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Mechanism and recent updates on insulin-related disorders

世界临床病例杂志 2023年第25期11卷 5840-5856页

作者： shashank kumar Sabyasachi Senapati Neetu Bhattacharya Amit Bhattacharya shashank kumar maurya Hadiya Husain Jasvinder Singh Bhatti Abhay kumar Pandey Department of Biochemistry Central University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia Department of Zoology Dyal Singh CollegeUniversity of DelhiNew Delhi 110003India Department of Zoology Ramjas CollegeUniversity of DelhiNew Delhi 110007India Department of Zoology University of DelhiNew Delhi 110007India Department of Zoology University of LucknowLucknow 226007India Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular *** metabolic dysfunctions are related to insulin-mediated altered glucose *** of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological *** syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and ***,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and *** are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic *** revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and *** this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

关键词： Insulin disorder Diabetes Metabolic syndrome Neurological disorder Obesity Cancer

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Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain kumar Prabhash Venkatraman Radhakrishnan shashank Srinivasan Pfizer Products India Private Limited Mumbai India Tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.

关键词： Epidemiology Epidermal Growth Factor Receptor Adenocarcinoma Non-Small Cell Lung Cancer India

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Varna-based optimization:a novel method for capacitated controller placement problem in SDN

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Frontiers of Computer Science 2020年第3期14卷 87-111页

作者： Ashutosh kumar SINGH Saurabh maurya shashank SRIVASTAVA Department of Computer Science&Engineering Motilal Nehru National Institute of Technology AllahabadAllahabad 211004U.P.India

Recently,software defined networking(SDN)is a promising paradigm shift that decouples the control plane from the data *** can centrally monitor and control the network through softwarization,i.e.,*** controllers are a necessity of current SDN based *** multiple controllers in an optimum way is known as controller placement problem(CPP).Earlier,solutions of CPP only concentrated on propagation latency but overlooked the capacity of controllers and the dynamic load on switches,which is a significant factor in real *** this paper,we develop a novel optimization algorithm named varna-based optimization(VBO)and use it to solve *** the best of our knowledge,this is the first attempt to minimize the total average latency of SDN along with the implementation of TLBO and Jaya algorithms to solve CPP for all twelve possible *** experimental results show that TLBO outperforms PSO,and VBO outperforms TLBO and Jaya algorithms in all scenarios for all topologies.

关键词： SDN controller placement CPP latency VBO

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Role of prostate cancer stem-like cells in the development of antiandrogen resistance

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Cancer Drug Resistance 2022年第2期5卷 459-471页

作者： Prem Prakash Kushwaha Shiv Verma shashank kumar Sanjay Gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA. The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA. Molecular Signaling and Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India. Department of Pathology Case Western Reserve UniversityClevelandOH 44106USA. Department of Pharmacology Case Western Reserve UniversityClevelandOH 44106USA. Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA. Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA.

Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate *** with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer(CRPC).Present research establishes that prostate cancer stem-like cells(CSCs)play a central role in the development of treatment resistance followed by disease *** CSCs are capable of self-renewal,differentiation,and regenerating tumor *** stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants,epigenetic and genetic modifications leading to alteration in the tumor microenvironment,changes in ATP-binding cassette(ABC)transporters,and adaptations in molecular signaling *** reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1(ALDH1A1),Prominin 1(PROM1/CD133),Indian blood group(CD44),SRY-Box Transcription Factor 2(Sox2),POU Class 5 Homeobox 1(POU5F1/Oct4),Nanog and ABC *** markers indicate enhanced self-renewal and stemness stimulating CRPC evolution,metastatic colonization,and resistance to *** this review,we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC,their isolation,identification and characterization,as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities.

关键词： Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy

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Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise

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World Journal of Hepatology 2023年第1期15卷 1-18页

作者： Amit kumar Singh Shiv Vardan Singh Ramesh kumar shashank kumar Sabyasachi Senapati Abhay K Pandey Department of Botany Government Naveen Girls CollegeBalod(Hemchand Yadav University)DurgChattisgarhIndia Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia Department of Biochemistry School of Basic and Applied SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia

Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after *** carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver *** for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime *** advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic *** and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline *** metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC *** has also been implicated in liver ***-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer *** review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关键词： Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products Chemopreventive

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Security Attacks in Named Data Networking: A Review and Research Directions

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Journal of Computer Science & Technology 2019年第6期34卷 1319-1350页

作者： Naveen kumar Ashutosh kumar Singh Abdul Aleem shashank Srivastava Department of Computer Science and Engineering Motilal Nehru National Institute of Technology Allahabad Prayagraj 211004India

Contents such as audios,videos,and images,contribute most of the Internet traffic in the current *** content sharing is a tedious *** existing security solutions do not secure data but secure the communicating *** data networking(NDN)secures the data by enforcing the data publisher to sign the *** user can verify the data by using the public key of the *** is resilient to most of the probable security attacks in the TCP/IP model due to its new ***,new types of attacks are possible in *** article surveys the most significant security attacks in NDN such as interest flooding attacks,cache privacy attacks,cache pollution attacks,and content poisoning *** attack is classified according to their behavior and discussed for their detection techniques,countermeasures,and the affected *** article is an attempt to help new researchers in this area to gather the domain knowledge of *** article also provides open research issues that could be addressed by researchers.

关键词： named data networking(NDN) interest flooding attack cache privacy attack cache pollution attack content poisoning attack

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Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 20-32页

作者： Prem Prakash Kushwaha Santosh kumar maurya Amit Singh kumari Sunita Prajapati Atul kumar Singh Mohd Shuaib shashank kumar Molecular Signaling&Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India Department of Computational Sciences Central University of PunjabBathinda 151401India.

Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(***)***:Several previous studies and databases were used to retrieve the ligands and target protein *** molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics ***:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter *** score analysis revealed that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead ***:The in-silico study demonstrated that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings.

关键词： Cancer drug resistance ABC-transporter natural inhibitors Bulbine frutescens MM-GBSA

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An assessment of oil spill detection using Sentinel 1 SAR-C images

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Journal of Ocean Engineering and Science 2020年第2期5卷 116-135页

作者： Sudhir kumar Chaturvedi Saikat Banerjee shashank Lele Department of Aerospace Engineering University of Petroleum and Energy StudiesDehradun 248007India Wingbotics Kolkata 700086West BengalIndia Metric Global Pune 411036India

Identification of an oil spill is additionally essential to evaluate the potential spread and float from the source to the adjacent coastal *** such manner,usage of Synthetic Aperture RADAR(SAR)information for the recognition and checking of oil spills has gotten extensive consideration as of late,because of their wide zone inclusion,day-night and all-weather *** present examination studies an oil spill occurred in the Al Khafji region by applying Sentinel 1 SAR-C *** Khafji is on the borderline between Saudi Arabia and Kuwait in the Persian Gulf and it is detected as an unbiased *** Khafji region can possibly deliver in excess of 7472.403 m³barrels of oil for every day(m³/d).Approaches dependent on multi-sensor satellite images examination have been produced for distinguishing oil spills from referred to common leaks just as oil slick *** this paper,one of these techniques is associated with Sentinel 1 images of a known region of natural oil leakage and of an ongoing oil slick incident in Al Khafji *** Synthetic Aperture Radar(SAR)is perceived as the most significant remote sensing apparatus for the ocean and ocean waters oil slick examination,recording,documentation and ***,this paper examines oil spills recognition in the Persian Gulf surveyed by utilizing Sentinel-1(SAR-C)*** demonstrated the significance of the VV polarization of the Sentinel-1 for recognizing oil-spills just as the diminished utility of the VH polarization in this sole circumstance.

关键词： Sentinel-1 Oil-spill SAR Ocean Poll Polarimetry Phase Speckle filter Ocean mask Surface Scattering Sigma

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An Improved Methodology to Overcome Key Issues in Human Fecal Metagenomic DNA Extraction

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Genomics, Proteomics & Bioinformatics 2016年第6期14卷 371-378页

作者： Jitendra kumar Manoj kumar shashank Gupta Vasim Ahmed Manu Bhambi Rajesh Pandey Nat Singh Chauhan Department of Biochemistry Maharshi Dayanand UniversityRohtak 124001India Ayurgenomics Unit Translational Research and Innovative Science Through AyurgeomicsCouncil of Scientific and Industrial ResearchInstitute of Genomics and Integrative BiologyNew Delhi 110020India

Microbes are ubiquitously distributed in nature, and recent culture-independent studies have highlighted the significance of gut microbiota in human health and disease. Fecal DNA is the primary source for the majority of human gut microbiome studies. However, further improvement is needed to obtain fecal metagenomic DNA with sufficient amount and good quality but low host genomic DNA contamination. In the current study, we demonstrate a quick, robust, unbiased, and cost-effective method for the isolation of high molecular weight （〉 23 kb） metagenomic DNA （260/280 ratio 〉 1.8） with a good yield （55.8 ± 3.8 ng/mg of feces）. We also confirm that there is very low human genomic DNA contamination （eubacterial： human genomic DNA marker genes = 227.9：1） in the human feces. The newly-developed method robustly performs for fresh as well as stored fecal samples as demonstrated by 16S rRNA gene sequencing using 454 FLX＋. Moreover, 16S rRNA gene analysis indicated that compared to other DNA extraction methods tested, the fecal metagenomic DNA isolated with current methodology retains species richness and does not show microbial diversity biases, which is further confirmed by qPCR with a known quantity of spike-in genomes. Overall, our data highlight a protocol with a balance between quality, amount, user-friendliness, and cost effectiveness for its suitability toward usage for cultureindependent analysis of the human gut microbiome, which provides a robust solution to overcome key issues associated with fecal metagenomic DNA isolation in human gut microbiome studies.

关键词： Metagenomic DNAextraction Gut microbiome Human feces 16S rRNA

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Emerging targets in cancer drug resistance

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Cancer Drug Resistance 2019年第2期2卷 161-177页

作者： shashank kumar Prem Prakash Kushwaha Sanjay Gupta School of Basic and Applied Sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Urology Case Western Reserve UniversityClevelandOhio 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOhio 44106USA Department of Nutrition Case Western Reserve UniversityClevelandOhio 44106USA Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOhio 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOhio 44106USA.

Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer *** cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and *** the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic *** review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.

关键词： Drug resistance transforming growth factor-β Keap1-Nrf2 PI3K-Akt FOXO transcription factors focal adhesion kinases annexins MIEN1 gene splicing sphingolipids microRNA

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