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Prevalence of viral HBV and HCV among different group patients in Gujrat Pakistan

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Advances in Bioscience and Biotechnology 2012年第4期3卷 423-436页

作者： Muhammad Irshad Muhammad Naem Raza Zahid Anwar Nadia Ikram Amber afroz Hafiz Muhammad Nasir Iqbal Department of Biochemistry and Molecular Biology University of Gujrat Pakistan Department of Biochemistry NSMC University of Gujrat Pakistan Department of Chemistry and Biochemistry University of Agriculture Faisalabad Pakistan

In this study we analyzed blood samples collected from 400 high risk patients for the prevalence of an inflammatory viral disease hepatitis B virus (HBV) and hepatitis C virus (HCV) with the help of standard kit assay and Enzyme-linked immunosorbent assay (ELISA). All the samples were selected randomly from the various places of District Gujrat, Pakistan. All the selected cases were first divided into four groups according to the age and sex (Group 1, Male below age 35 years;Group 2, Male above age 35 years;Group 3, Female below age 35 years;Group 4, Female above age 35 years), each group was comprised of 100 individual patients and analyzed for different parameters for the presence of HBV and HCV in comparison with positive and negative controls. The prevalence of HBV and HCV was higher in groups 2 (22%) and 4 (39%) respectively. Assay profile revealed that the incidence of HCV was higher in female patients as compare to the male patients. The present study indicates that more than 60% of the cirrhosis and hepatocellular carcinoma in the Region is attributable to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

关键词： HBV HCV Liver Inflammation LFTs ELISA ALP Bilirubin

Estimation of HCV viral load and liver enzymes among different patients groups of District Gujrat, Pakistan

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Advances in Bioscience and Biotechnology 2013年第9期4卷 866-871页

作者： Asim Mushtaq Mujahid Azeem Tariq Umer Rashid Amber afroz Nadia Zeeshan Abdul R. Asif Muzna Zahur Department of Biochemistry and Molecular Biology University of Gujrat Gujrat Pakistan Department of Clinical Chemistry University Medical Centre Goettingen Germany Department of Pathology Hashmat Medical College Gujrat Pakistan

Hepatitis C has a 3% of the global disease burden that remains endemic in many regions of the world. According to a general statistical survey it has approximately 5.3% seroprevalence in Pakistan. HCV is a persistent and silent disease thus making the primary diagnosis complicated. Occasionally HCV positive population could not be diagnosed by routine HCV antibody testing therefore requires molecular diagnosis. This study is aimed to determine the prevalence of HCV and to estimate the HCV viral load by quantitative analysis among different patient groups of District Gujrat, Pakistan. A total of 597 samples were collected from clinically diagnosed liver patients that were categorized into three age groups: 1) up to 25 years;2) 26-50 years 3) above 50 years. All samples were subjected to real time PCR for determination and quantification of HCV RNA. Activity of liver aminotransferases was measured. The overall prevalence of HCV-RNA was 73.87%. Females had slightly higher HCV prevalence which is 74.06% while 73.45% in males. Highest prevalence of active HCV infection was found in age group 26-50. In addition, liver function tests showed that 28.12% HCV-positive patients do not have elevated ALT level whereas 32.65% did not show elevated AST levels. It may be assumed that there is not a significant relationship between increased viral load and liver amino transferases. The study concluded a significantly higher rate of HCV infection in young population. Moreover screening with antibody and liver function tests alone does not exclude the possibility of HCV infection.

关键词： Hepatitis C Viral Load Alanine Aminotransferase Aspartate Aminotransferase HCV RNA Gujrat

Isolated Endophytic Fungi from the Plant <i>Curcuma longa</i>and Their Potential Bioactivity—A Review

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Pharmacology & Pharmacy 2019年第5期10卷 244-270页

作者： Kazi Jannatul Ferdous Farhana afroz Md. Rakibul Islam Md. Abdul Mazid Md. Hossain Sohrab Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Pharmaceutical Sciences Research Division Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh Department of Pharmaceutical Chemistry University of Dhaka Dhaka Bangladesh

Endophytes (both fungi and bacteria) represent a treasure house for bioactive compounds such as anticancer, immunomodulatory, antioxidant, antiparasitic, insecticidal etc. for use in the pharmaceutical and agrochemical industries. Endophytic population is greatly influenced by climatic conditions and location where the host plant grows. Curcuma longa L. (Turmeric) is a medicinal plant belonging to the Zingiberaceae family that is usually used as spice and preservative. Traditionally it is used to treat various conditions and symptoms such as digestive disorders, arthritis, cardiovascular conditions, cancer, bacterial infections etc. In recent times, there have been different discoveries on endophytic fungi and their biological activity from C. longa. But there is no comprehensive review on endophytic fungi of C. longa. The aim of this review is to analyze the published report based on the endophytic fungi to provide for the first time an updated information about their isolation from different tissues, their biological activities including the phytochemistry of C. longa. This will lead the way to forecast the missing link for future research work.

关键词： Curcuma longa Endophytes Compounds Bioactivity

玫瑰茄花萼乙醇提取物的抗痛觉敏感、抗炎及止泻作用的实验研究(英文)

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中西医结合学报 2011年第6期9卷 626-631页

作者： Md.Khadem Ali Ayesha Ashraf Nripendra Nath Biswas Utpal Kumar Karmakar Shamima afroz Biotechnology and Genetic Engineering Discipline Life Science SchoolKhulna UniversityKhulna-9208Bangladesh Pharmacy Discipline Life Science SchoolKhulna UniversityKhulna-9208Bangladesh

目的:研究玫瑰茄(Hibiscus sabdariffa)花萼的乙醇提取物的抗痛觉敏感、抗炎及止泻作用。方法:使用95%乙醇提取玫瑰茄花萼干品用于测定其功效。用小鼠扭体实验检测其抗痛觉敏感作用,二甲苯致耳水肿模型小鼠检测其抗炎症作用,蓖麻油致腹... 详细信息

目的:研究玫瑰茄(Hibiscus sabdariffa)花萼的乙醇提取物的抗痛觉敏感、抗炎及止泻作用。方法:使用95%乙醇提取玫瑰茄花萼干品用于测定其功效。用小鼠扭体实验检测其抗痛觉敏感作用,二甲苯致耳水肿模型小鼠检测其抗炎症作用,蓖麻油致腹泻模型小鼠检测其止泻作用。结果:在乙酸致小鼠扭体实验中,玫瑰茄花萼的乙醇提取物对小鼠扭体的抑制与空白对照组相比差异有统计学意义(P<0.01),对二甲苯致耳水肿模型小鼠的耳水肿的抑制与空白对照组相比差异有统计学意义(P<0.01),且显著减少了蓖麻油致腹泻小鼠的排便次数并增加了排便间隔时间(P<0.01)。结论:本研究的结果证实了玫瑰茄花萼的乙醇提取物具有显著的抗痛觉敏感、抗炎及止泻作用,验证了其在传统医学中的应用。

关键词：木槿属植物提取物镇痛药抗炎剂止泻药小鼠

Advances in lignocellulosic biotechnology: A brief review on lignocellulosic biomass and cellulases

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Advances in Bioscience and Biotechnology 2014年第3期5卷 246-251页

作者： Tanzila Shahzadi Sajid Mehmood Muhammad Irshad Zahid Anwar Amber afroz Nadia Zeeshan Umer Rashid Kalsoom Sughra Department of Biochemistry and Molecular Biology University of Gujrat Gujrat Pakistan Department of Biochemistry Nawaz Sharif Medical College University of Gujrat Gujrat Pakistan

From the last few decades, there has been an increasing research interest in the value of lignocellulosic biomass. Lignoellulosic biomass is an inexpensive, renewable abundant and provides a unique natural resource for large-scale and cost-effective bio-energy collection. In addition, using lignocellulosic materials and other low-cost biomass can significantly reduce the cost of materials used for ethanol production. Therefore, in this background, the rapidly evolving tools of biotechnology can lower the conversion costs and also enhance a yield of target products. In this context, a biological processing presents a promising approach to converting lignocellulosic materials into energy-fuels. The present summarized review work begins with an overview on the physio-chemical features and composition of major agricultural biomass. The information is also given on the processing of agricultural biomass to produce industrially important enzymes, e.g., ligninases or cellulases. Cellulases provide a key opportunity for achieving tremendous benefits of biomass utilization.

关键词： Lignicellulosic Biomass Eco-Friendly Bio-Ethanol Industrial Enzyme

Phytochemical screening, antibacterial and anthelmintic activities of leaf and seed extracts of Coix lacryma-jobi L.

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Journal of Coastal Life Medicine 2017年第8期5卷 360-364页

作者： Sajan Das Rumana Akhter Sumana Khandaker Sumaiya Huque Promit Das Md.Rafi Anwar Kaniz afroz Tanni Samia Shabnaz Mohammad Shahriar Phytochemistry Research Laboratory Department of PharmacyUniversity of Asia PacificDhaka-1215Bangladesh

Objective: To evaluate the possible phytochemical constituents, antibacterial and anthelmintic activity of Coix lacryma-jobi L. (Job's tears) using the chloroform leaves and seed extracts. Methods: The test for antibacterial activity and minimum inhibitory concentration was conducted by the disc diffusion and two-fold dilution method, respectively. In anthelmintic activity test, using Pheretima posthuma model, vermifuge and vermicidal activity were determined by using the chloroform extract at various concentrations. Results: The preliminary phytochemical screening of chloroform extracts of Job's tears leaves indicated the presence of alkaloid, carbohydrate, saponin, glycosides, flavonoids, phenols, tannins and steroids whereas the seeds extract contained glycosides, flavonoids, phenols and steroids, which revealed highest antimicrobial activity against Bacillus cereus and Klebsiella pneumoniae. The lowest minimum inhibitory concentration (12.5–50 mg/mL) was observed against all selected bacteria. On the other hand, it has been observed that chloroform leaves extracts showed shortest time of paralysis (P = 8.17 min) and death (D = 18.23 min) at 100 mg/mL concentration, in comparison with seed extracts (P = 36.83 min and D = 62.33 min) at 100 mg/mL concentration and albendazole (10 mg/mL) used as reference drug (P = 20.17 min and D = 43.67 min), which indicated the plant possessed mild anthelmintic activity. Conclusions: The chloroform extracts (leaves and seeds) showed efficacy for both bacterial infections and parasitic diseases, which ensure the traditional uses of Coix lacryma-jobi L.

关键词： Coix lacryma-jobi L. Phytochemical screening Antibacterial activity Anthelmintic activity

ABO Blood Groups and Their Relationship with Coagulation Factor VIII in Healthy Adults

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Journal of Biosciences and Medicines 2021年第9期9卷 49-58页

作者： Afrina Binte Azad Qazi Shamima Akhter Mohammad Aminul Islam Farzana Yeasmin Mukta Lily afroz Khushbun Nahar Layla Tahmina Akter Shamanta Islam A. Z. M. Adnan National Institute of Traumatology and Orthopaedics Rehabilitation Dhaka Bangladesh Department of Physiology Dhaka Medical College and Hospital Dhaka Bangladesh Department of Orthopaedics National Institute of Traumatology and Orthopaedics Rehabilitation Dhaka Bangladesh Department of Cardiology Kurmitola General Hospital Dhaka Bangladesh Department of Physiology Mymensingh Medical College and Hospital Mymensingh Bangladesh Department of Physiology Ibrahim Medical College and Hospital Dhaka Bangladesh Bhairab Upazila Health Complex Kishoreganj Bangladesh Department of Nephrology Chattogram Medical College and Hospital Chattogram Bangladesh

Background: ABO blood group distribution defers with racial and geographic variations. They are related to diseases like cardiovascular diseases, cerebral thromboembolism. ABO blood group system may influence coagulation factor VIII which may increase the future risk of thrombosis. Aim: To assess the relation of ABO blood group with coagulation factor VIII in healthy adults. Material and Methods: A prospective type of analytical cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2019 to June 2020. After obtaining ethical clearance, a total of 190 healthy adults were selected from different areas of Dhaka city based on inclusion and exclusion criteria, with ages ranging from 18 - 45 years. The subjects were interviewed and detailed history regarding personal, family, medical and drug were taken. Prior to sample collection, informed written consent was taken from the participants. Individuals of blood group A were selected as group A, blood group B as group B, blood group AB as group AB and blood group O as group O. Coagulation factor VIII was measured in the Department of Hematology and BMT Unit, Dhaka Medical College Hospital, Dhaka. Blood grouping was done in the Department of Physiology, Dhaka Medical College, Dhaka. Statistical Analysis: For statistical analysis, ONE way ANOVA followed by Bonferroni test were considered using SPSS 25.0 version. Results: In this study, blood group B was most common (33.2%). Coagulation factor VIII was significantly higher (p Conclusions: It can be concluded that blood group A, B, AB individuals may have more chance of thrombosis due to significan

关键词： ABO Blood Group Coagulation Factor VIII Healthy Adults