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Psychology Re.e.rch 2017年第8期7卷 445-452页

作者： Mark Cogburn Rita Horton shawn e. mcneil Louisiana State.Unive.sity He.lth Scie.ce. Ce.te. Shreveport USA

MicroRNA e.pre.sion and function in prostate.cance.： a re.ie. of curre.t knowle.ge.and opportunitie. for discove.y

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Asian Journal of Andrology 2016年第4期18卷 559-567页

作者： Binod Kumar shawn e.Lupold The.Jame. Buchanan Brady Urological Institute Department of Urology Johns Hopkins School of Medicine Baltimore MD USA.

MicroRNAs （miRNAs） are.we.l-conse.ve. noncoding RNAs that broadly re.ulate.ge.e.e.pre.sion through posttranscriptional sile.cing of coding ge.e.. Dysre.ulate. miRNA e.pre.sion in prostate.and othe. cance.s implicate. the.r role.in cance. biology. More.ve., functional studie. provide.support for the.contribution of miRNAs to se.e.al ke. pathways in cance. initiation and progre.sion. Comparative.analyse. of miRNA ge.e.e.pre.sion be.we.n malignant and nonmalignant prostate.tissue., he.lthy controls and prostate.cance. （PCa） patie.ts, as we.l as le.s aggre.sive.ve.sus more.aggre.sive.dise.se.indicate.that miRNAs may be.future.diagnostic or prognostic biomarke.s in tumor tissue. blood, or urine. Furthe., miRNAs may be.future.the.ape.tics or the.ape.tic targe.s. In this re.ie., we.e.amine.the.miRNAs most commonly obse.ve. to be.de.re.ulate. in PCa ge.e.e.pre.sion analyse. and re.ie. the.pote.tial contribution of the.e.miRNAs to important pathways in PCa initiation and progre.sion.

关键词： miRNA prostate.cance. noncoding RNA

Alte.native.polyade.ylation:An untappe. source.for prostate.cance. biomarke.s and the.ape.tic targe.s?

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Asian Journal of Urology 2021年第4期8卷 407-415页

作者： Akira Kurozumi shawn e.Lupold The.Jame. Buchanan Brady Urologic Institute.and De.artme.t of Urology Johns Hopkins School of MedicineBaltimoreMDUSA The.De.artme.t of Oncology Sidney Kimmel Comprehensive Cancer CenterSchool of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Obje.tive.To re.ie. alte.native.polyade.ylation(APA)as a me.hanism of ge.e.re.ulation and conside. pote.tial role. for APA in prostate.cance.(PCa)biology and ***:An e.te.sive.re.ie. of mRNA polyade.ylation,APA,and PCa lite.ature.was *** re.ie. article.introduce. APA and its association with human dise.se.outline. the.me.hanisms and compone.ts of APA,re.ie.s APA in cance. biology,and conside.s whe.he. APA may contribute.to PCa progre.sion and/or produce.nove. biomarke.s and the.ape.tic targe.s for ***:e.karyotic mRNA 30-e.d cle.vage.and polyade.ylation play a critical role.in ge.e.*** human ge.e. e.code.more.than one.polyade.ylation signal,and produce.more.than one.transcript isoform,through *** can occur throughout the.ge.e.body to ge.e.ate.transcripts with diffe.ing 30-te.mini and coding *** in 30-untranslate. re.ions le.gth can modify post-transcriptional ge.e.re.ulation by microRNAs and RNA binding prote.ns,and alte. mRNA stability,translation e.ficie.cy,and subce.lular *** APA patte.ns are.associate. with human dise.se.,tissue.origins,and change. in ce.lular prolife.ation rate.and diffe.e.tiation *** e.e.ts may the.e.ore.ge.e.ate.unique.mRNA biomarke.s or the.ape.tic targe.s in ce.tain cance. type. or phe.otypic ***:The.full e.te.t of cance.-associate. and tissue.spe.ific APA e.e.ts have.ye. to be.de.ine.,and the.me.hanisms and functional conse.ue.ce. of APA in cance. re.ain incomple.e.y *** is e.ide.ce.that APA is active.in PCa,and that it may be.an untappe. re.ource.for PCa biomarke.s or the.ape.tic targe.s.

关键词： Prostate.cance. Polyade.ylation Alte.native.polyade.ylation 30-untranslate. re.ion microRNA Intronic polyade.ylation

Acce.e.ate. Gradie.t De.ce.t Me.hods for the.Uniaxially Constraine. Landau-de.Ge.ne. Mode.

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Advance. in Applie. Mathe.atics and Me.hanics 2022年第1期14卷 1-32页

作者： e.ison e.Chukwue.e.a shawn W.Walke. De.artme.t of Me.hanical e.gine.ring Louisiana State UniversityBaton RougeLA 70803USA De.artme.t of Mathe.atics and Ce.te. for Computation and Te.hnology(CCT) Louisiana State UniversityBaton RougeLA 70803USA

This pape. illustrate. the.e.ficacy of using acce.e.ate. gradie.t de.ce.t sche.e. for minimizing a uniaxially constraine. Landau-de.Ge.ne. mode. for ne.atic liquid ***(alte.nating dire.tion)minimization sche.e. are.applie. to a structure.pre.e.ving finite.e.e.e.t discre.ization of the.uniaxial mode.:a standard gradie.t de.ce.t me.hod,the.he.vy-ball”me.hod,and Ne.te.ov’s *** pe.formance.of the.sche.e. is me.sure. in te.ms of the.numbe. of ite.ations re.uire. to obtain the.e.uilibrium state.as we.l as the.total computational time.wall time..The.nume.ical e.pe.ime.ts cle.rly show that the.acce.e.ate. gradie.t de.ce.t sche.e. re.uce.the.numbe. of ite.ations and computational time.significantly,de.pite.the.hard uniaxial constraint that is not“smooth”whe. de.e.ts are.***,our re.ults show that acce.e.ate. sche.e. are.not hinde.e. whe. combine. with an alte.nating dire.tion minimization algorithm and are.e.sy to imple.e.t.

关键词： Liquid crystals Landau-de.Ge.ne. uniaxial he.vy-ball me.hod Ne.te.ov’s me.hod

A Finite.e.e.e.t Me.hod for a Phase.Fie.d Mode. of Ne.atic Liquid Crystal Drople.s

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Communications in Computational Physics 2019年第1期25卷 155-188页

作者： Amanda e.Die.e. shawn W.Walke. De.artme.t of Mathe.atics Louisiana State UniversityBaton RougeLA 70803-4918USA

We.de.e.op a nove. finite.e.e.e.t me.hod for a phase.fie.d mode. of ne.atic liquid crystal *** continuous mode. conside.s a fre. e.e.gy comprise. of thre. compone.ts:the.e.ickse.’s e.e.gy for liquid crystals,the.Cahn-Hilliard e.e.gy re.re.e.ting the.inte.facial e.e.gy of the.drople.,and an anisotropic we.k anchoring e.e.gy that e.force. a condition such that the.dire.tor fie.d is aligne. pe.pe.dicular to the.inte.face.of the.*** of the.mode. are.for finding minimize.s of the.fre. e.e.gy and e.ploring gradie.t flow *** pre.e.t a finite.e.e.e.t me.hod that utilize. a spe.ial discre.ization of the.liquid crystal e.astic e.e.gy,as we.l as mass-lumping to discre.ize.the.coupling te.ms for the.anisotropic surface.te.sion ***,we.pre.e.t a discre.e.gradie.t flow me.hod and show that it is monotone.e.e.gy ***,we.show that global discre.e.e.e.gy minimize.sΓ-conve.ge.to global minimize.s of the.continuous *** conclude.with nume.ical e.pe.ime.ts illustrating diffe.e.t gradie.t flow dynamics,including drople. coale.-ce.ce.and bre.k-up.

关键词： Ne.atic liquid crystal phase.fie.d e.ickse.’s e.e.gy Γ-conve.ge.ce gradie.t flow

e.fe.t of die.s on the.fe.ding be.avior and physiological prope.tie. of suspe.sion-fe.ding se. cucumbe. Cucumaria frondosa

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Journal of Oce.nology and Limnology 2020年第3期38卷 883-893页

作者： YU Zonghe.ROBINSON shawn MACDONALD Bruce.LANDe. Te.ralynn SMITH Craig Colle.e.of Marine.Scie.ce. South China Agricultural UniversityGuangzhou 510642China Fishe.ie. and Oce.ns Canada St.Andrews Biological StationSt.AndrewsNB E5B 2L9Canada Biology De.artme.t and Ce.tre.for Coastal Studie. and Aquaculture University of New BrunswickSaint JohnNB E2L 4L5Canada

The.suspe.sion-fe.ding se. cucumbe. Cucumaria frondosa has be.ome.comme.cially important in re.e.t *** prope. die.s is the.first important ste. for inte.sive.aquaculture.of this se. *** this study,adult *** we.e.e.pose. to one.of the.following die. tre.tme.ts:control(no die. provide.),two powde.e. se.we.ds(Ascophyllum nodosum and Saccharina latissima),a comme.cially available.microalgal die.(she.lfish die.)and natural *** e.fe.ts of die.s on the.fe.ding be.avior and physiological prope.tie. of se. cucumbe.s we.e.inve.tigate. afte. a 5-we.k re.ring *** show that se. cucumbe.s fe. with she.lfish die. e.hibite. a significantly highe. te.tacle.inse.tion rate.1.80±0.20 inse.tion/min)than the.e.fe. with se.we.d powde.s,and the.e.was no significant diffe.e.t be.we.n the.two groups fe. by se.we.d *** significant diffe.e.ce.was found on the.fe.al production rate.among the.fe.ding *** minimum oxyge. consumption rate.was obse.ve. in the.control group(5.76±0.99μg O2/(g·h)),which is significantly lowe. than individuals fe. with ***,she.lfish die.,and natural se.ton;howe.e.,no significant diffe.e.ce.was shown be.we.n those.of control and *** *** maximum ammonium e.cre.ion rate.was found in the.*** group(0.03±0.01μmol/(g·h)),which is significantly highe. than othe. *** minimum O/N ratio was obse.ve. in the.*** group(14.57±1.04),which is significantly lowe. than the.***,she.lfish die.,and natural se.ton *** fe. with se.we.d powde.s had similar physiological prope.tie. with the.e.fe. with microalgae.die. and natural se.ton,indicating that *** and *** can be.e.plore. as promising die.s for inte.sive.aquaculture.of ***.

关键词： se. cucumbe. Cucumaria frondosa physiological prope.ty fe.ding be.avior nutritional condition

A one.ste.,tunable.me.hod of se.e.tive.re.ctive.sputte. de.osition as a wrinkling approach for silve./polydime.hylsiloxane.for e.e.trically conductive.pliable.surface.

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Microsyste.s & Nanoe.gine.ring 2022年第4期8卷 221-231页

作者： Joe. Y.Y.Loh Ali Ze.ne.dine.Moe.n Shaye.annia Robyn mcneil Liam McRae.Nazir P.Khe.ani De.artme.t of e.e.trical and Computing e.gine.ring University of TorontoTorontoON M5S 3G4Canada De.artme.t of Mate.ial Scie.ce.and e.gine.ring University of TorontoTorontoON M5S 3E4Canada

The.wrinkle.pe.iod and morphology of a me.al thin film on an e.astic substrate.is typically controlle. by modifying the.substrate.be.ore.carrying out additional me.al de.osition ***,we.show that a simultane.usly se.e.tive.and re.ctive.sputte.ing plasma that modifie. the.surface.of a polydime.hylsiloxane.PDMS)substrate.while.not re.cting with the.me.al during the.de.osition proce.s de.re.se. the.wrinkle.wave.e.gth and induce. additional wrinkling compone.ts and fe.ture. such as ripple. or *** se.e.tive.re.ction of the.nitroge. plasma with PDMS functionalize. the.siloxane.surface.into silicon *** harde.s the.imme.iate.surface.of PDMS,with a quadratic incre.se.in the.Young’s modulus as a function of the.sputte.ing flow *** incre.se.in the.critical strain mismatch and the.corre.ponding pre.e.ce.of folds in the.nitroge.-modifie. wrinkle. silve. film form a suitable.plasmonic platform for surface.e.hance. Raman spe.troscopy(Se.S),yie.ding an e.hance.e.t factor of 4.8×105 for de.e.ting *** e.hance.e.t is linke. to the.e.e.ge.ce.of e.e.tromagne.ic hotspots from surface.plasmon polariton coupling be.we.n the.folds/wrinkle.,which in turn e.able. the.de.e.tion of low conce.trations of organics using ***,whe. straine.,the.nitroge.-modifie. wrinkle. e.hance.e.e.trical conductivity by a factor of 12 compare. with unmodifie. ***,the.optical prope.tie. of the.substrate.can be.tune. by alte.ing the.N2 *** simple.addition of nonre.ctive.nitroge. to silve. sputte.ing e.able. simultane.us PDMS harde.ing and growth of the.silve. film and toge.he. provide.a ne. ave.ue.for tuning wrinkling parame.e.s and e.hancing the.e.e.trical conductivity of pliable.surface..

关键词： silve. re.ctive film

SARS-COV-2 infe.tion(coronavirus dise.se.2019)for the.gastrointe.tinal consultant

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World Journal of Gastroe.te.ology 2020年第14期26卷 1546-1553页

作者： Kave. Hajifathalian Srihari Mahade. Robe.t e.Schwartz shawn Shah Kartik Sampath Fe.ice.Schnoll-Sussman Robe.t S Brown Jr David Carr-Locke.David e.Cohe. Re.m Z Sharaiha Division of Gastroe.te.ology and He.atology Weill Cornell MedicineNew York-Presbyterian HospitalNew YorkNY 10021United States

The.curre.t pande.ic due.to the.se.e.e.acute.re.piratory syndrome.coronavirus 2 has cause. an e.tre.e.burde. for he.lth care.syste.s globally,and the.numbe. of case. is e.pe.te. to continue.to incre.se.at le.st in the.imme.iate.*** virus is e.timate. to have.infe.te. more.than 1.5 million *** available.re.orts sugge.t that gastrointe.tinal(GI)involve.e.t in coronavirus dise.se.2019(COVID-19)is common and in some.case. the.GI symptoms may pre.e.e.the.re.piratory *** addition to dire.t e.fe.ts of se.e.e.acute.re.piratory syndrome.coronavirus 2,the.infe.te. patie.ts re.ain at risk for the.complications commonly manage. by gastroe.te.ology and he.atology *** most commonly re.orte. GI manife.tation of COVID-19 is diarrhe.,which is re.orte. in a third to up to more.than half of the.*** to mode.ate.e.e.ation of the.live. e.zyme. are.also common,although no case.of acute.live. failure.has be.n re.orte. so *** of the.me.ications use. for tre.tme.t of COVID-19 can also be.associate. with GI symptoms or live. injury and can be.include. in the.diffe.e.tial diagnosis in the.e.*** the.diagnosis of the.infe.tion is curre.tly base. on RNA analysis in re.piratory sample.,the.available.lite.ature.on fe.al she.ding of this virus sugge.ts that fe.al RNA te.ting might prove.to be.a use.ul diagnostic *** is re.sonable.to de.ay all non-urge.t e.doscopic proce.ure. during the.pe.k of the.pande.ic and use.additional prote.tive.e.uipme.t such as N95 re.pirators during e.doscopy while.most patie.ts can be.conside.e. high risk for having be.n e.pose. to the.virus.

关键词： SARS-CoV-2 COVID-19 Gastroe.te.ology He.atology Live.

Lithium-ion batte.y data and whe.e.to find it

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e.e.gy and AI 2021年第3期5卷 255-269页

作者： Gonçalo dos Re.s Calum Strange.Mohit Yadav shawn Li School of Mathe.atics University of EdinburghThe King’s BuildingsEdinburgh EH93FDUK Ce.tro de.Mate.ática e.Aplicaçõe.(CMA) FCTUNLQuinta da Torre2829-516 CaparicaPortugal Indian Institute.of Te.hnology KanpurIndia

Lithium-ion batte.ie. are.fue.ling the.advancing re.e.able.e.e.gy base. *** the.core.of transformational de.e.opme.ts in batte.y de.ign,mode.ling and manage.e.t is *** this work,the.datase.s associate. with lithium batte.ie. in the.public domain are.*** re.ie. the.data by mode.of e.pe.ime.tal te.ting,giving particular atte.tion to te.t variable. and data *** highlighte. tools and platforms,ove. 30 datase.s are.re.ie.e..

关键词： Lithium batte.y Public data Batte.y data Batte.y te.ts Machine.le.rning

Climate.change.24-hour move.e.t be.aviors,and he.lth:a mini umbre.la re.ie.

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Global He.lth Re.e.rch and Policy 2021年第1期6卷 350-363页

作者： e.aline.Zisis shawn Hakimi e.n-Young Le. School of Kine.iology and He.lth Studie. Queen’s UniversityKHS 30728 Division StKingstonON K7L3N6Canada De.artme.t of Ge.de. Studie. Queen’s UniversityKingstonONCanada

Background:The.worse.ing climate.change.and alarming pre.ale.ce.of communicable.and non-communicable.dise.se. continue.to thre.t human life.and *** e.ide.ce.sugge.ts that favorable.patte.ns of 24-h move.e.t be.aviors,high physical activity,low se.e.tary be.avior,and ade.uate.sle.p,may positive.y contribute.to achie.ing dual be.e.its of climate.change.mitigation and dise.se.*** purpose. of this mini umbre.la re.ie. we.e.to summarize.the.most up-to-date.high-le.e. e.ide.ce.e.ploring the.re.ationships be.we.n climate.change.24-h move.e.t be.aviors,and he.lth and e.aborate.on the.me.hanisms linking the.thre. variable. of ***:A syste.atic se.rch of e.e.tronic database. was pe.forme. in PubMe. and Google.Scholar during March–Octobe. *** crite.ia we.e.(1)syste.atic re.ie.;(2)re.ie.e. re.ationships be.we.n climate.change.and move.e.t be.aviors and/or he.lth in any dire.tions;(3)writte. in e.glish;(4)publishe. in 2010–*** synthe.is was conducte. to highlight the.main re.ationships obse.ve. and addre.s the.curre.t state.of knowle.ge.and prioritie. for future.*** orde. to illustrate.the.pote.tial me.hanisms be.we.n climate.change.move.e.t be.aviors,and he.lth,the.main re.ults from include. syste.atic re.ie.s we.e.summarize. and a conce.tual frame.ork was de.e.ope. for future.***:Base. on the.e.ide.ce.from e.ght syste.atic re.ie.s publishe. in the.past de.ade.multi-dire.tional(i.e.,uni-,bi-,or U-shape.)links we.e.obse.ve. be.we.n climate.change.and varying human he.lth ***,little.is unde.stood about the.association be.we.n climate.change.and 24-h move.e.t *** re.ie.s sugge.te. the.ne.ative.impact of climate.change.on sle.p and bi-dire.tional re.ationships be.we.n climate.change.and physical activity/*** re.ie. include. two studie. sugge.ting the.unfavorable.impact of climate.change.on se.e.tary be.avior;howe.e.,the.e.ide.ce.was ***,no re.ie.s e.amine. t

关键词： Population he.lth Chronic dise.se Global warming Natural disaste. Physical activity