this complex family functions in neurons to regulate the intricate genetic programs of axon growth and regeneration. By characterizing the molecular mechanisms of the KLF family in the nervous system, including binding partners and gene targets, and comparing them to defined mechanisms defined outside the nervous system, we may better understand how KLFs regulate neurite growth and axon regeneration.