检索结果-南通市图书馆

Development of Machine Learning Methods for Accurate Prediction of Plant Disease Resistance

Engineering 2024年第9期40卷 100-110页

作者： Qi Liu Shi-min Zuo shasha peng Hao Zhang Ye peng Wei Li Yehui Xiong Runmao Lin Zhiming Feng Huihui Li Jun Yang Guo-Liang Wang Houxiang Kang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Zhongshan Biological Breeding Laboratory&Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization and College of Agronomy Hunan Agricultural UniversityChangsha 410128China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Plant Protection Hunan Agricultural UniversityChangsha 410128China Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests Ministry of Education College of Plant ProtectionHainan UniversityHaikou 570228China MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests Department of Plant BiosecurityCollege of Plant ProtectionChina Agricultural UniversityBeijing 100193China Department of Plant Pathology Ohio State UniversityColumbusOH 43210USA

The traditional method of screening plants for disease resistance phenotype is both time-consuming and *** selection offers a potential solution to improve efficiency,but accurately predicting plant disease resistance remains a *** this study,we evaluated eight different machine learning(ML)methods,including random forest classification(RFC),support vector classifier(SVC),light gradient boosting machine(lightGBM),random forest classification plus kinship(RFC_K),support vector classification plus kinship(SVC_K),light gradient boosting machine plus kinship(lightGBM_K),deep neural network genomic prediction(DNNGP),and densely connected convolutional networks(DenseNet),for predicting plant disease *** results demonstrate that the three plus kinship(K)methods developed in this study achieved high prediction ***,these methods achieved accuracies of up to 95%for rice blast(RB),85%for rice black-streaked dwarf virus(RBSDV),and 85%for rice sheath blight(RSB)when trained and applied to the rice diversity panel I(RDPI).Furthermore,the plus K models performed well in predicting wheat blast(WB)and wheat stripe rust(WSR)diseases,with mean accuracies of up to 90%and 93%,*** assess the generalizability of our models,we applied the trained plus K methods to predict RB disease resistance in an independent population,rice diversity panel II(RDPII).Concurrently,we evaluated the RB resistance of RDPII cultivars using spray *** the predictions with the spray inoculation results,we found that the accuracy of the plus K methods reached 91%.These findings highlight the effectiveness of the plus K methods(RFC_K,SVC_K,and lightGBM_K)in accurately predicting plant disease resistance for RB,RBSDV,RSB,WB,and *** methods developed in this study not only provide valuable strategies for predicting disease resistance,but also pave the way for using machine learning to streamline genome-based crop breeding.

关键词： Predicting plant disease resistance Genomic selection Machine learning Genome-wide association study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纯钛支架和Vitallium 2000铸造支架义齿在牙列缺损修复中的临床应用效果比较

引用

中国美容医学 2024年第3期33卷 144-146,166页

作者：彭莎莎周翔江苏省盐城市第一人民医院口腔科江苏盐城224006 江苏省盐城市口腔医院种植科江苏盐城224005

目的:比较纯钛支架义齿和Vitallium 2000铸造支架义齿修复牙列缺损的疗效及对患者义齿性口炎发生率的影响。方法:选择2017年1月-2019年11月笔者医院收治的牙列缺损患者116例,根据支架材料不同分为纯钛组和Vitallium组,每组58例。修复2年... 详细信息

目的:比较纯钛支架义齿和Vitallium 2000铸造支架义齿修复牙列缺损的疗效及对患者义齿性口炎发生率的影响。方法:选择2017年1月-2019年11月笔者医院收治的牙列缺损患者116例,根据支架材料不同分为纯钛组和Vitallium组,每组58例。修复2年后,比较两组患者总体疗效、基托菌斑分布、基托菌斑指数情况、基托真菌培养结果、义齿性口炎发生情况及治疗满意度。结果:Vitallium组咀嚼效率、就位率高于纯钛组(P0.05),而纯钛组基托菌斑指数高于Vitallium组(P<0.05);纯钛组白色念珠菌、热带念珠菌、褶皱念珠菌、光滑念珠菌菌落数量高于Vitallium组(P<0.05);纯钛组义齿性口炎总发生率、平均发生频率高于Vitallium组(P<0.05);纯钛组治疗总满意度低于Vitallium组(P<0.05)。结论:Vitallium 2000作为牙列缺损患者可拆除局部支架材料总体疗效高,较纯钛材料更能降低口腔细菌感染和义齿性口炎的发生,患者满意度更高。

关键词：牙列缺损义齿性口炎纯钛材料 Vitallium 2000材料菌斑指数义齿修复

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

不同介入方案联合信迪利单抗及仑伐替尼治疗中晚期肝癌的临床疗效

引用

国际外科学杂志 2024年第4期51卷 253-259页

作者：张翔宇彭沙沙黄石市中心医院介入科黄石435000 黄石市中心医院肝胆胰腺外科黄石435000

目的探讨不同介入方案联合信迪利单抗及仑伐替尼治疗中晚期肝癌的临床疗效。方法采用回顾性病例对照的研究方法, 分析黄石市中心医院2020年1月-2023年1月收治的72例中晚期肝癌患者, 按照治疗方案不同分为经导管动脉化疗栓塞(TACE)组和... 详细信息

目的探讨不同介入方案联合信迪利单抗及仑伐替尼治疗中晚期肝癌的临床疗效。方法采用回顾性病例对照的研究方法, 分析黄石市中心医院2020年1月-2023年1月收治的72例中晚期肝癌患者, 按照治疗方案不同分为经导管动脉化疗栓塞(TACE)组和肝动脉灌注化疗(HAIC)组, 每组各36例, 其中TACE组采用TACE+信迪利单抗+仑伐替尼治疗, HAIC组采用HAIC+信迪利单抗+仑伐替尼治疗, 比较两组患者临床疗效, 肝功能[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素]、肿瘤标志物[血清甲胎蛋白、癌胚抗原、糖类抗原199(CA199)]及药物安全性, 治疗后采用电话或门诊随访, 统计两组患者疾病进展率、死亡率, 随访至患者病情进展或截止到2024年3月1日。正态分布的计量资料以均数±标准差(±s)表示, 组间比较采用t检验;计数资料组间比较采用χ^(2)检验。结果 TACE组客观缓解率为27.78%, HAIC组的为52.78%, HAIC组的客观缓解率更高, 两组相比差异有统计学意义(P0.05);治疗后, TACE组的AST、ALT、总胆红素分别为(36.65±4.80) U/L、(55.40±5.90) U/L、(19.65±2.25) μmol/L, HAIC组分别为(25.95±4.92) U/L、(41.15±6.15) U/L、(14.40±2.13) μmol/L, HAIC组各指标水平更低, 两组相比差异有统计学意义(P0.05);治疗后, TACE组的甲胎蛋白、癌胚抗原、CA199分别为(152.50±20.10) ng/mL、(3.93±1.42) ng/mL、(20.35±3.50) IU/mL, HAIC组分别为(102.35±18.10) ng/mL、(2.85±1.26) ng/mL、(21.48±3.31) IU/mL, HAIC组的甲胎蛋白及癌胚抗原水平降低更明显(P0.05)。对患者进行随访, 所有患者均完成治疗, TACE组患者4例病情进展, 1例死亡病例, 不良预后发生率为13.89%, HAIC组1例病情进展, 无死亡病例, 不良预后发生率为2.78%, 两组比较差异无统计学意义(P=0.088)。结论对于中晚期肝癌患者, 与TACE+信迪利单抗+仑伐替尼方案较, HAIC+信迪利单抗+仑伐替尼治疗的效果更好, 更能改善患者的肝功能、肿瘤标志物水平。

关键词：肝肿瘤抗肿瘤联合化疗方案治疗结果肝动脉灌注化疗信迪利单抗仑伐替尼

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chronological Link Between the Abrupt Change of the Loess Grain Size Sequence and the Formation of River Terraces on the Eastern Margin of the Qinghai-Tibetan Plateau Since the Late Early-Pleistocene

引用

Acta Geologica Sinica(English Edition) 2011年第3期85卷 723-732页

作者： LIU Dongyan QIAO Yansong LI Weiran XIE Ruihuang peng shasha College of Marine Geoscience Ocean University of China Qingdao 266100 China Key Laboratory of Submarine Science and Prospecting Techniques Ministry of Education Qingdao 266100 China Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China College of Physical andEnvironmental Oceanography Ocean University of China Qingdao 266100 China Department of Meteorology University of Hawaii at Manoa Honolulu 96822 USA

Based on the study of magnetostratigraphy,magnetic susceptibility and grain size of Garze A section on the southeastern margin of the Qinghai-Tibetan Plateau since the late early-Pleistocene,the basal age of Garze loess is located at～1.16 MaBP and a series of abrupt paleoclimatic changes is *** times of abrupt changes are of distinct series features,and the interval between each two adjacent abrupt changes is～50 kyr or～100 *** most significant abrupt changes occur at around 1.06,0.85,0.6,0.46,0.39 and 0.14 *** is a chronological link between the abrupt changes of paleoclimate and the formation of river terraces and it is almost simultaneous with a strengthening trend of neotectonic ***,maybe the climatic transition controll the timing of terrace formation,and the tectonic uplift originate potential energy and has a direct effect on channel incision, both the climatic transition and the tectonic uplift are *** are the products of the interaction of instable climatic variations and tectonic *** the loess-paleosol sequences,river terrace sequences are also controlled by the climate-tectonic coupling system and are ruled by climate-tectonic gyration with a～100 kyr paracycle,which may be the short eccentricity period of the earth.

关键词： Garze loess grain size terrace tectonic uplift the Qinghai-Tibetan Plateau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肝细胞癌根治术后辅助性经导管动脉化疗栓塞术治疗的研究进展

引用

国际外科学杂志 2024年第8期51卷 560-565页

作者：周佳辉程镉镉彭沙沙武汉科技大学医学部医学院武汉430000 黄石市中心医院湖北理工学院附属医院肝胆胰腺外科黄石435000

肝细胞癌是全世界最常见的消化道恶性肿瘤之一,其恶性程度高、侵袭性极强、术后复发率高、术后总生存率低。经导管动脉化疗栓塞术(TACE)是目前公认的最常用的肝癌局部治疗方法之一,对于具有高复发风险(如肿瘤的最大径>5cm、术前甲胎蛋... 详细信息

肝细胞癌是全世界最常见的消化道恶性肿瘤之一,其恶性程度高、侵袭性极强、术后复发率高、术后总生存率低。经导管动脉化疗栓塞术(TACE)是目前公认的最常用的肝癌局部治疗方法之一,对于具有高复发风险(如肿瘤的最大径>5cm、术前甲胎蛋白高水平、大血管侵犯、伴微血管侵犯等)的肝癌根治性切除术后患者,术后辅助性经导管动脉化疗栓塞术(PA-TACE)可以为其预后带来获益。同时,PA-TACE联合其他如抗病毒、分子靶向、免疫、消融放射以及中药治疗等已经显示出较好的疗效。本文就肝细胞癌根治术后以PA-TACE为主的研究进展进行综述.

关键词：癌,肝细胞复发抗肿瘤联合化疗方案经导管动脉化疗栓塞术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance

引用

Acta Geologica Sinica(English Edition) 2015年第1期89卷 316-317页

作者： QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu peng shasha GE Junyi Institute of Geomechanics Chinese Academy of Geological Sciences Key Laboratory of Neotectonic Movement & Geohazard School of Earth Sciences and Resources China University of Geosciences Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences

The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau （TP） are very useful in neotectonic and paleoclimatic studies. Firstly, the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon, and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon. Secondly, the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.

关键词： In Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intensification of the East Asian Monsoon in Southern China at about300-400 kaBP Inferred from Eolian Deposits in the Middle-lower Reaches of the Yangtze River

引用

Acta Geologica Sinica(English Edition) 2017年第3期91卷 1095-1108页

作者： QI Lin QIAO Yansong LI Yuehui WANG Yan peng shasha HE Zexin YANG Shuaibin HAN Chao ZHANG Xujiao School of Earth Sciences and Resources China University of Geosciences Institute of Geomechanics Chinese Academy of Geological Sciences Key Laboratory of Neotectonic Movement & Geohazard

In the East Asian monsoon region, eolian deposits widely distributed in the middle-lower reaches of the Yantgze River are among the best materials available for studies on Quaternary climate change in the subtropical zone of Southern China. Typical eolian deposits in this region include upper Xiashu Loess （XL） and underlying Vermiculated Red Soil （VRS） layers. In this paper, chronological and paleoclimatic studies are conducted on an eolian deposit sequence near Jiujiang （J J） city in northern Jiangxi province. A magnetostratigraphic study, combined with optically stimulated luminescence （OSL） dating, is conducted on the JJ section and provides further evidence that eolian deposits in the middle-lower reaches of the Yangtze River have been formed since the late Early Pleistocene, and that the boundary age between the XL and VRS layers is about 300-400 kaBP. In grain-size records of the JJ section, the median grain-size and content of the 〉30μn size fraction increase sharply after 300-400 kaBP, representing an East Asian winter monsoon intensification event. Further pollen analysis reveals differing pollen assemblages before and after 300-400 kaBP： there is an evident increase in plants adapted to grow in a warm humid environment after 300-400 kaBP, implying an increase in precipitation caused by intensification of the East Asian summer monsoon. Global ice volume and uplift of the Tibet Plateau （TP） are regarded as crucial factors influencing variations of the East Asian monsoon on a long-term scale. The deep-sea JlSO record, which reflects variations in global ice volume, shows no obvious change after 300-400 kaBP. Moreover, the influence of global ice volume changes on the East Asian summer and winter monsoons is inverse; the global ice volume increase （decrease） implies a strengthened （weakened） winter monsoon and weakened （strengthened） summer monsoon. We therefore interpret the coupled intensifications of the East Asian summer and winter monsoons at about 300-40

关键词： Middle-lower Yangtze River eolian deposit magnetostratigraphy grain-size pollen EastAsian monsoon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HSV-1即刻早期基因的5′UTR对报告基因mRNA翻译的影响

引用

云南大学学报（自然科学版） 2024年第5期46卷 980-992页

作者：徐朗希李丹丹李恒郑惠文彭沙沙张莹于丽廖芸刘龙丁李琦涵中国医学科学院北京协和医学院医学生物学研究所云南昆明650118 昆明医科大学云南昆明650500

mRNA疫苗的5′非翻译区(5’untranslated regions,5′UTR)对其表达起着重要作用,报告基因增强绿色荧光蛋白基因(enhanced green fluorescent protein,EGFP)用于检测5′UTR调控mRNA表达已经是一个较为成熟的实验方法.为研究单纯疱疹病毒1... 详细信息

mRNA疫苗的5′非翻译区(5’untranslated regions,5′UTR)对其表达起着重要作用,报告基因增强绿色荧光蛋白基因(enhanced green fluorescent protein,EGFP)用于检测5′UTR调控mRNA表达已经是一个较为成熟的实验方法.为研究单纯疱疹病毒1型(herpes simplex virus 1,HSV-1)即刻早期基因的5′UTR作为报告基因EGFP mRNA的5′UTR对其翻译的影响,本研究将4个即刻早期基因的5’UTR以及表达能力较强的人β珠蛋白基因(humanβGlobin,hBg)5′UTR插入报告基因EGFP 5’端,通过观察绿色荧光强度研究不同即刻早期基因5′UTR对mRNA翻译的影响.结果表明:经mRNA转染试剂和纳米脂质体颗粒分别递送进293T细胞和小鼠体内;RL2的5′UTR作为报告基因EGFP 5′UTR的表达水平与hBg 5′UTR相近,RS1、US1、US12表达水平明显弱于hBg 5′UTR.因此,RL2基因的5′UTR有潜力作为mRNA疫苗的5′UTR.

关键词：单纯疱疹病毒1型 5′UTR mRNA 蛋白表达水平

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

引用

Chinese Chemical Letters 2024年第7期35卷 360-366页

作者： Jingting Wang Yuanyuan Chen Linlin Han shasha Xia Xingyao Zhang peng Xue Yuejun Kang Jian Ming Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China College of Food Science Southwest UniversityChongqing 400715China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side ***(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory ***,it faces problems such as poor water solubility,photothermal instability,and low ***,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant *** vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of *** work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.

关键词： Oral administration Astaxanthin Nanocarrier Anti-oxidant activity Colon targeting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Edge Device Fault Probability Based Intelligent Calculations for Fault Probability of Smart Systems

引用

Tsinghua Science and Technology 2024年第4期29卷 1023-1036页

作者： shasha Li Tiejun Cui Wattana Viriyasitavat School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang 110159China Chulalongkorn Business School Faculty of Commerce and AccountancyChulalongkorn UniversityBangkok 10900Thailand

In a smart system, the faults of edge devices directly impact the system’s overall fault. Further, complexity arises when different edge devices provide varying fault data. To study the Smart System Fault Evolution Process (SSFEP) under different fault data conditions, an intelligent method for determining the Smart System Fault Probability (SSFP) is proposed. The data types provided by edge devices include the following: (1) only known edge device fault probability;(2) known Edge Device Fault Probability Distribution (EDFPD);(3) known edge device fault number and EDFPD;(4) known factor state of the edge device fault and EDFPD. Moreover, decision methods are proposed for each data case. Transfer Probability (TP) is divided into Continuity Transfer Probability (CTP) and Filterability Transfer Probability (FTP). CTP asserts that a Cause Event (CE) must lead to a Result Event (RE), while FTP requires CF probability to exceed a threshold before RF occurs. These probabilities are used to calculate SSFP. This paper introduces a decision method using the information diffusion principle for low-data SSFP determination, along with an improved method. The method is based on space fault network theory, abstracting SSFEP into a System Fault Evolution Process (SFEP) for research purposes.

关键词： smart systems intelligent science edge device fault probability decision method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：